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| 1 | Automated defect analysis in electron microscopic images显示文摘Electron microscopy and defect analysis are a cornerstone of materials science,as they offer detailed insights on the microstructure and performance of a wide range of materials and material systems.Building a robust and flexible platform for automated defect recognition and classification in electron microscopy will result in the completion of analysis orders of magnitude faster after images are recorded,or even online during image acquisition.Automated analysis has the potential to be significantly more efficient,accurate,and repeatable than human analysis,and it can scale with the increasingly important methods of automated data generation.Herein,an automated recognition tool is developed based on a computer vison–based approach;it sequentially applies a cascade object detector,convolutional neural network,and local image analysis methods.We demonstrate that the automated tool performs as well as or better than manual human detection in terms of recall and precision and achieves quantitative image/defect analysis metrics close to the human average.The proposed approach works for images of varying contrast,brightness,and magnification.These promising results suggest that this and similar approaches are worth exploring for detecting multiple defect types and have the potential to locate,classify,and measure quantitative features for a range of defect types,materials,and electron microscopic techniques. | Wei Li Kevin G.Field Dane Morgan | 2018 | npj Computational Materials2018，，1： | 5 |
| 2 | High-performance modified uni-traveling carrier photodiode integrated on a thin-film lithium niobate platform显示文摘Lithium niobate on insulator(LNOI)has become an intriguing platform for integrated photonics for applications in communications,microwave photonics,and computing.Whereas,integrated devices including modulators,resonators,and lasers with high performance have been recently realized on the LNOI platform,high-speed photodetectors,an essential building block in photonic integrated circuits,have not been demonstrated on LNOI yet.Here,we demonstrate for the first time,heterogeneously integrated modified uni-traveling carrier photodiodes on LNOI with a record-high bandwidth of 80 GHz and a responsivity of 0.6 A/W at a 1550-nm wavelength.The photodiodes are based on an n-down In GaAs/InP epitaxial layer structure that was optimized for high carrier transit time-limited bandwidth.Photodiode integration was achieved using a scalable wafer die bonding approach that is fully compatible with the LNOI platform. | XIANGWEN GUO LINBO SHAO LINGYAN HE KEVIN LUKE JESSE MORGAN KEYE SUN JUNYI GAO TA-CHING TZU YANG SHEN DEKANG CHEN BINGTIAN GUO FENGXIN YU QIANHUAN YU MASOUD JAFARI MARKO LONčAR MIAN ZHANG ANDREAS BELING | 2022 | Photonics Research2022，10，6： | 2 |
| 3 | Transepithelial leak in Barrett's esophagus patients: The role of proton pump inhibitors显示文摘AIM: To determine if the observed paracellular sucrose leak in Barrett's esophagus patients is due to their proton pump inhibitor (PPI) use. METHODS: The in vivo sucrose permeability test was administered to healthy controls, to Barrett's patients and to non-Barrett's patients on continuous PPI therapy. Degree of leak was tested for correlation with presence of Barrett's, use of PPIs, and length of Barrett's segment and duration of PPI use. RESULTS: Barrett's patients manifested a near 3-fold greater, upper gastrointestinal sucrose leak than healthy controls. A decrease of sucrose leak was observed in Barrett's patients who ceased PPI use for 7 d.Although initial introduction of PPI use (in a PPI-na ve population) results in dramatic increase in sucrose leak, long-term, continuous PPI use manifested a slow spontaneous decline in leak. The sucrose leak observed in Barrett's patients showed no correlation to the amount of Barrett's tissue present in the esophagus. CONCLUSION: Although future research is needed to determine the degree of paracellular leak in actual Barrett's mucosa, the relatively high degree of leak observed with in vivo sucrose permeability measurement of Barrett's patients reflects their PPI use and not their Barrett's tissue per se . | Christopher Farrell Melissa Morgan Owen Tully Kevin Wolov Keith Kearney Benjamin Ngo Giancarlo Mercogliano James J Thornton Mary Carmen Valenzano James M Mullin | 2012 | World Journal of Gastroenterology2012，18，22： | 2 |
