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| 1 | The Sunway TaihuLight supercomputer: system and applications显示文摘The Sunway Taihu Light supercomputer is the world's first system with a peak performance greater than 100 PFlops. In this paper, we provide a detailed introduction to the Taihu Light system. In contrast with other existing heterogeneous supercomputers, which include both CPU processors and PCIe-connected many-core accelerators(NVIDIA GPU or Intel Xeon Phi), the computing power of Taihu Light is provided by a homegrown many-core SW26010 CPU that includes both the management processing elements(MPEs)and computing processing elements(CPEs) in one chip. With 260 processing elements in one CPU, a single SW26010 provides a peak performance of over three TFlops. To alleviate the memory bandwidth bottleneck in most applications, each CPE comes with a scratch pad memory, which serves as a user-controlled cache. To support the parallelization of programs on the new many-core architecture, in addition to the basic C/C++and Fortran compilers, the system provides a customized Sunway Open ACC tool that supports the Open ACC2.0 syntax. This paper also reports our preliminary efforts on developing and optimizing applications on the Taihu Light system, focusing on key application domains, such as earth system modeling, ocean surface wave modeling, atomistic simulation, and phase-field simulation. | Haohuan FU Junfeng LIAO Jinzhe YANG Lanning WANG Zhenya SONG Xiaomeng HUANG Chao YANG Wei XUE Fangfang LIU Fangli QIAO Wei ZHAO Xunqiang YIN Chaofeng HOU Chenglong ZHANG Wei GE Jian ZHANG Yangang WANG Chunbo ZHOU Guangwen YANG | 2016 | Science China(Information Sciences)2016，59，7： | 45 |
| 2 | Permian–Triassic Conodonts from Dajiang(Guizhou, South China) and Their Implication for the Age of Microbialite Deposition in the Aftermath of the End-Permian Mass Extinction显示文摘The widespread microbialites deposition that followed the End-Permian mass extinction in the Tethyan realm have been intensively studied because of the evidence they provide on the nature of this crisis and its aftermath. However, the age of the microbialite event remains controversial. New conodont collection across the Permian–Triassic(P–T) transition from Dajiang(Guizhou Province, South China) in this study enable us to discriminate four conodont zones, in ascending order, they are: Hindeodus parvus zone, Isarcicella lobata zone, Isarcicella isarcica zone and Hindeodus sosioensis zone. The age of microbialite in the P–T transition at the Dajiang Section is considered to be within the Hindeodus parvus zone and thus to clearly post-date the main extinction crisis. Reviewing the age of onset of microbialites throughout the Tethyan regions reveals two different ages: a Hindeodus changxingensis zone age is dominant in south-western and westernmost Tethys, whilst most other regions show microbialite deposition began in the Hindeodus parvus zone. Our investigation also indicates that two conodont changes occur at this time: an increase of hindeodid species immediately following a sequence boundary and the mass extinction, and a phase of extinction losses in the earliest Triassic Isarcicella isarcica zone during highstand development. | Haishui Jiang Xulong Lai Yadong Sun Paul B Wignall Jianbo Liu Chunbo Yan | 2014 | Journal of Earth Science2014，25，3： | 20 |
