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| 1 | Saeng-Kankunbi-Tang(生肝健脾汤) Protects Liver against Oxidative Damage through Activation of ERK/Nrf2 Pathway显示文摘Objective: To investigate the cytoprotective effects of Saeng-kankunbi-tang(生肝健脾汤, SKT), a herbal prescription consisting of Artemisia capillaris and Alisma canaliculatum, and its underlying mechanism involved. Methods: In mice, blood biochemistry and histopathology were assessed in carbon tetrachloride(CCl4)-induced oxidative hepatic injury in vivo. The animal groups included vehicle-treated control, CCl4, SKT 500 mg/(kg·day) CCl4+SKT 200 or 500 mg/(kg·day). In Hep G2 cell, tert-butyl hydroperoxide(t BHP) induced severe oxidative stress and mitochondrial dysfunction in vitro. The cyto-protective effects of SKT were determined by 3-(4,5-dimethylthiazol)-2,5-diphenyltetrazolium bromide(MTT) assay, fluorescence activated cell sorting analysis and western blotting. Results: The administration of SKT prevented liver damage induced by CCl4 in mice, by inhibition of hepatocyte degeneration and inflammatory cell infiltration as well as plasma parameters such as alanine aminotransferase(P<0.01). Moreover, treatment with t BHP induced hepatocyte death and cellular reactive oxygen species production in hepatocyte cell line. However, SKT pretreatment(30–300 μg/m L) reduced this cell death and oxidative stress(P<0.01). More importantly, SKT inhibited the ability of t BHP to induce changes in mitochondrial membrane transition in cell stained with rhodamine 123(P<0.01). Furthermore, treatment with SKT induced extracellular signal-regulated kinases-mediated nuclear factor erythroid-2-related factor 2(Nrf2) activation as well as the expressions of heme oxygenase 1 and glutamate-cystein ligase catalytic, Nrf2 target genes. Conclusion: SKT has the ability to protect hepatocyte against oxidative stress and mitochondrial damage mediated by Nrf2 activation. | In Woo Lee Hee Yoon Choi Ju-Hee Lee Sun-Dong Park Seung Mo Kim Sae Kwang Ku 赵容杰 Sang Chan Kim Young Woo Kim Hong Sik Choi | 2016 | Chinese Journal of Integrative Medicine2016，22，8： | 3 |
| 2 | Valuation of European options in the market with daily price limit显示文摘 | Ban junhwa Hyeong In Choi and Hyijin Ku | 2000 | Applied Mathematical Finance2000，，7： | 1 |
| 3 | Effects of gel concentration,human fibronectin,ond cation supplement on the tissue-engineered cartilage显示文摘 | Kuo YC Ku IN | | 0，，： | 1 |
| 4 | Ultrasonic inspection of long steel pipes using Lamb waves显示文摘 | Moon Ho Park In Sup Kim Young Ku yoon | 1996 | NDT & E International1996，29，1： | 1 |
| 5 | Surface plasmon excitation in semitransparent inverted polymer photovoltaic devices and their applications as label-free optical sensors显示文摘Herein,we report on surface plasmon(SP)-sensitive semitransparent inverted polymer photovoltaic(PV)devices that are based on multilayered material systems consisting of poly(3-hexylthiophene):fullerene-derivative bulk-heterojunction PV layers and thin gold or silver anodes.We demonstrate that these PV devices allow the simultaneous generation of both electrical power and SPs on their anodes for photoexcitation just above the optical absorption edge of the PV layers,resulting not only in attenuated total reflection,but also in attenuated photocurrent generation(APG)under the SP resonance(SPR)condition.Moreover,we also confirm that the biomolecular interaction of biotin–streptavidin on the PV devices can be precisely detected via apparent SPR angle shifts in the APG spectra,even without the need for complex attenuated total reflection configurations.We highlight our view that APG measurements made using these PV devices show great potential for the development of future generations of compact and highly sensitive SPR-based optical sensors. | Byoungchoo Park Soo Hong Yun Chan Youn Cho Young Chan Kim Jung Chul Shin Hong Goo Jeon Yoon Ho Huh Inchan Hwang Ku Youn Baik Young In Lee Han Sup Uhm Guang Sup Cho Eun Ha Choi | 2014 | Light(Science & Applications)2014，3，1： | 1 |
