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| 1 | AXL is a candidate receptor for SARS-CoV-2 that promotes infection of pulmonary and bronchial epithelial cells显示文摘The current coronavirus disease 2019(COVID-19)pandemic presents a global public health challenge.The viral pathogen responsible,severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),binds to the host receptor ACE2 through its spike(S)glycoprotein,which mediates membrane fusion and viral entry.Although the role of ACE2 as a receptor for SARS-CoV-2 is clear,studies have shown that ACE2 expression is extremely low in various human tissues,especially in the respiratory tract.Thus,other host receptors and/or co-receptors that promote the entry of SARS-CoV-2 into cells of the respiratory system may exist.In this study,we found that the tyrosine-protein kinase receptor UFO(AXL)specifically interacts with the N-terminal domain of SARS-CoV-2 S.Using both a SARS-CoV-2 virus pseudotype and authentic SARS-CoV-2,we found that overexpression of AXL in HEK293T cells promotes SARS-CoV-2 entry as efficiently as overexpression of ACE2,while knocking out AXL significantly reduces SARS-CoV-2 infection in HI 299 pulmonary cells and in human primary lung epithelial cells.Soluble human recombinant AXL blocks SARS-CoV-2 infection in cells expressing high levels of AXL.The AXL expression level is well correlated with SARS-CoV-2 S level in bronchoalveolar lavage fluid cells from COVID-19 patients.Taken together,our findings suggest that AXL is a novel candidate receptor for SARS-CoV-2 which may play an important role in promoting viral infection of the human respiratory system and indicate that it is a potential target for future clinical intervention strategies. | Shuai Wang Zongyang Qiu Yingnan Hou Xiya Deng Wei Xu Tingting Zheng Peihan Wu Shaofang Xie Weixiang Bian Chong Zhang Zewei Sun Kunpeng Liu Chao Shan Aifu Lin Shibo Jiang Youhua Xie Qiang Zhou Lu Lu Jing Huang Xu Li | 2021 | Cell Research2021，31，2： | 39 |
| 2 | Recent advances of phase engineering in group VI transition metal dichalcogenides显示文摘As the crystal quality and phase structure of two-dimensional(2D)transition metal dichalcogenides(TMDs)have significant impacts on their properties such as electroconductivity,superconductivity and chemical stability,the precise synthesis,which plays an important role in fundamental researches and industrial applications,is highly required.Group VI TMDs,such as MoS_(2),usually exhibit diverse polymorphs including semiconducting 1H and metallic 1T phases.Even great efforts are devoted to revealing the structure-dependent physicochemical nature of TMDs by modulating their phases from the stable to the metastable at the atomic scale,there are still challenges on the phase-controlled synthesis of Group VI TMDs with metallic or semimetal properties.In this review,methods such as ion intercalation,chemical doping,strain engineering,defect triggering,and electric-field treatment are examined in detail.Finally,challenges and opportunities in this research field are proposed. | Lingjia Meng Yang Ma Kunpeng Si Shiyu Xu Jinliang Wang Yongji Gong | 2019 | Tungsten2019，1，1： | 6 |
| 3 | Estimation of Crop Biomass Using GF-3 Polarization SAR Data Based on Genetic Algorithm Feature Selection显示文摘In recent years,Polarization SAR(PolSAR)has been widely used in the filed of crop biomass estimation.However,high dimensional features extracted from PolSAR data will lead to information redundancy which will result in low accuracy and poor transfer ability of the estimation model.Aiming at this problem,we proposed a estimation method of crop biomass based on automatic feature selection method using genetic algorithm(GA).Firstly,the backscattering coefficient,the polarization parameters and texture features were extracted from PolSAR data.Then,these features were automatically pre-selected by GA to obtain the optimal feature subset.Finally,based on this subset,a support vector regression machine(SVR)model was applied to estimate crop biomass.The proposed method was validated using the GaoFen-3(GF-3)QPSΙ(C-band,quad-polarization)SAR data.Based on wheat and rape biomass samples acquired from a synchronous field measurement