| 4 | The Regional Innovation Paradox:Innovation Policy and Industrial Policy显示文摘 | Christine Oughton Mikel Landabaso Kevin Morgan | 2002 | Journal of Technology Transfer2002，27，： | 1 |
| 5 | The Regional Innovation Paradox: Innovation Policy and Industrial Policy显示文摘 | Christine Oughton Mikel Landabaso Kevin Morgan | 2002 | The Journal of Technology Transfer2002，，1： | 1 |
| 6 | Spaces of Innovation: Learning, Proximity and the Ecological Turn显示文摘 | Adrian Healy Kevin Morgan | 2012 | Regional Studies2012，，8： | 1 |
| 7 | Discovery of azetidinone acids as conformationally-constrained dual PPARα/γ agonists显示文摘 | Wei Wang Pratik Devasthale Dennis Farrelly Liqun Gu Thomas Harrity Michael Cap Cuixia Chu Lori Kunselman Nathan Morgan Randy Ponticiello Rachel Zebo Litao Zhang Kenneth Locke Jonathan Lippy Kevin O’Malley Vinayak Hosagrahara Lisa Zhang Pathanjali Kadiyala | 2008 | Bioorganic & Medicinal Chemistry Letters2008，，6： | 1 |
| 8 | Fractional Anisotropy Changes After Several Weeks of Daily Left High-Frequency Repetitive Transcranial Magnetic Stimulation of the Prefrontal Cortex to Treat Major Depression显示文摘 | F. Andrew Kozel Kevin A. Johnson Ziad Nahas Paul A. Nakonezny Paul S. Morgan Berry S. Anderson Samet Kose Xingbao Li Kelvin O. Lim Madhukar H. Trivedi Mark S. George | 2011 | The Journal of ECT2011，，1： | 1 |
| 9 | The Learning Region: Institutions, Innovation and Regional Renewal显示文摘 | Morgan Kevin | 1997 | Regional Studies1997，31，5： | 1 |
| 10 | The Regional Innovation Paradox: Innovation Policy and Industrial Policy 显示文摘 | Christine Oughton Mikel Landabaso Kevin Morgan | 2002 | Journal of Technology Transfer2002，27，： | 1 |
| 11 | The Regional Innovation Paradox:Innovation Policy and Industrial Policy显示文摘 | Mikel Landabaso Kevin Morgan | 2002 | Journal of Technology Transfer2002，，27： | 1 |
| 12 | The Regional Innovation Paradox: Innovation Policy and Industrial policy 显示文摘 | aChristine Oughton Mikel Landabaso Kevin Morgan | 2002 | Journal of Technology Transfer2002，27，11： | 1 |
| 13 | The Exaggerated Death of Geograp Learning, Proximity and Territorial Innovation Systems 显示文摘 | Morgan Kevin | 2004 | Journal of Economic Geography2004，14，1： | 1 |
| 14 | Sustainable agriculture, Food supply chains and regional development: editorial introduction 显示文摘 | Terry Marsden Jon Murdoch & Kevin Morgan | 1999 | International Planning Studies1999，4，3： | 1 |
| 15 | Bond Market Discipline of Banks:The Asset Test 显示文摘 | Morgan Donald P Kevin J Stiroh | 2001 | Journal of Financial Services Research2001，20，23： | 1 |
| 16 | Optical DE/MUX Components for Datacomunication Applications显示文摘This paper reviews the potential for WDM systems to be implemented within datacommunication systems, and indicates future network functions. Spectral and temporal multiplexing functions are reviewed, with particular focus being placed on 2DIO and amplifier based crosspoint components. | Ian H White Richard V Penty Kevin A Williams Chris N Morgan | 2003 | 光学学报2003，23，S1： | 1 |
| 17 | Immunoregulatory effects of freeze injured whole tumour cells on human dendritic cells using an in vitro cryotherapy model显示文摘 | Mohamed Ismail Richard Morgan Kevin Harrington John Davies Hardev Pandha | 2010 | Cryobiology2010，，3： | 1 |
