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130篇 您的检索式:作者名="Xiaoli Cheng"
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1Effects of Saikosaponin-D on syndecan-2,matrix metalloproteinases and tissue inhibitor of metalloproteinases-2 in rats with hepatocellular carcinoma显示文摘OBJECTIVE:To investigate effects of Saikosaponin D(SSd) on syndecan-2,matrix metalloproteinases(MMPs) and tissue inhibitor of metalloproteinases-2(TIMP-2) in livers of rat with hepatocellular carcinoma(HCC).METHODS:Male SD rats were divided into control(n=10),model(n=20) and SSd(n=20) groups,and model and SSd groups given intragastric 0.2%(w/v) N-diethylnitrosamine to induce HCC.SSd group received 0.03%(w/v) SSd in saline.Liver samples were analysed immunohistochemically for syndecan-2,MMP-2,MMP-13 and TIMP-2 at 16 weeks.RESULTS:The model group had more malignant nodules than the SSd group;all model-group HCC cells were grade III;SSd-group HCC cells were grades I-II.Controls showed normal hepatic cell phenotypes and no syndecan-2 + staining.Syndecan-2 + staining was greater in the model group(35.2%,P≤0.001) than in controls or the SSd group(16.5%,P ≤ 0.001).The model group had more intense MMP-2 + staining than controls(0.37 vs 0.27,P≤0.01) or the SSd group(0.31 vs 0.37,P≤0.05);and higher MMP-13 + staining(72.55%) than in controls(12.55%,P≤0.001) and SSd group(20.18%,P≤0.01).The model group also had more TIMP-2 + staining(57.2%) than controls(20.9%,P≤0.001) and SSd group(22.7%,P≤0.001).Controls and SSd group showed no difference in TIMP-2 + rates.CONCLUSION:SSd inhibited HCC development,and downregulated expression of syndecan-2,MMP-2,MMP-13 and TIMP-2 in rat HCC liver tissue.Xiaoli Jia Shuangsuo Dang Yanan Cheng Xin Zhang Mei Li Yaping Li Siyuan Li 2012Journal of Traditional Chinese Medicine2012,32,3:12
2TNF-α suppresses sweat gland differentiation of MSCs by reducing FTO-mediated m^6 A-demethylation of Nanog mRNA显示文摘An effect of inhibition of tumor necrosis factor-α(TNF-α)on differentiation of mesenchymal stromal cells(MSCs)has been demonstrated,but the exact mechanisms that govern MSCs differentiation remain to be further elucidated.Here,we show that TNF-αinhibits the differentiation of MSCs to sweat glands in a specific sweat gland-inducing environment,accompanied with reduced expression of Nanog,a core pluripotency factor.We elucidated that fat mass and obesity-associated protein(FTO)-mediated m^6 A demethylation is involved in the regulation of MSCs differentiation potential.Exposure of MSCs to TNF-αreduced expression of FTO,which demethylated Nanog m RNA.Reduced expression of FTO increased Nanog m RNA methylation,decreased Nanog m RNA and protein expression,and significantly inhibited MSCs capacity for differentiation to sweat gland cells.Our finding is the first to elucidate the functional importance of m^6 A modification in MSCs,providing new insights that the microenvironment can regulate the multipotency of MSCs at the post-transcriptional level.Moreover,to maintain differentiation capacity of MSCs by regulating m^6 A modification suggested a novel potential therapeutic target for stem cellmediated regenerative medicine.Yihui Wang Rui Wang Bin Yao Tian Hu Zhao Li Yufan Liu Xiaoli Cui Liuhanghang Cheng Wei Song Sha Huang Xiaobing Fu 2020Science China(Life Sciences)2020,63,1:9
3Multifunctional MgF_2/Polydopamine Coating on Mg Alloy for Vascular Stent Application显示文摘Mg alloy is of great potential in the application of vascular stent due to its degradation in physical environment and proper mechanical property.However its mechanical integrity does not meet the clinical requirement due to relatively fast degradation.Besides,in order to accelerate the reendothelialization of Mg-based stents,it needs surface modification to improve the attachment,growth and adhesion of endothelial cells(ECs).To solve the main obstacles,an anti-corrosion and quick endothelialization coating was prepared on novel Mg-Zn-Y-Nd alloy via a simple two-step immersion method in the present study,first in hydrofluoric acid(HF) then in dopamine tris-Hydrochloric acid(tris-HC1) solution.The coating was uniform and thin,which consisted of two layers—the upper was polydopamine(PDA) layer and the lower was MgF_2 