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| 1 | Role of surgical resection for multiple hepatocellular carcinomas显示文摘AIM:To clarify the role of surgical resection for multiple hepatocellular carcinomas(HCCs)compared to transarterial chemoembolization(TACE)and liver transplantation(LT). METHODS:Among the HCC patients who were managed at Yonsei University Health System between January 2003 and December 2008,160 patients who met the following criteria were retrospectively enrolled:(1) two or three radiologically diagnosed HCCs;(2)no radiologic vascular invasion;(3)Child-Pugh class A;(4) main tumor smaller than 5 cm in diameter;and(5) platelet count greater than 50 000/mm3.Long-term outcomes were compared among the following three treatment modalities:surgical resection or combined radiofrequency ablation(RFA)(n=36),TACE(n=107), and LT(n=17).The survival curves were computed using the Kaplan-Meier method and compared with a log-rank test.To identify the patients who gained a survival benefit from surgical resection,we also investigated prognostic factors for survival following surgical resection.Multivariate analyses of the prognostic factors for survival were performed using the Cox proportional hazard model. RESULTS:The overall survival(OS)rate was significantly higher in the surgical resection group than in the TACE group(48.1%vs 28.9%at 5 years,P<0.005). LT had the best OS rate,which was better than that of the surgical resection group,although the difference was not statistically significant(80.2%vs 48.1%at 5 years,P=0.447).The disease-free survival rates were also significantly higher in the LT group than in the surgical resection group(88.2%vs 11.2%at 5 years, P<0.001).Liver cirrhosis was the only significant prognostic factor for poor OS after surgical resection. Clinical liver cirrhosis rates were 55.6%(20/36)in the resection group and 93.5%(100/107)in the TACE group.There were 19 major and 17 minor resections. En bloc resection was performed in 23 patients,multisite resection was performed in 5 patients,and combined resection with RFA was performed in 8 patients. In the TACE group,only 34 patients(31.8%)were recorded as having complete remission after primary TACE.Seventy-two patients(67.3%)were retreated with repeated TACE combined with other therapies. In patients who underwent surgical resection,the 16 patients who did not have cirrhosis had higher 5-year OS and disease-free survival rates than the 20 patients who had cirrhosis(80.8%vs 25.5%5-year OS rate, P=0.006;22.2%vs 0%5-year disease-free survival rate,P=0.048).Surgical resection in the 20 patients who had cirrhosis did not provide any survival benefit when compared with TACE(25.5%vs 24.7%5-year OS rate,P=0.225).Twenty-nine of the 36 patients who underwent surgical resection experienced recur-rence.Of the patients with cirrhosis,80%(16/20) were within the Milan criteria at the time of recurrence CONCLUSION:Among patients with two or three HCCs, no radiologic vascular invasion,and tumor diameters≤ 5 cm,surgical resection is recommended only in those without cirrhosis. | Sung Hoon Choi Gi Hong Choi Seung Up Kim Jun Yong Park Dong Jin Joo Man Ki Ju Myoung Soo Kim Jin Sub Choi Kwang Hyub Han Soon Il Kim | 2013 | World Journal of Gastroenterology2013，19，3： | 12 |
| 2 | Characterization of smooth muscle, enteric nerve, interstitial cells of Cajal, and fibroblast-like cells in the gastric musculature of patients with diabetes mellitus显示文摘AIM To investigate histologic abnormalities in the gastric smooth muscle of patients with diabetes mellitus(DM).METHODS Full-thickness gastric specimens were obtained from patients undergoing surgery for gastric cancer. H&E stain and Masson's Trichrome stain were performed to assess the degree of fibrosis. Immunohistochemical staining using various antibodies was also performed [antibodies against protein gene product 9.5(PGP9.5), neuronal nitric oxide synthase(n NOS), vasoactive intestinal peptide(VIP), neurokinin-1(NK1) receptor, c-Kit, and platelet-derived growth factor