campaign,the proposed method achieve relative high validation accuracy(over 80%)in both crop types.For further analyzing the improvement of proposed method,validation accuracies of biomass estimation models based on several different feature selection methods were compared.Compared with feature selection based on linear correlation,GA method has increased by 5.77%in wheat biomass estimation and 11.84%in rape biomass estimation.Compared with the method of recursive feature elimination(RFE)selection,the proposed method has improved crops biomass estimation accuracy by 3.90%and 5.21%,respectively. | Kunpeng XU Lei ZHAO Kun LI Erxue CHEN Wangfei ZHANG Hao YANG | 2020 | Journal of Geodesy and Geoinformation Science2020，3，4： | 3 |
| 4 | Low-temperature synthesis of DME from CO 2 /H 2 over Pd-modified CuO–ZnO–Al 2 O 3 –ZrO 2 /HZSM-5 catalysts显示文摘 | Kunpeng Sun Weiwei Lu Min Wang Xianlun Xu | 2004 | Catalysis Communications2004，，7： | 1 |
| 5 | Subdivision Surface-Based Isogeometric Boundary Element Method for Steady Heat Conduction Problems with Variable Coefficient显示文摘The present work couples isogeometric analysis(IGA)and boundary element methods(BEM)for three dimensional steady heat conduction problems with variable coefficients.The Computer-Aided Design(CAD)geometries are built by subdivision surfaces,and meantime the basis functions of subdivision surfaces are employed to discretize the boundary integral equations for heat conduction analysis.Moreover,the radial integration method is adopted to transform the additional domain integrals caused by variable coefficients to the boundary integrals.Several numerical examples are provided to demonstrate the correctness and advantages of the proposed algorithm in the integration of CAD and numerical analysis. | Xiuyun Chen Xiaomeng Yin Kunpeng Li Ruhui Cheng Yanming Xu Wei Zhang | 2021 | Computer Modeling in Engineering & Sciences2021，，10： | 1 |
| 6 | Electric field controlled superlubricity of fullerene-based host–guest assembly显示文摘Controlling friction by the electric field is a promising way to improve the tribological performance of a variety of movable mechanical systems.In this work,the assembly structure and microscale superlubricity of a host–guest assembly are effectively controlled by the electric field.With the help of the scanning tunneling microscopy(STM)technique,the host–guest assembly structures constructed by the co-assembly of fullerene derivative(Fluorene-C60)with macrocycles(4B2A and 3B2A)are explicitly characterized.Combined with density functional theory(DFT),the distinct different assembly behaviors of fullerene derivatives are revealed at different probe biases,which is attributed to the molecular polarity of the fullerene derivative.Through the control on the adsorption behavior,the friction coefficient of host–guest assembly is demonstrated to be controllable in the electric field by using atomic force microscopy(AFM).At positive probe bias,the friction coefficient of the host–guest assembly is significantly reduced and achieves superlubricity(μmin=0.0049).The efforts not only help us gain insight into the host–guest assembly mechanism controlled by the electric field,but also promote the further application of fullerene in micro-electro-mechanical systems(MEMS). | Shanchao Tan Hongyu Shi Xin Du Kunpeng Wang Haijun Xu Junhua Wan Ke Deng Qingdao Zeng Yuhong Liu | 2023 | Nano Research2023，16，1： | 1 |
| 7 | A highly efficient and selective catalyst for liquid phase hydrogenation of maleic anhydride to butyric acid 显示文摘 | Xu Jian Sun Kunpeng Zhang Li | 2005 | Catalysis Communications2005，6，7： | 1 |
| 8 | A novel synthesis route of butyric acid from hydrogenation of maleic anhydride over Pd/TiO2 catalysts 显示文摘 | Xu Jian Sun Kunpeng Zhang Li | 2006 | Catalysis Letters2006，107，： | 1 |
| 9 | Low-temperature catalytic combustion of methane over Pd/CeO2 prepared by deposition-precipitation method显示文摘 | Sun Kunpeng Xu Xianlun | 2005 | Catalysis Communications2005，6，： | 1 |
| 10 | HZSM-5 Sup- ported Silica-Zirconia and Its Application in One-Step Synthesis of Methyl Isobutyl Ketone 显示文摘 | Liu Yanxia Sun Kunpeng Xu Xianlun | 2010 | Ca tal Commun2010，11，5： | 1 |