layer.The alloy with the coating demonstrated dramatic corrosion resistance enhancement in vitro by immersion test and electrochemical test.Moreover the HFPDA-treated Mg alloy exhibited great performance of cell adhesion and proliferation.The coating created a favorable environment for ECs to have a competitive advantage over vascular smooth muscle cells(VSMCs),which was preferable for re-endothelialization.The results suggest that HF-PDA-treated Mg-Zn-Y-Nd alloy has great potential in the application of vascular stent and the surface coating method is of great application value in biodegradable Mg alloy stent due to its simplicity and effectiveness.Xiaoli Liu Zhen Zhen Jing Liu Tingfei Xi Yudong Zheng Shaokang Guan Yufeng Zheng Yan Cheng 2015Journal of Materials Science & Technology2015,31,7:8
4A DNA Computing Model for the Graph Vertex Coloring Problem Based on a Probe Graph显示文摘Jin xu Xiaoli Qiang Kai Zhang Cheng Zhang Jing Yang 2018Engineering2018,4,1:8
5A novel computing model of the maximum clique problem based on circular DNA显示文摘A novel DNA-based model is developed to calculate NP-complete problems, which is made of circular DNA molecules, streptavidin-coated magnetic beads and DNA circligase. To test the feasibility of the model, we apply it to compute a five-node maximum clique problem (MCP). During the computation, DNA molecule structures were transformed between linear DNA and circular DNA by streptavidin-coated magnetic beads and circligase, in order to search for the truth solutions. This greatly reduces the quantity of time and space consumed in calculation, and its time and space complexity both are O(n + m). Compared with the brute force method, using this algorithm searching process at most needs in n + 1 test tubes for an MCP with n vertices, while brute force method requires 2n test tubes. Furthermore, the constructed unenumerable initial solution space greatly improved the processing ability of the DNA computer. This novel model indicates that it may be a powerful DNA-based computer for solving some NP-complete problems.YANG Jing ZHANG Cheng XU Jin LIU XiangRong QIANG XiaoLi 2010Science China(Information Sciences)2010,53,7:7
6SARS-CoV-2 envelope protein causes acute respiratory distress syndrome (ARDS)-like pathological damages and constitutes an antiviral target显示文摘Cytokine storm and multi-organ failure are the main causes of SARS-CoV-2-related death.However,the origin of excessive damages caused by SARS-CoV-2 remains largely unknown.Here we show that the SARS-CoV-2 envelope(2-E)protein alone is able to cause acute respiratory distress syndrome(ARDS)-like damages in vitro and in vivo.Bingqing Xia Xurui Shen Yang He Xiaoyan Pan Feng-Liang Liu Yi Wang Feipu Yang Sui Fang Yan Wu Zilei Duan Xiaoli Zuo Zhuqing Xie Xiangrui Jiang Ling Xu Hao Chi Shuangqu Li Qian Meng Hu Zhou Yubo Zhou Xi Cheng Xiaoming Xin Lin Jin Hai-Lin Zhang Dan-Dan Yu Ming-Hua Li Xiao-Li Feng Jiekai Chen Hualiang Jiang Gengfu Xiao Yong-Tang Zheng Lei-Ke Zhang Jingshan Shen Jia Li Zhaobing Gao 2021Cell Research2021,31,8:7
7Three Cases of COVID-19 Variant Delta With and Without Vaccination——Chengdu City,Sichuan Province,April-May,2021显示文摘On April 26,2021,a 33-year-old male Chinese sailor returning from India via Kathmandu,Nepal,tested positive for the coronavirus disease 2019(COVID-19)by Chengdu Customs and was confirmed positive by Chengdu CDC(Case A).On May 2,2021,a housewife in the same flight tested positive for COVID-19 by Pengzhou CDC in Sichuan Province during her quarantine period and was confirmed positive by Chengdu CDC the next day(Case B).Heng Chen Yi Mao Zhenhua Duan Liang Wang Yue Cheng Yingxue Dai Haixia Luo Wenjun Xie Shuangfeng Fan Yuzhen Zhou Jingpei Xu Lan Feng Liwen Hu Zhu Liu Xian Liang Liangshuang Jiang Xiaoli Tuo 2021China CDC weekly2021,3,25:5
