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| 1 | Geochronological,geochemical,and Nd-Hf isotopic studies of the Qinling Complex,central China:Implications for the evolutionary history of the North Qinling Orogenic Belt显示文摘The Qinling Complex of central China is thought to be the oldest rock unit and the inner core of the North Qinling Orogenic Belt(NQOB).Therefore,the Qinling Complex is the key to understanding the prePaleozoic evolution of the NQOB.The complex,which consists of metagraywackes and marbles,underwent regional amphibolite-facies metamorphism.In this study,we constrained the formation age of the Qinling Complex to the period between the late Mesoproterozoic and the early Neoproterozoic(ca.1062-962 Ma),rather than the Paleoproterozoic as previously thought.The LA-ICP-MS data show two major metamorphic ages(ca.499 and ca.420-400 Ma) for the Qinling Complex.The former age is consistent with the peak metamorphic age of the high- and ultra-high pressure(HP-UHP) rocks in the Qinling Complex,indicating that both the HP-UHP rocks and their country rocks experienced intensive regional metamorphism during the Ordovician.The latter age may constrain the time of partial melting in the NQOB between the late Silurian and early Devonian.The Qinling Complex is mostly affiliated with subduction-accretion processes along an active continental margin,and should contain detritus deposited in a forearc basin.The available data indicate that the NQOB was an independent micro-continent at least prior to the Neoproterozoic,and included a portion of the Grenville orogenic belt during the period of 1.2-0.8 Ga.The NQOB has experienced a unique geological history,which is obviously different from that of the North China Craton(NCC) and the Yangtze Craton during the Precambrian.The Neoproterozoic granitoids that intruded the Qinling Complex can be interpreted as the products of assembly of the supercontinent Rodinia.The NQOB was separated from Rodinia at ca.830-740 Ma.Subsequently,the NQOB moved closer to the northern margin of the NCC,and the initial accretion or collision with the NCC occurred from the late Cambrian to the early Ordovician. | Chunrong Diwu Yong Sun Yan Zhao BingXiang Liu Shaocong Lai | 2014 | Geoscience Frontiers2014，5，4： | 27 |
| 2 | Acupuncture for ischemic stroke:cerebellar activation may be a central mechanism following Deqi显示文摘The needling sensation of Deqi during acupuncture is a key factor of influencing acupuncture outcome.Recent studies have mainly focused on the brain function effects of Deqi in a physiological state.Functional magnetic resonance imaging(f MRI)on the effects of acupuncture at Waiguan(SJ5)in pathological and physiological states is controversial.In this study,12 patients with ischemic stroke received acupuncture at Waiguan(SJ5)and simultaneously underwent f MRI scanning of the brain,with imaging data of the activated areas obtained.Based on the patient’s sensation,imaging data were allocated to either the Deqi group or non-Deqi group.In the Deqi group,the activated/deactivated areas were the left superior temporal gyrus(BA39)/right anterior lobe of the cerebellum and left thalamus.In the non-Deqi group,the activated areas included the medial frontal gyrus of the right frontal lobe(BA11),right limbic lobe(BA30,35),and left frontal lobe(BA47),while the only deactivated area was the right parietal lobe(BA40).Compared with the non-Deqi group,the Deqi group exhibited marked activation of the right anterior lobe of the cerebellum and right limbic lobe(BA30).These findings confirm that the clinical effect of Deqi during acupuncture is based on brain functional changes.Cerebellar activation may be one of the central mechanisms of acupuncture in the treatment of ischemic stroke. | Miao-keng Li Yu-jie Li Gui-feng Zhang Jun-qi Chen Ji-ping Zhang Ji Qi Yong Huang Xin-sheng Lai Chun-zhi Tang | 2015 | Neural Regeneration Research2015，10，12： | 24 |
