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| 1 | Characteristics of Volcanic Rocks in the Shoshonite Province, Eastern China, and Their Metallogenesis显示文摘The shoshonite province in eastern China is characterized by extensive distribution (ca. 80000 km2) of Late Jurassic-Early Cretaceous (165-100 Ma) shoshonite series with subordinate high-K calc-alkali series. It was formed in a dominantly tensile stress field. In comparison with their analogues in island arcs and active continental margins in other countries, the volcanic rocks in the shoshonite province have their specific characteristics in petrology, mineralogy and geochemistry as well as related mineralization association, which are the comprehensive reflection of the special composition and structure of the mantle and crust of the province and the special Mesozoic regional tectonic setting. | Wang Dezi, Ren Qijiang, Qiu Jiansheng, Chen Kerong,Xu Zhaowen and Zeng Jiahu Department of Earth Sciences, Nanjing University, Nanjing, Jiangsu | 1996 | Acta Geologica Sinica(English Edition)1996，70，3： | 10 |
| 2 | Biodegradable Zn-Sr alloy for bone regeneration in rat femoral condyle defect model: In vitro and in vivo studies显示文摘Bone defects are commonly caused by severe trauma,malignant tumors,or congenital diseases and remain among the toughest clinical problems faced by orthopedic surgeons,especially when of critical size.Biodegradable zinc-based metals have recently gained popularity for their desirable biocompatibility,suitable degradation rate,and favorable osteogenesis-promoting properties.The biphasic activity of Sr promotes osteogenesis and inhibits osteoclastogenesis,which imparts Zn-Sr alloys with the ideal theoretical osteogenic properties.Herein,a biodegradable Zn-Sr binary alloy system was fabricated.The cytocompatibility and osteogenesis of the Zn-Sr alloys were significantly better than those of pure Zn in MC3T3-E1 cells.RNA-sequencing illustrated that the Zn-0.8Sr alloy promoted osteogenesis by activating the wnt/β-catenin,PI3K/Akt,and MAPK/Erk signaling pathways.Furthermore,rat femoral condyle defects were repaired using Zn-0.8Sr alloy scaffolds,with pure Ti as a control.The scaffold-bone integration and bone ingrowth confirmed the favorable in vivo repair properties of the Zn-Sr alloy,which was verified to offer satisfactory biosafety based on the hematoxylin-eosin(H&E)staining and ion concentration testing of important organs.The Zn-0.8Sr alloy was identified as an ideal bone repair material candidate,especially for application in critical-sized defects on load-bearing sites due to its favorable biocompatibility and osteogenic properties in vitro and in vivo. | Bo Jia Hongtao Yang Zechuan Zhang Xinhua Qu Xiufeng Jia Qiang Wu Yu Han Yufeng Zheng Kerong Dai | 2021 | Bioactive Materials2021，6，6： | 9 |
| 3 | Fabrication of kW-level chirped and tilted fiber Bragg gratings and filtering of stimulated Raman scattering in high-power CW oscillators显示文摘Suppression of stimulated Raman scattering(SRS)by means of chirped and tilted fiber Bragg gratings(CTFBGs)has become a key topic.However,research on high-power systems is still lacking due to two problems.Firstly,after the inscription,there are a large number of hydroxyl compounds and hydrogen molecules in CTFBGs that cause significant heating due to their strong infrared absorption.Secondly,CTFBGs can couple Stokes light from the core to the cladding and the coating,which causes serious heating in the coating of the CTFBG.Aimed at overcoming these bottlenecks,a process that combines constant-low-temperature and variable-high-temperature annealing is used to reduce the thermal slope of the CTFBG.Also,a segmented-corrosion cladding power stripping technology is used on the CTFBG to remove the Stokes light which is coupled to the cladding,which solves the problem of overheating in the coating of the CTFBG.Thereby,a CTFBG with both a kilowatt-level power-carrying load and the ability to suppress SRS in a fiber laser has been developed.Further,we establish a kW-level CW oscillator to test the CTFBG.Experimental results demonstrate that the power-carrying load of the CTFBG is close to 1 kW,the thermal slope is lower than 0.015 ℃/W,and the SRS suppression ratio is nearly 23 dB. | Kerong Jiao Jian Shu Hua Shen Zhiwen Guan Feiyan Yang Rihong Zhu | 2019 | High Power Laser Science and Engineering2019，7，2： | 9 |
