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| 1 | Taking the pulse of COVID-19:a spatiotemporal perspective显示文摘The sudden outbreak of the Coronavirus disease(COVID-19)swept across the world in early 2020,triggering the lockdowns of several billion people across many countries,including China,Spain,India,the U.K.,Italy,France,Germany,Brazil,Russia,and the U.S.The transmission of the virus accelerated rapidly with the most confirmed cases in the U.S.,India,Russia,and Brazil.In response to this national and global emergency,the NSF Spatiotemporal Innovation Center brought together a taskforce of international researchers and assembled implementation strategies to rapidly respond to this crisis,for supporting research,saving lives,and protecting the health of global citizens.This perspective paper presents our collective view on the global health emergency and our effort in collecting,analyzing,and sharing relevant data on global policy and government responses,human mobility,environmental impact,socioeconomical impact;in developing research capabilities and mitigation measures with global scientists,promoting collaborative research on outbreak dynamics,and reflecting on the dynamic responses from human societies. | Chaowei Yang Dexuan Sha Qian Liu Yun Li Hai Lan Weihe Wendy Guan Tao Hu Zhenlong Li Zhiran Zhang John Hoot Thompson Zifu Wang David Wong Shiyang Ruan Manzhu Yu Douglas Richardson Luyao Zhang Ruizhi Hou You Zhoua Cheng Zhong Yifei Tian Fayez Beaini Kyla Carte Colin Flynn Wei Liu Dieter Pfoser Shuming Bao Mei Li Haoyuan Zhang Chunbo Liu Jie Jiang Shihong Du Liang Zhao Mingyue Lu Lin Li Huan Zhou Andrew Ding | 2020 | International Journal of Digital Earth2020，13，10： | 2 |
| 2 | Caregiver burden is increased in Parkinson’s disease with mild cognitive impairment (PD-MCI)显示文摘Background:There is limited evidence on caregiver outcomes associated with mild cognitive impairment in patients with Parkinson’s disease(PD-MCI)and the coping strategies used by these caregivers.Methods:To investigate this relationship,we examined levels of burden,depression,anxiety,coping strategies and positive aspects of caregiving in the informal caregivers of 96 PD patients.The PD patients were classified using MDS-Task Force Level II criteria as showing either normal cognition(PD-N;n=51),PD-MCI(n=30)or with dementia(PDD;n=15).Results:Mean Zarit Burden Interview(ZBI)score increased significantly between carers of PD-N(M=13.39,SD=12.22)compared to those of PD-MCI patients(M=22.00,SD=10.8),and between carers of PD-MCI and PDD patients(M=29.33,SD=9.59).Moreover,the proportion of carers showing clinically significant levels of burden(ZBI score≥21)also increased as the patients’cognitive status declined(18% for PD-N;60% for PD-MCI;and 80%for PDD)and was mirrored by an increasing amount of time spent providing care by the caregivers.Caregiver ZBI score was independent of patient neuropsychiatric symptoms,motor function,disease duration and time that caregivers spent caregiving.Caregiver use of different coping strategies increased with worsening cognition.However,we found only equivocal evidence that the use of problem-focused,emotion-focused and dysfunctional coping mediated the association between patient cognitive status and caregiver burden,because the inverse models that used caregiver burden as the mediator were also significant.Conclusions:The study highlights the impact of Parkinson’s disease on those providing care when the patient’s cognition is poor,including those with MCI.Caregiver well-being has important implications for caregiver support,nursing home placement and disease course. | Ann J.Jones Roeline G.Kuijer Leslie Livingston Daniel Myall Kyla Horne Michael MacAskill Toni Pitcher Paul T.Barrett Tim J.Anderson John C.Dalrymple-Alford | 2017 | Translational Neurodegeneration2017，6，1： | 2 |
| 3 | 数字相机和扫描仪超级指南显示文摘 | Kyla K.Carlson Dave Johnson ChrisO’Malley 宋荣 马宗奎 | 1998 | 电子与电脑1998，，12： | 1 |
