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| 1 | Correlation of fatty liver and abdominal fat distribution using a simple fat computed tomography protocol显示文摘AIM: To evaluate the relationship between hepatic fat infiltration and abdominal fat volume by using computed tomography (CT).METHODS: Three hundred and six patients who visited our obesity clinic between November 2007 and April 2008 underwent fat protocol CT scans.The age range of the patients was 19 to 79 years and the mean age was 49 years.The male to female ratio was 116:190.Liver and spleen attenuation measurements were taken with three regions of interests (ROIs) from the liver and two ROIs from the spleen.Hepatic attenuation indices (HAIs) were measured as follows: (1) hepatic parenchymal attenuation (CTLP);(2) liver to spleen attenuation ratio (LS ratio);and (3) difference between hepatic and splenic attenuation (LSdif).Abdominal fat volume was measured using a 3 mm slice CT scan starting at the level of the umbilicus and was automatically calculated by a workstation.Abdominal fat was classified into total fat (TF),visceral fat (VF),and subcutaneous fat (SF).We used a bivariate correlation method to assess the relationship between the three HAIs and TF,VF,and SF.RESULTS: There were significant negative correlations between CTLP,LS ratio,and LSdif with TF,VF,and SF,respectively.The CTLP showed a strong negative correlation with TF and VF (r = -0.415 and -0.434,respectively,P < 0.001).The correlation between CTLP and SF was less significant (r = -0.313,P < 0.001).CONCLUSION: Fatty infiltration of the liver was correlated with amount of abdominal fat and VF was more strongly associated with fatty liver than SF. | Seonah Jang Chang Hee Lee Kyung Mook Choi Jongmee Lee Jae Woong Choi Kyeong Ah Kim Cheol Min Park | 2011 | World Journal of Gastroenterology2011，17，28： | 5 |
| 2 | Extraction and identification of three major aldose reductase inhibitors from Artemisia montana显示文摘 | Hyun Ah Jung M.D. Nurul Islam Yong Soo Kwon Seong Eun Jin You Kyung Son Jin Ju Park Hee Sook Sohn Jae Sue Choi | 2010 | Food and Chemical Toxicology2010，，2： | 2 |
| 3 | Methylation and microsatellite status and recurrence following adjuvant FOLFOX in colorectal cancer显示文摘 | Sae‐Won Han Hyun‐Jung Lee Jeong Mo Bae Nam‐Yun Cho Kyung‐Hun Lee Tae‐Yong Kim Do‐Youn Oh Seock‐Ah Im Yung‐Jue Bang Seung‐Yong Jeong Kyu Joo Park Jae‐Gahb Park Gyeong Hoon Kang Tae‐You Kim | 2012 | Int J Cancer2012，，9： | 2 |
| 4 | 来自一项艾日布林联合吉西他滨对比紫杉醇联合吉西他滨作为HER2阴性转移性乳腺癌的一线化疗的Ⅱ期、多中心、随机试验的包含神经病变相关量表的生活质量结果:韩国癌症研究组试验(KCSG BR13-11)显示文摘背景与目的一项比较艾日布林联合吉西他滨(eribulin plus gemcitabine,EG)或紫杉醇联合吉西他滨(paclitaxel plus gemcitabine,PG)作为转移性乳腺癌(metastatic breast cancer,MBC)患者一线化疗方案的II期临床试验发现,EG方案的神经毒性较低,但疗效与PG方案相似。在本研究中,我们分析了该临床实验中的癌症患者生命质量测评量表–紫杉烷(functional assessment of cancer therapy-taxane,FACT-Taxane)问卷评分以确定他们的生活质量(quality of life,QoL)。方法使用韩国版的FACT-Taxane问卷评估QoL。在评估基线之后,前12个疗程中每2个疗程评估1次QoL,之后每3个疗程评估1次QoL。使用线性混合模型评估EG组和PG组QoL的差异。结果在118例入组患者中,117例在基线时回复了FACT-Taxane问卷,PG组中有1例患者没有回复。EG组和PG组之间的基线QoL评分没有差异。在治疗期间,除了第11个疗程外,在第2–13个化疗疗程后,PG组紫杉烷亚量表评分显著高于EG组(均P<0.05)。神经病变特异性分析显示PG组患者的神经病症状比EG组患者更早出现且更严重(P<0.001)。结论在我们的QoL分析中,与PG方案相比,EG方案延迟并减少神经病变的发生。因此,艾日布林是MBC一线化疗药物紫杉醇的合理替代品。 | Ji‑Yeon Kim Seri Park Seock‑Ah Im Sung‑Bae Kim Joohyuk Sohn Keun Seok Lee Yee Soo Chae Ki Hyeong Lee Jee Hyun Kim Young‑Hyuck Im Tae‑Yong Kim Kyung‑Hun Lee Jin‑Hee Ahn Gun Min Kim In Hae Park Soo Jung Lee Hye Sook Han Se Hyun Kim Kyung Hae Jung Yeon Hee Park Korean Cancer Study Group | 2019 | 癌症2019，38，8： | 2 |