| 4 | Serum zinc levels and multiple health outcomes: Implications for zinc-based biomaterials显示文摘Background:Zinc-based biomaterials,including biodegradable metal,nanoparticles,and coatings used in medical implants release zinc ions that may increase the whole-body and serum zinc concentrations.The impact of serum zinc concentrations on major health outcomes can provide insights for device design and clinical transformation of zinc-based biomaterials.Methods:This nationally representative cross-sectional study enrolled participants from the National Health and Nutrition Examination Survey(NHANES,2011-2014)including 3607 participants.Using unadjusted and multivariate-adjusted logistic regression analyses,two-piecewise linear regression model with a smoothing function and threshold level analysis,we evaluated the associations between elevated serum zinc levels and major health outcomes.Results:Elevated serum zinc levels were significantly associated with an increase in total spine and total femur bone mineral density(BMD).Every 10μg/dL increase was associated with a 1.12-fold increase in diabetes mellitus(DM)and 1.23-fold and 1.29-fold increase in cardiovascular diseases(CVD)and coronary heart disease(CHD),in participants with serum zinc levels≥100μg/dL.It had no significant linear or nonlinear associations with risk of fractures,congestive heart failure,heart attack,thyroid disease,arthritis,osteoarthritis,rheumatoid arthritis,dyslipidemia and cancer.Conclusion:Serum zinc levels are significantly associated with increased BMD in the total spine and total femur,and risk of DM,and CVD/CHD among participants with serum zinc levels≥100μg/dL. | Xinhua Qu Hongtao Yang Zhifeng Yu Bo Jia Han Qiao Yufeng Zheng Kerong Dai | 2020 | Bioactive Materials2020，5，2： | 7 |
| 5 | Regeneration dynamics of subalpine fir (Abies fargesii) forest across the altitudinal range in the Shennongjia Mountains, central China显示文摘Aims Age structure and regeneration dynamics have been used to infer population response to environmental events and reconstruct forest development history.The aim of this study was to characterize and examine the differences of the age structure and regeneration dynamics of subalpine fir(Abies fargesii)forest across the altitudinal range in the north and south aspects in the Shennongjia Mountains,central China.Methods Ten plots(20×20 m)at each altitudinal zone(i.e.the low elevation,the middle elevation and the high elevation)were established in both the north and south aspects of the Shennongjia Mountains,central China.Dendroecological techniques were applied to obtain information about ages of the trees in the plots.The population age structure was analyzed to investigate the regeneration dynamics across the altitudinal range.Important findings Fir regeneration dynamics and age structure were similar in both aspects,and a unimodal population age structure was found at different altitudinal sites of both aspects,indicating that environmental factors might play an important role in shaping the regeneration dynamics and age structure of A.fargesii across its altitudinal range.There was a sustained recruitment during the 19th century,but the regeneration was rarer in the last century at low and midelevations.A significant greater number of fir seedlings and saplings recruited at high elevations in the last century,and fir tree density at high elevations was significantly higher than that at low elevations.Thus,the fir population at the high elevations showed a significant increase in recruitment and stem density in the last century,and we propose that the gradual infilling of fir seedlings might result in changes in regeneration dynamics and stand structure of the subalpine fir forest at high elevations in the Shennongjia Mountains,central China. | Haishan Dang Kerong Zhang Yanjun Zhang Xunzhang Tong Quanfa Zhang | 2013 | Journal of Plant Ecology2013，6，1： | 6 |