| 11 | Unraveling Passivation Mechanism of Imidazolium-Based Ionic Liquids on Inorganic Perovskite to Achieve Near-Record-Efficiency CsPbI_(2)Br Solar Cells显示文摘The application of ionic liquids in perovskite has attracted wide-spread attention for its astounding performance improvement of perovskite solar cells(PSCs).However,the detailed mechanisms behind the improvement remain mysterious.Herein,a series of imidazolium-based ionic liquids(IILs)with different cations and anions is systematically investigated to elucidate the passivation mechanism of IILs on inorganic perovskites.It is found that IILs display the following advantages:(1)They form ionic bonds with Cs^(+)and Pb^(2+)cations on the surface and at the grain boundaries of perovskite films,which could effectively heal/reduce the Cs^(+)/I−vacancies and Pb-related defects;(2)They serve as a bridge between the perovskite and the hole-transport-layer for effective charge extraction and transfer;and(3)They increase the hydrophobicity of the perovskite surface to further improve the stability of the CsPbI_(2)Br PSCs.The combination of the above effects results in suppressed non-radiative recombination loss in CsPbI_(2)Br PSCs and an impressive power conversion efficiency of 17.02%.Additionally,the CsPbI_(2)Br PSCs with IILs surface modification exhibited improved ambient and light illumination stability.Our results provide guidance for an indepth understanding of the passivation mechanism of IILs in inorganic perovskites. | Jie Xu Jian Cui Shaomin Yang Yu Han Xi Guo Yuhang Che Dongfang Xu Chenyang Duan Wenjing Zhao Kunpeng Guo Wanli Ma Baomin Xu Jianxi Yao Zhike Liu Shengzhong Liu | 2022 | Nano-Micro Letters2022，14，1： | 1 |
| 12 | Transgenic strategies to generate heterogeneous hepatic cancer models in zebrafish显示文摘Intratumor heterogeneity describes phenomena that cancer cells from a single focal population can be highly diverse in morphology,gene expression,metabolism,motility,proliferation,metastatic potential,and drug sensitivity(McGranahan and Swanton,2017). | Fei Fei Lei Wang Shaoyang Sun Kunpeng Lv Yuxiao Yao Jingjing Wang Min Yu Xu Wang | 2019 | Journal of Molecular Cell Biology2019，11，11： | 1 |
| 13 | Understanding the Correlations between Social Attention and Topic Trends of Scientific Publications显示文摘Purpose:We propose and apply a simplified nowcasting model to understand the correlations between social attention and topic trends of scientific publications.Design/methodology/approach:First,topics are generated from the obesity corpus by using the latent Dirichlet allocation(LDA) algorithm and time series of keyword search trends in Google Trends are obtained.We then establish the structural time series model using data from January 2004 to December 2012,and evaluate the model using data from January 2013.We employ a state-space model to separate different non-regression components in an observational time series(i.e.the tendency and the seasonality) and apply the 'spike and slab prior' and stepwise regression to analyze the correlations between the regression component and the social media attention.The two parts are combined using Markov-chain Monte Carlo sampling techniques to obtain our results.Findings:The results of our study show that(1) the number of publications on child obesity increases at a lower rate than that of diabetes publications;(2) the number of publication on a given topic may exhibit a relationship with the season or time of year;and(3) there exists a correlation between the number of publications on a given topic and its social media attention,i.e.the search frequency related to that topic as identified by Google Trends.We found that our model is also able to predict the number of publications related to a given topic.Research limitations:First,we study a correlation rather than causality between topics' trends and social media.As a result,the relationships might not be robust,so we cannotpredict the future in the long run.Second,we cannot identify the reasons or conditions that are driving obesity topics to present such tendencies and seasonal patterns,so we might need to do 'field' study in the future.Third,we need to improve the efficiency of our model by finding more efficient variable selection