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| 1 | Epidemiological characteristics of thyroid nodules and risk factors for malignant nodules: a retrospective study from 6 304 surgical cases显示文摘 | Huan Qin Wang Kun Lou Fuchen Zhang Li Huang Qingxian Han Yunfeng Sun Hancheng Zhu Lei Lin Peng Song Jun Liu Fuqiang Wang Qian Hou Weikai | 2014 | Chinese Medical Journal2014，，12： | 20 |
| 2 | Combined obeticholic acid and apoptosis inhibitor treatment alleviates liver fibrosis显示文摘Obeticholic acid(OCA), the first FXR-targeting drug, has been claimed effective in the therapy of liver fibrosis. However, recent clinical trials indicated that OCA might not be effective against liver fibrosis, possibly due to the lower dosage to reduce the incidence of the side-effect of pruritus. Here we propose a combinatory therapeutic strategy of OCA and apoptosis inhibitor for combating against liver fibrosis. CCl4-injured mice, D-galactosamine/LPS(GalN/LPS)-treated mice and cycloheximide/TNFα(CHX/TNFα)-treated HepG2 cells were employed to assess the effects of OCA, or together with IDN-6556, an apoptosis inhibitor. OCA treatment significantly inhibited hepatic stellate cell(HSC)activation/proliferation and prevented fibrosis. Elevated bile acid(BA) levels and hepatocyte apoptosis triggered the activation and proliferation of HSCs. OCA treatment reduced BA levels but could not inhibit hepatocellular apoptosis. An enhanced anti-fibrotic effect was observed when OCA was co-administrated with IDN-6556. Our study demonstrated that OCA inhibits HSCs activation/proliferation partially by regulating BA homeostasis and thereby inhibiting activation of HSCs. The findings in this study suggest that combined use of apoptosis inhibitor and OCA at lower dosage represents a novel therapeutic strategy for liver fibrosis. | Jiyu Zhou Ningning Huang Yitong Guo Shuang Cui Chaoliang Ge Qingxian He Xiaojie Pan Guangji Wang Hong Wang Haiping Hao | 2019 | Acta Pharmaceutica Sinica B2019，9，3： | 13 |
| 3 | A process for enhan- cing the accessibility and reactivity of hardwood kraft-based dissol- ving pulp for viscose rayon production by cellulose treatment 显示文摘 | Miao Qingxian Chen Lihui Huang Liulian | 2014 | Bioresource Technology2014，154，： | 1 |
| 4 | Advances in the control of dissolved and colloidal substances present in papermaking processes: a brief review显示文摘 | Qingxian Miao Liulian Huang Lihui Chert | 2013 | BioResources2013，8，1： | 1 |
| 5 | PCR–RFLP technique for species identification of molted feathers in six species of co-occurring Ardeids显示文摘 | Xunhe Huang Xiaoping Zhou Qingxian Lin Wenzhen Fang Xiaolin Chen | 2013 | Conservation Genetics Resources2013，，： | 1 |
| 6 | A process for enhancing the accessibility and reactivity of hardwood kraft-based dissolving pulp for viscose rayon production by cellulase treatment显示文摘 | MIAO Qingxian CHEN Lihui HUANG Liulian | 2014 | Bioresource Technology2014，154，： | 1 |
| 7 | Feedforward plus feedback fuzzy robust tracking control for a class of uncertain non- linear systems 显示文摘 | WANG Yuhui Wu Qingxian JIANG Changsheng HUANG Guoyong | 2008 | International Journal of Innovative Computing Information and Control2008，4，8： | 1 |
| 8 | Advances in the control of dissolved and colloidal substances present in papermaking proces- ses : a brief review显示文摘 | Miao Qingxian Huang liulian Chen Lihui | 2013 | Bioresources2013，8，1： | 1 |
| 9 | Advances in the control of dissolved and colloidal substances present in papermaking proces- ses: a brief review 显示文摘 | Miao Qingxian Huang Liulian Chen Lihui | 2013 | BioResources2013，8，1： | 1 |
| 10 | Advances in the control of dissolved and colloidal substances present in papermaking proces- ses: a brief review显示文摘 | Miao Qingxian Huang Liulian Chen Lihui | 2013 | BioResources2013，8，1： | 1 |
| 11 | Abound Hepatic Mitosis:Unusual Morphology in the Intrahepatic Cholelithiasis Patient显示文摘To explore the clinicopathological features of abound mitosis of the hepatocytes in intrahepatic cholelithiasis.The clinicopathological data of one case diagnosed as intrahepatic cholelithiasis was collected from Yantai Yuhuangding Hospital and the clinicopathological characters were discussed.A 68-year-old man suffered from the pain in the right upper quadrant and radiology showed multiple stones in the gallbladder and left liver.The images suggested intrahepatic cholelithiasis.The patient received gallbladder and partial hepatectomy.A large number of mitosis was observed and twelve nuclear fissions were found under high magnification,even in some area pathological nuclear fission could be observed in morphology.On the basis of detection in laboratory,the diagnosis of intrahepatic cholelithiasis was made.The patient did not receive any therapy after surgery.The patient was in a good condition after 18 months follow-up.Increased number of hepatic mitosis might be due to the stimulation from stones,hepatic biliary or secondary inflammatory.High index of proliferation should be prevented from the potential misdiagnosis of hepatic tumor. | Yunjun Wang Lei Jiang Xiumei Wang Qingxian Huang Shishou Wu Ying Yin Jun Wang Xubo Pan Guohua Yu | 2022 | Journal of Oncology Research2022，4，1： | 0 |
| 12 | Time of Liver Function Abnormal Identification on Prediction of the Risk of Anti-tuberculosis-induced Liver Injury显示文摘Background and Aims:Anti-tuberculosis(anti-TB)druginduced liver injury(AT-DILI)is the most common side effect in patients who received anti-TB therapy.AT-DILI management includes monitoring liver function until symptoms arise in patients without high-risk factors for liver damage.The present study aimed to investigate the effect of liver function test(LFT)abnormal identification on the risk of DILI,including liver failure and anti-TB drug resistance in patients without high-risk factors.Methods:A total of 399 patients without high-risk factors for liver damage at baseline and who experienced LFT abnormal during the 6 months of first-line anti-TB treatment were enrolled.The Roussel Uclaf Causal Relationship Assessment Method(RUCAM,2016)was applied in suspected DILI.The correlations between the time of LFT abnormal identification and DILI,liver failure,and anti-TB drug resistance were analyzed by smooth curve fitting and multivariable logistic regression models.Results:Among all study patients,131 met the criteria for DILI with a mean RUCAM causality score of 8.86±0.63.26/131 and 105/131 were in the probable grading and highly probable grading,respectively.The time of abnormal LFT identification was an independent predictor of DILI,liver failure,and anti-TB drug resistance in the crude model and after adjusting for other risk patient factors.The time of abnormal LFT identification was positively correlated with DILI,liver failure,and anti-TB drug resistance.The late identification group(>8 weeks)had the highest risk of DILI,followed by liver failure compared with the other two groups.Conclusions:The time to identification of LFT was positively correlated with DILI,liver failure,and anti-TB drug resistance.The risk of DILI and liver failure was significantly increased in the late identification group with abnormal LFT identified after 8 weeks compared with 4 and 8 weeks.Early monitoring of LFT is recommended for patients without the high-risk factor of DILI after anti-TB treatment is initiated. | Deliang Huang Jinghan Peng Lin Lei Yuanyuan Chen Zhibing Zhu Qingxian Cai Yongcong Deng Jun Chen | 2023 | Journal of Clinical and Translational Hepatology2023，11，2： | 0 |
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