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| 1 | High circulating tumor cell concentrations in a specific subtype of gastric cancer with diffuse bone metastasis at diagnosis显示文摘AIM: To clarify the biological feature contributing to gastric cancer with diffuse bone metastases at diagnosis.METHODS: The participants visited the Department of Clinical Oncology, Akita University Hospital, from January 2014 to August 2015. The selection criterion for gastric cancer with diffuse bone metastases at diagnosis includes over 29 hot spots of bone scintigraphy. Circulating tumor cell were collected from 20 m L of peripheral venous blood drawn using a Cell Search kit and a Cell Tracks Auto Prep system by SRL, a clinical laboratory. The endpoints of this study were correlations between circulating tumor cells(CTC) count and therapeutic outcomes. RESULTS: Among 39 patients with gastric cancer, 5 patients met the criterion. The incidence of this subtype was 12.8%. CTC counts ranged from 235 to 6440 cells/7.5 m L of peripheral blood(median of 1724). These values were much higher than common gastric cancers(2 cells). In chemo-sensitive cases, CTC counts decreased within 14 d(median) from 275, 235 and 1724 to 2, 7 and 66, respectively. On the other hand, CTC counts increased after treatment failure or insensitive case from 2, 7 and 6440 to 787, 513 and 7885, respectively. The correlation between CTC count and survival time showed a trend, but did not reach significance(Y = 234.6- 0.03 X, P = 0.085).CONCLUSION: High CTC count is a biological hallmark of this subtype, and can be used as a direct and definitive indicator of therapeutic outcome. | Kazuhiro Shimazu Koji Fukuda Taichi Yoshida Masahiro Inoue Hiroyuki Shibata | 2016 | World Journal of Gastroenterology2016，22，26： | 9 |
| 2 | Pegylated interferon plus ribavirin for genotype Ib chronic hepatitis C in Japan显示文摘AIM:To evaluate the efficacy of pegylated interferon α-2b(peg-IFNα-2b) plus ribavirin(RBV) therapy in Japanese patients with chronic hepatitis C(CHC) genotype Ib and a high viral load.METHODS:One hundred and twenty CHC patients(58.3% male) who received peg-IFNα-2b plus RBV therapy for 48 wk were enrolled.Sustained virological response(SVR) and clinical parameters were evaluated.RESULTS:One hundred(83.3%) of 120 patients completed 48 wk of treatment.53 patients(44.3%) achieved SVR.Early virological response(EVR) and end of treatment response(ETR) rates were 50% and 73.3%,respectively.The clinical parameters(SVR vs non-SVR) associated with SVR,ALT(108.4 IU/L vs 74.5 IU/L,P = 0.063),EVR(76.4% vs 16.4%,P < 0.0001),adherence to peg-IFN(≥ 80% of planned dose) at week 12(48.1% vs 13.6%,P = 0.00036),adherence to peg-IFN at week 48(54.7% vs 16.2%,P < 0.0001) and adherence to RBV at week 48(56.1% vs 32.1%,P = 0.0102) were determined using univariate analysis,and EVR and adherence to peg-IFN at week 48 were determined using multivariate analysis.In the older patient group(> 56 years),SVR in females was significantly lower than that in males(17% vs 50%,P = 0.0262).EVR and adherence to Peg-IFN were demonstrated to be the main factors associated with SVR.CONCLUSION:Peg-IFNα-2b plus RBV combination therapy demonstrated good tolerability in Japanese patients with CHC and resulted in a SVR rate of 44.3%.Treatment of elderly female patients is still challenging and maintenance of adherence to peg-IFNα-2b is important in improving the SVR rate. | Takayuki Kogure Yoshiyuki Ueno Koji Fukushima Futoshi Nagasaki Yasuteru Kondo Jun Inoue Yasunori Matsuda Eiji Kakazu Takeshi Yamamoto Hiroyoshi Onodera Yutaka Miyazaki Hiromasa Okamoto Takehiro Akahane Tomoo Kobayashi Yutaka Mano Takao Iwasaki Motoyasu Ishii Tooru Shimosegawa | 2008 | World Journal of Gastroenterology2008，14，47： | 7 |