8Baicalein suppresses vasculogenic mimicry through inhibiting RhoA/ROCK expression in lung cancer A549 cell line显示文摘Vasculogenic mimicry(VM)refers to a new tubular network of the blood supply system with abundant extracellular matrix.VM is similar to capillaries but does not involve endothelial cells.As a traditional herbal medicine commonly used in China,baicalein possesses anti-inflammatory and lipoxygenase activities.However,the effects of baicalein on the process of VM formation in nonsmall cell lung cancer(NSCLC)and the underlying mechanisms have remained poorly understood.In this study,baicalein was found to inhibit the viability and motility of A549 cells and induced the breakage of the cytoskeletal actin filament network.In addition,baicalein significantly decreased the formation of VM and downregulated the expressions of VM-associated factors,such as VEcadherin,EphA2,MMP14,MMP2,MIVIP9,PI3K and LAMC2,similar to the effects of ROCK inhibitors.In deed,baicalei n inhibited RhoA/ROCK expression in vitro and in vivo,suggesting the underlying mechanisms of reduced VM formation.Collectively,baicalein suppressed the formation of VM in NSCLC by targeting the RhoA/ROCK signaling pathway,indicating that baicalein might serve as an emerging drug for NSCLC.Zhe Zhang Li Nong Menglei Chen Xiaoli Gu Weiwei Zhao Minghui Liu Wenwu Cheng 2020Acta Biochimica et Biophysica Sinica2020,52,9:5
9Automatic recognition of ingestive-related behaviors of dairy cows based on triaxial acceleration显示文摘Ingestive-related behaviors including feeding and ruminating are important indexes to measure the health and welfare of dairy cows.The purpose of this study is to develop a method based on triaxial acceleration to automatically recognize feeding and ruminating of dairy cows.During the experiment,five diary cows raised in a barn were used as experimental subjects.A triaxial acceleration sensor was used as the device to collect jawmovement data of dairy cows,and the behaviors of dairy cows were classified into three categories:feeding,ruminating and other behavior.The features of time-domain and frequency-domain were extracted from the raw acceleration data.Three machine learning algorithms including k-nearest neighbor,support vector machine and probabilistic neural network were used for the classification and the results based on four different data segment lengths were compared.The results show that the three algorithms can be used for recognition of feeding and ruminating with high accuracy.Under the condition that the sampling frequency of the sensor is 5 Hz,the combination of data segment length of 256 and k-nearest neighbor algorithm is the best scheme for recognition of feeding and ruminating in this study.The precision and recall of recognition for feeding were 92.8%and 95.6%respectively,and those of recognition for ruminating were 93.7%and 94.3%respectively.The specificity and AUC of recognition for feeding were 96.1%and 0.959 respectively,and those of recognition for ruminating were 97.5%and 0.959 respectively.This will provide an effective method for real-time monitoring of ingestive-related behaviors of dairy cows and lay a foundation for prediction of dairy cows’health status and welfare to further achieve the purpose of disease prediction and adjusting feeding and management methods.Weizheng Shen Fei Cheng Yu Zhang Xiaoli Wei Qiang Fu Yonggen Zhang 2020Information Processing in Agriculture2020,7,3:5
10Study on oil–source correlation by analyzing organic geochemistry characteristics: a case study of the Upper Triassic Yanchang Formation in the south of Ordos Basin, China显示文摘In the south of the Ordos Basin, the oil source of the Upper Triassic Yanchang Formation is confused all the time, which affects further exploration. In this study, oil sources from the oil layers of Ch6, Ch8 and Ch9 are all analyzed and confirmed. Through their carbon isotope value and biomarkers, characteristics of crude oils from the Yanchang Formation are analyzed. Then, the oil–source relation is discussed, with the source rocks' features.Finally, the oil–source relation is calculated through cluster analysis. It is believed that the oils from the Yanchang Formation deposit in a similar redox environment, with weak oxidation–weak reduction, and have all entered maturity stage. Ch9 crude oil is more mature than crude oils from Ch6 and Ch8, and has more advanced plants and fewer algae. Gas chromatography(GC) and gas chromatography–mass spectrometry(GC–MS) analysis show that crude oils from Ch6 and Ch8 may come from Ch7, and Ch9 crude oil may not. Cluster analysis displays that crude oils from Ch6 and Ch8 have closer squared Euclidean distance with Ch7 source rocks than Ch9 crude oil does,indicating crude oils from Ch6 and Ch8 stem from Ch7 source rocks. And Ch9 crude oil has rather close squared Euclidean distance with Ch9 source rocks, illustrating Ch9 crude oil may be from Ch9 source rocks. This research may provide the theoretical basis for the next exploration deploy in the south of Ordos Basin.Delu Li Rongxi Li Baoping Wang Zhi Liu Xiaoli Wu Futian Liu Bangsheng Zhao Jinghua Cheng Wenbin Kang 2016Acta Geochimica2016,35,4:5