| 4 | Poor CD4 count is a predictor of untreated depression in human immunodeficiency virus-positive African-Americans显示文摘AIM: To determine if efforts to improve antiretroviral therapy(ART) adherence minimizes the negative impact of depression on human immunodeficiency virus(HIV) outcomes. METHODS: A cross-sectional study of a clinic-based cohort of 158 HIV seropositive(HIV+) African Americans screened for major depressive disorder(MDD) in 2012. CD4 T lymphocyte(CD4+) counts were obtained from these individuals. Self-report on adherence to ART was determined from questionnaire administered during clinic visits. The primary outcome measure was conditional odds of having a poorer CD4+ count(< 350 cells/mm3). Association between CD4+ count and antidepressant-treated or untreated MDD subjects was examined controlling for self-reported adherence and other potential confounders. RESULTS: Out of 147 individuals with available CD4+ T lymphocyte data, 31% had CD4+ count < 350 cells/mm^3 and 28% reported poor ART adherence. As expected the group with > 350 cells/mm^3 CD4+ T lymphocyte endorsed significantly greater ART adherence compared to the group with < 350 cells/mm3 CD4+ T lymphocyte count(P < 0.004). Prevalence of MDD was 39.5% and 66% of individuals with MDD took antidepressants. Poor CD4+ T lymphocyte count was associated with poor ART adherence and MDD. Adjusting for ART adherence, age, sex and education, which were potential confounders, the association between MDD and poor CD4+ T lymphocyte remained significant only in the untreated MDD group.CONCLUSION: Therefore, CD4+ count could be a clinical marker of untreated depression in HIV+. Also, mental health care may be relevant to primary care of HIV+ patients. | Sasraku Amanor-Boadu MariaMananita S Hipolito Narayan Rai Charlee K McLean Kyla Flanagan Flora T Hamilton Valerie Oji Sharon F Lambert Huynh Nhu Le Suad Kapetanovic Evaristus A Nwulia | 2016 | World Journal of Psychiatry2016，6，1： | 1 |
| 5 | Resistance training and pioglitazone lead to improvements in muscle power during voluntary weight loss in older adults显示文摘 | Marsh Anthony P Kyla Shea M Vance Locke Rachel M | 2013 | J Gerontol A Biol Sci Med Sci2013，68，7： | 1 |
| 6 | γ- Carboxylation of osteocalcin and insulin resistance in older men and women 显示文摘 | M Kyla Shea Caren M Gundberg James B Meig | 2009 | Am J Clin Nutr2009，90，： | 1 |
| 7 | Optimization of the first dimension for separation by two-dimensional gel electrophoresis of basic proteins from human brain tissue显示文摘 | KYLA P EMMA M CLARE L B | 2004 | Proteomics2004，4，： | 1 |
| 8 | Effectiveness of Laparoscopic Computer Simulator Versus Usage of Box Trainer for Endoscopic Surgery Training of Novices显示文摘 | Diana L. Diesen Loretta Erhunmwunsee Kyla M. Bennett Kfir Ben-David Basil Yurcisin Eugene P. Ceppa Philip A. Omotosho Alexander Perez Aurora Pryor | 2011 | Journal of Surgical Education2011，，4： | 1 |
| 9 | The DNA repair proteins BRCA1 and ERCC1 as predictive markers in sporadic ovarian cancer显示文摘 | Johanne Weberpals Kyla Garbuio Anna O'Brien | 2009 | Int J Cancer2009，124，： | 1 |
| 10 | Neural plasticity and treatment-induced recovery of sentence processing in agrammatism显示文摘 | Cynthia K. Thompson Dirk-Bart den Ouden Borna Bonakdarpour Kyla Garibaldi Todd B. Parrish | 2010 | Neuropsychologia2010，，11： | 1 |
| 11 | The confidence of speech - language pathology students regarding communicating with peo- ple with aphasia显示文摘 | Emma F Jennifer F Kyla B | 2013 | BMC Medical Education2013，13，： | 1 |
| 12 | Inflammation and immunosuppression in severe acute pancreatitis显示文摘 | Kyla np a ML Repo H Puolakkainen PA | 2008 | World J Gastroenterol2008，14，41： | 1 |
| 13 | 从复印机的困境中解脱出来显示文摘问题仍在利用传统的方式进行复印吗? 解决方案使用新一代的数字复印机,你的办公效率会得到提高。 | Kyla K.Carlson 韦华 | 1999 | 电子与电脑1999，6，6： | 0 |
| 14 | Ashley's Diving Dog显示文摘美国新墨西哥州的小女孩艾希莉和她的拉布拉多寻回犬引起了轰动,这是怎么回事呢? | Kyla Oliver | 2012 | 英语画刊(初三版)2012，0，12： | 0 |
| 15 | Reservoir construction from the Newberry Volcano EGS Demonstration显示文摘The Newberry Volcano EGS Demonstration in central Oregon tests recent technological advances designed to reduce the cost of power generated by EGS in a hot,dry well(NWG 55-29) drilled in 2008. An EGS reservoir was created by injecting large volumes of cold water,causing existing fractures to slip in shear(known as hydroshearing) generating the seismic waves that can be used to map fracture location and size. At the Newberry Demonstration the final injectivity ranged between 1.4 and 1.7 L/s/MPa a ~6x improvement over the initial injectivity of the well. The injectivity improvement and seismic analysis indicate that previously impermeable fractures were enhanced during the NWG 55-29 stimulation. | Trenton T Cladouhos Susan Petty Yini Nordin Michael Moore Kyla Grasso Matt Uddenberg Michael W Swyer | 2014 | Journal of Groundwater Science and Engineering2014，2，3： | 0 |
