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| 1 | Additive manufacturing frontier: 3D printing electronics显示文摘3D printing is disrupting the design and manufacture of electronic products. 3D printing electronics offers great potentialto build complex object with multiple functionalities. Particularly, it has shown the unique ability to make embedded electronics,3D structural electronics, conformal electronics, stretchable electronics, etc. 3D printing electronics has beenconsidered as the next frontier in additive manufacturing and printed electronics. Over the past five years, a large numberof studies and efforts regarding 3D printing electronics have been carried out by both academia and industries. In thispaper, a comprehensive review of recent advances and significant achievements in 3D printing electronics is provided.Furthermore, the prospects, challenges and trends of 3D printing electronics are discussed. Finally, some promising solutionsfor producing electronics with 3D printing are presented. | Bingheng Lu Hongbo Lan Hongzhong Liu | 2018 | Opto-Electronic Advances2018，1，1： | 3 |
| 2 | Targeting a novel inducible GPX4 alternative isoform to alleviate ferroptosis and treat metabolic-associated fatty liver disease显示文摘Metabolic-associated fatty liver disease(MAFLD),which is previously known as non-alcoholic fatty liver disease(NAFLD),represents a major health concern worldwide with limited therapy.Here,we provide evidence that ferroptosis,a novel form of regulated cell death characterized by iron-driven lipid peroxidation,was comprehensively activated in liver tissues from MAFLD patients.The canonical-GPX4(cGPX4),which is the most important negative controller of ferroptosis,is downregulated at protein but not mRNA level.Interestingly,a non-canonical GPX4 transcript-variant is induced(inducible-GPX4,iGPX4)in MAFLD condition.The high fat-fructose/sucrose diet(HFFD)and methionine/choline-deficient diet(MCD)-induced MAFLD pathologies,including hepatocellular ballooning,steatohepatitis andfibrosis,were attenuated and aggravated,respectively,in cGPX4-and iGPX4-knockin mice.cGPX4 and iGPX4 isoforms also displayed opposing effects on oxidative stress and ferroptosis in hepatocytes.Knockdown of iGPX4 by siRNA alleviated lipid stress,ferroptosis and cell injury.Mechanistically,the triggered iGPX4 interacts with cGPX4 to facilitate the transformation of cGPX4 from enzymatic-active monomer to enzymatic-inactive oligomers upon lipid stress,and thus promotes ferroptosis.Co-immunoprecipitation and nano LC–MS/MS analyses confirmed the interaction between iGPX4 and cGPX4.Our results reveal a detrimental role of non-canonical GPX4 isoform in ferroptosis,and indicate selectively targeting iGPX4 may be a promising therapeutic strategy for MAFLD. | Jie Tong Dongjie Li Hongbo Meng Diyang Sun Xiuting Lan Min Ni Jiawei Ma Feiyan Zeng Sijia Sun Jiangtao Fu Guoqiang Li Qingxin Ji Guoyan Zhang Qirui Shen Yuanyuan Wang Jiahui Zhu Yi Zhao Xujie Wang Yi Liu Shenxi Ouyang Chunquan Sheng Fuming Shen Pei Wang | 2022 | Acta Pharmaceutica Sinica B2022，12，9： | 3 |
| 3 | Delineating spatiotemporal and hierarchical development of human fetal innate lymphoid cells显示文摘Whereas the critical roles of innate lymphoid cells(ILCs)in adult are increasingly appreciated,their developmental hierarchy in early human fetus remains largely elusive.In this study,we sorted human hematopoietic stem/progenitor cells,lymphoid progenitors,putative ILC progenitor/precursors and mature ILCs in the fetal hematopoietic,lymphoid and non-lymphoid tissues,from 8 to 12 post-conception weeks,for single-cell RNA-sequencing,followed by computational analysis and functional validation at bulk and single-cell levels.We delineated the early phase of ILC lineage commitment from hematopoietic stem/progenitor cells,which mainly occurred in fetal liver and intestine.We further unveiled interleukin-3 receptor as a surface marker for the lymphoid progenitors in fetal liver with T,B,ILC and myeloid potentials,while IL-3RA–lymphoid progenitors were predominantly B-lineage committed.Notably,we determined the heterogeneity and tissue distribution of each ILC subpopulation,revealing the proliferating characteristics shared by the precursors of each ILC subtype.Additionally,a novel unconventional ILC2 subpopulation(CRTH2–CCR9+ILC2)was identified in fetal thymus.Taken together,our study illuminates the precise cellular and molecular features underlying the stepwise formation of human fetal ILC hierarchy with remarkable spatiotemporal heterogeneity. | Chen Liu Yandong Gong Han Zhang Hua Yang Yang Zeng Zhilei Bian Qian Xin Zhijie Bai Man Zhang Jian He Jing Yan Jie Zhou Zongcheng Li Yanli Ni Aiqing Wen Yu Lan Hongbo Hu Bing Liu | 2021 | Cell Research2021，31，10： | 2 |