| 3 | Acupuncture at Waiguan(SJ5) and sham points influences activation of functional brain areas of ischemic stroke patients: a functional magnetic resonance imaging study显示文摘Most studies addressing the specificity of meridians and acupuncture points have focused mainly on the different neural effects of acupuncture at different points in healthy individuals. This study examined the effects of acupuncture on brain function in a pathological context. Sixteen patients with ischemic stroke were randomly assigned to true point group(true acupuncture at right Waiguan(SJ5)) and sham point group(sham acupuncture). Results of functional magnetic resonance imaging revealed activation in right parietal lobe(Brodmann areas 7 and 19), the right temporal lobe(Brodmann area 39), the right limbic lobe(Brodmann area 23) and bilateral occipital lobes(Brodmann area 18). Furthermore, inhibition of bilateral frontal lobes(Brodmann area 4, 6, and 45), right parietal lobe(Brodmann areas 1 and 5) and left temporal lobe(Brodmann area 21) were observed in the true point group. Activation in the precuneus of right parietal lobe(Brodmann area 7) and inhibition of the left superior frontal gyrus(Brodmann area 10) was observed in the sham group. Compared with sham acupuncture, acupuncture at Waiguan in stroke patients inhibited Brodmann area 5 on the healthy side. Results indicated that the altered specificity of sensation-associated cortex(Brodmann area 5) is possibly associated with a central mechanism of acupuncture at Waiguan for stroke patients. | Ji Qi Junqi Chen Yong Huang Xinsheng Lai Chunzhi Tang Junjun Yang Hua Chen Shanshan Qu | 2014 | Neural Regeneration Research2014，9，3： | 19 |
| 4 | Daclatasvir plus asunaprevir in treatment-na?ve patients with hepatitis C virus genotype 1b infection显示文摘AIM To assess daclatasvir plus asunaprevir(d UAL) in treatment-na?ve patients from China's Mainland, Russia and South Korea with hepatitis C virus(HCV) genotype 1 b infection. METHODS Patients were randomly assigned(3:1) to receive 24 wk of treatment with d UAL(daclatasvir 60 mg once daily and asunaprevir 100 mg twice daily) beginning on day 1 of the treatment period(immediate treatment arm) or following 12 wk of matching placebo(placebodeferred treatment arm). The primary endpoint was a comparison of sustained virologic response at posttreatment week 12(SVR12) compared with the historical SVR rate for peg-interferon plus ribavirin(70%) among patients in the immediate treatment arm. The first 12 wk of the study were blinded. Safety was assessed in d UAL-treated patients compared with placebo patients during the first 12 wk(doubleblind phase), and during 24 wk of d UAL in both arms combined.RESULTS In total, 207 patients were randomly assigned to immediate(n = 155) or placebo-deferred(n = 52) treatment. Most patients were Asian(86%), female(59%) and aged < 65 years(90%). Among them, 13% had cirrhosis, 32% had IL28 B non-CC genotypes and 53% had baseline HCV RNA levels of ≥ 6 million IU/m L. Among patients in the immediate treatment arm, SVR12 was achieved by 92%(95% confidence interval: 87.2-96.0), which was significantly higher than the historical comparator rate(70%). SVR12 was largely unaffected by cirrhosis(89%), age ≥ 65 years(92%), male sex(90%), baseline HCV RNA ≥ 6 million(89%) or IL28 B non-CC genotypes(96%), although SVR12 was higher among patients without(96%) than among those with(53%) baseline NS5 A resistanceassociated polymorphisms(at L31 or Y93 H). during the double-blind phase, aminotransferase elevations were more common among placebo recipients than among patients receiving d UAL. during 24 wk of d UAL therapy(combined arms), the most common adverse events(≥ 10%) were elevated alanine aminotransferase and upper respiratory tract infection; emergent grade 3-4 laboratory abnormalities were infrequently observed, and all grade 3-4 aminotransferase abnormalities(alanine aminotransferase, n = 9; aspartate transaminase, n = 6) reversed within 8-11 d. Two patients discontinued d UAL treatment; one due to aminotransferase elevations, nausea, and jaundice and the