| 16 | An Exome-seq Based Tool for Mapping and Selection of Candidate Genes in Maize Deletion Mutants显示文摘Despite the large number of genomic and transcriptomic resources in maize, there is still much to learn about the function of genes in developmental and biochemical processes. Some maize mutants that were generated by gamma-irradiation showed clear segregation for the kernel phenotypes in B73 ? Mo17 F2 ears. To better understand the functional genomics of kernel development,we developed a mapping and gene identi?cation pipeline, bulked segregant exome sequencing(BSEx-seq), to map mutants with kernel phenotypes including opaque endosperm and reduced kernel size. BSEx-seq generates and compares the sequence of the exon fraction from mutant and normal plant F2 DNA pools. The comparison can derive mapping peaks, identify deletions within the mapping peak, and suggest candidate genes within the deleted regions. We then used the public kernel-speci?c expression data to narrow down the list of candidate genes/mutations and identi?ed deletions ranging from several kb to more than 1 Mb. A full deletion allele of the Opaque-2 gene was identi?ed in mutant 531, which occurs within a $200-kb deletion. Opaque mutant 1486 has a 6248-bp deletion in the mapping interval containing two candidate genes encoding RNA-directed DNA methylation 4(RdDM4) and AMP-binding protein, respectively. This study demonstrates the ef?-ciency and cost-effectiveness of BSEx-seq for causal mutation mapping and candidate gene selection,providing a new option in mapping-by-sequencing for maize functional genomics studies. | Shangang Jia Kyla Morton Chi Zhang David Holding | 2018 | Genomics, Proteomics & Bioinformatics2018，16，6： | 0 |
| 17 | 经济实惠的彩色打印机显示文摘想与众不同吗?想使您的想法引人注目吗?想获得超群的工作效果吗?那就采纳专家的劝告:使用彩色,彩色会使一切更美好。 很简单——购买一台彩色打印机就是使您的报告和文档拥有最佳效果的便宜而又简便易行的途径。 | Kyla K.Carlson 宋荣 | 1998 | 电子与电脑1998，5，7： | 0 |
| 18 | Improving Your Oral English显示文摘The most common question my students ask is 'How can I improve my oral English?' My answer is always the same: practice. There is no quick way to learn another lan-guage. | Kyla Free | 2007 | 语数外学习(高中版)2007，，10： | 0 |
| 19 | Ashley's Diving Dog显示文摘美国新墨西哥州的小女孩艾希莉和她的拉布拉多寻回犬引起了轰动。这是怎么回事呢? | Kyla Oliver | 2012 | 英语画刊(初二版)2012，，12： | 0 |
| 20 | Risk factors for fracture in adult kidney transplant recipients显示文摘AIM: To determine the general and transplant-specific risk factors for fractures in kidney transplant recipients.METHODS: We conducted a cohort study of all adults who received a kidney-only transplant(n = 2723) in Ontario, Canada between 2002 and 2009. We used multivariable Cox proportional hazards regression to determine general and transplant-specific risk factors for major fractures(proximal humerus, forearm, hip, and clinical vertebral). The final model was established using the backward elimination strategy, selecting risk factors with a P-value ≤ 0.2 and forcing recipient age and sex into the model. We also assessed risk factors for other fracture locations(excluding major fractures, and fractures involving the skull, hands or feet). RESULTS: There were 132 major fractures in the follow-up(8.1 fractures per 1000 person-years). General risk factors associated with a greater risk of major fracture were older recipient age [adjusted hazard ratio(a HR) per 5-year increase 1.11, 95%CI: 1.03-1.19] and female sex(a HR = 1.81, 95%CI: 1.28-2.57). Transplant-specific risk factors associated with a greater risk of fracture included older donor age(5-year increase)(a HR = 1.09, 95%CI: 1.02-1.17) and end-stage renal disease(ESRD) caused by diabetes(a HR = 1.72, 95%CI: 1.09-2.72) or cystic kidney disease(a HR = 1.73, 95%CI: 1.08-2.78)(compared to glomerulonephritis as the reference cause). Risk factors across the two fracture locations were not consistent(major fracture locations vs other). Specifically, general risk factors associated with an increased risk of other fractures were diabetes and a fall with hospitalization prior to transplantation, while length of time on dialysis, and renal vascular disease and other causes of ESRD were the transplant-specific risk factors associated with a greater risk of other fractures.CONCLUSION: Both general and transplant-specific risk factors were associated with a higher risk of fractures in kidney transplant recipients. Results can be used for clinical prognostication. | Kyla L Naylor Guangyong Zou William D Leslie Anthony B Hodsman Ngan N Lam Eric McArthur Lisa-Ann Fraser Gregory A Knoll Jonathan D Adachi S Joseph Kim Amit X Garg | 2016 | World Journal of Transplantation2016，6，2： | 0 |
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