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| 1 | Multiple genetic alterations and behavior of cellular biology in gastric cancer and other gastric mucosal lesions:H.pylori infection,histological types and staging显示文摘AIM To investigate the expression of multiplegenes and the behavior of cellular biology ingastric cancer(GC)and other gastric mucosallesions and their relations to Helicobacter pylori(H.pylori)infection,tumor staging andhistological subtypes.METHODS Three hundred and twenty-sevenspecimens of gastric mucosa obtained viaendoscopy or surgical resection,and ABCimmunohistochemical staining were used todetect the expression of p53,p16,Bcl-2 andCOX-2 proteins.H.pylori was determined byrapid urea test combined with pathologicalstaining or14C urea breath test.Cellular image analysis was performed in 66 patients withintestinal metaplasia(IM)and/or dysplasia(Dys).In 30 of them,both cancer and theparacancerous tissues were obtained at the timeof surgery.Histological pattern,tumor staging,lymph node metastasis,grading ofdifferentiation and other clinical data werestudied in the medical records.RESULTS p16 expression of IM or Dys wassignificantly lower in positive H.pylori chronicatrophic gastritis(CAG)than those withnegative H.pylori(CAG:54.8% vs 88.0%,IM:34.4% vs 69.6%,Dys:23.8% vs 53.6%,allP<0.05),Bcl-2 or COX-2 expression of IM orDys in positive H.pylori cases was significantlyhigher than that without H.pylori(Bcl-2:68.8%vs23.9%,90.5% vs 60.7%;COX-2:50.0% vs10.8%,61.8% vs 17.8%;all P<0.05).Themean number of most parameters of cellularimage analysis in positive H.pylori group wassignificantly higher than that in negative H.pylori group(Ellipser:53±14,40±12μm,Area1:748±572,302±202 μm2,Area2:3050±1661,1681±1990 μm2,all P<0.05;Ellipseb:79±23,58±15 μm,Ratio1:22%±5%,13%±4%,Ratio2:79%±17%,53%±20%,all P<0.01).There was significant correlation between Bcl-2and histologic pattern of gastric carcinoma,andbetween COX-2 and tumor staging or lymph nodemetastasis(Bcl-2:75.0% vs 16.7%;COX-2:76.0% vs 20.0%,79.2% vs 16.7%;allP<0.05).CONCLUSION p1l6, Bcl-2, and COX-2 but not p53 gene may play a role in the early genesis/ progression of gastric carcinoma and are associated with H. pylori infection. p53 gene is relatively late event in gastric tumorigenesis and mainly relates to its progression. There is more cellular-biological behavior of malignant tumor in gastric mucosal lesions with H. pylori infection. Aberrant Bcl-2 protein expression appears to be preferentially associated with the intestinal type cancer. COX-2 seems to be related to tumor staging and lymph node metastasis. | Heng Jun Gao Lian Zhen Yu Jian Feng Bai Yan Shen Peng Gu Sun Han Lin Zhao Kun Miu Xiu Zhen Lü Xiao Yong Zhang Zhi Quan Zhao | 2000 | World Journal of Gastroenterology2000，6，6： | 52 |
| 2 | 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents显示文摘Syncope belongs to the transient loss of consciousness(TLOC), characterized by a rapid onset, short duration, and spontaneous complete recovery. It is common in children and adolescents, accounting for 1% to 2% of emergency department visits.Recurrent syncope can seriously affect children's physical and mental health, learning ability and quality of life and sometimes cardiac syncope even poses a risk of sudden death. The present guideline for the diagnosis and treatment of syncope in children and adolescents was developed for guiding a better clinical management of pediatric syncope. Based on the globally recent development and the evidence-based data in China, 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents was jointly prepared by the Pediatric Cardiology Society, Chinese Pediatric Society, Chinese Medical Association(CMA)/Committee on Pediatric Syncope, Pediatricians Branch, Chinese Medical Doctor Association(CMDA)/Committee on Pediatric Cardiology, Chinese College of Cardiovascular Physicians, Chinese Medical Doctor Association(CMDA)/Pediatric Cardiology Society, Beijing Pediatric Society, Beijing Medical Association(BMA). The present guideline