other due to a fatal adverse event unrelated to treatment. There were no treatment-related deaths.CONCLUSION d UAL was well-tolerated during this phase 3 study, and SVR12 with d UAL treatment(92%) exceeded thehistorical SVR rate for peg-interferon plus ribavirin of 70%. | Lai Wei Fu-Sheng Wang Ming-Xiang Zhang Ji-Dong Jia Alexey A Yakovlev Wen Xie Eduard Burnevich Jun-Qi Niu Yong Jin Jung Xiang-Jun Jiang Min Xu Xin-Yue Chen Qing Xie Jun Li Jin-Lin Hou Hong Tang Xiao-guang Dou Yash Gandhi Wen-Hua Hu Fiona McPhee Stephanie Noviello Michelle Treitel Ling Mo Jun Deng | 2018 | World Journal of Gastroenterology2018，24，12： | 17 |
| 5 | Metabolic engineering and flux analysis of Corynebacterium glutamicum for L-serine production显示文摘L-Serine plays a critical role as a building block for cell growth, and thus it is difficult to achieve the direct fermentation of L-serine from glucose. In this study, Corynebacterium glutamicum ATCC 13032 was engineered de novo by blocking and attenuating the conversion of L-serine to pyruvate and glycine, releasing the feedback inhibition by L-serine to 3-phosphoglycerate dehydrogenase (PGDH), in combination with the co-expression of 3-phosphoglycerate kinase (PGK) and feedback-resistant PGDH (PGDHr). The resulting strain, SER-8, exhibited a lower specific growth rate and significant differences in L-serine levels from Phase I to Phase V as determined for fed-batch fermentation. The intracellular L-serine pool reached (14.22±1.41) μmol gCDM 1, which was higher than glycine pool, contrary to fermentation with the wild-type strain. Furthermore, metabolic flux analysis demonstrated that the over-expression of PGK directed the flux of the pentose phosphate pathway (PPP) towards the glycolysis pathway (EMP), and the expression of PGDHr improved the L-serine biosynthesis pathway. In addition, the flux from L-serine to glycine dropped by 24%, indicating that the deletion of the activator GlyR resulted in down-regulation of serine hydroxymethyltransferase (SHMT) expression. Taken together, our findings imply that L-serine pool management is fundamental for sustaining the viability of C. glutamicum, and improvement of C1 units generation by introducing the glycine cleavage system (GCV) to degrade the excessive glycine is a promising target for L-serine production in C. glutamicum. | LAI ShuJuan ZHANG Yun LIU ShuWen LIANG Yong SHANG XiuLing CHAI Xin WEN TingYi | 2012 | Science China(Life Sciences)2012，55，4： | 15 |
| 6 | Fetal Hemodynamics and Fetal Growth Indices by Ultrasound in Late Pregnancy and Birth Weight in Gestational Diabetes Mellitus显示文摘 | Fang Liu Yong Liu Ya-Ping Lai Xiao-Ning Gu Dong-Mei Liu Min Yang | 2016 | Chinese Medical Journal2016，，17： | 15 |
| 7 | Mogroside V inhibits LPS-induced COX-2 expression/ROS production and overexpression of HO-1 by blocking phosphorylation of AKT1 in RAW264.7 cells显示文摘Momordica grosvenori is a valuable edible plant with medicinal purposes, and it is widely used in medicated diets and traditional Chinese medicine in Asia. Mogroside V (MV), the main bioactive component from M. grosvenori, is comm only used as a natural sweetener. M. grosvenori extracts have been reported to exert potent anti-inflammatory property, however the underlying molecular mechanism still remains unknown. In the present study, the biological effect of MV in inflammation was investigated in lipopolysaccharide (LPS)-stimulated RAW264.7 cells. The ELISA and western blot analysis results showed that MV significantly inhibited LPS-induced prostaglandin E2 (PGE2) production and cyclooxygenase-2 (COX-2) expression. MV markedly decreased the phosphorylation of IxB-a, increased IkB-oc, and reduced nuclear p-65 and C/EBP6. Furthermore, MV attenuated LPS-induced phosphorylation of MAPKs and AKT1, and only the phosphorylation status of AKT1 was found to be consistent with the expression trend of COX-2. Moreover, MV reduced ROS level and restored overexpressed HO-1 and AP-1 to basal level, which can be markedly reversed by AKT1 inhibitor