11A density functional theory study on the decomposition of aliphatic hydrocarbons and cycloalkanes during coal pyrolysis in hydrogen plasma显示文摘To get deep understanding of the reaction mechanism of coal pyrolysis in hydrogen plasma, the decomposition reaction pathways of aliphatic hydrocarbons and cycloalkanes, which are two main components in volatiles from coal, were investigated. Methane and cyclohexane were chosen as the model compounds. Density functional theory was employed, and many reaction pathways were involved. Calculations were carried out in Gaussian 09 at the B3LYP/6-31G(d,p) level of the theory. The results indicate that the main pyrolysis products of methane and cyclohexane in hydrogen plasma are both hydrogen and acetylene, and the participation of active hydrogen atoms makes dehydrogenation reactions more favorable. H2 mainly comes from dehydrogenation process, while many reaction pathways are responsible for acetylene formation. During coal pyrolysis in hydrogen plasma, three main components in volatiles like aliphatic hydrocarbons, cycloalkanes and aromatic hydrocarbons lead to the formation of hydrogen and acetylene, but their contributions to products distribution are different.Xiaoyuan Huang Dangguo Cheng Fengqiu Chen Xiaoli Zhan 2015Journal of Energy Chemistry2015,24,1:5
12Redirecting differentiation of mammary progenitor cells by 3D bioprinted sweat gland microenvironment显示文摘Background:Mammary progenitor cells(MPCs)maintain their reproductive potency through life,and their specific microenvironments exert a deterministic control over these cells.MPCs provides one kind of ideal tools for studying engineered microenvironmental influence because of its accessibility and continually undergoes postnatal developmental changes.The aim of our study is to explore the critical role of the engineered sweat gland(SG)microenvironment in reprogramming MPCs into functional SG cells.Methods:We have utilized a three-dimensional(3D)SG microenvironment composed of gelatin-alginate hydrogels and components from mouse SG extracellular matrix(SG-ECM)proteins to reroute the differentiation of MPCs to study the functions of this microenvironment.MPCs were encapsulated into the artificial SG microenvironment and were printed into a 3D cell-laden construct.The expression of specific markers at the protein and gene levels was detected after cultured 14 days.Results:Compared with the control group,immunofluorescence and gene expression assay demonstrated that MPCs encapsulated in the bioprinted 3D-SG microenvironment could significantly express the functional marker of mouse SG,sodium/potassium channel protein ATP1a1,and tend to express the specific marker of luminal epithelial cells,keratin-8.When the Shh pathway is inhibited,the expression of SG-associated proteins in MPCs under the same induction environment is significantly reduced.Conclusions:Our evidence proved the ability of differentiated mouse MPCs to regenerate SG cells by engineered SG microenvironment in vitro and Shh pathway was found to be correlated with the changes in the differentiation.These results provide insights into regeneration of damaged SG by MPCs and the role of the engineered microenvironment in reprogramming cell fate.Rui Wang Yihui Wang Bin Yao Tian Hu Zhao Li Yufan Liu Xiaoli Cui Liuhanghang Cheng Wei Song Sha Huang Xiaobing Fu 2019Burns & Trauma2019,7,1:5