receptor-alpha,(PDGFRα)]. Immunofluorescent staining and evaluation with confocal microscopy were also conducted.RESULTS Twenty-six controls and 35 diabetic patients(21 shortduration patients and 14 long-duration patients) were included. There were no significant differences in basic demographics between the two groups except in mean body mass index(BMI)(higher in the DM group). Proportions of moderate-to-severe intercellular fibrosis in the muscle layer were significantly higher in the DM group than in the control group(P < 0.01). On immunohistochemical staining, c-Kit- and PDGFRα-positive immunoreactivity were significantly decreased in the DM group compared with the control group(P < 0.05). There were no statistically significant differences in PGP9.5, n NOS, VIP, and neurokinin 1 expression. On immunofluorescent staining, cellularity of interstitial cells of Cajal(ICC) was observed to decrease with increasing duration of DM.CONCLUSION Our study suggests that increased intercellular fibrosis, loss of ICC, and loss of fibroblast-like cells are found in the smooth muscle of DM patients. These abnormalities may contribute to changes in gastric motor activity in patients with DM. | Kyung Sik Park Kwang Bum Cho Il Seon Hwang Jae Hyung Park Byung Ik Jang Kyeong Ok Kim Sung Woo Jeon Eun Soo Kim Chang Sik Park Joong Goo Kwon | 2016 | World Journal of Gastroenterology2016，22，46： | 11 |
| 3 | Risk prediction of hepatitis B virus-related hepatocellular carcinoma in the era of antiviral therapy显示文摘Hepatocellular carcinoma(HCC)is a grave primary liver cancer that has a limited therapeutic option because it is generally diagnosed later in an advanced stage due to its aggressive biologic behavior.The early detection of HCC has a great impact on the treatment efficacy and survival of patients at high risk for cancer.Potential host,environmental,and virus-related risk factors have been introduced.Hepatitis B virus(HBV)is a major cause of end-stage liver diseases such as liver cirrhosis or HCC in endemic areas,and its serologic or virologic status is considered an important risk factor.HCC risk prediction derived from the identification of major risk factors is necessary for providing adequate screening/surveillance strategies to high-risk individuals.Several risk prediction models for HBV-related HCC have been presented recently with simple,efficient,and readily available to use parameters applicable to average-or unknown-risk populations as well as high-risk individuals.Predictive scoring systems of risk estimation to assess HCC development can provide the way to an evidence-based clinical approach for cost-and effort-effective outcomes,capable of inducing a personalized surveillance program according to risk stratification.In this review,the concepts and perspectives of the risk prediction of HCC are discussed through the analysis of several risk prediction models of HBV-related HCC. | Il Han Song So Mi Kim Young Kwang Choo | 2013 | World Journal of Gastroenterology2013，19，47： | 7 |
| 4 | Alpha-fetoprotein-targeted reporter gene expression imaging in hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC) is one of the most common cancers in Eastern Asia, and its incidence is increasing globally. Numerous experimental models have been developed to better our understanding of the pathogenic mechanism of HCC and to evaluate novel therapeutic approaches. Molecular imaging is a convenient and up-to-date biomedical tool that enables the visualization, characterization and quantification of biologic processes in a living subject. Molecular imaging based on reporter gene expression, in particular, can elucidate tumor-specific events or processes by acquiring images of a reporter gene's expression driven by tumor-specific enhancers/promoters. In this review, we discuss the advantages and disadvantages of various experimental HCC mouse models and we present in vivo images of tumorspecific reporter gene expression driven by an alphafetoprotein(AFP) enhancer/promoter system in a mouse model of HCC. The current mouse models of HCC development