includes the underlying diseases of syncope in children and adolescents, the diagnostic procedures, methodology and clinical significance of standing test and headup tilt test, the clinical diagnosis vasovagal syncope, postural orthostatic tachycardia syndrome, orthostatic hypotension and orthostatic hypertension, and the treatment of syncope as well as follow-up. | Cheng Wang Yaqi Li Ying Liao Hong Tian Min Huang Xiangyu Dong Lin Shi Jinghui Sun Hongfang Jin Junbao Du Jindou An Jie Chen Mingwu Chen Qi Chen Sun Chen Yonghong Chen Zhi Chen Adolphus Kai-tung Chau Junbao Du Zhongdong Du Junkai Duan Hongyu Duan Xiangyu Dong Lin Feng Lijun Fu Fangqi Gong Yonghao Gui Ling Han Zhenhui Han Bing He Zhixu He Xiufen Hu Yimin Hua Guoying Huang Min Huang Ping Huang Yujuan Huang Hongfang Jin Mei Jin Bo Li Fen Li Tao Li Xiaohui Li Xiaoyan Liu Yan Li Haitao Lv Tiewei Lv Zipu Li Luyi Ma Silin Pan Yusheng Pang Hua Peng Yuming Qin Jie Shen Lin Shi Kun Sun Jinghui Sun Hong Tian Jie Tian Cheng Wang Hong Wang Lei Wang Jinju Wang Wendi Wang Yuli Wang Rongzhou Wu Tianhe Xia Yanyan Xiao Chunhong Xie Yanlin Xing Zhenyu Xiong Baoyuan Xu Yi Xu Hui Yan Shiwei Yang Qijian Yi Xia Yu Xianyi Yu Yue Yuan Hongyan Zhang Huili Zhang Li Zhang Qingyou Zhang Xi Zhang Yanmin Zhang Zhiwei Zhang Cuifen Zhao Bin Zhou Hua Zhu | 2018 | Science Bulletin2018，63，23： | 54 |
| 3 | Mortality and Morbidity of Extremely Low Birth Weight Infants in the Mainland of China: A Multi-center Study显示文摘 | Hui-Jia Lin Li-Zhong Du Xiao-Lu Ma Li-Ping Shi Jia-Hua Pan Xiao-Mei Tong Qiu-Ping Li Jian-Guo Zhou Bing Yi Ling Liu Yun-Bing Chen Qiu-Fen Wei Hui-Qing Wu Mei Li Cui-Qing Li Xi-Rong Gao Shi-Wen Xia Wen-Bin Li Chao-Ying Ya Ling He Kun Liang Xiao-Yu Zhou Shu-Ping Han Qin Lyu Yin-Ping Qiu Wen Li Dong-Mei Chen Hong-Ru Lu Xiao-Hong Liu Hong Liu Zhen-Lang Lin Li Liu Jia-Jun Zhu Hong Xiong Shao-Jie Yue Si-Qi Zhuang | 2015 | Chinese Medical Journal2015，，20： | 49 |
| 4 | Prevalence and evolution of drug resistance HIV-1 variants in Henan, China显示文摘To understand the prevalence and evolution of drug resistant HIV strains in Henan China after the implementation of free antiretroviral therapy for AIDS patients. 45 drug nave AIDS patients, 118 AIDS patients who received three months antiretroviral therapy and 124 AIDS patients who received six months antiretroviral treatment were recruited in the southern part of Henan province. Information on general condition, antiretroviral medicines, adherence and clinical syndromes were collected by face to face interview. Meanwhile, 14ml EDTA anticoagulant blood was drawn. CD4/CD8 T cell count, viral load and genotypic drug resistance were tested. The rates of clinical improvement were 55.1% and 50.8% respectively three months and six months after antiretroviral therapy. The mean CD4 cell count after antiretroviral therapy was significantly higher than in drug nave patients. The prevalence rate of drug resistant HIV strains were 13. 9%, 45.4% and 62.7% in drug nave patients, three month treatment patients and six month treatment patients, respectively. The number of resistance mutation codons and the frequency of mutations increased significantly with continued antiretroviral therapy. The mutation sites were primarily at the 103, 106 and 215 codons in the three-month treatment group and they increased to 15 codon mutations in the six-month treatment group. From this result, the evolution of drug resistant strains was inferred to begin with the high level NNRTI resistant strain, and then develop low level resistant strains to NRTIs. The HIV strains with high level resistance to NVP and low level resistance to AZT and DDI were highly prevalent because of the AZT+DDI+NVP combination therapy. These HIV strains were also cross resistant to DLV, EFV, DDC and D4T. Poor adherence to therapy was believed to be the main reason for the emergence and prevalence of drug resistant HIV strains. The prevalence of drug resistant HIV strains was increased with the continu- ation of antiretroviral therapy in the southern part of Henan province. Measures, that could promote high level adherence, provide new drugs and change ART regimens in failing patients, should be implemented as soon as possible. | Jing Yun LI Han Ping LI Lin LI Hong LI Zhe WANG Kun YANG Zuo Yi BAO Dao Min ZHUANG Si Yang LIU Yong Jian LIU Hui XING Yi Ming SHAO | 2005 | Cell Research2005，15，11： | 34 |