| 6 | Cough variant asth2ma is assdciated w ith a h igher w heezing th reho ld thenclassic asthma显示文摘 | Chae SA M in KU | 1993 | Clin Exp A llergy1993，2366，： | 1 |
| 7 | Cartilage regeneration by novel polyethylene oxide/chitin/chitosan scaffolds 显示文摘 | Kuo YC Ku IN | 2008 | Biomacromolecules2008，9，10： | 1 |
| 8 | (castor bean) by leaf to air vapour pressure deficit显示文摘 | INi Z Edwards G E Ku M S IK Control of photosynthesis andstomatal conductance in Ricinus comrnunis L | 1992 | Plant Physiology1992，99，： | 1 |
| 9 | Fermented garlic protects diabetic, obese mice when fed a high-fat diet by antioxidant effects显示文摘 | Young-Mi Jung Seon-Ha Lee Dong-Sub Lee Myung-Jin You In Kwon Chung Woo Hyun Cheon Young-Sam Kwon Young-Joon Lee Sae-Kwang Ku | 2011 | Nutrition Research2011，，5： | 1 |
| 10 | Adolescents'reports of reproductive health education, 1988- 1995显示文摘 | Lindberg LD Ku L and Sonenste in F | 2000 | Familly Planning Perspectives2000，32，5： | 1 |
| 11 | Effects of gel concentration,human fibronectin, and cation supplement on the tissue-engineered cartilage 显示文摘 | Kuo YC Ku IN | 2007 | Biotechnol Progress2007，23，： | 1 |
| 12 | Effects of gel concentration, human fibronectin, and cation supplement on the tissue - engineered cartilage 显示文摘 | Kuo YC Ku IN | 2007 | Bioteehnol Progress2007，23，： | 1 |
| 13 | 7 macrophages 显示文摘 | Ku CS Park Y Coleman SL et aL Unsaturated fatty acids repress expression of ATP binding cassette transporter A1 and G1 in RAW 264 | 2012 | J Nutr Biochem2012，23，10： | 1 |
| 14 | Herbal medicines for trea ring tic disorders= a systematic review of randomized con trolled trials显示文摘 | syndrome in chil- & Neonatology Kim YH Son CG Ku BC | 2014 | Chinese Medicine2014，9，1： | 1 |
| 15 | Effect of let concentration human fibronectin, and cation supplement on the tissue-engineered carrilafe显示文摘 | Kuo YC Ku IN | 2007 | Biotechmol Prog2007，23，1： | 1 |
| 16 | Ultrasonic inspection of long steel pipes using Lamb waves显示文摘 | Moon Ho Park In Sup Kim Young Ku Yoon | 1996 | NDT & E International1996，29，1： | 1 |
| 17 | Cartilage regeneration by novel polyethyleneoxide / chitin / chitosan scafolds 显示文摘 | Kuo YC Ku IN | 2008 | Biornacromolecules2008，10，： | 1 |
| 18 | Cough variant asthma is associated with a high wheezing threshold than classic asthma显示文摘 | Kon YY Chas SA M in KU | 1993 | Clinical Exper Allergy1993，23，8： | 1 |
| 19 | Regulation of c-SMAC formation and AKT-mTOR signaling by the TSG101-IFT20 axis in CD4^(+)T cells显示文摘CD4^(+)T cells play major roles in the adaptive immune system,which requires antigen recognition,costimulation,and cytokines for its elaborate orchestration.Recent studies have provided new insight into the importance of the supramolecular activation cluster(SMAC),which comprises concentric circles and is involved in the amplification of CD4^(+)T cell activation.However,the underlying mechanism of SMAC formation remains poorly understood.Here,we performed single-cell RNA sequencing of CD4^(+)T cells left unstimulated and stimulated with anti-CD3 and anti-CD28 antibodies to identify novel proteins involved in their regulation.We found that intraflagellar transport 20(IFT20),previously known as cilia-forming protein,was upregulated in antibody-stimulated CD4^(+)T cells compared to unstimulated CD4^(+)T cells.We also found that IFT20 interacted with tumor susceptibility gene 101(TSG101),a protein that endocytoses ubiquitinated T-cell receptors.The interaction between IFT20 and TSG101 promoted SMAC formation,which led to amplification of AKT-mTOR signaling.However,IFT20-deficient CD4^(+)T cells showed SMAC malformation,resulting in reduced CD4^(+)T cell proliferation,aerobic glycolysis,and cellular respiration.Finally,mice with T-cell-specific IFT20 deficiency exhibited reduced allergen-induced airway inflammation.Thus,our data suggest that the IFT20-TSG101 axis regulates AKT-mTOR signaling via SMAC formation. | Jiung Jeong In Kang Yumin Kim Keun Bon Ku Jang Hyun Park Hyun-Jin Kim Chae Won Kim Jeongwoo La Hi Eun Jung Hyeon Cheol Kim Young Joon Choi Jaeho Kim Joon Kim Heung Kyu Lee | 2023 | Cellular & Molecular Immunology2023，20，5： | 0 |
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