| 3 | The China Alzheimer Report 2022显示文摘China’s population has rapidly aged over the recent decades of social and economic development as neurodegenerative disorders have proliferated,especially Alzheimer’s disease(AD)and related dementias(ADRD).AD’s incidence rate,morbidity,and mortality have steadily increased to make it presently the fifth leading cause of death among urban and rural residents in China and magnify the resulting financial burdens on individuals,families and society.The‘Healthy China Action’plan of 2019-2030 promotes the transition from disease treatment to health maintenance for this expanding population with ADRD.This report describes related epidemiological trends,evaluates the economic burden of the disease,outlines current clinical diagnosis and treatment status and delineates existing available public health resources.More specifically,it examines the public health impact of ADRD,including prevalence,mortality,costs,usage of care,and the overall effect on caregivers and society.In addition,this special report presents technical guidance and supports for the prevention and treatment of AD,provides expertise to guide relevant governmental healthcare policy development and suggests an information platform for international exchange and cooperation. | Rujing Ren Jinlei Qi Shaohui Lin Xinya Liu Peng Yin Zhihui Wang Ran Tang Jintao Wang Qiang Huang Jianping Li Xinyi Xie Yongbo Hu Shishuang Cui Yuan Zhu Xiaoping Yu Pengfei Wang Yikang Zhu Yiran Wang Yanyan Huang Yisong Hu Ying Wang Chunbo Li Maigeng Zhou Gang Wang | 2022 | General Psychiatry2022，35，1： | 20 |
| 4 | General structure design and field experiment of pneumatic rice direct-seeder显示文摘In order to meet the requirement of field direct seeding for super hybrid rice:1-3 seeds per hill,a pneumatic rice direct-seeder with six seeding metering devices was designed.Transmission system of pneumatic rice direct-seeder and seed metering device were analyzed in this study.And the pipeline structure and vortex pump were designed and selected.The pressure distribution of the pipeline was tested.The pressure value of each sub-pipeline under the conditions of different main pipeline pressure value was obtained and the reasons for pressure loss were analyzed.The results showed that the variation coefficient between sub-pipelines was less than 5%.The pipeline pressure could be evenly distributed.Further,the field experiments were carried out on super hybrid rice Peizataifeng using two-factor testing,by which the effects of different negative pressure and different forward speed(namely,rotational speed of suction plate)for seeding precision were studied.It found that:(1)the optimal negative pressure was 2 kPa;(2)under the optimal negative pressure,the probabilities of 1-3 seeds per hill for the direct-seeder were 93.41%,95.47%and 97.50%,respectively,when the forward speed of the direct-seeded was high,medium and low speed;(3)the probability of empty hole was less than 2%,which satisfied the field direct seeding requirements of super hybrid rice.Additionally,hill spacing was measured,and the factors affecting the hill spacing were analyzed.The results showed that the fluctuation of hill spacing in the small range will not affect the seeding effect.In this study,a new type of pneumatic rice direct-seeder was designed.The main working components were tested and analyzed.The best parameters of field work were obtained.It provides the basis for the field application of the pneumatic rice precision seeder. | Xing He Wang Zaiman Luo Xiwen Cao Xiaoman Liu Chunbo Zang Ying | 2017 | International Journal of Agricultural and Biological Engineering2017，10，6： | 10 |
| 5 | Overview on the Development of Nanostructured Thermal Barrier Coatings显示文摘热障碍涂层(TBC ) 成功地在煤气的汽轮机引擎被使用了增加操作温度和改善引擎效率。在免职技术 beendeveloped.Recently 有的过去的三十年,许多 TBC 材料和 TBC, nanostructured TBC 在各种各样的工业与在工业上的应用的潜力出现。在这篇论文,象空气血浆那样的 TBC 材料和 TBC 免职技术祈祷( APS ),电子横梁物理蒸汽免职( EB-PVD ),帮助化学蒸汽免职( LACVD )是的激光简短, reviewed.Nanostructured 7-8 wt %氧化钇稳定了氧化锆( 7-8YSZ )坐飞机,血浆与新奇结构喷洒粉末和新 TBC 由答案先锋血浆水花( SPPS )扔了的 TBC 被比较。血浆水花条件,形成机制的涂层,微观结构,阶段作文,热传导性,和 APS nanostructured TBC 和 SPPS nanostructured TBC 的热骑车生命被讨论。nanostructured TBC 的研究机会和挑战坐飞机扔了血浆水花被勘探。 | Xianliang JIANG2 Chunbo LIU Feng LIN | 2007 | Journal of Materials Science & Technology2007，23，4： | 5 |
