|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | A long-form α-neurotoxin from cobra venom produces potent opioid-independent analgesia显示文摘Aim:In light of the antinociceptive activity of the short-chain neurotoxin,cobrotoxin,and other acetylcholine antagonists,the antinociceptive activity andmechanisms of cobratoxin(CTX),a long-chain postsynaptic α-neurotoxin,wasinvestigated in rodent pain models.Methods:CTX was administered intraperito-neally(30,45,68 μg/kg),intra-cerebral ventricularly(4.5 μg/kg)or microinjectedinto periaqueductal gray(PAG;4.5 μg/kg).The antinociceptive action was testedusing the hot-plate and acetic acid writhing tests m mice and rats.The involve-ment of the cholinergic system and opioid system in CTX-induced analgesia wasexamined by pretreatment of animals with atropine(0.5 mg/kg,im;or 10 mg/kg,ip)or naloxone(1 and 5 mg/kg,ip).The effect of CTX on motor activity was testedusing the Animex test.Results:CTX exhibited a dose-dependent analgesic ac-tion in mice as determined by both the hot-plate and acetic acid writhing tests.The peak effect of analgesia was seen 3 h after administration.In the mouse aceticacid writhing test,the intra-cerebral ventricular administration of CTX at 4.5 μg/kg(1/12th of a systemic dose)produced marked analgesic effects.Microinjection ofCTX(4.5 μgkg)into the PAG region did not elicit an analgesic action in rats in thehot-plate test.Atropine at 0.5 mg/kg(im)and naloxone at 1 and 5 mg/kg(ip)bothfailed to block the analgesic effects of CTX,but atropine at 10 mg/kg(ip)didantagonize the analgesia mediated by CTX in the mouse acetic acid writhing test.Acetylsalicylic acid(300 mg/kg)did not enhance the analgesic effects of CTX.Atthe highest effective dose of 68 μg/kg the neurotoxin did not change the sponta-neous mobility of mice.Conclusion:CTX has analgesic effects,which are medi-ated in the central nervous system though not through the PAG.The centralcholinergic system but not opioid system appears to be involved in theantinociceptive action of CTX. | Zhi-xin CHEN Hui-ling ZHANG Zhen-lun GU Bo-wen CHEN Rong HAN Paul F REID Laurence N RAYMOND Zheng-hong QIN | 2006 | Acta Pharmacologica Sinica2006，27，4： | 7 |
| 2 | Suppression of complete Freund's adjuvant-induced adjuvant arthritis by cobratoxin显示文摘 | Yan-li LIU Hai-ming LIN Rong ZOU Jun-chao WU Rong HAN Laurence N RAYMOND Paul F REID Zheng-hong QIN | 2009 | Acta Pharmacologica Sinica2009，30，2： | 6 |
| 3 | Biochemical markers of liver fibrosis in patients with hepatitis C virus infection:a prospective study显示文摘 | Inbert-Bismut F Ratziu V Laurence PL | 2001 | Lancet2001，357，2： | 1 |
| 4 | Design and synthesis of energetic materials 显示文摘 | Fried Laurence E Manaa M Biad Pagoria Philip F | 2001 | Annual Review of Materials Research2001，31，： | 1 |
| 5 | Pantoprazole-induced recurrent anaphylactic shock 显示文摘 | Laurence F Hassane I Magali C | 2002 | Am J Gastroenterology2002，97，11： | 1 |
| 6 | Transpapillary iridium-192 wire in the treatment of malignant bile duct obstruction显示文摘 | LEVITT M D LAURENCE B H CAMERON F | 1988 | Gut1988，29，2： | 1 |
| 7 | Practical spread spectrum pulse compression for ultrasonic tissue imaging显示文摘 | Laurence R W Martin D F | 1998 | IEEE Transactions on Ultrason Ferroelectrics and Frequency Control1998，45，2： | 1 |
| 8 | Density-Dependent Natural Selection in Drosophila:Evolution of Pupation Height显示文摘 | Mueller Laurence D Sweet Vaughn F | 1986 | Evolution1986，40，6： | 1 |
| 9 | Investigation of some factors affecting non flame generation and suppression of SO3显示文摘 | Zetlmeisl M J McCarthy K J Laurence D F | 1983 | Industrial Engineering and Chemistry Product Research and Development1983，，22： | 1 |
| 10 | Intraoperative identification of esophageal sentinel lymph nodes with near - infrared fluorescence imaging显示文摘 | Parungo C P Ohnishi S Kim S W Kim S Laurence R G Soltesz E G Chen F Y Colson Y L Cohn L H Bawendi M G Frangioni J V | 2005 | The Journal of Thoracic and Cardiovascular Surgery2005，129，4： | 1 |
| 11 | Mesoscale modeling of irreversible volume growth in powders of anisotropic crystals显示文摘 | Richard H G Amitesh M Laurence E F | 2007 | Applied Physics Letters2007，90，2541： | 1 |
| 12 | Specialization in service industry employment as a state policy 显示文摘 | Laurence F H | 1980 | Growth & change1980，11，： | 1 |
| 13 | Li-O2and Li-S batteries with high energy storage显示文摘 | PETER G B STEPHEN A F LAURENCE J H | 2012 | Nature Materials2012，11，： | 1 |
| 14 | Aggressive variant of a papillary glioneuronal tumor显示文摘 | Ramin JJ Laurence D Jason F | 2009 | Neurosurg Pediatr2009，3，1： | 1 |
| 15 | Experimental design methodology for the preparation of carbonaceous sorbents from sewage sludge bychemical activation application to air and water treatments显示文摘 | SEBASTIEN R CATHERINE F B LAURENCE L C | 2005 | Chemosphere2005，58，： | 1 |
| 16 | What Designers of Bus and Network Architectures Should Know about Hypercubes显示文摘 | Laurence E LaForge Kirk F Korver M Sami Fadali | 2003 | IEEE Transactions on Computers (S0018-9340)2003，52，4： | 1 |
| 17 | Angiotensin II Type 1 Receptor Gene Polymorphisms in Human Essential Hypertension显示文摘 | Alain Bonnardeaux Eleanor Davies Xavier Jeunemaitre Isabelle Féry Anne Charru Eric Clauser Laurence Tiret Fran?ois Cambien Pierre Corvol Florent Soubrier | 1994 | Hypertension1994，，1： | 1 |
| 18 | Poly(methylmethacrylate-dimethylsiloxane) triblock copolymers synthesized by transition metal mediated living radical polymerization: bulk and surface characterization显示文摘 | Laurence Bes Kim Huan Ezat Khoshdel Martin J Lowe Christopher F McConville David M Haddleton | 2002 | European Polymer Journal2002，，1： | 1 |
| 19 | Characterization of a multigene family encoding an endopolygalacturonase in Sclerotinia sclerotiorum显示文摘 | Laurence Fraissinet-Tachet Pascale Reymond-Cotton Michel Fèvre | 1995 | Current Genetics1995，，1： | 1 |
| 20 | Evidence of human papilloma virus infection but lack of Epstein-Barr virus in lymphoepithelioma-like carcinoma of uterine cervix: report of two cases and review of the literature 显示文摘 | Jean-Christophe N Laurence L Isabelle F | 2001 | Human Pathology2001，32，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员