are established by xenograft, carcinogen induction and genetic engineering, representing the spectrum of tumor-inducing factors and tumor locations. The imaging analysis approach of reporter genes driven by AFP enhancer/promoter is presented for these different HCC mouse models. Such molecular imaging can provide longitudinal information about carcinogenesis and tumor progression. We expect that clinical application of AFP-targeted reporter gene expression imaging systems will be useful for the detection of AFP-expressing HCC tumors and screening of increased/decreased AFP levels due to disease or drug treatment. | Kwang Il Kim Hye Kyung Chung Ju Hui Park Yong Jin Lee Joo Hyun Kang | 2016 | World Journal of Gastroenterology2016，22，27： | 6 |
| 5 | Antioxidative phytoceuticals to ameliorate pancreatitis in animal models: An answer from nature显示文摘Despite enthusiastic efforts directed at elucidating critical underlying mechanisms towards the identification of novel therapeutic targets for severe acute pancreatitis(SAP), the disease remains without a specific therapy to be executed within the first hours to days after onset of symptoms. Although earlier management for SAP should aim to either treat organ failure or reduce infectious complications, the current standard of care for the general management of AP in the first hours to days after onset of symptoms include intravenous fluid replacement, nutritional changes, and the use of analgesics with a close monitoring of vital signs. Furthermore, repeated evaluation of severity is very important, as the condition is particularly unstable in the early stages. In cases where biliary pancreatitis is accompanied by acute cholangitis or in cases where biliary stasis is suspected,an early endoscopic retrograde cholangiopancreatography is recommended.However,practice guidelines regarding the treatment of pancreatitis are suboptimal.In chronic pancreatitis,conservative management strategies include lifestyle modifications and dietary changes followed by analgesics and pancreatic enzyme supplementation.Recently,attention has been focused on phytoceuticals or antioxidants as agents that could surpass the limitations associated with currently available therapies.Because oxidative stress has been shown to play an important role in the pathogenesis of pancreatitis,antioxidants alone or combined with conventional therapy may improve oxidativestress-induced organ damage.Interest in phytoceuticals stems from their potential use as simple,accurate tools for pancreatitis prognostication that could replace older and more tedious methods.Therefore,the use of antioxidative nutrition or phytoceuticals may represent a new direction for clinical research in pancreatitis.In this review article,recent advances in the understanding of the pathogenesis of pancreatitis are discussed and the paradigm shift underway to develop phytoceuticals and antioxidants to treat it is introduced.Despite the promise of studies evaluating the effects of antioxidants/phytoceuticals in pancreatitis,translation to the clinic has thus far been disappointing.However,it is expected that continued research will provide solid evidence to justify the use of antioxidative phytoceuticals in the treatment of pancreatitis. | Jong-Min Park Sooyeon Lee Mi Kyung Chung Sung-Hun Kwon Eun-Hee Kim Kwang Hyun Ko Chang Il Kwon Ki Baik Hahm | 2014 | World Journal of Gastroenterology2014，20，44： | 5 |
| 6 | Clinical outcome of Fitz-Hugh-Curtis syndrome mimicking acute biliary disease显示文摘AIM: To analyze the clinical characteristics of patients diagnosed with Fitz-Hugh-Curtis syndrome.METHODS: The clinical courses of patients that visited St. Mary's Hospital with abdominal pain from January 2005 to December 2006 and were diagnosed with Fitz-Hugh-Curtis syndrome were examined.RESULTS: Fitz-Hugh-Curtis syndrome was identified in 22 female patients of childbearing age; their mean age was 31.0 ± 8.1 years. Fourteen of these cases presented with pain in the upper right abdomen alone or together with pain in the lower