| 6 | A 3D-Bioprinted dual growth factor-releasing intervertebral disc scaffold induces nucleus pulposus and annulus fibrosus reconstruction显示文摘Regeneration of Intervertebral disc(IVD)is a scientific challenge because of the complex structure and composition of tissue,as well as the difficulty in achieving bionic function.Here,an anatomically correct IVD scaffold composed of biomaterials,cells,and growth factors were fabricated via three-dimensional(3D)bioprinting technology.Connective tissue growth factor(CTGF)and transforming growth factor-β3(TGF-β3)were loaded onto polydopamine nanoparticles,which were mixed with bone marrow mesenchymal stem cells(BMSCs)for regenerating and simulating the structure and function of the nucleus pulposus and annular fibrosus.In vitro experiments confirmed that CTGF and TGF-β3 could be released from the IVD scaffold in a spatially controlled manner,and induced the corresponding BMSCs to differentiate into nucleus pulposus like cells and annulus fibrosus like cells.Next,the fabricated IVD scaffold was implanted into the dorsum subcutaneous of nude mice.The reconstructed IVD exhibited a zone-specific matrix that displayed the corresponding histological and immunological phenotypes:primarily type II collagen and glycosaminoglycan in the core zone,and type I collagen in the surrounding zone.The testing results demonstrated that it exhibited good biomechanical function of the reconstructed IVD.The results presented herein reveal the clinical application potential of the dual growth factors-releasing IVD scaffold fabricated via 3D bioprinting.However,the evaluation in large mammal animal models needs to be further studied. | Binbin Sun Meifei Lian Yu Han Xiumei Mo Wenbo Jiang Zhiguang Qiao Kerong Dai | 2021 | Bioactive Materials2021，6，1： | 5 |
| 7 | Potential association of long noncoding RNA HA117 with tetralogy of Fallot显示文摘Tetralogy of Fallot(TOF)is a congenital heart disease characterized by abnormal cardiomyocyte differentiation in the right ventricular outflow tract(RVOT),and HA117 is a novel long noncoding RNA(lncRNA)with anti-differentiation roles.To investigate the potential association of HA117 with TOF,we collected 84 RVOT tissues from patients with TOF.We determined the expression of HA117 in RVOT samples from TOF patients and collected clinical data to conduct a cross-sectional and short-term follow-up study.McGoon ratio,Nakata index,and left ventricular end-diastolic volume index(LVEDVI)were negatively correlated with the expression of HA117 based on subgroup analysis,correlation analysis and logistic regression analysis.Additionally,cardiopulmonary bypass(CPB)time and ICU stay were longer in patients with higher expression of HA117 than in patients with lower expression of HA117.Furthermore,percentage improvement in SPO2 was significantly reduced in patients with increased HA117 expression at 6 months after surgery.Our results suggested that the increased expression of the novel lncRNA HA117 is a risk factor for unfavorable McGoon ratio,Nakata index and LVEDVI in TOF patients.Additionally,an increased expression of HA117 might lead to adverse short-term outcomes in TOF patients. | Quan Wang Zhili Wang Chun Wu Zhengxia Pan Li Xiang Hang Liu Xin Jin Kerong Tong Shulei Fan Xianqing Jin | 2018 | Genes & Diseases2018，5，2： | 5 |