models,because the stepwise regression method is time consuming,especially for a large number of variables.Practical implications:This paper analyzes publication topic trends from three perspectives:tendency,seasonality,and correlation with social media attention,providing a new perspective for identifying and understanding topical themes in academic publications.Originality/value:To the best of our knowledge,we are the first to apply the state-space model to examine the relationships between healthcare-related publications and social media to investigate the relationships between a topic's evolvement and people's search behavior in social media.This paper thus provides a new viewpoint in the correlation analysis area,and demonstrates the value of considering social media attention in the analysis of publication topic trends. | Xianlei Dong Jian Xu Ying Ding Chenwei Zhang Kunpeng Zhang Min Song | 2016 | Journal of Data and Information Science2016，1，1： | 1 |
| 14 | Low-tempera- ture synthesis of DME from COdI-I2 over Pd-modifed CuO-ZnO-AI203 -ZrOdHZSM-5 catalysts显示文摘 | Kunpeng Sun Weiwei Lu Min Wang Xianlun Xu | 2004 | Catalysis Communications2004，，5： | 1 |
| 15 | Catalytic combustion of ethyl acetate on supported copper oxide catalysts 显示文摘 | Yang Yuxia Xu Xianlun Sun Kunpeng | 2007 | Journal of Hazardous Materials2007，139，： | 1 |
| 16 | A clinical assessment of the Glidescope videolaryngoscope in nasotracheal intubation with general anesthesia显示文摘 | Fushan Xue Guohua Zhang Jin Liu Xuanying Li Haitao Sun Xiao Wang Chengwen Li Kunpeng Liu Yachao Xu Yi Liu | 2006 | Journal of Clinical Anesthesia2006，，8： | 1 |
| 17 | Activation of Notch1 signaling by marrow-derived mesenchymal stem cells through cell–cell contact inhibits proliferation of hepatic stellate cells显示文摘 | Si Chen linan Xu Nan Lin Weidong Pan Kunpeng Hu Ruiyun Xu | 2011 | Life Sciences2011，，25： | 1 |
| 18 | A chromosome-scale reference genome of Aquilegia oxysepala var.kansuensis显示文摘The genus Aquilegia(Ranunculaceae)has been cultivated as ornamental and medicinal plants for centuries.With petal spurs of strikingly diverse size and shape,Aquilegia has also been recognized as an excellent system for evolutionary studies.Pollinator‐mediated selection for longer spurs is believed to have shaped the evolution of this genus,especially the North American taxa.Recently,however,an opposite evolutionary trend was reported in an Asian lineage,where multiple origins of mini-or even nonspurred morphs have occurred.Interesting as it is,the lack of genomic resources has limited our ability to decipher the molecular and evolutionary mechanisms underlying spur reduction in this special lineage.Using long-read sequencing(PacBio Sequel),in combination with optical maps(BioNano DLS)and Hi–C,we assembled a high-quality reference genome of A.oxysepala var.kansuensis,a sister species to the nonspurred taxon.The final assembly is approximately 293.2 Mb,94.6%(277.4 Mb)of which has been anchored to 7 pseudochromosomes.A total of 25,571 protein-coding genes were predicted,with 97.2%being functionally annotated.When comparing this genome with that of A.coerulea,we detected a large rearrangement between Chr1 and Chr4,which might have caused the Chr4 of A.oxysepala var.kansuensis to partly deviate from the“decaying”path that was taken before the split of Aquilegia and Semiaquilegia.This high-quality reference genome is fundamental to further investigations on the development and evolution of petal spurs and provides a strong foundation for the breeding of new horticultural Aquilegia cultivars. | Jinghe Xie Haifeng Zhao Kunpeng Li Rui Zhang Yongchao Jiang Meimei Wang Xuelian Guo Ben Yu Hongzhi Kong Yuannian Jiao Guixia Xu | 2020 | Horticulture Research2020，7，1： | 1 |
| 19 | Direct synthesis of DME over bifunctional catalyst: surface properties and catalystic performance显示文摘 | Kunpeng Sun Weiwei Lu Xianlun Xu | 2003 | Appl Catal A: Gen2003，252，： | 1 |
| 20 | Synthesis and photovohaic properties of novel solution- processable triphenyl- amine-based dendrimers withsulfonyl-dibenzene cores 显示文摘 | Li Kunpeng Qu Jialin Xu Bin | 2009 | New Journal of Chemistry2009，33，10： | 1 |
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