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| 1 | 2018加拿大心境障碍与焦虑障碍治疗协作组/国际双相障碍学会指南:双相障碍的管理显示文摘加拿大心境障碍与焦虑障碍治疗协作组(Canadian Network for Mood and Anxiety Treatments,CANMAT)曾于2005年发布了第1版双相障碍管理指南,并分别于2007、2009和2013年对该指南进行了更新,其中最近的2次更新是与国际双相障碍学会(International Society for Bipolar Disorders,ISBD)合作完成。2018版CANMAT/ISBD双相障碍治疗指南(以下简称指南)反映了自2005年首版指南发表以来本领域取得的重大进展,包括疾病诊断与疾病管理的更新以及药物治疗与心理治疗的近期研究进展。这些前沿进展中综合考虑了循证证据的级别,并基于治疗疗效、临床实践经验、安全性、耐受性和药物导致的转相风险等,对一线、二线及三线治疗方案进行了简明而清晰的推荐。本指南中新增内容涵盖了双相Ⅰ型障碍(BD-Ⅰ)的躁狂发作急性期、抑郁发作急性期和双相障碍维持期的一线及二线治疗推荐等级划分。这种对治疗推荐等级的划分综合考虑了治疗方法对双相障碍不同时相的影响,将进一步帮助临床医生做出基于循证证据的治疗决策。锂盐、喹硫平、双丙戊酸盐、阿塞那平、阿立哌唑、帕利哌酮、利培酮和卡利拉嗪单药或联合使用被推荐为躁狂发作急性期的一线治疗选择。BD-Ⅰ抑郁期的一线治疗选择包括喹硫平、鲁拉西酮、锂盐、拉莫三嗪单药,鲁拉西酮联合锂盐或双丙戊酸盐或拉莫三嗪辅助治疗。尽管急性期治疗有效的药物通常应继续用于BD-Ⅰ的维持期治疗,但也存在一些特殊情况(例如抗抑郁药)。现有数据表明,锂盐、喹硫平、双丙戊酸盐、拉莫三嗪、阿塞那平和阿立哌唑单药或联合治疗应被视为维持治疗的初始或更换治疗方案时的一线选择。除了探讨BD-Ⅰ的相关问题外,本指南中还对双相Ⅱ型障碍(BD-Ⅱ)的临床管理进行了系统回顾并给予治疗推荐,同时针对特殊人群也有相关推荐,如处于各个生殖周期的女性、儿童、青少年和老年人。此外,本指南中还讨论了特定精神疾病及共病(如物质滥用、焦虑障碍和代谢性疾病)的影响。最后,本指南中概述了安全性和药物监测的相关问题。CANMAT/ISBD工作组希望本指南能够成为全球临床医生的实用工具。 | Lakshmi N Yatham Sidney H Kennedy Sagar V Parikh Ayal Sehaffer David J Bond Benicio N Frey Verinder Sharma Benjamin I Goldstein Soham Rej Serge Beaulieu Martin Alda Glenda MaeQueen Roumen V Milev Arun Ravindran Claire O'Donovan Diane Mclntosh Raymond W Lam Gustavo Vazquez Flavio Kapczinski Roger S Melntyre Jan Kozicky Shigenobu Kanba Beny Lafer Trisha Suppes Joseph R Calabrese Eduard Vieta Gin Malhi Robert M Post Michael Berk 胡晨(译) 王刚(译) | 2019 | 中华精神科杂志2019，52，1： | 25 |
| 2 | Connective tissue growth factor and IGF-1 are produced by human renal fibroblasts and cooperate in the induction of collagen production by high glucose 显示文摘 | Lam S van der Geest R N Verhagen N A | 2003 | Diabetes2003，52，12： | 1 |
| 3 | A fuzzy neural network approach for contractor prequalification 显示文摘 | LAM K C HU T THOMAS S N | 2001 | Journal of Construction Management and Economics2001，19，2： | 1 |
| 4 | A study of lacunarity-based texture analysis approaches to improve urban image classification显示文摘 | MYINT S W LAM N | 2005 | Comput En- viron Urban Syst2005，29，： | 1 |
| 5 | Relationship of gabbro and pillow lavas in the Lupar Formation, West Sarawak: implications for the interpretation of the Lubok Antu M lange and the Lupar Line显示文摘 | Haile N S Lam S K Banda R M | 1994 | Bulletin of the Geological Society of Malaysia1994，36，： | 1 |
| 6 | Robust stabilization for uncertain discrete singular systems显示文摘 | Xu S Y Cheng W Y Yu G N James Lam | 2001 | Automatica2001，37，5： | 1 |
| 7 | Modulation of E2F complexes during G to S phase transition in human p rimary Blymphocytes显示文摘 | Vander Sman J Thomas N S Lam E W | 1999 | J Biol Chem1999，274，17： | 1 |