| 5 | Chemerin and apelin are positively correlated with inflammation in obese type 2 diabetic patients显示文摘 | YU Shan ZHANG Ying LI Mei-zhen XU Hua WANG Qian SONG Jun LIN Peng ZHANG Li LIU Qian HUANG Qing-xian WANG Kun HOU Wei-kai | 2012 | Chinese Medical Journal2012，，19： | 27 |
| 6 | Preparation of Artificial Antigen and Egg Yolk-derived Immunoglobulin(IgY) of Citrinin for Enzyme-Linked Immunosorbent Assay显示文摘To prepare artificial antigens and anti-citrinin egg yolk-derived immunoglobulin(IgY) to build an enzyme-linked immunosorbent assay(ELISA) for citrinin(CTN).Methods CTN was conjugated with bovine serum albumin(BSA),ovalbumin(OVA) with formaldehyde condensation method to prepare artificial antigens and identified by ultraviolet(UV) spectrometry and Infrared(IR) spectrometry.Artificial antigens for CTN and anti-CTN IgY were purified with polyethylene glycol two-step precipitation method and identified by sodium dodecyl sulfate-polyacrylamide gel electrophoresis(SDS-PAGE).ELISA with IgY was established.Cross-reactivity of IgY with various structural similarities to CTN and possible co-occurrence with CTN in agricultural commodities were studied.Results UV and IR absorption spectra suggested that CTN was correlated with the carrier protein of BSA or OVA.SDS-PAGE patterns showed that the anti-CTN IgY was almost pure with a molecular weight of approximate 100 KD.The indirect competitive ELISA showed that the detection limit of CTN was 10 ng·mL-1,with a good linearity ranging 20-640 ng·mL-1.Conclusion Artificial antigens of CTN can be successfully synthesized.The established ELISA can be used to determine CTN-contaminated samples. | ZHAO-HUI DUAN ZHUANG-SEN LIN HE-RUI YAO YAN-HONG GAO KUN ZHANG Su-QING ZHAO ZHEN-YU ZHU | 2009 | Biomedical and Environmental Sciences2009，22，3： | 21 |
| 7 | Epidemiological characteristics of thyroid nodules and risk factors for malignant nodules: a retrospective study from 6 304 surgical cases显示文摘 | Huan Qin Wang Kun Lou Fuchen Zhang Li Huang Qingxian Han Yunfeng Sun Hancheng Zhu Lei Lin Peng Song Jun Liu Fuqiang Wang Qian Hou Weikai | 2014 | Chinese Medical Journal2014，，12： | 20 |
| 8 | Surveillance-based evidence:elimination of schistosomiasis as a public health problem in the Peoples’Republic of China显示文摘Background:A steady progress on schistosomiasis control in the Peoples’Republic of China(P.R.China)was achieved and broadened into the twelve-year medium and long term national plan(MLNP)which marled the implementation of an integrated control strategy across all endemic areas in P.R.China in 2004.To understand the endemic trends of schistosomiasis to assess the effectiveness of an integrated strategy,we conducted an analysis of schistosomiasis surveillance data spanned from 2005 to 2015.Methods:The schistosomiasis sentinel surveillance data from sentinel sites were collected and analyzed from 2005 to 2015.In these sentinel sites,residents aged 6 years or above were screened annually by indirect hemagglutination assay(IHA),while only antibody positives were followed by stool examination either Kato-katz method(KK)and/or hatching technique(HT).Domestic animals raised in sentinel sites were examined by HT for confirming the infection of schistosomes.Snail investigation was conducted each year through systematic sampling method combined with environmental sampling method.The snails collected from field were tested by microscopic dissection method.The infection rates of schistosomes in residents,domestic animals and snails,as well as the indicators reflecting the snails’distribution were calculated and analyzed.ANOVA analysis was used to examine the changes of the number of eggs per gram feces in population and Chi-square