LY294002. These results revealed that AKT1 plays a key role in LPS-induced COX-2 expression, and acts as a mediator to keep the redox balance in LPS-stimulated RAW264.7 cells. MV exerts anti-inflammatory property by blocking AKT1-mediated NF-kB and C/EBP6 activation, ROS generation and AP-1/ HO-1 expression. Therefore, the present study indicated that MV has a significant chemopreventive effect on the inflammatory lesions and suggested that AKT1 is a potential specific target of MV for relieving inflammation. | Yong Li Luyan Zou Tao Li Dengni Lai Yanyang Wu Si Qin | 2019 | Acta Biochimica et Biophysica Sinica2019，51，4： | 14 |
| 8 | Progress and records in the study of endogenetic mineralization during collisional orogenesis显示文摘To develop and perfect the theory of plate tectonics and regional metallogeny, metal-logenesis during collisional orogenesis should be thoroughly studied and will attract increasing at-tention of more and more scientists. This paper presents the main aspects of research and discus-sions on metallogenesis during collisional orogenesis after the development of plate tectonics, and accordingly divides the study history into two stages, i.e. the junior stage during 1971-1990 and the senior stage after 1990. Beginning with the negation of mineralization in the collision regime by Guild (1971), the focus of study was put on whether there occurred any mineralization during collisional orogenesis at the junior stage. At the senior stage, which is initiated by the advance of met-allogenic and petrogenic model for collisional orogenesis, scientists begin to pay their attention to the geodynamic mechanism of metallogenesis, spatial and temporal distribution of ore deposits, ore-forming fluidization, relationship | Yanjing Chen Huayong Chen Yulin Liu Guangjun Guo Yong Lai Shan Qin Baoling Huang Zengjie Zheng Yinghui Sui Chao Li et al. | 2000 | Chinese Science Bulletin2000，45，1： | 13 |
| 9 | Piglets cloned from induced pluripotent stem cells显示文摘 | Nana Fan Jijun Chen Zhouchun Shang Hongwei Dou Guangzhen Ji Qingjian Zou Lu Wu Lixiazi He Fang Wang Kai Liu Na Liu Jianyong Han Qi Zhou Dengke Pan Dongshan Yang Bentian Zhao Zhen Ouyang Zhaoming Liu Yu Zhao Lin Lin Chongming Zhong Quanlei Wang Shouqi Wang Ying Xu Jing Luan Yu Liang Zhenzhen Yang Jing Li Chunxia Lu Gabor Vajta Ziyi Li Hongsheng Ouyang Huayan Wang Yong Wang Yang Yang Zhonghua Liu Hong Wei Zhidong Luan Miguel A Esteban Hongkui Deng Huanming Yang Duanqing Pei Ning Li Gang Pei Lin Liu Yutao Du Lei Xiao Liangxue Lai | 2013 | Cell Research2013，23，1： | 12 |
| 10 | Short Texts Classification Through Reference Document Expansion显示文摘With the rapid development of information technology, short texts arising from socialized human interaction are gradually predominant in network information streams. Accelerating demands are requiring the industry to provide more effective classification of the brief texts.However, faced with short text documents, each of which contains only a few words, traditional document classification models run into difficulty. Aggressive documents expansion works remarkably well for many cases but suffers from the assumption of independent, identically distributed observations. We formalize a view of classification using Bayesian decision theory, treat each short text as observations from a probabilistic model, called a statistical language model, and encode classification preferences with a loss function defined by the language models and the external reference document. According to Vapnik's methods of Structural risk minimization(SRM), the optimal classification action is the one that minimizes the structural risk, which provides a result that allows one to trade off errors on the training sample against improved generalization performance. We conduct experiments by using several corpora of microblog-like data, and analyze the experimental results. With respect to established baselines,results of these experiments show that applying our proposed document expansion method produces better chance to achieve the improved classification performance. | YANG Zhen FAN Kefeng LAI Yingxu GAO Kaiming WANG Yong | 2014 | Chinese Journal of Electronics2014，23，2： | 11 |