| 4 | The Diversity of Soil Fauna Communities in the Karst Cave Wetland of Maolan Nature Reserve显示文摘From March 2014 to February 2015, the soil fauna community in the karst cave wetland of Maolan Nature Reserve was investigated. A total of 3,820 soil fauna was obtained, belonging to 31 orders, 11 classes, and 3 phyla. The dominant groups were Araneae, Coleoptera and Hymenoptera, accounting for 48.90% of the total catch. There were 18 common groups and 10 rare groups. The diversity analysis showed that the Banzhai karst cave wetland had the largest soil fauna community diversity index and evenness index and that the Dongsai karst cave wetland had the largest number of groups and individuals. The seasonal variation of the soil fauna in the karst cave wetlands was analyzed: the number of soil fauna individuals showed a downtrend in summer, autumn, spring and winter; there were the highest number of phytophagous soil fauna, followed by predatory soil fauna and saprophagous soil fauna. | LAN Hongbo RAN Jingcheng YAO Wuqing WANG Wanhai YAO Zhengming MENG Huili | 2018 | Journal of Landscape Research2018，10，6： | 2 |
| 5 | An internet-based intelligent design system for injection moulds显示文摘 | C K Mok K S Chin Hongbo Lan | 2008 | Robotics and Computer-Integrated Manufacturing2008，24，： | 1 |
| 6 | A study of thin liquid films as related to the stability of crude oil emulsions显示文摘 | Fang Hongbo Zhang Lu Luo Lan | 2001 | Journal of Colloid and Interface Science2001，238，： | 1 |
| 7 | Web-based Rapid Prototyping And manufacturing Systems:A review显示文摘 | Hongbo Lan | | 0，，60： | 1 |
| 8 | Mold deformation in soft UV-nanoimprint lithography显示文摘UV-nanoimprint lithography (UV-NIL) using a soft mold is a promising technique with low cost and high throughput for producing the submicron scale large-area patterns. However, the deformations of the soft mold during imprinting process which can cause serious consequences have to be understood for the practical application of the process. This paper investigated the deformation of the soft mold by theoretical analyses, numerical simulations, and experimental studies. We simulated the mold deformation using a simplified model and finite element method. The simulation and the related experimental results agree well with each other. Through the investigation, the mechanism and affected factors of the mold deformation are revealed, and some useful conclusions have been achieved. These results will be valuable in optimizing the imprinting process conditions and mold design for improving the quality of transferred patterns. | LAN HongBo DING YuCheng LIU HongZhong QUE YeRong TAO WeiWei LI HanSong LU BingHeng | 2009 | Science China(Technological Sciences)2009，52，2： | 1 |
| 9 | An intergrated manufacturing system for rapid tooling based on rapid prototyping显示文摘 | Yucheng Ding Hongbo Lan Jun Hong Dianliang Wu | 2004 | Robotics and Computer-Intergrated Manufacturing2004，20，： | 1 |
| 10 | A Web- based Manufacturing Service System for Rapid Product Development显示文摘 | Lan Hongbo Ding Yucheng Hong Jun | 2004 | Computers in Industry2004，54，1： | 1 |
| 11 | Ultrasound aided photochemical synthesis of Ag loaded TiO 2 nanotube arrays to enhance photocatalytic activity显示文摘 | Lan Sun Jing Li Chenglin Wang Sifang Li Yuekun Lai Hongbo Chen Changjian Lin | 2009 | Journal of Hazardous Materials2009，，1： | 1 |
| 12 | Web - based rapid prototyping and manufacturing systems: a review 显示文摘 | Lan Hongbo | 2009 | Computers in Industry2009，60，9： | 1 |
| 13 | Web- based rapid prototyping and manufacturing systems: A review 显示文摘 | Hongbo Lan | 2009 | Computers in Industry2009，，609： | 1 |
| 14 | Review of the wafer stage for nanoimprint lithography显示文摘 | Lan Hongbo Ding Yucheng Liu Hongzhong | 2007 | Microelectr Eng2007，84，： | 1 |