13Performance Analysis of Cooperative NOMA with Energy Harvesting in Multi-Cell Networks显示文摘In this paper,an energy harvesting enabled cooperative non-orthogonal multiple access(NOMA)system for a multi-cell network is investigated.Particularly,during the direct transmission phase,base stations send their superposed messages to the near users and far users simultaneously according to a NOMA principle,while the near users act as energy harvesting enabled relays employing a power splitting protocol.During the cooperative phase,the near users transmit their decoded messages to the corresponding far users using harvested energy.Using tools from stochastic geometry,we firstly calculate the signal to interference ratios of the users in each NOMA group including one near user and one far user.Then,the closed-form expressions of the coverage probability,ergodic rate,and energy efficiency are derived respectively.Numerical results validate the derived expressions and show that the energy harvesting enabled cooperative NOMA system in a multi-cell network can improve the coverage probability,ergodic rate,and energy efficiency compared to its counterpart OMA system.Cheng Guo Jie Xin Liqiang Zhao Xiaoli Chu 2019China Communications2019,16,11:5
14Studies on the structure and catalytic performance of S and P promoted Na-W-Mn-Zr/SiO_2 catalyst for oxidative coupling of methane显示文摘A series of Na-W-Mn-Zr/SiO2 catalysts promoted by different contents of S or/and P were prepared and their catalytic performance for oxidative coupling of methane was investigated to clarify the effect of S and P on the Na-W-Mn-Zr/SiO2 catalyst. The catalysts were characterized by X-ray diffraction (XRD) and X-ray photoelectron spectroscopy (XPS). From the characterization results, it is found that the addition of S and P to the Na-W-Mn-Zr/SiO2 catalyst helps the formation of active phases, such as α-cristobalite, Na2WO4, ZrO2, and Na2SO4. Moreover, the addition of S and P increases the concentration of surface-active oxygen species by improving the migration of active components from the bulk phase to the surface of the catalyst. According to the activity test, impressive methane conversion and C2 hydrocarbons yield were obtained at a low temperature of 1023 K over the six-component Na-W-Mn-Zr-S-P/SiO2 catalyst, which contained 2 wt% S and 0.4 wt% P simultaneously. The deactivation of Na-W-Mn-Zr-S-P/SiO2 was due to the loss of surface active components.Wen Zheng, Dangguo Cheng, Ning Zhu, Fengqiu Chen, Xiaoli Zhan Department of Chemical and Biochemical Engineering, Zhejiang University, Hangzhou 310027, Zhejiang, China 2010Journal of Natural Gas Chemistry2010,19,1:4
15Aluminum impregnated silica catalyst for Friedel–Crafts reaction:Influence of ordering mesostructure显示文摘Friedel–Crafts alkylation of benzene with linear chain ole fin(C_(10)–C_(14)),which is an important reaction of synthetic detergent,was studied via different catalysts of aluminum impregnated silica molecular sieves.AlCl_3 was immobilized on silica molecular sieves with different channel structures,hexagonal packing channels network(SBA-15,MCM-41),and disordered channel network(SiO_2,SiO_2-Gel) by impregnation.XRD and N_2 adsorption–desorption isotherms con firmed that the speci fic mesoporous structures were maintained for order channel network catalyst after impregnation.Catalytic activities were investigated under different conditions.The in fluences of channel structure were discussed.The results showed that catalyst based on mesoporous like SBA-15 had the highest catalytic activities and 2-LAB selectivity compared with other catalysts in this work.The highest 2-LAB selectivity was nearly 50% when 1-dodecene conversion was nearly 100%.At low 1-dodecene conversion or higher benzene/1-dodecene molar ratio,2-LAB selectivity was nearly 60%.Yibo He Qinghua Zhang Xiaoli Zhan Dangguo Cheng Fengqiu Chen 2017Chinese Journal of Chemical Engineering2017,25,10:3
16HEIHE WATERSHED ALLIED TELEMETRY EXPERIMENTAL RESEARCH (HiWATER): Scientific Objectives and Experimental Design显示文摘Li Xin Cheng Guodong Liu Shaomin Xiao Qing Ma Mingguo Jin Rui Che Tao Liu Qinhuo Wang Weizhen Qi Yuan Wen Jianguang Li Hongyi Zhu Gaofeng Guo Jianwen Ran Youhua Wang Shuoguo Zhu Zhongli Zhou Jian Hu Xiaoli Xu Ziwei 2013Bulletin of the American Meteorological Society2013,,8:3