| 18 | Label-Free Virtual HER2 Immunohistochemical Staining of Breast Tissue using Deep Learning显示文摘The immunohistochemical(IHC)staining of the human epidermal growth factor receptor 2(HER2)biomarker is widely practiced in breast tissue analysis,preclinical studies,and diagnostic decisions,guiding cancer treatment and investigation of pathogenesis.HER2 staining demands laborious tissue treatment and chemical processing performed by a histotechnologist,which typically takes one day to prepare in a laboratory,increasing analysis time and associated costs.Here,we describe a deep learning-based virtual HER2 IHC staining method using a conditional generative adversarial network that is trained to rapidly transform autofluorescence microscopic images of unlabeled/label-free breast tissue sections into bright-field equivalent microscopic images,matching the standard HER2 IHC staining that is chemically performed on the same tissue sections.The efficacy of this virtual HER2 staining framework was demonstrated by quantitative analysis,in which three board-certified breast pathologists blindly graded the HER2 scores of virtually stained and immunohistochemically stained HER2 whole slide images(WSIs)to reveal that the HER2 scores determined by inspecting virtual IHC images are as accurate as their immunohistochemically stained counterparts.A second quantitative blinded study performed by the same diagnosticians further revealed that the virtually stained HER2 images exhibit a comparable staining quality in the level of nuclear detail,membrane clearness,and absence of staining artifacts with respect to their immunohistochemically stained counterparts.This virtual HER2 staining framework bypasses the costly,laborious,and time-consuming IHC staining procedures in laboratory and can be extended to other types of biomarkers to accelerate the IHC tissue staining used in life sciences and biomedical workflow. | Bijie Bai Hongda Wang Yuzhu Li Kevin de Haan Francesco Colonnese Yujie Wan Jingyi Zuo Ngan B.Doan Xiaoran Zhang Yijie Zhang Jingxi Li Xilin Yang Wenjie Dong Morgan Angus Darrow Elham Kamangar Han Sung Lee Yair Rivenson Aydogan Ozcan | 2022 | Biomedical Engineering Frontiers2022，3，1： | 0 |
| 19 | 新复兴叙事——多层级政体中的地方发展显示文摘引言几乎在不被察觉的情况下,“新复兴叙事”(NRN:new regeneration narrative)已经在经济发展共同体中站稳了脚跟。政治家、政策制定者与学者和从业者一道,开始使用这样一种语言,它的词汇似乎具有某种诱惑性,但实际上一些非常重要的问题却被忽略掉了。尽管其中有些词汇的出现早于1997年,但“新叙事”是在新工党政府时期才开始形成和传播的。与所有的“叙事”一样,“新复兴叙事”(NRN)的目的在于讲述一个故事, | Kevin Morgan 曹新新 | 2007 | 国际城市规划2007，22，4： | 0 |
| 20 | X-ray focusing with efficient high-NA multilayer Laue lenses显示文摘Multilayer Laue lenses are volume diffraction elements for the efficient focusing of X-rays.With a new manufacturing technique that we introduced,it is possible to fabricate lenses of sufficiently high numerical aperture(NA)to achieve focal spot sizes below 10 nm.The alternating layers of the materials that form the lens must span a broad range of thicknesses on the nanometer scale to achieve the necessary range of X-ray deflection angles required to achieve a high NA.This poses a challenge to both the accuracy of the deposition process and the control of the materials properties,which often vary with layer thickness.We introduced a new pair of materials—tungsten carbide and silicon carbide—to prepare layered structures with smooth and sharp interfaces and with no material phase transitions that hampered the manufacture of previous lenses.Using a pair of multilayer Laue lenses(MLLs)fabricated from this system,we achieved a two-dimensional focus of 8.4×6.8 nm2 at a photon energy of 16.3 keV with high diffraction efficiency and demonstrated scanning-based imaging of samples with a resolution well below 10 nm.The high NA also allowed projection holographic imaging with strong phase contrast over a large range of magnifications.An error analysis indicates the possibility of achieving 1 nm focusing. | Saša Bajt Mauro Prasciolu Holger Fleckenstein Martin Domaracký Henry N Chapman Andrew J Morgan Oleksandr Yefanov Marc Messerschmidt Yang Du Kevin T Murray Valerio Mariani Manuela Kuhn Steven Aplin Kanupriya Pande Pablo Villanueva-Perez Karolina Stachnik Joe PJ Chen Andrzej Andrejczuk Alke Meents Anja Burkhardt David Pennicard Xiaojing Huang Hanfei Yan Evgeny Nazaretski Yong S Chu Christian E Hamm | 2017 | Light(Science & Applications)2017，6，1： | 0 |
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