| 8 | Zinc alloy-based bone internal fixation screw with antibacterial and anti-osteolytic properties显示文摘There is no targeted effective treatment for patients undergoing internal fixation surgery/two-stage total joint revision surgery with a high risk of postoperative infection and osteolysis,while the rate of reoperation due to infection and osteolysis remains high.In this study,we report a pioneering application of implants made of biodegradable Zn-Ag alloy with active antibacterial and anti-osteolytic properties in three classical animal models,illustrating antibacterial,anti-osteolysis,and internal fixation for fractures.The antibacterial activity of the Zn-2Ag alloy was verified in a rat femur osteomyelitis prevention model,while the anti-osteolytic properties were evaluated using a mouse cranial osteolysis model.Moreover,the Zn-2Ag based screws showed similar performance in bone fracture fixation compared to the Ti-6Al-4V counterpart.The fracture healed completely after 3 months in the rabbit femoral condyle fracture model.Furthermore,the underlying antibacterial mechanism may include inhibition of biofilm formation,autolysis-related pathways,and antibiotic resistance pathways.Osseointegration mechanisms may include inhibition of osteoclast-associated protein expression,no effect on osteogenic protein expression,and no activation of related inflammatory protein expression.The empirical findings here reveal the great potential of Zn-Ag-based alloys for degradable biomaterials in internal fixation surgery/two-stage total joint revision surgery for patients with a high risk of postoperative infection and osteolysis. | Xinhua Qu Hongtao Yang Bo Jia Minqi Wang Bing Yue Yufeng Zheng Kerong Dai | 2021 | Bioactive Materials2021，6，12： | 4 |
| 9 | 3D Printing Hip Prostheses Offer Accurate Reconstruction,Stable Fixation,and Functional Recovery for Revision Total Hip Arthroplasty with Complex Acetabular Bone Defect显示文摘Complicated and large acetabular bone defects present the main challenges and difficulty in the revision of total hip arthroplasty(THA).This study aimed to explore the advantages of three-dimensional(3D)printing technology in the reconstruction of such acetabular bone defects.We retrospectively analyzed the prognosis of four severe bone defects around the acetabulum in three patients who were treated using 3D printing technology.Reconstruction of bone defect by conventional methods was difficult in these patients.In this endeavor,we used radiographic methods,related computer software such as Materialise's interactive medical image control system and Siemens NX software,and actual surgical experience to estimate defect volume,prosthesis stability,and installation accuracy,respectively.Moreover,a Harris hip score was obtained to evaluate limb function.It was found that bone defects could be adequately reconstructed using a 3D printing prosthesis,and its stability was reliable.The Harris hip score indicated a very good functional recovery in all three patients.In conclusion,3D printing technology had a good therapeutic effect on both complex and large bone defects in the revision of THA.It was able to achieve good curative effects in patients with large bone defects. | Yongqiang Hao Lei Wang Wenbo Jiang Wen Wu Songtao Ai Lu Shen Shuang Zhao Kerong Dai | 2020 | Engineering2020，6，11： | 4 |
| 10 | Long-term follow-up for Shang Ring male circumcision显示文摘 | Cheng Yue Wu Kerong Yan Zejun Yang Shuwei Li Fang Su Xinjun | 2014 | Chinese Medical Journal2014，，10： | 4 |
| 11 | Geographical Differences and Influencing Factors of Rural Energy Consumption in Southwest Mountain Areas in China:A Case Study of Zhaotong City显示文摘China is a mountainous country,and Southwest mountain areas cover the most mountain areas in China and have the most serious problems.Taking Zhaotong city as the study area,based on 902 rural household questionnaires of 11 villages in 2 counties and Tobit model,this paper analyzes the geographical differences and influencing factors of energy consumption for non-production purposes of rural households living in different terrain conditions.This research finds that:(1) Coal takes up the main part of energy consumption in valley areas and coal consumption is mainly affected by per capita cultivated land area,household income,proportion of rural household energy expenditure in total expenditure,coal price,and family population size.Firewood takes up the main part of energy consumption in high mountain areas and firewood consumption is mainly affected by per capita firewood forest area,distance to purchase coal,household income,electricity price,and coal price.