17Intake of Vitamin A,Thiamine,Riboflavin,Vitamin C,and Niacin Among Children Aged 6−11 Years Old—China,2016−2017显示文摘Summary What is already known on this topic?Insufficient intake of vitamins is one of the major nutritional problems in children aged 6-11 years old in China,and the problem is particularly severe for rural populations.What is added by this report?Among children aged 6-11 years old in 2016-2017,the average intakes of vitamin A,thiamine.Wei Piao Lahong Ju Hongyun Fang Qiya Guo Shuya Cai Xiaoli Xu Shujuan Li Xue Cheng Liyun Zhao Dongmei Yu 2021China CDC weekly2021,3,11:3
18Ca-P Conversion Coating on AZ60 Magnesium Alloy for Biomedical Application显示文摘CHENG Zhongji LIAN Jianshe HU Xiaoli YANG Xiaohong LI Guangyu 2014Chemical Research in Chinese Universities2014,30,4:3
19Cooking Oil and Salt Intakes Among Children Aged 6−17 Years——China,2016−2017显示文摘Summary What is already known on this topic?High-level intakes of both cooking oil and salt are issues of concern in China as they can lead to an increased risk of chronic diseases later in life.Reducing intakes of cooking oil and salt should be prioritized in children.What is added by this report?Among children aged 6-17 years in China in 2016-2017,the median intake of cooking oil and salt were 27.7 and 6.1 g/d,respectively.The percentages of children with intake of cooking oil and salt that exceeded the recommended guidelines were 50.4%and 67.8%,respectively.Lahong Ju Dongmei Yu Wei Piao Hongyun Fang Qiya Guo Xiaoli Xu Shujuan Li Xue Cheng Shuya Cai Liyun Zhao 2021China CDC weekly2021,3,31:3
20Spatial–temporal variability of terrestrial vegetation productivity in the Yangtze River Basin during 2000–2009显示文摘Aims Terrestrial net primary production(NPP),the balance of gross primary production(GPP)and autotrophic respiration(AR),is a critical measure of carbon sequestration capacity for the Earth’s land surface.The aim of this study was to understand the spatio-temporal variability of NPP associated with GPP and AR in the Yangtze River Basin(YRB),China,from 2000 to 2009 during which the basin warmed significantly.Methods We first derived AR and carbon-use efficiency(CUE)from the improved Moderate Resolution Imaging Spectroradiometer GPP/NPP products(MOD17)and then conducted spatial analysis to quantify how NPP relates to GPP,AR and their relationship with key observed climate variables(temperature,precipitation and sunshine percentage)in the YRB during 2000–2009.Important Findings The spatial pattern of NPP in the YRB was predominantly determined by GPP and further modified by AR.Higher GPP and relatively low AR made the southern Jinshajiang sub-basin the most productive area in NPP in the YRB.A large portion of the YRB experienced a warmer and drier climate trend in the growing season during 2000–2009.In the upper reaches of the basin,possessing a relatively low temperature base,increases in temperature led to greater increases in GPP than those in AR,resulting in greater increased NPP.However,in the middle and lower reaches of the basin where the base temperature is relatively high,increases in temperature led to greater increases in AR than those in GPP,leading to decreases in NPP.Overall,86.7%of the vegetated area showed a consistent GPP and NPP trend through time with 71.3%of the vegetated area having a positive trend both in GPP and NPP,and the remaining 13.3%of vegetated areas showed an opposite trend in GPP and NPP,with positive GPP and negative NPP trajectories dominating(10.1%of vegetated area)the trend.Although climate warming generally had positive effects on vegetation growth in most areas of the basin,areas with increased NPP(74.5%)were less extensive than those with increased GPP(81.4%)due to the wider increase in AR(82.2%).During the study period,increases in AR offset 62%of the total increased GPP,leading to a substantial decline of CUE,particularly in the warmer lower altitude regions in the southeast.Our work reveals the diverse responses of NPP associated with GPP and AR as the climate warms and generally suggests that NPP in the middle and lower sub-basins in the YRB is more sensitive to future climate warming.These findings enhance our understanding of terrestrial ecosystem carbon dynamics in response to global warming and provide a scientific basis for managing ecosystem productivity in the YRB,China.Yulong Zhang Conghe Song Kerong Zhang Xiaoli Cheng Quanfa Zhang 2014Journal of Plant Ecology2014,7,1:3
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