| 15 | Fine Mapping and in silico Isolation of the EUI1 Gene Controlling Upper Internode Elongation in Rice显示文摘 | Hongli Ma Shubiao Zhang Lan Ji Hongbo Zhu Shulan Yang Xuanjun Fang Rencui Yang | 2006 | Plant Molecular Biology2006，，1： | 1 |
| 16 | Expert consensus on the management process of gynecological emergency under the regular epidemic prevention and control of COVID-19显示文摘At present,China is in the stage of the COVID-19 epidemic where regular prevention and control measures are required to contain the spread of disease.Reports of new sporadic cases are still widespread across China and medical personnel remain at high risk of exposure to infection.This is especially the case for medical staff working within emergency departments.Most gynecological emergency cases are complex and a high proportion require emergency surgical treatment.By referring to national regulations and requirements on COVID-19 prevention and control,and by summarizing our experiences in the battle against COVID-19 within Wuhan,this consensus report provides recommendations on the triage,reception,consultation,admission and surgical management of gynecological emergency patients.We also make suggestions for the environmental layout and disinfection and the medical waste management.This consensus aims to optimize the diagnosis and treatment process of gynecological emergency patients and reduce the exposure risk of medical staff within the current context of routine COVID-19 prevention and control. | Hongbo Wang Wei Zhang Xin Du Yan Kuang Xiaomao Li Xiaoxin Ma Lan Xiao Xiaojun Chen Yu Zhang Donglin Li Lang Zheng Yanhui Li Jianliu Wang | 2021 | Gynecology and Obstetrics Clinical Medicine2021，1，2： | 0 |
| 17 | Additive Manufacturing of Large-scale Metal Mesh with Core-shell Composite Structure for Transparent Electromagnetic Shielding/glass Heater显示文摘Transparent electromagnetic(EM)shielding glass with a metal mesh has significant potential for application in different fields of EM radiation and anti-EM interference light-transmitting observation windows.In particular,a transparent EM-shielding glass with a large-aspect-ratio metal mesh can effectively alleviate the contradictory problems of shielding effectiveness and light-transmission performance constraints.However,the fabrication of high-aspect-ratio metal meshes on glass substrates has problems such as high cost,complex processes,low efficiency,small area,and easy damage issues,which limit their application in the field of high-performance,transparent EM-shielding glass.Therefore,this paper proposes a composite additive manufacturing process based on electric-field-driven microjet 3D printing and electroplating.By fabricating metal meshes with an Ag-Cu core-shell structure on a glass substrate,EM-shielding glass with high shielding efficiency and light transmission can be manufactured without increasing the aspect ratio of the metal meshes.The prepared Ag-Cu composite metal mesh has excellent optoelectronic properties(period 250��m,line width 10��m,90.1%transmission at 550 nm visible light,square resistance 0.21Ω/sq),efficient electrothermal effect(3 V DC voltage can reach 189°C steady-state temperature),stable EM-shielding effectiveness(average shielding effectiveness 23 dB at X-band),and acceptable mechanical and environmental stability(less than 3%change in square resistance after 150-times adhesion test and less than 6%and 0.6%change in resistance after 72 h in acid and alkali environments,respectively).This method provides a new solution for the mass production of high-performance large-area transparent electric heating/EM-shielding glass. | Yuping Tai Junyi Zhou Xiaoyang Zhu Houchao Zhang Hongke Li Zhenghao Li Rui Wang Fan Zhang Guangming Zhang Chaohong Liu Hongbo Lan | 2023 | Chinese Journal of Mechanical Engineering(Additive Manufacturing Frontiers)2023，2，3： | 0 |