(2) Only when the distance is greater than 20 kilometers,that is the average distance of rural households living in middle mountain areas(1,600m^1,800m) to purchase coal,the transportation condition has a significant impact on coal consumption.(3) In high mountain areas,prices of coal and electricity are the main factors influencing energy consumption choice of rural households.Too high prices of coal and electricity would to some extent lead rural households to choose firewood as the main energy consumption type.Compared to coal,rural households prefer to choose electricity. | SUN Wei HAN Xiaoxu SHENG Kerong FAN Jie | 2012 | Journal of Mountain Science2012，9，6： | 4 |
| 12 | Biodegradable ZnLiCa ternary alloys for critical-sized bone defect regeneration at load-bearing sites:In vitro and in vivo studies显示文摘A novel biodegradable metal system,ZnLiCa ternary alloys,were systematically investigated both in vitro and in vivo.The ultimate tensile strength(UTS)of Zn0.8Li0.1Ca alloy reached 567.60±9.56 MPa,which is comparable to pure Ti,one of the most common material used in orthopedics.The elongation of Zn0.8Li0.1Ca is 27.82±18.35%,which is the highest among the ZnLiCa alloys.The in vitro degradation rate of Zn0.8Li0.1Ca alloy in simulated body fluid(SBF)showed significant acceleration than that of pure Zn.CCK-8 tests and hemocompatibility tests manifested that ZnLiCa alloys exhibit good biocompatibility.Real-time PCR showed that Zn0.8Li0.1Ca alloy successfully stimulated the expressions of osteogenesis-related genes(ALP,COL-1,OCN and Runx-2),especially the OCN.An in vivo implantation was conducted in the radius of New Zealand rabbits for 24 weeks,aiming to treat the bone defects.The Micro-CT and histological evaluations proved that the regeneration of bone defect was faster within the Zn0.8Li0.1Ca alloy scaffold than the pure Ti scaffold.Zn0.8Li0.1Ca alloy showed great potential to be applied in orthopedics,especially in the load-bearing sites. | Zechuan Zhang Bo Jia Hongtao Yang Yu Han Qiang Wu Kerong Dai Yufeng Zheng | 2021 | Bioactive Materials2021，6，11： | 3 |
| 13 | Spatial–temporal variability of terrestrial vegetation productivity in the Yangtze River Basin during 2000–2009显示文摘Aims Terrestrial net primary production(NPP),the balance of gross primary production(GPP)and autotrophic respiration(AR),is a critical measure of carbon sequestration capacity for the Earth’s land surface.The aim of this study was to understand the spatio-temporal variability of NPP associated with GPP and AR in the Yangtze River Basin(YRB),China,from 2000 to 2009 during which the basin warmed significantly.Methods We first derived AR and carbon-use efficiency(CUE)from the improved Moderate Resolution Imaging Spectroradiometer GPP/NPP products(MOD17)and then conducted spatial analysis to quantify how NPP relates to GPP,AR and their relationship with key observed climate variables(temperature,precipitation and sunshine percentage)in the YRB during 2000–2009.Important Findings The spatial pattern of NPP in the YRB was predominantly determined by GPP and further modified by AR.Higher GPP and relatively low AR made the southern Jinshajiang sub-basin the most productive area in NPP in the YRB.A large portion of the YRB experienced a warmer and drier climate trend in the growing season during 2000–2009.In the upper reaches of the basin,possessing a relatively low temperature base,increases in temperature led to greater increases in GPP than those in AR,resulting in greater increased NPP.However,in the middle and lower reaches of the basin where the base temperature is relatively high,increases in temperature led to greater increases in AR than those in GPP,leading to decreases in NPP.Overall,86.7%of the vegetated area showed a consistent GPP and NPP trend through time with 71.3%of the vegetated area having a positive trend both in GPP and NPP,and the remaining 13.3%of vegetated areas