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| 1 | Capsaicin enhances the antitumor activity of sorafenib in hepatocellular carcinoma cells and mouse xenograft tumors through increased ERK signaling显示文摘Sorafenib,酷氨酸蛋白质 kinases 的一个小禁止者,当前是为先进 hepatocellular 癌(HCC ) 的治疗的标准化疗药。尽管 sorafenib 改进 HCC 病人的幸存,它的功效不是最佳的并且要求进一步的改进。Capsaicin,从类辣椒的红辣椒辣椒的主要活跃部件,是 TRPV1 隧道,而且显示 antitumor 活动的不仅收缩筋并且提高癌症房间的敏感到细胞毒素的药。在这研究,我们在 vitro 和异种皮移植肿瘤在 HCC 房间上调查了联合 sorafenib 和 capsaicin 的 antitumor 效果。有 capsaicin 的治疗 dose-dependently 独自分别地与 137, 108 和 140.7 mol/L 的 IC 50 价值禁止了 HCC 房间线 PLC/PRF/7, HuH7 和 HepG2 的增长。TRPV1 隧道的明显的表示都没在 3 根 HCC 房间线被检测, TRPV1 隧道 blockers 没减轻 capsaicin 的 cytotoxicity。由对比,显著地联合 capsaicin 和 sorafenib 在房间增长上提高了抑制,完成高级 synergistic 效果(超过 50% 的抑制率) 并且支持 HCC 房间 apoptosis。在有 PLC/PRF/5 异种皮移植的裸体老鼠,联合了 capsaicin 的管理,没有明显的粗野毒性, sorafenib 显著地独自与任何一个代理人相比在肿瘤生长上提高了抑制。机械学地, capsaicin (10-200 mol/L ) dose-dependently 在 PLC/PRF/5 房间增加了 phosphorylated 英皇家空军之阶级最低之兵(津贴) 的层次,因此导致在肿瘤房间上提高了 sorafenib 敏感和 synergistic 抑制。一起拿,我们的结果建议英皇家空军之阶级最低之兵的增加 capsaicin 的 phosphorylation 贡献 sorafenib,和 capsaicin 的提高的 antitumor 活动可能在为 HCC 的处理改进 sorafenib 的功效有用。 | Su-shan ZHANG Yu-hao NI Chen-ru ZHAO Zhen QIAO Hong-xia YU Lu-yao WANG Jin-yan SUN Chen DU Jia-haoZHANG Li-ying DONG KeWei WANG Jian-jun GAO | 2018 | Acta Pharmacologica Sinica2018，39，3： | 4 |
| 2 | Phosphatase activity and culture conditions of the yeast Candida mycoderma sp. and analysis of organic phosphorus hydrolysis ability显示文摘Orthophosphate is an essential but limiting macronutrient for plant growth. About 67%cropland in China lacks sufficient phosphorus, especially that with red soil. Extensive soil phosphorus reserves exist in the form of organic phosphorus, which is unavailable for root uptake unless hydrolyzed by secretory acid phosphatases. Thus, many microorganisms with the ability to produce phosphatase have been exploited. In this work, the activity of an extracellular acid phosphatase and yeast biomass from Candida mycoderma was measured under different culture conditions, such as p H, temperature, and carbon source. A maximal phosphatase activity of 8.47 × 105± 0.11 × 105U/g was achieved by C. Mycoderma in 36 hr under the optimal conditions. The extracellular acid phosphatase has high activity over a wide p H tolerance range from 2.5 to 5.0(optimum p H 3.5). The effects of different phosphorus compounds on the acid phosphatase production were also studied. The presence of phytin, lecithin or calcium phosphate reduced the phosphatase activity and biomass yield significantly. In addition, the p H of the culture medium was reduced significantly by lecithin. The efficiency of the strain in releasing orthophosphate from organic phosphorus was studied in red soil(used in planting trees) and rice soil(originating as red soil). The available phosphorus content was increased by 230% after inoculating20 days in rice soil and decreased by 50% after inoculating 10 days in red soil. This work indicates that the yeast strain C. mycoderma has potential application for enhancing phosphorus utilization in plants that grow in rice soil. | Mang Yan Liufang Yu Liang Zhang Yuexia Guo Kewei Dai Yuru Chen | 2014 | Journal of Environmental Sciences2014，26，11： | 2 |