| 5 | A case of hypereosinophilic syndrome presenting with intractable gastric ulcers显示文摘We report a rare case of hypereosinophilic syndrome(HES)presenting with intractable gastric ulcers.A 71-year-old man was admitted with epigastric pain.Initial endoscopic findings revealed multiple,active gastric ulcers in the gastric antrum.He underwent Helicobacter pylori(H pylori)eradication therapy followed by proton pump inhibitor(PPI)therapy.However,follow-up endoscopy at 4,6,10 and 14 mo revealed persistent multiple gastric ulcers without significant improvement.The proportion of his eosinophil count increased to 43%(total count:7903/mm 3).Abdominal-pelvic and chest computed tomography scans showed multiple small nodules in the liver and both lungs.The endoscopic biopsy specimen taken from the gastric antrum revealed prominent eosinophilic infiltration,and the liver biopsy specimen also showed eosinophilic infiltration in the portal tract and sinusoid.A bone marrow biopsy disclosed eosinophilic hyperplasia as well as increased cellularity of 70%.The patient was finally diagnosed with HES involving the stomach,liver,lung,and bone marrow.When gastric ulcers do not improve despite H pylori eradication and prolonged PPI therapy,infiltrative gastric disorders such as HES should be considered. | Tae Young Park Chang Hwan Choi Suh Yoon Yang InSoo Oh In-Do Song Hyun Woong Lee Hyung Joon Kim Jae Hyuk Do Sae Kyung Chang Ah Ra Cho Young Joo Cha | 2009 | World Journal of Gastroenterology2009，15，48： | 2 |
| 6 | 每日一次与按需使用乌地那非对治疗2型糖尿病患者勃起功能障碍的有效性和安全性比较显示文摘通过一项为期12周的多中心、随机、开放、平行组试验,比较每日一次与按需使用乌地那非对治疗2型糖尿病患者勃起功能障碍的有效性和安全性。按需服用乌地那非200mg能够改善勃起功能障碍的161名患者,被随机分为200mg按需治疗组(n=80)和50mg每日一次组仰=81),两组分别接受相应治疗8周,8周后停药并随访4周,这些患者均通过性活动日志中Q2(插入成功率)和Q3(性交中保持勃起至完成性交的成功率)进行评估。主要的疗效指标是国际勃起功能问卷.勃起功能分级(IIEF.EFD)评分的变化。次要的疗效指标包括性活动日志02、Q3,国际勃起功能问卷的Q3、Q4及其他部分,全球评估问卷,以及正常率(EFD_〉26)的变化。我们也对血管内皮细胞标志物进行了检测。经过8周的治疗,两组的IIEF.EFD评分都得到改善fP〈O.0001),且两组之间没有显著的统计学差异。但这种改善并没有维持到无治疗随访期之后。次要的疗效指标也有类似的结果。在血管内皮标志物方面,两组之间无显著差异。患者对每日一次乌地那非具有更好的耐受性,且两组之间药物不良反应以及不良事件方面无显著性差异。其中脸红和头痛是最常见的不良反应。这两种方案都能改善糖尿病患者的勃起功能障碍,且均有良好的患者耐受性。乌地那非每日给药对糖尿病患者勃起功能障碍的治疗作用值得进一步研究。 | Soon Hyun Park Sung Woo Park Bong Yun Cha Ie Byung Park Kyung Wan Min Yeon Ah Sung Tae Hwa Kim Jae Min Lee Kang Seo Park | 2015 | Asian Journal of Andrology2015，17，1： | 2 |
| 7 | 显示文摘 | Lee Seol Ah Park Kyung Won | 2002 | Journal of The Electrochemical Society2002，149，10： | 1 |
| 8 | Therapeutic target achievement in type 2 diabetic patients after hyperglycemia, hypertension, dyslipidemia management 显示文摘 | Ah Young Kang Su Kyung Park So Young Park | 2011 | DiabetesMetab J2011，35，3： | 1 |
| 9 | Therapeutic target achievement in type 2 diabetic patients after hyperglycemia, hypertension, dyslipidemia management 显示文摘 | Ah Young Kang Su Kyung Park So Young Park | 2011 | Diabetes Metab J2011，35，3： | 1 |
| 10 | Therapeutic target achievement in type 2 diabetic patients after hyperglycemia,hypertension,dyslipidemia management显示文摘 | Ah Young Kang Su Kyung Park So Young Park | 2011 | Diabetes Metab J2011，35，3： | 1 |
| 11 | Experience-Dependent Plasticity of Cerebellar Vermis in Basketball Players显示文摘 | In Sung Park Kea Joo Lee Jong Woo Han Nam Joon Lee Won Teak Lee Kyung Ah Park Im Joo Rhyu | 2009 | The Cerebellum2009，，3： | 1 |
| 12 | Methylation and microsatellite status and recurrence following adjuvant FOLFOX in colorectal cancer显示文摘 | Sae‐Won Han Hyun‐Jung Lee Jeong Mo Bae Nam‐Yun Cho Kyung‐Hun Lee Tae‐Yong Kim Do‐Youn Oh Seock‐Ah Im Yung‐Jue Bang Seung‐Yong Jeong Kyu Joo Park Jae‐Gahb Park Gyeong Hoon Kang Tae‐You Kim | 2012 | Int. J. Cancer2012，，9： | 1 |