showed an opposite trend in GPP and NPP,with positive GPP and negative NPP trajectories dominating(10.1%of vegetated area)the trend.Although climate warming generally had positive effects on vegetation growth in most areas of the basin,areas with increased NPP(74.5%)were less extensive than those with increased GPP(81.4%)due to the wider increase in AR(82.2%).During the study period,increases in AR offset 62%of the total increased GPP,leading to a substantial decline of CUE,particularly in the warmer lower altitude regions in the southeast.Our work reveals the diverse responses of NPP associated with GPP and AR as the climate warms and generally suggests that NPP in the middle and lower sub-basins in the YRB is more sensitive to future climate warming.These findings enhance our understanding of terrestrial ecosystem carbon dynamics in response to global warming and provide a scientific basis for managing ecosystem productivity in the YRB,China. | Yulong Zhang Conghe Song Kerong Zhang Xiaoli Cheng Quanfa Zhang | 2014 | Journal of Plant Ecology2014，7，1： | 3 |
| 14 | High-precision,gelatin-based,hybrid,bilayer scaffolds using melt electro-writing to repair cartilage injury显示文摘Articular cartilage injury is a common disease in the field of orthopedics.Because cartilage has poor self-repairing ability,medical intervention is needed.Using melt electro-writing(MEW)technology,tissue engineering scaffolds with high porosity and high precision can be prepared.However,ordinary materials,especially natural polymer materials,are difficult to print.In this study,gelatin was mixed with poly(lactic-co-glycolic acid)to prepare high-concentration and high-viscosity printer ink,which had good printability and formability.A composite scaffold with full-layer TGF-β1 loading mixed with hydroxyapatite was prepared,and the scaffold was implanted at the cartilage injury site;microfracture surgery was conducted to induce the mesenchyme in the bone marrow.Quality stem cells thereby promoted the repair of damaged cartilage.In summary,this study developed a novel printing method,explored the molding conditions based on MEW printing ink,and constructed a bioactive cartilage repair scaffold.The scaffold can use autologous bone marrow mesenchymal stem cells and induce their differentiation to promote cartilage repair. | Yu Han Bo Jia Meifei Lian Binbin Sun Qiang Wu Benlin Sun Zhiguang Qiao Kerong Dai | 2021 | Bioactive Materials2021，6，7： | 2 |
| 15 | Sequential city growth: Theory and evidence from the US显示文摘城市生长模式在城市的地理研究正在吸引更多的注意。这份报纸检验城市怎么从美国在新经济地理框架和实验证据下面基于一个理论模型在大规模经济在尺寸分发的上面的尾巴发展并且成长。结果证明城市在一个顺序的模式成长。有最好的经济条件的城市是第一变得最快直到他们到达一种批评尺寸,然后,他们的生长率慢下来,更小的城市远在城市的层次击倒在顺序成为快成长的。这份报纸也揭示城市的系统的三个相关特征。首先,城市尺寸分发演变从低级在一条转换 U 字形的路径平衡到首领和最后高级的平衡模式。第二,在那里存在坚持的断绝,或差距,在城市尺寸类之间。第三,在上面的尾巴的城市尺寸展出有条件的集中特征。这份报纸不能仅仅贡献提高都市化过程和城市尺寸分发动力学的理解,而且广泛地在做有效政策并且科学城市的计划被使用。 | SHENG Kerong SUN Wei FAN Jie | 2014 | Journal of Geographical Sciences2014，24，6： | 2 |
| 16 | Double-edged effects caused by magnesium ions and alkaline environment regulate bioactivities of magnesium-incorporated silicocarnotite in vitro显示文摘Magnesium(Mg)is an important element for its enhanced osteogenic and angiogenic properties in vitro and in vivo,however,the inherent alkalinity is the adverse factor that needs further attention.In order to study the role of alkalinity in regulating osteogenesis and angiogenesis in vitro,magnesium-silicocarnotite[Mg-Ca5(PO4)2SiO4,Mg-CPS]was designed and fabricated.In this study,Mg-CPS showed better osteogenic and angiogenic properties than CPS within 10wt.%magnesium oxide(MgO),since the adversity of alkaline condition was covered by the benefits of improved Mg ion concentrations through activating Smad2/3-Runx2 signaling pathway in MC3T3-E1 cells and PI3K-AKT signaling pathway in human umbilical vein endothelial cells in vitro.Besides,provided that MgO was incorporated with 15wt.%in CPS,the bioactivities had declined due to the environment consisting of higher-concentrated Mg ions,stronger alkalinity and lower Ca/P/Si ions caused.According to the results,it indicated that bioactivities of Mg-CPS in vitro were regulated by the double-edged effects,which were the consequence of Mg ions and alkaline environment combined.Therefore,if MgO is properly incorporated in CPS,the improved bioactivities could cover alkaline adversity,making Mg-CPS bioceramics promising in orthopedic clinical application for its enhancement of osteogenesis and angiogenesis in vitro. | Qiang Wu Shunxiang Xu Fei Wang Bo He Xin Wang Ye Sun Congqin Ning Kerong Dai | 2021 | Regenerative Biomaterials2021，8，6： | 2 |