test was used to examine any change in proportions among groups.Results:A total of 148902 residents from sentinel sites attended this study and 631676 blood samples were examined by IHA test during the 11 covered years.The annual average antibody positive rates presented a significant decrease trends,from 17.48%(95%CI:17.20–17.75%)in 2005 to 5.93%(95%CI:5.71–6.15%)(χ2=8890.47,P<0.001)in 2015.During 2005–2015,the average infection rate of schistosomes in residents declined from 2.07%(95%CI:1.96–2.17%)to 0.13%(95%CI:0.09–0.16%),accompanied by significant decrease of infection intensity in population.In 2015,the stool positives were only found in farmers,fishermen and boatmen with infection rate of 0.16%(95%CI:0.11–0.20%),0.17%(95%CI:0–0.50%)respectively.The infection rate of schistosomes in domestic animals dropped from 9.42%(538/5711,95%CI:8.66–10.18%)to 0.08%(2/2360,95%CI:0–0.20%)from 2005 to 2015.Infections were found in eight species of domestic animals at the beginning of surveillance while only two cattle were infected in 2015.Totally 98 ha of new snail habitats were found,while 94.90%(93/98)distributed in lake and marshland regions.The percentage of frames with snails decreased from 16.96%(56884/335391,95%CI:16.83–17.09%)in 2005 to 4.28%(18121/423755,95%CI:4.22–4.34%)in 2014,with a slightly increase in 2015.Meanwhile,the infection rate of schistosomes in snails was decreased from 0.26%(663/256531,95%CI:0.24–0.28%)to zero during 2005–2015.Conclusions:The infection rate of schistosomes declined significantly,providing evidence that the goal of the MLNP was achieved.Elimination of schistosomiasis as a public health problem defined as WHO was also reached in P.R.China nationwide.Surveillance-response system should be improved and strengthened to realize the final goal of schistosomiasis elimination. | Jing Xu Shi-Zhu Li Li-Juan Zhang Robert Bergquist Hui Dang Qiang Wang Shan Lv Tian-Ping Wang Dan-Dan Lin Jian-Bing Liu Guang-Hui Ren Kun Yang Yang Liu Yi Dong Shi-Qing Zhang Xiao-Nong Zhou | 2020 | Infectious Diseases of Poverty2020，9，3： | 20 |
| 9 | Prognostic value of CD4^+CD25^+ Tregs as a valuable biomarker for patients with sepsis in ICU显示文摘BACKGROUND: Sepsis is a common complication ofinfections, burns, traumas, surgeries, poisonings, and post-cardiopulmonary resuscitation. The present study aimed to investigate prognostic value of CD4+CD25+ regulatory T cells(Treg) in peripheral blood of patients with sepsis.METHODS: Periphery blood from 28 patients diagnosed with sepsis was collected on day 1 and 7 after hospitalization in the ICU of Shanghai Changzheng Hospital between December 2013 to April 2014. The blood was used for analyses of Treg ratio using flow cytometry and for analyses of blood routine test, C-reactive protein(CRP), bilirubin, procalcitonin(PCT), and coagulation. APACHE II and sequential organ failure assessment(SOFA) scores were also investigated. The results were compared between two outcome groups of survival or death to evaluate prognostic value for sepsis.RESULTS: The patients had an average age of 60.36±15.03 years, APACHE II score 16.68±7.00, and SOFA score 7.18±3.78. Among the 28 patients, 12 had severe trauma(42.9%), 10 had septic shock(35.7%), and 9(32.2%) died. The median ratio of Tregs was 2.10%(0.80%, 3.10%) in the survival group vs. 1.80%(1.15%, 3.65%) in the death group(Z=–0.148, P=0.883) on day 1; however it was signifi cantly changed to 0.90%(0.30%, 2.80%) vs. 5.70%(2.60%, 8.30%)(Z=–2.905, P=0.004).CONCLUSION: With better prospects for clinical application, dynamic monitoring of Tregs ratio in peripheral blood has potential value in predicting prognosis of sepsis. | Kun Chen Qiu-xiang Zhou Hong-wei Shan Wen-fang Li Zhao-fen Lin | 2015 | World Journal of Emergency Medicine2015，6，1： | 19 |