| 3 | Fulminant hepatic failure in a case of autoimmune hepatitis in hepatitis C during peg-interferon-alpha 2b plus ribavirin treatment显示文摘A 27-year-old Caucasian female with hepatitis C virus (HCV) infection treated with interferon (IFN) who developed severe autoimmune hepatitis (AIH) is described. The infecting viral strain was of genotype Ib and the pre-treatment HCV viral load was at a high level. The patient was treated with pegylated IFN-alpha 2b and ribavirin,and her HCV-RNA became negative at wk 12,but after that she developed fulminant hepatic failure. The patient recovered after steroid pulse therapy consisting of methylprednisolone 1000 mg/d for three days which was administered twice. A needle liver biopsy revealed the typical pathological findings of AIH. | Takayuki Kogure Yoshiyuki Ueno Koji Fukushima Futoshi Nagasaki Jun Inoue Eiji Kakazu Yasunori Matsuda Osamu Kido Yu Nakagome Osamu Kimura Noriyuki Obara Yuta Wakui Takao Iwasaki Tooru Shimosegawa | 2007 | World Journal of Gastroenterology2007，13，32： | 5 |
| 4 | A potent chemotherapeutic strategy in prostate cancer: S-(methoxytrityl)-L-cysteine, a novel Eg5 inhibitor显示文摘基于 Docetaxel 的联合化疗为阉割抵抗的前列腺癌症仍然是占优势的治疗。然而, taxane 相关的药抵抗和 neurotoxicity 提示了我们开发代用品治疗策略。Eg5 (kinesin 锭子蛋白质) 为双极的锭子形成关键并且在有丝分裂的早阶段期间复制染色体分离,为癌症化疗作为一个吸引人的目标出现了。这研究的目的是调查 S-(methoxytrityl )-L-cysteine (S (MeO ) TLC ) 的 anticancer 功效,在前列腺癌症的一个新奇 Eg5 禁止者。Eg5 表示在人的前列腺癌症房间线被检验,织物 microarrays 从临床的标本被构造。在前列腺癌症房间的 S (MeO ) TLC 的 Antiproliferative 活动被房间生存能力试金估计。anticancer 效果和在前列腺癌症房间的 S (MeO ) TLC 的禁止的机制被 Hoechst 染色,流动 cytometry 和 immunofluorescence 进一步探索。另外,下的异种皮移植模型上的 S (MeO ) TLC 的 antitumor 效果被估计。Eg5 表示在 PC3, DU145 和 LNCaP 房间被识别。多于前列腺癌症的一半,临床的标本显示了 Eg5 表示。S (MeO ) TLC 与测试的另外的四个 Eg5 禁止者相比在前列腺癌症房间展出了更多的强大的 anticancer 活动。S (MeO ) TLC 在逮捕与不同 monopolar 锭子形成在有丝分裂划分房间以后导致了房间死亡。S (MeO ) TLC 展出了它的重要禁止的活动(P < 0.05 ) 通过有丝分裂的拘捕的正式就职也在下的异种皮移植上当模特儿。我们断定 Eg5 是为前列腺癌症化疗的一个好目标,并且 S (MeO ) TLC 是在前列腺癌症答应 anticancer 代理人的一个有势力。 | Nai-Dong Xing Sen-Tai Ding Ryoichi Saito Koji Nishizawa Takashi Kobayashi Takahiro Inoue Shinya Oishi Nobutaka Fujii Jia-Jv Lv Osamu Ogawax Hiroyuki Nishiyama | 2011 | Asian Journal of Andrology2011，13，2： | 4 |
| 5 | Beh et's disease complicated by multiple aseptic abscesses of the liver and spleen显示文摘Aseptic abscesses are an emergent entity and have been described in inflammatory bowel disease,especially in Crohn's disease,and in other diseases.However,aseptic abscesses associated with Beh et's disease are extremely rare.We report a Japanese male diagnosed with an incomplete type of Beh et's disease who developed multiple aseptic abscesses of the spleen and liver.In 2002,the spleen abscesses were accompanied by paroxysmal oral aphthous ulcers and erythema nodosum.As the patient's response to antibiotic treatment was inadequate,a splenectomy was performed.Severe inflammatory cell infiltration,largely of polymorphonuclear neutrophils,was observed without evidence of bacterial or fungal growth.Although the patient had no history of ocular symptoms or genital ulcers,a diagnosis of incomplete Beh et's disease was made according to the Japanese diagnostic criteria because of the presence of paroxysmal arthritis and epididymitis since 2002.In 2005,multiple liver abscesses developed with right hypochondrial pain and seemed to be attributed to Beh et's disease because the abscesses yielded negative results during a microbiologic investigation and failed to go into remission under antibiotic therapy.Oral prednisone(15 mg/d) was started in May 2006,and the abscesses dramatically disappeared 4 wk after treatment.Although the patient had a relapse of the liver abscesses in association with the tapering of prednisone,the augmentation of prednisone dosage yielded a response.The abscesses of the liver and spleen were strongly suggested to be attributed to Beh et's disease.Clinician should be aware of the existence of aseptic abscesses as uncommon manifestations of Beh et's disease. | Keisuke Maeshima Koji Ishii Megumi Inoue Katsuro Himeno Masataka Seike | 2013 | World Journal of Gastroenterology2013，19，20： | 3 |