| 3 | Roles of metal element substitutions from the bimetallic solid state electrolytes in lithium batteries显示文摘All-solid-state lithium batteries(ASSLBs),receiving extensive attentions and studies,exhibit better safety,environmental friendliness,stability,wider electrochemical stability window and higher energy density than traditionally liquid lithium batteries.In a variety of inorganic materials,with highly replaceable,the non-lithium metal elements emerge in endlessly and affect performances in diversiform ways.Due to facile preparation,convertible structures and excellent properties,the lithium-containing bimetallic granular materials are often applied as important components of electrolytes in lithium batteries.In this review,in terms of the properties of substituted elements,changing crystal structures,increasing vacancies or defects and improving the interfacial conductions,the roles of metal element substitutions of inorganic particles on the improvement of solid-state electrolytes are expounded.And the applications of substituted strategies in ASSLBs as the host of inorganic particles electrolytes and as fillers or modifications for composite electrolytes are also investigated and discussed.It also summarizes the current concerns and obstacles that need to be broken through,as well as provides a basis guide for the selection and optimization of inorganic particles. | Wen Yu Nanping Deng Lin Tang Kewei Cheng Bowen Cheng Weimin Kang | 2022 | Particuology2022，20，6： | 2 |
| 4 | LMI optimization approach on robustness and H-infinity control analysis for observer-based control of uncertain systems 显示文摘 | LIAN Changhua YU Kewei | 2008 | Solitons & Fractals2008，36，3： | 1 |
| 5 | Enrichment-induced exercise to quantify the effect of different housing conditions: A tool to standardize enriched environment protocols显示文摘 | Hongyu Xie Yi Wu Jie Jia Gang Liu Qi Zhang Kewei Yu Zhenzhen Guo Li Shen Ruiping Hu | 2013 | Behavioural Brain Research2013，，： | 1 |
| 6 | A possible assignment for the ground scalar meson nonet显示文摘 | Li Demin Wei Kewei Yu Hong | 2005 | Eur Phys J A2005，25，： | 1 |
| 7 | Nitrous oxide and methane transport through rice plants 显示文摘 | YU Kewei WANG Zhengping CHEN Guanxiong | 1997 | Biology and Fertility of Soils1997，24，3： | 1 |
| 8 | Enriched environment induces angiogenesis and improves neural function outcomes in rat stroke model显示文摘 | Kewei Yu Yi Wu Qi Zhang Hongyu Xie Gang Liu Zhenzhen Guo Fang Li Jie Jia Shenyi Kuang Ruiping Hu | 2014 | Journal of the Neurological Sciences2014，，： | 1 |
| 9 | A possible assign- ment for the ground scalar meson nonet 显示文摘 | Li Detain Wei Kewei Yu Hong | 2005 | Eur Phys J A2005，25，： | 1 |
| 10 | The effects of measurement errors in the plasma radioactivity curve on parameter estimation in positron emission tomography 显示文摘 | CHEN Kewei HUANG Sungchen Yu Danchu | 1991 | Phys Med Biol1991，36，9： | 1 |
| 11 | Activation of hydrogen peroxide by molybdenum disulfide as Fenton-like catalyst and cocatalyst:Phase-dependent catalytic performance and degradation mechanism显示文摘Molybdenum disulfide(Mo S_(2))has attracted great attention in hydrogen peroxide(H_(2)O_(2))activation as a Fenton-like catalyst and cocatalyst,but the distinct mechanism of generating^(·)OH remains unclear.In this paper,the metallic 1T phase and semiconducting 2H phase of Mo S_(2)nanosheets were prepared and applied in MoS_(2)/H_(2)O_(2)and MoS_(2)/Fe^(2+)/H_(2)O_(2)systems with and without light irradiation.Compared with2H-MoS_(2),1T-MoS_(2)exhibited superior removal rates in degrading organic pollutants in the two systems under light irradiation.However,the phase had little effect on activating H_(2)O_(2)in the Mo S_(2)/H_(2)O_(2)system under dark conditions.This is because it was difficult for the surface^(·)OH_(ads)generated in the Mo S_(2)/H_(2)O_(2)system to diffuse into solution,while the^(·)OH_(free)radicals were mainly responsible for degrading organic pollutants.When introducing light irradiation,external energy may accelerate the desorption of^(·)OH_(ads)into^(·)OH_(free.)Interestingly,the