| 10 | Red-emitting YAG:Ce,Mn transparent ceramics for warm WLEDs application显示文摘A series of YAG:Ce,Mn transparent ceramics were prepared via a solid-state reaction-vacuum sintering method.The effects of various Mn^2+–Si4+pair doping levels on the structure,transmittance,and luminescence properties were systematically investigated.These transparent ceramics have average grain sizes of 10–16μm,clean grain boundaries,and excellent transmittance up to 83.4%at 800 nm.Under the excitation of 460 nm,three obvious emission peaks appear at 533,590,and 745 nm,which can be assigned to the transition 5 d→4 f of Ce^3+and 4 T1→6 A1 of Mn^2+.Thus,the Mn^2+–Si4+pairs can effectively modulate the emission spectrum by compensating broad orange-red and red spectrum component to yield high quality warm white light.After the optimized YAG:Ce,Mn transparent ceramic packaged with blue light-emitting diode(LED)chips,correlated color temperature(CCT)as low as 3723 K and luminous efficiency(LE)as high as 96.54 lm/W were achieved,implying a very promising candidate for application in white light-emitting diodes(WLEDs)industry. | Junrong LING Youfu ZHOU Wentao XU He LIN Shuai LU Bin WANG Kun WANG | 2020 | Journal of Advanced Ceramics2020，9，1： | 15 |
| 11 | Magnolol additive as a replacer of antibiotic enhances the growth performance of Linwu ducks显示文摘Magnolol rich in Magnolia officinalis is a bioactive polyphenolic compound. The aim of this study was to examine the effects of magnolol additive(MA) on growth performance, expression levels of antioxidantrelated genes, and intestinal mucosal morphology of Linwu ducks aged from 49 to 70 days, comparing with that of an antibiotic additive(colistin sulfate [CS]). A total of 275,49-day-old ducks were assigned to5 groups with 5 cages of 11 ducks each and fed diets supplemented with 0,100, 200 and 300 mg of MA/kg and 300 mg of CS/kg for 3 weeks, respectively. The results showed that the average daily body weight gain(ADG) was increased significantly in MA-fed groups(200 and 300 mg/kg), compared with the basal diet(BD) group(P < 0.05). The mRNA levels of superoxide dismutase-1(SOD1), manganese superoxide dismutase-2(MnSOD2) and catalase(CAT) were also increased significantly in MA groups(P < 0.05). In addition, hematoxylin and eosin staining revealed that Linwu ducks fed the diets with MA had more intact intestinal mucosa than those fed the BD and CS diets. In addition, ileal villus height, ileal villus height/crypt depth ratio(V/C) and duodenal V/C were also improved significantly(P < 0.05). Taken together, these data demonstrated that MA is an effective feed additive to enhance the growth performance of the Linwu ducks by improving the antioxidant and intestinal mucosal status, suggesting that MA will be a potential additive to replace antibiotic(CS). | Qian Lin Jianfei Zhao Kun Xie Yushi Wang Guili Hu Guitao Jiang Qiuzhong Dai Zhiyong Fan Jianhua He Xi He De-Xing Hou | 2017 | Animal Nutrition2017，，2： | 14 |
| 12 | Comparsion analysis of data mining models applied to clinical research in Traditional Chinese Medicine显示文摘OBJECTIVE: To help researchers selecting appropriate data mining models to provide better evidence for the clinical practice of Traditional Chinese Medicine(TCM) diagnosis and therapy.METHODS: Clinical issues based on data mining models were comprehensively summarized from four significant elements of the clinical studies:symptoms, symptom patterns, herbs, and efficacy.Existing problems were further generalized to determine the relevant factors of the performance of data mining models, e.g. data type, samples, parameters, variable labels. Combining these relevant factors, the TCM clinical data features were compared with regards to statistical characters and informatics properties. Data models were compared simultaneously from the view of applied conditions and suitable scopes.RESULTS: The main application problems were the inconsistent data type and the small samples for the used data mining models, which caused the inappropriate results, even the mistake results. These features, i.e. advantages, disadvantages, satisfied data types, tasks of data mining, and the TCM issues, were summarized and compared.CONCLUSION: By aiming at the special features of different data mining models, the clinical doctors could select the suitable data mining models to resolve the TCM problem. | Yufeng Zhao Qi Xie Liyun He Baoyan Liu Kun Li Xiang Zhang Wenjing Bai Lin Luo Xianghong Jing Ruili Huo | 2014 | Journal of Traditional Chinese Medicine2014，34，5： | 14 |