| 6 | Laparoscopic and endoscopic cooperative surgery for duodenal tumor resection显示文摘 | Fumitoshi Hirokawa Michihiro Hayashi Yoshiharu Miyamoto Mitsuhiro Asakuma Tetsunosuke Shimizu Koji Komeda Yoshihiro Inoue Eiji Umegaki Kazuhisa Uchiyama | 2014 | Endoscopy2014，，： | 3 |
| 7 | 64-slice multidetector computed tomography evaluation of gastrointestinal tract perforation site: detectability of direct findings in upper and lower GI tract显示文摘 | Sota Oguro Tomohiro Funabiki Koji Hosoda Yukio Inoue Takashi Yamane Michihiro Sato Mitsuhide Kitano Masahiro Jinzaki | 2010 | European Radiology2010，，6： | 3 |
| 8 | Prognostic Nutritional Index Predicts Postoperative Outcome in Colorectal Cancer显示文摘 | Yasuhiko Mohri Yasuhiro Inoue Koji Tanaka Junichirou Hiro Keiichi Uchida Masato Kusunoki | 2013 | World Journal of Surgery2013，，11： | 3 |
| 9 | Serum miR-200c Is a Novel Prognostic and Metastasis-Predictive Biomarker in Patients With Colorectal Cancer显示文摘 | Yuji Toiyama Keun Hur Koji Tanaka Yasuhiro Inoue Masato Kusunoki C. Richard Boland Ajay Goel | 2014 | Annals of Surgery2014，，4： | 3 |
| 10 | Effects of oral tacrolimus as a rapid induction therapy in ulcerative colitis显示文摘AIM:To determine the efficacy and safety of rapid induction therapy with oral tacrolimus without a meal in steroid-refractory ulcerative colitis(UC)patients.METHODS:This was a prospective,multicenter,observational study.Between May 2010 and August 2012,49 steroid-refractory UC patients(55 flare-ups)were consecutively enrolled.All patients were treated with oral tacrolimus without a meal at an initial dose of 0.1mg/kg per day.The dose was adjusted to maintain trough whole-blood levels of 10-15 ng/m L for the first 2 wk.Induction of remission at 2 and 4 wk after tacrolimus treatment initiation was evaluated using Lichtiger’s clinical activity index(CAI).RESULTS:The mean CAI was 12.6±3.6 at onset.Within the first 7 d,93.5%of patients maintained high trough levels(10-15 ng/m L).The CAI significantly decreased beginning 2 d after treatment initiation.At 2wk,73.1%of patients experienced clinical responses.After tacrolimus initiation,31.4%and 75.6%of patients achieved clinical remission at 2 and 4 wk,respectively.Treatment was well tolerated.CONCLUSION:Rapid induction therapy with oral tacrolimus shortened the time to achievement of appropriate trough levels and demonstrated a high remission rate 28 d after treatment initiation.Rapid induction therapy with oral tacrolimus appears to be a useful therapy for the treatment of refractory UC. | Ken Kawakami Takuya Inoue Mitsuyuki Murano Ken Narabayashi Sadaharu Nouda Kumi Ishida Yosuke Abe Koji Nogami Nobuyuki Hida Hirokazu Yamagami Kenji Watanabe Eiji Umegaki Shiro Nakamura Tetsuo Arakawa Kazuhide Higuchi | 2015 | World Journal of Gastroenterology2015，21，6： | 3 |
| 11 | Associations between circulating microRNAs (miR-21, miR-34a, miR-122 and miR-451) and non-alcoholic fatty liver显示文摘 | Hiroya Yamada Koji Suzuki Naohiro Ichino Yoshitaka Ando Akira Sawada Keisuke Osakabe Keiko Sugimoto Koji Ohashi Ryouji Teradaira Takashi Inoue Nobuyuki Hamajima Shuji Hashimoto | 2013 | Clinica Chimica Acta2013，，： | 3 |
| 12 | Delayed perforation: A hazardous complication of endoscopic resection for non‐ampullary duodenal neoplasm显示文摘 | Takuya Inoue Noriya Uedo Takeshi Yamashina Sachiko Yamamoto Noboru Hanaoka Yoji Takeuchi Koji Higashino Ryu Ishihara Hiroyasu Iishi Masaharu Tatsuta Hidenori Takahashi Hidetoshi Eguchi Hiroaki Ohigashi | 2014 | Digestive Endoscopy2014，，2： | 3 |