| 11 | Elevated expression of mature miR-21 and miR-155 in cancerous gastric tissues from Chinese patients with gastric cancer显示文摘Objective:MicroRNA (miRNA) expression is deregulated in many types of human cancers.We sought to investigate the expression patterns of the miRNAs,miR-21,miR-145 and miR-155 in sporadic gastric cancer in a Chinese population.Methods:Total RNA was extracted from archived gastric cancer tissues and adjacent non-cancerous tissues from 20 pairs of paraffin-embedded specimens.Expression levels of miR-21,miR- 145 and miR-155 were detected by quantitative reverse transcriptase PCR using a specific stem-loop primer,with U6 as the internal reference gene.Results:The expression of miR-21 and miR-155 in gastric cancer samples was significantly higher than in paired non-cancerous samples(P<0.05).There was no statistically significant difference in expression levels of miR-145 between cancerous and non-cancerous tissues(P>0.05).Conclusion:In Chinese sporadic gastric cancer tissues,the expressions of the oncogenic miR-21 and miR-155 were significantly up-regulated,while the expression of the tumor suppressor miR-145 was decreased,although this decrease was not statistically significant.Thus there is specificity in the miRNA expression pattern in gastric cancers in the Chinese population. | Li Liu Qi Chen Rensheng Lai Xiaobin Wu Xiaoyu Wu Fukun Liu Guohua Xu Yong Ji | 2010 | The Journal of Biomedical Research2010，24，3： | 11 |
| 12 | Effect of temperature on the development of sclerotia in Villosiclava virens显示文摘The sclerotia of Villosiclava virens were found commonly in high altitude and the temperate regions, where the temperatures are relatively low in rice filling stage. To make sure if low temperature induce the sclerotial formation in V. virens, the inoculated rice panicles in laboratory and the diseased rice panicles cut from paddy fields were treated under different temperatures. The results showed that 3 days of night temperature at 15°C were enough to induce the sclerotial formation. The low temperature was much more effective for young balls with intact membranes. After appearance of chlamydospores on the ball surfaces, the sclerotium could not differentiate anymore. The sclerotia began to differentiate below the chlamydospore layer and gradually grew onto the ball surfaces. This suggests that low temperature in the early development stage of false smut balls is an important factor to induce the sclerotial differentiation, and rice cultivars with long growth periods are able to produce more sclerotium-bearing balls, which will produce mass of spores in paddy field in the coming year. | FAN Lin-lin YONG Ming-li LI Dan-yang LIU Yi-jia LAI Chao-hui CHEN Hong-ming CHENG Fang-min HU Dong-wei | 2016 | Journal of Integrative Agriculture2016，15，11： | 11 |
| 13 | Contribution of elF-4E inhibition to the expression and activity of heparanase in human colon adenocarcinoma cell line:LS-174T显示文摘AIM: Heparanase degrades heparan sulfate proteoglycans (HSPGs) and is a critical mediator of tumor metastasis and angiogenesis. Recently, it has been cloned as a single gene family and found to be a potential target for antimetastasis drugs. However, the molecular basis for the regulation of heparanase expression is still not quite clear. The aim of this study was to determine whether the expression of eukaryotic initiation factor 4E (eIF-4E) correlated with the heparanase level in tumor cells and to explore the correlation between heparanase expression and metastatic potential of LS- 174T cells.METHODS: A 20-met antisense s-oligodeoxynucleotide (asODN) targeted against the translation start site of eIF-4E mRNA was introduced into LS-174T cells by lipid-mediated DNA-transfection. eIF-4E protein and mRNA levels were detected by Western blot analysis and RT-PCR, respectively.Heparanase