| 17 | Utilizing phase-shifted long-period fiber grating to suppress spectral broadening of a high-power fiber MOPA laser system显示文摘Suppressing nonlinear effects in high-power fiber lasers based on fiber gratings has become a hotspot.At present,research is mainly focused on suppressing stimulated Raman scattering in a high-power fiber laser.However,the suppression of spectral broadening,caused by self-phase modulation or four-wave mixing,is still a challenging attribute to the close distance between the broadened laser and signal laser.If using a traditional fiber grating with only one stopband to suppress the spectral broadening,the signal power will be stripped simultaneously.Confronting this challenge,we propose a novel method based on phase-shifted long-period fiber grating(PS-LPFG)to suppress spectral broadening in a high-power fiber master oscillator power amplifier(MOPA)laser system in this paper.A PS-LPFG is designed and fabricated on 10/130 passive fiber utilizing a point-by-point scanning technique.The resonant wavelength of the fabricated PS-LPFG is 1080 nm,the full width at half maximum of the passband is 5.48 nm,and stopband extinction exceeds 90%.To evaluate the performance of the PS-LPFG,the grating is inserted into the seed of a kilowattlevel continuous-wave MOPA system.Experiment results show that the 30 dB linewidth of the output spectrum is narrowed by approximately 37.97%,providing an effective and flexible way for optimizing the output linewidth of highpower fiber MOPA laser systems. | Yinxu Bian Kerong Jiao Xuecheng Wu Hua Shen Feiyan Yang Rihong Zhu | 2021 | High Power Laser Science and Engineering2021，9，3： | 2 |
| 18 | Generating 3D-cultured organoids for pre-clinical modeling and treatment of degenerative joint disease显示文摘Dear Editor,Human cell-based and personalized in vitro cartilage models are urgently needed for osteoarthritis treatment in pre-clinical regenerative medicine development.Cellular self-assemblies and condensations of the appropriate stem cells could initiate the formation of transient tissue structures programmed for specific organogenesis processes.1 This recapitulation of developmental events has previously been demonstrated for the formation of cardiac,epithelial and liver organoids.However,there has been very limited progress in the development of human cartilage organoids for osteoarthritis(OA).2 Here,we describe the fabrication of functional bioengineered cartilage organoid suitable for OA treatment.Briefly,agarose microwell inserts for formation of a high number of synovial mesenchymal stromal cell(SMSC)organoids with homogeneous size distribution were created as previously described by Leijten et al.33D-cultured SMSC organoids were generated and phenotypically analyzed for potential applications in OA modeling and treatment(Fig.1a). | Ye Sun Qiang Wu Kerong Dai Yongqing You Wenbo Jiang | 2021 | Signal Transduction and Targeted Therapy2021，6，12： | 2 |
| 19 | Effect of body fat stores on total and regional bone mineral density in perimenopausal Chinese women显示文摘 | Zhifeng Yu Zhenan Zhu Tingting Tang Kerong Dai Shijing Qiu | 2009 | Journal of Bone and Mineral Metabolism2009，，3： | 1 |
| 20 | Proliferation and osteoblastic differentiation of human bone marrow-derived stromal cells on akermanite-bioactive ceramics显示文摘 | Hongli Sun Chengtie Wu Kerong Dai Jiang Chang Tingting Tang | 2006 | Biomaterials2006，，33： | 1 |
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