| 13 | Knowledge of, attitudes towards, and practice relating to schistosomiasis in two subtypes of a mountainous region of the People’s Republic of China显示文摘Background:Schistosomiasis japonica is still endemic in the People’s Republic of China(P.R.China)in five provinces of lake and marshland regions and in two provinces of mountainous regions.Studies elucidated that individual and community perception,attitudes towards schistosomiasis,and hygiene behaviors were crucial factors for preventing schistosomiasis.This study sought to assess the knowledge of,attitudes towards,and practices(KAP)relating to schistosomiasis in two subtypes of a mountainous region in Eryuan County,Yunnan Province,P.R.China.The study’s aim is to make suggestions for establishing more specific and effective control measures for disease transmission and interruption in two subtypes of a mountainous region with low-level infection rates.Methods:A cross-sectional study of 3,000 inhabitants was carried out in the Yongle(plateau basin)and Xinzhuang(plateau canyon)communities of Eryuan County,Yunnan Province in November and December 2011.Stratified cluster random sampling was undertaken using a uniform set of quantitative questionnaires administered by trained assistants.This was further supported with qualitative data from in-depth interviews(IDIs)conducted with ten farmers and ten students.All participants were examined for schistosomiasis using both a serological test(indirect hemagglutination assay[IHA])and a stool examination(Kato-Katz).Results:The total schistosomiasis knowledge rate in Yongle(83.4%)was significantly lower than that in Xinzhuang(95.5%).In both communities,among the respondents aged 15 years or below,more than one third didn’t know the name,endemic areas,and animal reservoirs of schistosomiasis.The majority of respondents in Eryuan acquired their schistosomiasis knowledge from doctors,followed by handouts and hearing from others.The infection rate was once the highest in Yongle,but is now the highest in Xinzhuang,where there are more risk factors for schistosomiasis,such as frequently grazing cattle,digging vegetables or cutting grass in the field,as well as raising cattle by free grazing.Conclusion:In short,Eryuan County’s overall knowledge rate of schistosomiasis was found to be high.Due to various dominating risk factors,different control strategies should be designed keeping in mind the two different subtypes of endemic areas for schistosomiasis in mountainous regions,namely plateau basins and plateau canyons. | Lu Liu Guo-Jing Yang Hong-Ru Zhu Kun Yang Lin Ai | 2014 | Infectious Diseases of Poverty2014，3，1： | 14 |
| 14 | HBx-DNA probe preparation and its application in study of hepatocarcinogenesis显示文摘HBxDNAprobepreparationanditsapplicationinstudyofhepatocarcinogenesisGAOFengGuang,SUNWenSheng,CAOYingLin,ZHANGLiNing,SON... | GAO FengGuang, SUN WenSheng, CAO YingLin, ZHANG LiNing, SONG Jing, LI HuaFen and YAN ShiKunKeywords hepatitis B virus liver neoplasms/etiology carcinoma, hepatocellular/etiology DNA probe | 1998 | World Journal of Gastroenterology1998，4，4： | 12 |
| 15 | Seasonal dynamics of water bloom-forming Microcystis morphospecies and the associated extracellular microcystin concentrations in large,shallow,eutrophic Dianchi Lake显示文摘The increasing occurrence of Microcystis blooms is of great concern to public health and ecosystem due to the potential hepatotoxic microcystins(MCs)produced by these colonial cyanobacteria.In order to interpret the relationships between variations of Microcystis morphospecies and extracellular MC concentrations,the seasonal dynamics of phytoplankton community composition,MC concentrations,and environmental parameters were monitored monthly from August,2009 to July,2010.The results indicated that Microcystis