activity was defined as the ability to degrade high molecular weight (40-100 kDa) radiolabeled HS (heparan sulfate) substrate into low molecular weight (5-15 kDa) HS fragments that could be differentiated by gel filtration chromatography. The invasive potential of tumor cell in vitro was observed by using a Matrigel invasion assay system.RESULTS: The 20-mer asODN against eIF-4E specifically and significantly inhibited eIF-4E expression at both transcriptional and translational levels. As a result, the expression and activity of heparanase were effectively retarded and the decreased activity of heparanase resulted in the decreased invasive potential of LS-174T.CONCLUSION: eIF-4E is involved in the regulation of heparanase production in colon adenocarcinoma cell line LS-174T, and its critical function makes it a particularly interesting target for heparanase regulation. This targeting strategy in antisense chemistry may have practical applications in experimental or clinical anti-metastatic gene therapy of human colorectal carcinoma. | Yu-Jie Yang Ya-Li Zhang Xu Li Han-Lei Dan Zhuo-Sheng Lai Ji-De Wang Qun-Ying Wang Hai-Hong Cui Yong Sun Ya-Dong Wang, Chinese PLA Institute of Digestive Disease, Nanfang Hospital, First Military Medical University, Guangzhou 510515, Guangdong Province, China | 2003 | World Journal of Gastroenterology2003，9，8： | 10 |
| 14 | Functional Outcome of Pronation-External Rotation-Weber C Ankle Fractures with Supracollicular Medial Malleolar Fracture Treated with or without Syndesmotic Screws: A Retrospective Comparative Cohort Study显示文摘背景: 在脚关节骨折的治疗, intraoperative 压力测试被用来估计 syndesmotic 损害和不稳定性。然而, strees 测试预定优化应该被使用是否在里面 pre 多骨或 bony 以后固定在操作期间是很少在以前的研究被报导。压力测试预定上的不同策略将在内转外部的旋转的一种类型以内展出相反的结果(每) 有 supracollicular 的破裂中间踝(SMM ) 断裂。这研究被设计基于二不同 intraoperative 压力测试 strategies.Methods 的结果每破裂估计专辑的3年的功能的结果与或没有 syndesmotic transfixation :这回顾的队研究每损害包括了 61 -- Weber C 脚关节破裂与 SMM 破裂结合了在北京 Jishuitan 被对待在 2013 和 2014 之间的医院并且列在后面在上面为 3 年。压力测试 intraoperatively 被执行两次。在多骨的固定以后的以前多骨的固定和否定 intraoperative 压力测试在这些被发现的积极 intraoperative 压力测试包括了病人。没有补加的 syndesmotic 螺丝钉固定, 29 个病人(组 1 ) 被对待,根据在多骨的固定以后的否定 intraoperative 应力测试,当 32 个病人(组 2 ) 在多骨的固定前基于积极 intraoperative 应力测试与另外的 syndesmotic 螺丝钉固定被对待时。为疼痛分数的美国整形外科的脚和脚关节社会(AOFAS ) Ankle-Hindfoot 规模和视觉模拟规模(管) 是结果的主要大小。人口统计的数据的统计索引,骨折词法数据,后续的时间间隔, AOFAS 和管被社会科学统计套装软体 21.0 软件通过菲希尔记录并且估计准确测试和变化的单程的分析。在主要结果和有影响的因素之间的协会被线性回归 models.Results 评估: 我们没在年龄,性别,联系的以后的踝(下午) 的存在,骨折脱臼,和在二个治疗组之间的联系下午的固定的分发观察差别。与可得到的数字,没有统计上重要的协会能关于 AOFAS 被检测(组 1 对组 2, 96.72 ? ¨慓畭汥? ??敗摮 y 吗?? | Yong Wu Qi-Fei He Liang-Peng Lai Xia Li Jun-Lin Zhou | 2018 | Chinese Medical Journal2018，，21： | 9 |
| 15 | Acupuncture at Waiguan (TE5) influences activation/deactivation of functional brain areas in ischemic stroke patients and healthy people A functional MRI study显示文摘In the present study, 10 patients with ischemic stroke in the left hemisphere and six healthy controls were subjected to acupuncture at right Waiguan (TE5). In ischemic stroke subjects, functional MRI showed enhanced activation in Broadmann areas 5, 6, 7, 18, 19, 24, 32, the hypothalamic inferior lobe, the mamillary body, and the ventral posterolateral nucleus of the left hemisphere, and Broadmann areas 4, 6, 7, 18, 19 and 32 of the right hemisphere, but attenuated activation of Broadmann area 13, the hypothalamic inferior lobe, the posterior lobe of the tonsil of cerebellum, and the culmen of the anterior lobe of hypophysis, in the left hemisphere and Broadmann area 13 in the right hemisphere. In ischemic stroke subjects, a number of deactivated brain areas were enhanced, including Broadmann areas 6, 11, 20, 22, 37, and 47, the culmen of the anterior lobe of hypophysis, alae lingulae cerebella, and the posterior lobe of the tonsil of cerebellum of the left hemisphere, and Broadmann areas 8, 37, 45 and 47, the culmen of the anterior lobe of hypophysis, pars tuberalis adenohypophyseos, inferior border of lentiform nucleus, lateral globus pallidus, inferior temporal gyrus, and the parahippocampal gyrus of the right hemisphere. These subjects also exhibited attenuation of a number of deactivated brain areas, including Broadmann area 7. These data suggest that acupuncture at Waiguan specifically alters brain function in regions associated with sensation, vision, and motion in ischemic stroke patients. By contrast, in normal individuals, acupuncture at Waiguan generally activates brain areas associated with insomnia and other functions. | Junqi Chen Yong Huang Xinsheng Lai Chunzhi Tang Junjun Yang Hua Chen Tongjun Zeng Junxian Wu Shanshan Qu | 2013 | Neural Regeneration Research2013，8，3： | 8 |