abdomen, and six patients presented with pain only in the lower abdomen. The first impression at the time of visit was acute cholecystitis or cholangitis in 10 patients and acute appendicitis or pelvic inflammatory disease in eight patients. Twenty-one patients were diagnosed by abdominal computer tomograghy (CT), and the results of abdominal sonography were normal for 10 of these patients. Chlamydia trichomatis was isolated from 18 patients. Two patients underwent laparoscopic adhesiotomy and 20 patients were completely cured by antibiotic treatment.CONCLUSION: For women of childbearing age with acute pain in the upper right abdomen alone or together with pain in the lower abdomen, Fitz-Hugh-Curtis syndrome should be considered during differential diagnosis. Moreover, in cases suspected to be Fitz-Hugh-Curtis syndrome, abdominal CT, rather than abdominal sonography, assists in the diagnosis. | Seong Yong Woo Jin Il Kim Dae Young Cheung Se Hyun Cho Soo-Heon Park Joon-Yeol Han Jae Kwang Kim | 2008 | World Journal of Gastroenterology2008，14，45： | 5 |
| 7 | Electrolyte changes after bowel preparation for colonoscopy:A randomized controlled multicenter trial显示文摘AIM:To investigate the electrolyte changes between 2-L polyethylene glycol with ascorbic acid 20 g(PEGAsc) and 4-L PEG solutions.METHODS:From August 2012 to February 2013,a total of 226 patients were enrolled at four tertiary hospitals.All patients were randomly allocated to a PEG-Asc group or a 4-L PEG.Before colonoscopy,patients completed a questionnaire to assess bowel preparation-related symptoms,satisfaction,and willingness.Endoscopists assessed the bowel preparation using the Boston Bowel Preparation Scale(BBPS).In addition,blood tests,including serum electrolytes,serum osmolarity,and urine osmolarity were evaluated both before and after the procedure.RESULTS:A total of 226 patients were analyzed.BBPS scores were similar and the adequate bowel preparation rate(BBPS≥6)was not different between the two groups(PEG-Asc vs 4-L PEG,73.2%vs 76.3%,P=0.760).Bowel preparation-related symptoms also were not different between the two groups.The taste of PEG-Asc was better(41.1%vs 16.7%,P<0.001),and the willingness to undergo repeated bowel preparation was higher in the PEG-Asc group(73.2%vs 59.3%,P=0.027)than in 4-L PEG.There were no significant changes in serum electrolytes in either group.CONCLUSION:In this multicenter trial,bowel preparation with PEG-Asc was better than 4-L PEG in terms of patient satisfaction,with similar degrees of bowel preparation and electrolyte changes. | Kyong Joo Lee Hong Jun Park Hyun-Soo Kim Kwang Ho Baik Yeon Soo Kim Sung Chul Park Hyun Il Seo | 2015 | World Journal of Gastroenterology2015，21，10： | 3 |
| 8 | Efficacy of endoscopic and percutaneous treatments for biliary complications after cadaveric and living donor liver transplantation显示文摘 | Ju Sang Park Myung-Hwan Kim Sung Koo Lee Dong Wan Seo Sang Soo Lee Jimin Han Young Il Min Shin Hwang Kwang Min Park Young Joo Lee Seung Gyu Lee Kyu Bo Sung | 2003 | Gastrointestinal Endoscopy2003，，1： | 2 |
| 9 | New antireflux self‐expandable metal stent for malignant lower biliary obstruction: In vitro and in vivo preliminary study显示文摘 | Dong Uk Kim Chang‐Il Kwon Dae Hwan Kang Kwang Hyun Ko Sung Pyo Hong | 2012 | Digestive Endoscopy2012，，1： | 2 |
| 10 | Inhibition of Histone Deacetylation Blocks Cardiac Hypertrophy Induced by Angiotensin II Infusion and Aortic Banding显示文摘 | Hae Jin Kee Il Suk Sohn Kwang Il Nam Jong Eun Park Yong Ri Qian Zhan Yin Youngkeun Ahn Myung Ho Jeong Yung-Jue Bang Nacksung Kim Jong-Keun Kim Kyung Keun Kim Jonathan A. Epstein Hyun Kook | 2006 | Circulation2006，，1： | 2 |
| 11 | Endoscopic resection yields reliable outcomes for small rectal neuroendocrine tumors显示文摘 | Joon Han Jeon Dae Young Cheung Seong Jin Lee Hyun Jin Kim Hye Kang Kim Hyung Jun Cho In Kyu Lee Jin Il Kim Soo‐Heon Park Jae Kwang Kim | 2014 | Digestive Endoscopy2014，，4： | 1 |
| 12 | Doxorubiein Enhances the Expression of Transgene Under Control of the CMV Promoter in Anaplastic Thyroid Carcinoma Cells显示文摘 | Kwang Il Kim | 2007 | Journal of Nuclear Medicine2007，48，9： | 1 |