conversion between Mo^(4+)and Mo^(5+)triggered the decomposition of H_(2)O_(2)in the Fenton-like reaction,while the cycle of Mo^(4+)/Mo^(6+)promoted the regeneration of Fe^(3+)when employing 1T-MoS_(2)as a cocatalyst.Meanwhile,the 1T-MoS_(2)catalysts exhibited excellent stability and ability to degrade various organics in the two systems.This work offers deeper insight into the Mo S_(2)-based Fenton-like and cocatalytic mechanisms. | Yue Li Bo Yu Huimin Li Bo Liu Xiang Yu Kewei Zhang Gang Qin Jiahao Lu Lihui Zhang Longlu Wang | 2023 | Chinese Chemical Letters2023，34，5： | 1 |
| 12 | Systematic review and meta-analysis of comparative studies reporting early outcomes after robot-assisted radical cystectomy versus open radical cystectomy显示文摘 | Kaiwen Li Tianxin Lin Xinxiang Fan Kewei Xu Liangkuan Bi Yu Duan Yu Zhou Min Yu Jielin Li Jian Huang | 2013 | Cancer Treatment Reviews2013，，： | 1 |
| 13 | Kinetics of desensitization and recovery from desensitization for human α4β2-nicotinic acetylcholine receptors stably expressed in SH-EP1 cells显示文摘 | Kewei D YU Qjang LIU Jie WU Ronald J LUKA | 2009 | Acta Pharmacologica Sinica2009，30，6： | 1 |
| 14 | A possible assignment for the ground sealar meson nonet显示文摘 | Li Detain Wei Kewei Yu Hong | 2005 | Eur Phys J A2005，25，： | 1 |
| 15 | Influence of salinity level on sediment denitrification in a Louisiana estuary receiving diverted Mississippi River water显示文摘 | Dong Cheol Seo Kewei Yu Ronald D. Delaune | 2008 | Archives of Agronomy and Soil Science2008，，3： | 1 |
| 16 | Mg-based inorganic nanofibers constructing fast and multi-dimensional ion conductive pathways for all-solid-state lithium metal batteries显示文摘Solid-state electrolytes(SSEs),which replace flammable and toxic liquid electrolytes,have attracted widely attention.However,there exist still some challenges in actual application such as poor interfacial compatibility and slow ionic migration.In this study,Mg O nanofibers and MgF;nanofibers were prepared via the electro-blow spinning and high-temperature calcination methods,and were applied to all-solid-state lithium metal batteries for the first time.The organic-inorganic composite SSEs exhibited continuous conduction paths based on the virtue of the nanofibers with high length-to-diameter ratio,which were designed and prepared by mixing prepared fillers into the poly(ethylene oxide)(PEO)/lithium bis(trifluoromethane)sulfonilimide(Li TFSI)system.The effect of filler with different morphologies,doping ratios and component on ionic conductivity,electrochemical stability and cycle performance were explored under two kinds of[EO]/[Li^(+)]ratios and ambient temperatures.The ionic conductivities of electrolytes containing Mg O and MgF;nanofibers can reach up to 1.19×10^(-4) and 1.39×10^(-4) S cm^(-1) at 30℃,respectively.They were attributed to specific ionic conductive enhancement at the organicinorganic interface,reduced crystallinity and Lewis acid interaction,which can effectively promote the dissociation of the lithium salts.Especially MgF_(2) nanofiber,combining low electronic conductance,excellent electrochemical stability and outstanding inhibition for lithium dendrites of fluorides,endowed the battery with an initial specific capacity of 140.6 m Ah g^(-1) and capacity decay rate per cycle of 0.055%after500 cycles at 50℃.The work can provide an idea to design SSE with fast and multi-dimensional Li conductive paths and excellent interfacial compatibility. | Wen Yu Nanping Deng Zirui Yan Lu Gao Kewei Cheng Xiaohui Tian Lin Tang Bowen Cheng Weimin Kang | 2022 | Journal of Energy Chemistry2022，31，4： | 1 |