| 13 | Overexpression of ETS-1 is associated with malignan' biological features of prostate cancer显示文摘E26 transformation-specific-1 ( ETS-1 ),一个 et 家庭抄写因素,被报导了在前列腺癌症( PCa )在 ETS-1 表示的许多生理、病理学的过程,而是临床的含意起一个重要作用,特别地高风险的案例,包括对雄激素剥夺的反应,治疗( ADT )还得被阐明。我们用针活体检视从 69 个主要先进的 PCa 病人获得的嵌入石蜡的前列腺癌织物染色的 immunohistochemical 检验了 ETS-1 的表示。ETS-1 表示与 69 个病人的 clinicopathological 特征相比,包括 25 作为主要治疗经历了 ADT。作为结果,有 ETS-1 的更高的表示的 PCa 病人是显著地,可能舞台高的更多得分(P< 0.05 ) 。在 ETS-1 表示和起始的前列腺特定的抗原(PSA ) 水平之间没有重要协会。在 ADT 对待的 25 个病人,为 ETS-1 的染色的分数显著地在 24 个月以内与阉割抵抗的疾病的快速的开发被联系(P< 0.05 ) ,而格利森分数和 PSA 水平不是。在结论,增加了 ETS-1 表示与到阉割抵抗的前进的一个更高的阶段,更高级的格利森分数和更短的时间被联系。这些数据建议为 ETS-1 的 immunostaining 能是为为 PCa 病人预言差的临床的结果的一个分子的标记,特别地那些与高风险的疾病。 | Bo Li Yosuke Shimizu Takashi Kobayashi Naoki Terada Koji Yoshimura Tomomi Kamba Yoshiki Mikami Takahiro Inoue Hiroyuki Nishiyama Osamu Ogawa | 2012 | Asian Journal of Andrology2012，14，6： | 2 |
| 14 | Vitamin D receptor expression is associated with colon cancer in ulcerativecolitis显示文摘 | Koji Wada Hiroaki Tanaka Kiyoshi Maeda Toru Inoue Eiji Noda Ryosuke Amano Naoshi Kubo Kazuya Muguruma Nobuya Yamada Masakazu Yashiro Tetsuji Sawada Bunzo Nakata Masaichi Ohira Kosei Hirakawa | 2009 | Oncology Reports2009，，5： | 2 |
| 15 | Performance tests of newly developed adsorption/plasma combined system for decomposition of volatile organic compounds under continuous flow condition显示文摘The adsorption/plasma decomposition with the combination of adsorption honeycomb-sheets and a plasma element is a new technology for small-sized apparatuses to decompose volatile organic compounds(VOCs) at concentrations lower than about 100 ppm.The feasibility of the prototype adsorption/plasma decomposition apparatus was evaluated with the simulated exhausts containing one VOC component and with real exhausts from a painting booth and an adhesion factory.The apparatus decomposed VOCs effectively at the painting booth exhaust but not always satisfactorily at the adhesion factory exhaust.The performance test results with real exhausts were discussed with respect to the concentration and discharge pattern of the exhausts and the basic properties of the system such as cooperation of adsorption and plasma reaction and the concentration dependence of the performance. | Koji Inoue Hiroshi Okano Yukihiko Yamagata Katsunori Muraoka Yasutake Teraoka | 2011 | Journal of Environmental Sciences2011，23，1： | 2 |
| 16 | Single‐incision laparoscopic and endoscopic cooperative surgery for gastrointestinal stromal tumor arising from the duodenum显示文摘 | Masaki Ohi Hiromi Yasuda Yoshito Ishino Masaki Katsurahara Susumu Saigusa Kyosuke Tanaka Koji Tanaka Yasuhiko Mohri Yasuhiro Inoue Keiichi Uchida Masato Kusunoki | 2013 | Asian J Endosc Surg2013，，4： | 2 |
| 17 | Efficacy of atorvastatin for the treatment of nonalcoholic steatohepatitis with dyslipidemia显示文摘 | Hideyuki Hyogo Susumu Tazuma Koji Arihiro Keiko Iwamoto Yoshitaka Nabeshima Motoki Inoue Tomokazu Ishitobi Michihiro Nonaka Kazuaki Chayama | 2008 | Metabolism2008，，12： | 2 |
| 18 | A large, solitary, semipedunculated gastric polyp in pediatric juvenile polyposis syndrome显示文摘 | Kohei Otake Keiichi Uchida Mikihiro Inoue Kohei Matsushita Kiyoshi Hashimoto Yuji Toiyama Koji Tanaka Kaname Nakatani Kazuo Kawai Masato Kusunoki | 2010 | Gastrointestinal Endoscopy2010，，6： | 1 |
| 19 | Correlation of CCL20 expression in rectal mucosa with the developmentof ulcerative colitis?associated neoplasia显示文摘 | Kiyoshi Hashimoto Susumu Saigusa Toshimitsu Araki Koji Tanaka Yoshiki Okita Hiroyuki Fujikawa Mikio Kawamura Yoshinaga Okugawa Yuji Toiyama Yasuhiro Inoue Keiichi Uchida Yasuhiko Mohri Masato Kusunoki | 2013 | Oncology Letters2013，，5： | 1 |
| 20 | Cupping of compressed wood resulting from set recovery显示文摘 | Masafumi Inoue Koji Adachi Kanayama | 2001 | Wood Research2001，47，3： | 1 |
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