dominated total phytoplankton abundance from May to December(96%–99%of total biovolume),with toxic Microcystis viridis and non-toxic Microcystis wesenbergii dominating after July(constituting 65%–95%of the Microcystis population),followed by M.viridis as the sole dominant species from November to January(49%–93%).Correlation analysis revealed that water temperature and nutrient were the most important variables accounting for the occurrence of M.wesenbergii,while the dominance of M.viridis was related with nitrite and nitrate.The relatively low content of MCs was explained by the association with a large proportion of M.viridis and M.wesenbergii,small colony size of Microcystis populations,and low water temperature,pH and dissolved oxygen.The extracellular MC(mean of 0.5±0.2μg/L)of water samples analyzed by enzyme-linked immunosorbent assay(ELISA)demonstrated the low concentrations of MC in Dianchi Lake which implied the low potential risk for human health in the basin.The survey provides the first whole lake study of the occurrence and seasonal variability of Microcystis population and extracellular MCs that are of particular interest for water quality monitoring and management. | Yanlong Wu Lin Li Nanqin Gan Lingling Zheng Haiyan Ma Kun Shan Jin Liu Bangding Xiao Lirong Song | 2014 | Journal of Environmental Sciences2014，26，9： | 12 |
| 16 | New Families in the Stable Homotopy of Spheres Revisited | LIN Jin Kun Department of Mathematics. Nankai University. Tianjin 300071. P. R. China | 2002 | Acta Mathematica Sinica,English Series2002，18，1： | 12 |
| 17 | Altered angiotensin-converting enzyme and its effects on the brain in a rat model of Alzheimer disease显示文摘背景 Alzheimer 疾病(广告)是与在场的 aging.At 有关的 neurodegenerative 疾病,它的病理学的机制 unclear.Family 留下高血压蛋白原酶血管收缩素系统(地岬)的成员祈祷在 neuronal 粘性的一个角色,以及学习和记忆的形成在这研究,我们探索改变的变换血管收缩素的酶(王牌)的效果,并且调查 perindopril 的可能的机制,一个王牌禁止者在在广告的一个老鼠模型的大脑结构和功能上。 | HOU De-ren WANG Yan ZHOU Lin CHEN Kun TIAN Yi SONG Zhi BAO Juan YANG Qi-dong | 2008 | Chinese Medical Journal2008，，22： | 11 |
| 18 | Effects of professional rehabilitation training on the recovery of neurological function in young stroke patients显示文摘Young stroke patients have a strong desire to return to the society,but few studies have been conducted on their rehabilitation training items,intensity,and prognosis.We analyzed clinical data of young and middle-aged/older stroke patients hospitalized in the Department of Neurological Rehabilitation,China Rehabilitation Research Center,Capital Medical University,China from February 2014 to May 2015.Results demonstrated that hemorrhagic stroke(59.6%) was the primary stroke type found in the young group,while ischemic stroke(60.0%)was the main type detected in the middle-aged/older group.Compared with older stroke patients,education level and incidence of hyperhomocysteinemia were higher in younger stroke patients,whereas,incidences of hypertension,diabetes,and heart disease were lower.The average length of hospital stay was longer in the young group than in the middle-aged/older group.The main risk factors observed in the young stroke patients were hypertension,drinking,smoking,hyperlipidemia,hyperhomocysteinemia,diabetes,previous history of stroke,and heart disease.The most accepted rehabilitation program consisted of physiotherapy,occupational therapy,speech therapy,acupuncture and moxibustion.Average rehabilitation training time was 2.5 hours/day.Barthel Index and modified Rankin Scale scores were increased at discharge.Six months after discharge,the degree of occupational and economic satisfaction declined,and there were no changes in family life satisfaction.The degrees of other life satisfaction(such as friendship) improved.The degree of disability and functional status improved significantly in young stroke patients after professional rehabilitation,but the number of patients who returned to society within 6 months after stroke was still small. | Chao-jin-zi Li Xiao-xia Du Kun Yang Lu-ping Song Peng-kun Li Qiang Wang Rong Sun Xiao-ling Lin Hong-yu Lu Tong Zhang | 2016 | Neural Regeneration Research2016，11，11： | 11 |