| 13 | Incidence and Etiology of Overt Gastrointestinal Bleeding in Adult Patients with Aplastic Anemia显示文摘 | Yong Bum Park Jong-Wook Lee Byung Sik Cho Woo-Sung Min Dae Young Cheung Jin Il Kim Se Hyun Cho Soo-Heon Park Jae Kwang Kim Sok Won Han | 2010 | Digestive Diseases and Sciences2010，，1： | 1 |
| 14 | CD11b+ Gr1+ bone marrow cells ameliorate liver fibrosis by producing interleukin‐10 in mice显示文摘 | Yang‐Gun Suh Ja Kyung Kim Jin‐Seok Byun Hyon‐Seung Yi Young‐Sun Lee Hyuk Soo Eun So Yeon Kim Kwang‐Hyub Han Kwan Sik Lee Gregg Duester Scott L. Friedman Won‐Il Jeong | 2012 | Hepatology2012，，5： | 1 |
| 15 | Recurrence of hepatitis B is associated with cumulative corticosteroid dose and chemotherapy against hepatocellular carcinoma recurrence after liver transplantation显示文摘 | Nam‐Joon Yi Kyung‐Suk Suh Jai Young Cho Choon Hyuck Kwon Kwang‐Woong Lee Jae Won Joh Suk‐Koo Lee Soon Il Kim Kuhn Uk Lee | 2007 | Liver Transpl2007，，3： | 1 |
| 16 | Case studies of chemi-cal incidents and emergency information service in Korea显示文摘 | SANG Tae chung KWANG Il Kim | 2009 | Journal of Loss Prevention in the Process Industries2009，22，4： | 1 |
| 17 | Neuroprotective effects of tadalafil on gerbil dopaminergic neurons following cerebral ischemia显示文摘Impairment of dopamine function,which is known to have major effects on behaviors and cognition,is one of the main problems associated with cerebral ischemia.Tadalafil,a long-acting phosphodiesterase type-5 inhibitor,is known to ameliorate neurologic impairment induced by brain injury,but not in dopaminergic regions.We investigated the neuroprotective effects of treatment with tadalafil on cyclic guanosine monophosphate level and dopamine function following cerebral ischemia.Forty adult Mongolian gerbils were randomly and evenly divided into five groups (n=8 in each group):Sham-operation group,cerebral ischemia-induced and 0,0.1,1,and 10 mg/kg tadalafil-treated groups,respectively.Tadalafil dissolved in distilled water was administered orally for 7 consecutive days,starting 1 day after surgery.Cyclic guanosine monophosphate assay and immunohistochemistry were performed for thyrosine hydroxylase expression and western blot analysis for dopamine D 2 receptor expression.A decrease in cyclic guanosine monophosphate level following cerebral ischemia was found with an increase in thyrosine hydroxylase activity and a decrease in dopamine D 2 receptor expression in the striatum and substantia nigra region.However,treatment with tadalafil increased cyclic guanosine monophosphate expression,suppressed thyrosine hydroxylase expression and increased dopamine D 2 receptor expression in the striatum and substantia nigra region in a dose-dependent manner.Tadalafil might ameliorate cerebral ischemia-induced dopaminergic neuron injury.Therefore,tadalafil has the potential as a new neuroprotective treatment strategy for cerebral ischemic injury. | Kwang Taek Kim Kyung Jin Chung Han Sae Lee Il Gyu Ko Chang Ju Kim Yong Gil Na Khae Hawn Kim | 2013 | Neural Regeneration Research2013，8，8： | 1 |
| 18 | Treatment of branchial cleft cyst with intracystic injection of OK-432显示文摘 | Jong-Lyel Roh Myung-Whun Sung Kwang Hyun Kim Chan Il Park | 2006 | Acta Oto-Laryngologica2006，，5： | 1 |
| 19 | In Vitro Radionuclide Therapy and In Vivo Scintigraphic Imaging of Alpha-Fetoprotein-Producing Hepatocellular Carcinoma by Targeted Sodium Iodide Symporter Gene Expression显示文摘 | Kwang Il Kim Yong Jin Lee Tae Sup Lee Inho Song Gi Jeong Cheon Sang Moo Lim June-Key Chung Joo Hyun Kang | 2013 | Nuclear Medicine and Molecular Imaging2013，，1： | 1 |
| 20 | In vivo bioluminescent imaging of α‐fetoprotein‐producing hepatocellular carcinoma in the diethylnitrosamine‐treated mouse using recombinant adenoviral vector显示文摘 | Kwang Il Kim Ju Hui Park Yong Jin Lee Tae Sup Lee Jae Jun Park Inho Song Sang‐Soep Nahm Gi Jeong Cheon Sang Moo Lim June‐Key Chung Joo Hyun Kang | 2012 | J Gene Med2012，，8： | 1 |
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