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| 1 | Widespread use of gastric acid inhibitors in infants:Are they needed? Are they safe?显示文摘Gastroesophageal reflux is a common phenomenon in infants,but the differentiation between gastro-esophageal reflux and gastroesophageal reflux disease can be difficult.Symptoms are non-specific and there is increasing evidence that the majority of symptoms may not be acid-related.Despite this,gastric acid inhibitors such as proton pump inhibitors are widely and increasingly used,often without objective evidence or investigations to guide treatment.Several studies have shown that these medications are ineffective at treating symptoms associated with reflux in the absence of endoscopically proven oesophagitis.With a lack of evidence for efficacy,attention is now being turned to the potential risks of gastric acid suppression.Previously assumed safety of these medications is being challenged with evidence of potential side effects including GI and respiratory infections,bacterial overgrowth,adverse bone health,food allergy and drug interactions. | Mark Safe Wei H Chan Steven T Leach Lee Sutton Kei Lui Usha Krishnan | 2016 | World Journal of Gastrointestinal Pharmacology and Therapeutics2016，7，4： | 2 |
| 2 | Abnormal liver chemistries as a predictor of COVID-19 severity and clinical outcomes in hospitalized patients显示文摘BACKGROUND Abnormal liver chemistries are common findings in patients with Coronavirus Disease 2019(COVID-19).However,the association of these abnormalities with the severity of COVID-19 and clinical outcomes is poorly understood AIM We aimed to assess the prevalence of elevated liver chemistries in hospitalized patients with COVID-19 and compare the serum liver chemistries to predict the severity and in-hospital mortality.METHODS This retrospective,observational study included 3380 patients with COVID-19 who were hospitalized in the Johns Hopkins Health System(Baltimore,MD,United States).Demographic data,clinical characteristics,laboratory findings,treatment measures,and outcome data were collected.Cox regression modeling was used to explore variables associated with abnormal liver chemistries on admission with disease severity and prognosis RESULTS A total of 2698(70.4%)had abnormal alanine aminotransferase(ALT)at the time of admission.Other more prevalent abnormal liver chemistries were aspartate aminotransferase(AST)(44.4%),alkaline phosphatase(ALP)(16.1%),and total bilirubin(T-Bil)(5.9%).Factors associated with liver injury were older age,Asian ethnicity,other race,being overweight,and obesity.Higher ALT,AST,T-Bil,and ALP levels were more commonly associated with disease severity.Multivariable adjusted Cox regression analysis revealed that abnormal AST and T-Bil were associated with the highest mortality risk than other liver injury indicators during hospitalization.Abnormal AST,T-Bil,and ALP were associated with a need for vasopressor drugs,whereas higher levels of AST,T-Bil,and a decreased albumin levels were associated with mechanical ventilation CONCLUSION Abnormal liver chemistries are common at the time of hospital admission in COVID-19 patients and can be closely related to the patient’s severity and prognosis.Elevated liver chemistries,specifically ALT,AST,ALP,and T-Bil levels,can be used to stratify risk and predict the need for advanced therapies in these patients. | Arunkumar Krishnan Laura Prichett Xueting Tao Saleh A Alqahtani James P Hamilton Esteban Mezey Alexandra T Strauss Ahyoung Kim James J Potter Po-Hung Chen Tinsay A Woreta | 2022 | World Journal of Gastroenterology2022，28，5： | 2 |
| 3 | Emergence of a new antibiotic resistance mechanism in India, Pakistan, and the UK: a molecular, biological, and epidemiological study 显示文摘 | Kumarasamy KK Toleman MA Walsh TR Bagaria J Butt F Balakrishnan R Chaudhary U Doumith M Giske CG Irfan S Krishnan P Kumar AV Maharjan S Mushtaq S Noorie T Paterson DL Pearson A Perry C Pike R Rao B Ray U Sarma JB Sharma M Sheridan E Thirunarayan MA Turton J Upadhyay S Warner M Welfare W Livermore DM Woodford N | 2010 | Lancet Infect Dis2010，10，9： | 1 |
| 4 | Treacy young's modulus of single-walled nanotubes显示文摘 | KRISHNAN A DUJARDIN E EBBESEN T W | 1998 | Physical Review B1998，58，14： | 1 |
| 5 | Production of Al-Zr master alloy starting from ZrO2 显示文摘 | RAJAGOPALAN p K SHARMA I G KRISHNAN T S | 1999 | Journal of Alloys and Compounds1999，285，3： | 1 |
| 6 | Impact of a late entrant on the diffusion of a new product/service显示文摘 | Krishnan T V Bass F M Kumar V | | 0，，： | 1 |
| 7 | Influence ofsalinity and temperature on the oxygen consumption in youngjuveniles of the Indian prawn Penaeus indicus显示文摘 | Kutty M N Murugapoopathy G Krishnan T S | 1971 | Mar Biol1971，11，： | 1 |
| 8 | HIF1alpha and HIF2alpha independently activate SRC to promote melanoma metastases显示文摘 | HANNA S C KRISHNAN B BAILEY S T | | 0，，05： | 1 |
| 9 | Purification of single-shell nanotubes显示文摘 | Dujardin E Ebbesen T W Krishnan A | 1998 | Adv Mater1998，10，8： | 1 |
| 10 | Guaranteed profit margins: A demonstration of retailer power显示文摘 | Krishnan T V Soni H | 1997 | International Journal of Research in Marketing1997，14，： | 1 |
| 11 | SCANNING ELECTRON Scanning Electron Microscopic Studies of New And Used Fan Nozzles For Agricultural Sprayers显示文摘 | Krishnan P Evans T Ballal K | 2004 | Applied Engineering in Agriculture2004，20，2： | 1 |
| 12 | Production of A1-Zr master alloy starting from ZrO2显示文摘 | Rajagopalan P K Sharma I G Krishnan T S | 1999 | Journal of Alloys aTut Compounds1999，285，： | 1 |
| 13 | Selective catalytic reduction of nitric oxide with ammonia at low temperatures显示文摘 | Krishnan A T Boehman A L | 1998 | Applied Catalysis B:Environmental1998，18，34： | 1 |
| 14 | Young's modulus of single-walled nanotubes显示文摘 | Krishnan A Dujardin E Ebbesen T W | 1998 | Phys Rev B1998，58，： | 1 |
| 15 | Function and characterization of metal oxide-naflon composite membranes for elevated-temperature H 2/O 2 PEM fuel cells显示文摘 | Adjemian K T Dominey R Krishnan L | 2006 | Chemistry of Materials2006，18，9： | 1 |
| 16 | Transdermal delivery of cyclosporine-A using electroporation显示文摘 | WANG S KARA M KRISHNAN T R | 1998 | J Control Release1998，50，： | 1 |
| 17 | Energy exchange and evapotranspiration over two temperate semi-arid grasslands in North America显示文摘 | KRISHNAN P MEYERS T P SCOTT R L | 2012 | Agricultural and Forest Meteorology2012，153，： | 1 |
| 18 | Impact of a late entrant on the diffusion of a new product/service显示文摘 | Krishnan T V Bass F M Kumar V | 2000 | Journal of Marketing Research2000，37，： | 1 |
| 19 | PtRu-LiCoO2-an efficient catalyst for hydrogen generation from sodium borohydride solutions显示文摘 | KRISHNAN P YANG T H LEE W Y | 2005 | Journal of Power Sources2005，143，12： | 1 |
| 20 | Product development decisions:a re-view of the literature显示文摘 | V KRISHNAN K T U | 2001 | Management Science2001，47，1： | 1 |
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