| 19 | Role of Contrast Enhanced Ultrasound in Radiofrequency Ablation of Metastatic Liver Carcinoma显示文摘Objective:To investigate the application of contrast enhanced ultrasound(CEUS) in planning and guiding for radiofrequency ablation(RFA) for metastatic liver carcinoma(MLC).Methods:One hundred and thirty-five patients with clinically and pathologically diagnosed MLC(from gastrointestinal tumors) were included in the present study,and 104 of them had received CEUS prior to RFA to assess the number,size,shape,infiltration,location and enhancing features of the lesions.Among the 104 patients,21(20.1%) were excluded from RFA treatment due to too many lesions or large infiltrative range based on CEUS.The remaining 83 patients with 147 lesions underwent RFA(group A).During the same period,other 31 patients with 102 lesions serving as control group were treated based on findings of conventional ultrasound without contrast(group B).The patients underwent follow-up enhanced CT at the 1st month,and then every 3-6 months after RFA.The tumor was considered as early necrosis if no contrast enhancement was detected in the treated area on the CT scan at the 1st month.Results:In group A,72 of 147 MLC lesions(48.9%) showed increased sizes on CEUS.Among them,48 lesions(66.6%) appeared enlarged in arterial phase,and 24(33.3%) showed enlarged hypoechoic area in parenchymal phase.CEUS showed total 61 additional lesions in 35 patients(42.1%)(ranged from 8 to 15 mm) compared with conventional ultrasound(US),and 42(68.8%) of them were visualized in parenchymal phase only.There were total 208 lesions in group A underwent RFA with CEUS planning,and the tumor necrosis rate was 94.2%(196/208).In this group,local recurrence was found in 16 lesions(7.7%) during 3-42 months' following up,and new metastases were seen in 30 cases(36.1%).For group B,the tumor necrosis rate was 86.3%(88/102),local recurrence in 17 lesions(16.7%),and new metastases in 13 cases(41.9%).Tumor early necrosis and recurrence rates were significantly different between the two groups(P=0.018,P=0.016,respectively).Conclusion: CEUS played an important role in RFA for liver metastases by candidate selecting and therapy planning, which helped to improve the outcome of the treatment. | Jin-yu Wu Min-hua Chen Wei Yang Shu-zhi Lin Wei Wu Shan-shan Yin HuiZhang Kun Yan | 2012 | Chinese Journal of Cancer Research2012，24，1： | 11 |
| 20 | 在胃的癌症的帮助 laparoscopy 对开的激进的 gastrectomy 的短期的功效显示文摘 AIM:To investigate the short-term benefits of laparoscopic radical gastrectomy(LARG)and open radical gastrectomy(ORG)in patients with gastric cancer.METHODS:A total of 400 patients with gastric cancer aged≤65 years who were treated at General Hospital of Lanzhou Military Region were enrolled.Among these,200 patients underwent LARG between October2008 and August 2012(LARG group);and 200 patients underwent ORG between March 2000 and September2008(ORG group).The short-term therapeutic benefits between the two groups were analyzed.RESULTS:The LARG procedure offered significantly better benefits to the patients compared to the ORG procedure,including less intraoperative blood loss(103.1±19.5 mL vs 163.0±32.9 mL,P<0.0001),shorter postoperative hospital stay(6.8±1.2 d vs 9.5±1.6 d,P<0.0001),less frequent occurrence of postoperative complications(6.5%vs 13.5%,P=0.02),shorter time to mobilization(1.0±0.3 vs 3.3±0.4 d,P<0.0001),shorter time to bowel opening(3.3±0.7 d vs 4.5±0.7 d,P<0.0001),and shorter time to normal diet(3.0±0.4 vs d 3.8±0.5 d,P<0.0001).However,LARG required a longer time to complete than the ORG procedure(192.3±20.9 min vs 180.0±26.9 min,P<0.0001).CONCLUSION:Compared to ORG,LARG is safer,more effective,and less invasive for treating gastric cancer,with better short-term efficacy. | Hong-Tao Li Xiao-Peng Han Lin Su Wan-Kun Zhu Wei Xu Kun Li Qing-Chuan Zhao Hua Yang Hong-Bin Liu | 2014 | World Journal of Gastrointestinal Surgery2014，6，4： | 10 |
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