| 16 | A stiffness-matching based evaluation approach for compliance of mechanical systems in shield tunneling machines显示文摘As the most important performance,compliance of shield tunneling machines(STM) is defined as the capability to accommodate the sudden change of the load induced by the variable geological conditions during excavation.Owing to the different requirements of the compliant tasks,the existing methods in the robotic field cannot be utilized in the analysis and design of the mechanical system of shield tunneling machines.In this paper,based on the stiffness of the mechanical system and the equivalent contact stiffness of the tunnel face,the tunneling interface-matching index(IMI) is proposed to evaluate the compliance of the machine.The IMI is defined as a metric to describe the coincidence of the stiffness curves of the mechanical system and the tunnel face.Moreover,a tunneling case is investigated in the paper as an example to expound the validation of IMI and the analytical process.In conclusion,the IMI presented here can be served as an appraisement of the capability in conforming to the load fluctuation,and give instructions for the design of the thrust system of shield tunneling machines. | ZHAO Yong WANG Hao YU HaiDong LAI XinMin LIN ZhongQin | 2012 | Science China(Technological Sciences)2012，55，10： | 7 |
| 17 | Genetically humanized pigs exclusively expressing human insulin are generated through custom endonuclease-mediated seamless engineering显示文摘Dear Editor,Type1diabetes(T1D)isa lifelong(chronic)disease and a major health problem throughout the world.This disease can be treatedby either insulin injection or islet transplantation.Islet transplantation is considered as a better treatment for T1D patients,because islets can produce and release insulin at the appropriate time,resulting in tight blood glucose control. | Yi Yang Kepin Wang Han Wu Qin Jin Degong Ruan Zhen Ouyang Bentian Zhao Zhaoming Liu Yu Zhao Quanjun Zhang Nana Fan Qishuai Liu Shimei Guo Lei Bu Yong Fan Xiaofang Sun Xiaoping Li Liangxue Lai | 2016 | Journal of Molecular Cell Biology2016，8，2： | 6 |
| 18 | Physical properties of WSTi3515S burn-resistant titanium alloy显示文摘Development of burn-resistant titanium alloys is the most direct way of mitigating the ignition and propagation of titanium fires in jet engines. WSTi3515S alloy(Ti–35V–15Cr–0.3Si–0.1C) is a new high alloying beta type burn-resistant titanium alloy, belonging to Ti–V–Cr type alloys which have been made significant progress in engineering technology in the past 5 years. The physical properties of WSTi3515S burn-resistant titanium alloy such as the elastic properties and thermal properties were measured and analyzed in different conditions. The results show that both the Young's modulus and shear modulus of WSTi3515S alloy decrease slightly with the temperature increasing at the tested temperature range. The Poisson's ratio of WSTi3515S alloy is around 0.36. However, the thermal properties such as the specific heat, thermal diffusivity, thermal conductivity and thermal expansion increase with the temperature increasing, which results from the strengthening of lattice heat vibration at elevated temperature. And the room temperature density of WSTi3515S alloy is 5.295 gácm^(-3). | Yun-Jin Lai Ping-Xiang Zhang Xue-Min Zhang Xiang-Hong Liu Yong Feng Hong-Chao Kou Fan-Jiao Ma Wei-Dong Zeng | 2016 | Rare Metals2016，35，5： | 5 |