| 6 | Cancer-associated adipocyte-derived G-CSF promotes breast cancer malignancy via Stat3 signaling显示文摘Adipocyte is the most predominant cell type in the tumor microenvironment of breast cancer and plays a pivotal role in cancer progression,yet the underlying mechanisms and functional mediators remain elusive.We isolated primary preadipocytes from mammary fat pads of human breast cancer patients and generated mature adipocytes and cancer-associated adipocytes(CAAs)in vitro.The CAAs exhibited significantly different gene expression profiles as assessed by transcriptome sequencing.One of the highly expressed genes in CAAs is granulocyte colony-stimulating factor(G-CSF).Treatment with recombinant human G-CSF protein or stable expression of human G-CSF in triple-negative breast cancer(TNBC)cell lines enhanced epithelial–mesenchymal transition,migration,and invasion of cancer cells,by activating Stat3.Accordantly,targeting G-CSF/Stat3 signaling with G-CSF-neutralizing antibody,a chemical inhibitor,or siRNAs for Stat3 could all abrogate CAA-or G-CSF-induced migration and invasion of breast cancer cells.The pro-invasive genes MMP2 and MMP9 were identified as target genes of G-CSF in TNBC cells.Furthermore,in human breast cancer tissues,elevated G-CSF expression in adipocytes is well correlated with activated Stat3 signal in cancer cells.Together,our results suggest a novel strategy to intervene with invasive breast cancers by targeting CAA-derived G-CSF. | Li Liu Yudong Wu Cheng Zhang Chong Zhou Yining Li Yi Zeng Chunbo Zhang Rong Li Daya Luo Lieliang Wang Long Zhang Shuo Tu Huan Deng Shiwen Luo Ye-Guang Chen Xiangyang Xiong Xiaohua Yan | 2020 | Journal of Molecular Cell Biology2020，12，9： | 4 |
| 7 | Targeted deletion of mouse Rad1 leads to deficient cellular DNA damage responses显示文摘The Rad1 gene is evolutionarily conserved from yeast to human.The fission yeast Schizosaccharomyces pombe Rad1 ortholog promotes cell survival against DNA damage and is required for G_(2)/M checkpoint activation.In this study,mouse embryonic stem(ES)cells with a targeted deletion of Mrad1,the mouse ortholog of this gene,were created to evaluate its function in mammalian cells.Mrad1^(−/−)ES cells were highly sensitive to ultraviolet-light(UV light),hydroxyurea(HU)and gamma rays,and were defective in G_(2)/M as well as S/M checkpoints.These data indicate that Mrad1 is required for repairing DNA lesions induced by UV-light,HU and gamma rays,and for mediating G_(2)/M and S/M checkpoint controls.We further demonstrated that Mrad1 plays an important role in homologous recombination repair(HRR)in ES cells,but a minor HRR role in differentiated mouse cells. | Chunbo Zhang Yuheng Liu Zhishang Hu Lili An Yikun He Haiying Hang | 2011 | Protein & Cell2011，2，5： | 3 |
| 8 | 3-epi-bufotalin suppresses the proliferation in colorectal cancer cells through the inhibition of the JAK1/STAT3 signaling pathway显示文摘Traditional Chinese medicine(TCM)has been increasingly employed in the last decades in China for both preventing and treating a variety of cancers.3-epi-bufotalin is an active ingredient of TCM“Chanpi”with anti-tumor potential.However,the effect and mechanism of 3-epi-bufotalin on colorectal cancers were not well disclosed.The present study demonstrated that 3-epi-bufotalin could reduce viability,trigger apoptosis,and block the cell cycle at the G2/M stage in colorectal cancer cell lines HT29,RKO,and COLO205 in vitro.Moreover,3-epi-bufotalin inhibited the JAK1/STAT3 signaling pathway.These results indicated the anti-proliferation ability of 3-epi-bufotalin in colorectal cancer cells. | SANHUA LI QINGHONG KONG XIAOKE ZHANG XINTING ZHU CHUNBO YU CHANGYAN YU NIAN JIANG JING HUI LINGJIE MENG YUN LIU | 2022 | BIOCELL2022，46，11： | 2 |