| 13 | Neuronal Properties, In Vivo Effects, and Pathology of a Huntington’s Disease Patient‐Derived Induced Pluripotent Stem Cells显示文摘 | Iksoo Jeon Nayeon Lee Jia‐Yi Li In‐Hyun Park Kyoung Sun Park Jisook Moon Sung Han Shim Chunggab Choi Da‐Jeong Chang Jihye Kwon Seung‐Hun Oh Dong Ah Shin Hyun Sook Kim Jeong Tae Do Dong Ryul Lee Manho Kim Kyung‐Sun Kang George Q. Daley Patrik Brundin Jihwa | 2012 | STEM CELLS2012，，9： | 1 |
| 14 | Therapeutictarget achievement in type 2diabetic patients after hyperglycemia,hypertension,dyslipidemia management显示文摘 | Ah Young Kang Su Kyung Park So Young Park | 2011 | Diabetes Metab J2011，35，3： | 1 |
| 15 | Reversine Induces Multipotency of Lineage-Committed Cells through Epigenetic Silencing of miR-133a显示文摘 | Munkyung Kim Sang Ah Yi Hyunwoo Lee So Young Bang Eun Kyung Park Min Gyu Lee Ki Hong Nam Ji Hee Yoo Dong Hoon Lee Hyun-Wook Ryu So Hee Kwon Jeung-Whan Han | 2014 | Biochemical and Biophysical Research Communications2014，，： | 1 |
| 16 | Electroactive Super-elongation of Carbon Nanotube Aggregates in Liquid Crystal Medium显示文摘 | Seok Jin Jeong Kyung Ah Park Seok Ho Jeong | 2007 | Nano Lett2007，7，8： | 1 |
| 17 | A nationwide seroepidemiology of hepatitis C virus infection in South Korea显示文摘 | Do Young Kim In Hee Kim Sook‐Hyang Jeong Yong Kyun Cho Joon Hyoek Lee Young‐Joo Jin Don Lee Dong Jin Suh Kwang‐Hyub Han Neung Hwa Park Ha Yan Kang Young Kul Jung Young Seok Kim Kyung‐Ah Kim Youn Jae Lee Byung Seok Lee Hyung Joon Yim Heon Ju Lee Soon Koo B | 2013 | Liver Int2013，，4： | 1 |
| 18 | Prospective comparison of prognostic values of modified Response Evaluation Criteria in Solid Tumours with European Association for the Study of the Liver criteria in hepatocellular carcinoma following chemoembolisation显示文摘 | Beom Kyung Kim Kyung Ah Kim Jun Yong Park Sang Hoon Ahn Chae Yoon Chon Kwang-Hyub Han Seung Up Kim Myeong-Jin Kim | 2012 | European Journal of Cancer2012，，： | 1 |
| 19 | Apoptosis signal regulating kinase 1 (ASK1):potential as a therapeutic target for Alzheimer's disease 显示文摘 | Song Juhyun Kyung Ah Park Won Taek Lee | 2014 | Int J Mol Sci2014，15，2： | 1 |
| 20 | Agmatine reduces nitric oxide synthase expression and peroxynitrite formation in the cerebral cortex in a rat model of transient global cerebral ischemia显示文摘Agmatine, an analog of L-arginine, is an endogenous substance synthesized by arginine decarboxylase, which has been shown to possess neuroprotective effects following brain ischemia. Nitric oxide is generated by sequential oxidation of the guanidinium group in L-arginine, and agmatine might protect the brain from ischemic injury by interfering with nitric oxide signaling. This study investigated the effects of agmatine on cerebral cortex neuronal injury following transient global cerebral ischemia and also detected nitric oxide synthase expression and peroxynitrite formation. Results demonstrated that intraperitoneal injection of agmatine in global cerebral ischemia/reperfusion alleviated ischemia/reperfusion-induced cerebral cortical cortex neuronal injury and cellular apoptosis, decreased neuronal and inducible nitric oxide synthase expression at 24, 48, and 72 hours following global cerebral ischemia and reperfusion, and greatly inhibited nitrotyrosine levels, which reflect the amount of peroxynitrite formed. These findings indicated that agmatine alleviates cerebral cortex neuronal injury following global cerebral ischemia and decreases nitric oxide synthase expression and peroxynitrite formation following ischemia/reperfusion. | Chin Hee Mun Won Taek Lee Kyung Ah Park Jong Eun Lee | 2010 | Neural Regeneration Research2010，5，23： | 0 |
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