| 17 | Voltammetric determination of dopamine and norepinphrine on a glassy carbon electrode modified with poly (L-aspartic acid)显示文摘 | ZHANGYU YU XIAOCHUN LI XUELIANG WANG XINYING MA XIA LI KEWEI CAO | 2012 | Journal of Chemical Sciences2012，，2： | 1 |
| 18 | MODIFICATION OF SEEMANN-BOHLIN METHOD FOR STRESS MEASUREMENT显示文摘The scattered distribution of the lattice parameters in the Seemann-Bohlin method forstress measurement was discussed.A linear relation can be achieved by modification withthe theory deduced from Kroner model.However,the Seemann-Bohlin method cannotachieve good accuracy in comparison with the Bragg-Brentauo method,particularly forlow stress values. | YU Ligen BAI Chendong CHEN Hua XU Kewei HE Jiawen Xi’an Jiaotong University,Xi’an,China Research Institute for Strength of Metals,Xi’an Jiaotong University,Xi’an 710049,China | 1993 | Acta Metallurgica Sinica(English Letters)1993，6，11： | 0 |
| 19 | Effects of Standardized Rehabilitation on Quality of Life of Stroke Patients at Convalescence and Sequelae Stages显示文摘Objective:To explore the effects of standardized rehabilitation on quality of life (QOL) of stroke patients at convalescence and sequelae stages. Method:A total of 251 stroke patients were randomly divided into a standardized rehabilitation group and a control group. The simplified Fugl-Meyer assessment(FMA) scale, the 36-item short-form health survey questionnaire (SF-36) and functional comprehensive assessment (FCA) were administered before as well as after 3, 6 and at 12 months a follow-up study respectively. Statistical analysis was conducted based on the evaluations at 4 testing time points. Result:There was no significant difference in FMA,SF-36 and FCA scores of the two groups before and after 3 months treatments, while FMA,SF-36 and FCA scores of the rehabilitation group were obviously higher than those of the control group either after 6 months treatments or of followup study. Moreover, after 6 months treatments FMA score was apparently higher than the score at the beginning and after 3 months treatments. The FMA, SF36 and FAC scores during the followup visit decreased when compared with scores after 6 months treatments, but increased significantly when compared with the scores at the beginning and after 3 months treatments. Conclusion:Standardized tertiary rehabilitation (STR) at convalescence and sequelae stages can significantly improve motor functions and QOL of stroke patients. | XU Dongyan JIA Jie WU Yi LI Mingfen XIE Hongyu YU Kewei GUO Zhenzhen | 2013 | 中国康复医学杂志2013，28，6： | 0 |
| 20 | Cold weather and Kashin-Beck disease显示文摘Kashin-Beck disease(KBD)is an endemic osteoarthropathy.Its distribution region covers a long and narrow belt on the Pacific side and belongs to continental climate with short summer,long frost period,and large temperature differences between day and night.In particular,KBD patients are typically scattered in the rural areas with seasonal features such as cold winters and rainy autumns.Etiological studies have demonstrated that the carrier of pathogenic factors is the grains produced in endemic areas.Risk factors for KBD include fungal contamination of grains due to poor storage conditions associated with cold weather.The epidemiological characteristics of KBD include agricultural area,early age of onset,gender equality,family aggregation,regional differences,and annual fluctuations.A series of preventive measures have been successfully taken in the past decades.National surveillance data indicate that the annual incidence of KBD is gradually declining. | Kewei Wang Jun Yu Dianjun Sun | 2023 | Frigid Zone Medicine2023，3，1： | 0 |
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