| 9 | Taking the pulse of COVID-19:a spatiotemporal perspective显示文摘The sudden outbreak of the Coronavirus disease(COVID-19)swept across the world in early 2020,triggering the lockdowns of several billion people across many countries,including China,Spain,India,the U.K.,Italy,France,Germany,Brazil,Russia,and the U.S.The transmission of the virus accelerated rapidly with the most confirmed cases in the U.S.,India,Russia,and Brazil.In response to this national and global emergency,the NSF Spatiotemporal Innovation Center brought together a taskforce of international researchers and assembled implementation strategies to rapidly respond to this crisis,for supporting research,saving lives,and protecting the health of global citizens.This perspective paper presents our collective view on the global health emergency and our effort in collecting,analyzing,and sharing relevant data on global policy and government responses,human mobility,environmental impact,socioeconomical impact;in developing research capabilities and mitigation measures with global scientists,promoting collaborative research on outbreak dynamics,and reflecting on the dynamic responses from human societies. | Chaowei Yang Dexuan Sha Qian Liu Yun Li Hai Lan Weihe Wendy Guan Tao Hu Zhenlong Li Zhiran Zhang John Hoot Thompson Zifu Wang David Wong Shiyang Ruan Manzhu Yu Douglas Richardson Luyao Zhang Ruizhi Hou You Zhoua Cheng Zhong Yifei Tian Fayez Beaini Kyla Carte Colin Flynn Wei Liu Dieter Pfoser Shuming Bao Mei Li Haoyuan Zhang Chunbo Liu Jie Jiang Shihong Du Liang Zhao Mingyue Lu Lin Li Huan Zhou Andrew Ding | 2020 | International Journal of Digital Earth2020，13，10： | 2 |
| 10 | Syntheses,structures and photoluminescence of a series of metal organic complexes with 1,3,5-benzenetricarboxylate and pyrazino-phenanthroline ligands显示文摘 | Che Guangbo Liu Chunbo Liu bo | 2008 | Cryst Eng Comm2008，10，： | 1 |
| 11 | Catena-Polyphenanthroline) copper(I)]-μ2-chloro]显示文摘 | Che Guangbo Xu Zhanlin Liu Chunbo | 2006 | Acta Cryst E2006，62，： | 1 |
| 12 | Controlled hydrothermal synthesis and magnetic properties of three-dimensional FeSe 2 rod clusters and microspheres显示文摘 | Weidong Shi Xian Zhang Guangbo Che Weiqiang Fan Chunbo Liu | 2013 | Chemical Engineering Journal2013，，： | 1 |
| 13 | Super rigid tris-spirobifluorenes:Syntheses and properties显示文摘In this work,a blue emitter with a 3 D rigid structure composed of multiple spirobifluorene(3-Spiro) has been synthesized and characterized.Through a detailed study of the electrochemical and photophysical properties of 3-Spiro,we have evidenced that 3-Spiro can be applied as an active component of organic light-emitting diodes(OLEDs).The device with 5% doping rate of 4 CzPNPh exhibits high external quantum efficiency(EQE) of 11%,which proves the potential of 3 D rigid structure emitters for OLEDs. | Luyao Zhao Chunbo Duan Dongxue Ding Shihui Liu Debin Xia Ying Guo Hui Xu Martin Baumgartend | 2021 | Chinese Chemical Letters2021，32，1： | 1 |
| 14 | 显示文摘 | Liu Chunbo Yu Liansheng Jiang Xianliang | 2007 | Transactions of Nonferrous Metals Society of China2007，17，5： | 1 |
| 15 | Combustion characteristics and nitric oxide release of the pulverized coals under oxy-enrich conditions 显示文摘 | Wang Chunbo Lei Ming Liu Huimin | 2012 | Industrial and Engineer- ing Chemistry Research2012，51，14： | 1 |
| 16 | The Research and Development of Networked Core-GIS for Mining显示文摘 | Liu Chunbo | 2002 | The 2nd Dynamic and Multi-Dimension GIS Conference2002，15，3： | 1 |
| 17 | Expression of endostatin mediated by a novel non-viral delivery system inhibits human umbilical vein endothelial cells in vitro显示文摘 | Chunmei Zhang Xueju Zhang Chunbo Liu Junfeng Wang Xinghan Liu Hulun Li Jinghua Wang Changjun Wu | 2010 | Molecular Biology Reports2010，，4： | 1 |
| 18 | A Novel Hysteretic Chaotic Neural Network and Its Applications显示文摘 | Liu Xiangdong Xiu Chunbo | 2007 | Neurocomputing2007，70，： | 1 |
| 19 | , Highly efficient phosphorescent organic light-emitting devices based on Re(CO)3Cl-bathophenanthroline 显示文摘 | Li Jiang Si Zhenjun Liu Chunbo | 2007 | Semicond Sci Technol2007，22，： | 1 |
| 20 | , Triphenylamine-functionalized rhenium (I) complex as a highly efficient yellow-green emitter in electrophosphorescent devices 显示文摘 | Liu Chunbo Li Jiang Li Bin | 2006 | Appl Phys Lett2006，89，24： | 1 |
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