| 19 | Outcome of laparoscopic cholecystectomy is not influenced by chronological age in the elderly显示文摘AIM:To evaluate the outcome of laparoscopic cholecystectomy(LC)in patients aged 80 years and older. METHODS:A total of 353 patients aged 65 to 79 years(group 1)and 35 patients aged 80 years and older(group 2)underwent LC.Patients were further classified into two other groups:those with uncomplicated gallbladder disease(group A)or those with complicated gallbladder disease(group B). RESULTS:There were no significant differences between the age groups(groups 1 and 2)with respect to clinical characteristics such as age,gender,comorbid disease,or disease presentation.Mean operative time,conversion rate,and the incidence of major postoperative complications were similar in groups 1 and 2.However,the percentage of high-risk patients was significantly higher in group 2 than in group 1 (20.0%vs 5.7%,P<0.01).Group A comprised 322 patients with a mean age of 71.0±5.3 years,and group B comprised 51 patients with a mean age of 69.9±4.8 years.In group B,mean operative time (78.4±49.3 min vs 58.3±35.8 min,P<0.01),mean postoperative hospital stay(7.9±6.5 d vs 5.0±3.7 d, P<0.01),and the incidence of major postoperative complications(9.8%vs 3.1%,P<0.05)were significantly greater than in group A.The conversion rate tended to be higher in group B,but this difference was not significant. CONCLUSION:Perioperative outcomes in elderly patients who underwent LC seem to be influenced by the severity of gallbladder disease,and not by chronologic age.In octogenarians,LC should be performed at an earlier,uncomplicated stage of the disease whenever possible to improve perioperative outcomes. | Hyung Ook Kim Jung Won Yun Jun Ho Shin Sang Il Hwang Yong Kyun Cho Byung Ho Son Chang Hak Yoo Yong Lai Park Hungdai Kim | 2009 | World Journal of Gastroenterology2009，15，6： | 5 |
| 20 | Relationship of the preoperative NRS 2002 score,PG-SGA score,and serum indices with postoperative complications in patients with gastric cancer显示文摘Objective To examine the utility of the Nutrition Risk Screening 2002(NRS 2002),Patient-Generated Subjective Global Assessment(PG-SGA)and serum factors for the preoperative evaluation of gastric cancer patients.Methods We examined 181 gastric cancer patients treated at the First Affiliated Hospital of Guangxi Medical University from January 2015 to January 2018.Nutritional assessments were administered within 48 h of admission.The body mass index(BMI)and serum factors were measured,and information on preoperative nutritional support and postoperative complications was recorded.Results Both the NRS 2002 and PG-SGA had positive correlations with age(P<0.05),and negative correlations with albumin,prealbumin,transferrin,hemoglobin,BMI,and bodyweight(P<0.05).The NRS 2002 and PG-SGA scores were positively correlated with each other(r=0.683,P<0.01),but had poor consistency(κ=0.357,P<0.01).During the preoperative period,33.2%of patients received nutritional support,mainly enteral nutrition.The nutritional risk group(NRS 2002≥3)received more support than the group without nutritional risk(NRS 2002<3;P<0.05).Patients with nutritional risk or malnutrition who received preoperative nutritional support had fewer postoperative complications than unsupported patients.The overall rate of complications was 12.2%,and the rate of severe complications(gradeⅢor above)was 5.5%.The malnutrition and nutritional risk groups had higher rates of severe complications.Conclusions The combined application of the NRS 2002,PG-SGA,BMI,and serum nutritional indices was useful for the nutritional screening and assessment of preoperative gastric cancer patients.The NRS 2002 and PG-SGA provided guidance on the need for nutritional support during the preoperative period. | Dao Lai Huang Xiang Hua Wu Chang Li Wang Jun Qiang Chen Kui Jia Jing Zhou Li Sheng Lu Yong Sheng Zhang Jing Jin Ke Ke Huang | 2021 | Journal of Nutritional Oncology2021，6，2： | 5 |
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