| 8 | Clinical characteristics of childhood erythema multiforme, Steven-Johson syndrome and toxic epidermal necrolysis in the children of Chinese Taiwan显示文摘 | LAM N S YANG Y H | 2004 | J Microbial lmmunol Infect2004，37，2： | 1 |
| 9 | On the issues of scale, resolution, and {ractal analysis in the mapping sciences 显示文摘 | Lam N S N Quattrochi D A | 1992 | Prof Geogr1992，44，1： | 1 |
| 10 | Prevention of hypotension during spinal anaesthesia for caesarean section:ephedrine infusion versus fluid preload显示文摘 | Chan W S Irwin M G Tong W N Lam Y H | 1997 | Anaesthesia1997，52，9： | 1 |
| 11 | Spatial interpolation methods: A review 显示文摘 | Lam N S | 1983 | TheAmerican Cartographer1983，10，2： | 1 |
| 12 | Bulk-quantity Si nanowires synthesized by SiO sublimation 显示文摘 | Zhang Y F Tang Y H Lam C Wang N Lee C S Bello I Lee S T | 2000 | Journal of Crystal Growth2000，212，2： | 1 |
| 13 | Fractal characterization of hyper spectral imagery显示文摘 | Qiu H L Lam N S N Quattrochi D A | 1991 | Photogrammetric Engineering and Remote Sensing1991，，65： | 1 |
| 14 | Mo- lecular detection of enteroviruses from an outbreak of hand, foot and mouth disease in Malaysia in 1997显示文摘 | Abubakar S Chee HY Shafee N Chua KB Lam SK | 1999 | Scand J In- fect Dis1999，31，4： | 1 |
| 15 | A photostable AIE luminogen for specific mitochondrial imaging and tracking显示文摘 | Leung C W T Hong Y N Chen S J Zhao E G Lam J W Y Tang B Z | 2013 | Journal of the American Chemical Society2013，135，1： | 1 |
| 16 | Removal of phosphate from water by a highly selective La(III)-chelex resin显示文摘 | Wu R S S Lam K H Lee J M N | 2007 | Chemosphere2007，69，2： | 1 |
| 17 | Impact of climate change on commercial sector air conditioning energy consumption in subtropical Hong Kong显示文摘 | LAM T N T WAN K K W WONG S L | 2010 | Applied Energy2010，87，7： | 1 |
| 18 | Discovery and development of dimeric podocarpic acid leads as potent agonists of liver X receptor with HDL cholesterol raising activity in mice and hamsters显示文摘 | Singh SB Ondeyka JG Liu W Chen S Chen TS Li X Bouffard A Dropinski J Jones AB McCormick S Hayes N Wang J Sharma N Macnaul K Hernandez M Chao YS Baffic J Lam MH Burton C Sparrow CP Menke JG | | 0，，11： | 1 |
| 19 | Fluid structure interaction be- tween rods and a cross flow-numerical approach 显示文摘 | SIMONEAUA J P THOMAS S MOUSSAL- LAM N | 2011 | Nuclear Engineering and Design2011，241，： | 1 |
| 20 | A comparison of fractal dimension estimators based on multiple surface generation algorithms显示文摘 | ZHOU Gui-yun Lam N S N | 2005 | Computers & Geosciences2005，，31： | 1 |
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