| 18 | Recommendations for the Diagnosis and Treatment of Maternal SARS-CoV-2 Infection显示文摘The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has spread worldwide and threatened human’s health.With the passing of time,the epidemiology of coronavirus disease 2019 evolves and the knowledge of SARS-CoV-2 infection accumulates.To further improve the scientific and standardized diagnosis and treatment of maternal SARS-CoV-2 infection in China,the Chinese Society of Perinatal Medicine of Chinese Medical Association commissioned leading experts to develop the Recommendations for the Diagnosis and Treatment of Maternal SARS-CoV-2 Infection under the guidance of the Maternal and Child Health Department of the National Health Commission.This recommendations includes the epidemiology,diagnosis,management,maternal care,medication treatment,care of birth and newborns,and psychological support associated with maternal SARS-CoV-2 infection.It is hoped that the recommendations will effectively help the clinical management of maternal SARS-CoV-2 infection. | Dunjin Chen Yue Dai Xinghui Liu Hongbo Qi Chen Wang Lan Wang Yuan Wei Xiaochao Xu Chuan Zhang Lingli Zhang Yuquan Zhang Ruihua Zhao Yangyu Zhao Borong Zhou Ai-Ling Wang Huixia Yang Li Song | 2023 | Maternal-Fetal Medicine2023，5，2： | 0 |
| 19 | Recent advances in nanofiber-based flexible transparent electrodes显示文摘Flexible and stretchable transparent electrodes are widely used in smart display,energy,wearable devices and other fields.Due to the limitations of flexibility and stretchability of indium tin oxide electrodes,alternative electrodes have appeared,such as metal films,metal nanowires,and conductive meshes.However,few of the above electrodes can simultaneously have excellent flexibility,stretchability,and optoelectronic properties.Nanofiber(NF),a continuous ultra-long one-dimensional conductive material,is considered to be one of the ideal materials for high-performance transparent electrodes with excellent properties due to its unique structure.This paper summarizes the important research progress of NF flexible transparent electrodes(FTEs)in recent years from the aspects of NF electrode materials,preparation technology and application.First,the unique advantages and limitations of various NF materials are systematically discussed.Then,we summarize the preparation technology of various advanced NF FTEs,and point out the future development trend.We also discuss the application of NFs in solar cells,supercapacitors,electric heating equipments,sensors,etc,and analyze its development potential in flexible electronic equipment,as well as problems that need to be solved.Finally,the challenges and future development trends are proposed in the wide application of NF FTEs in the field of flexible optoelectronics. | Houchao Zhang Xiaoyang Zhu Yuping Tai Junyi Zhou Hongke Li Zhenghao Li Rui Wang Jinbao Zhang Youchao Zhang Wensong Ge Fan Zhang Luanfa Sun Guangming Zhang Hongbo Lan | 2023 | International Journal of Extreme Manufacturing2023，5，3： | 0 |
| 20 | Successful clearance of persistent SARS-CoV-2 asymptomatic infection following a single dose of Ad5-nCoV vaccine显示文摘Persistent asymptomatic(PA)SARS-CoV-2 infections have been identified.The immune responses in these patients are unclear,and the development of effective treatments for these patients is needed.Here,we report a cohort of 23 PA cases carrying viral RNA for up to 191 days.PA cases displayed low levels of inflammatory and interferon response,weak antibody response,diminished circulating follicular helper T cells(cTfh),and inadequate specific CD4+and CD8+T-cell responses during infection,which is distinct from symptomatic infections and resembling impaired immune activation.Administration of a single dose of Ad5-nCoV vaccine to 10 of these PA cases elicited rapid and robust antibody responses as well as coordinated B-cell and cTfh responses,resulting in successful viral clearance.Vaccine-induced antibodies were able to neutralize various variants of concern and persisted for over 6 months,indicating long-term protection.Therefore,our study provides an insight into the immune status of PA infections and highlights vaccination as a potential treatment for prolonged SARS-CoV-2 infections. | Shaofu Qiu Zhao Chen Airu Zhu Qiuhui Zeng Hongbo Liu Xiaoqing Liu Feng Ye Yingkang Jin Jie Wu Chaojie Yang Qi Wang Fangli Chen Lan Chen Sai Tian Xinying Du Qingtao Hu Jinling Cheng Canjie Chen Fang Li Jing Sun Yanqun Wang Jingxian Zhao Jincun Zhao Hongbin Song | 2023 | Signal Transduction and Targeted Therapy2023，8，4： | 0 |
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