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| 1 | Axial strain enhances osteotomy repair with a concomitant increase in connexin43 expression显示文摘The mechanical environment is known to influence fracture healing. We speculated that connexin43(Cx43) gap junctions, which impact skeletal homeostasis, fracture healing and the osteogenic response to mechanical load,may play a role in mediating the response of the healing bone to mechanical strain. Here, we used an established rat fracture model, which uses a 2 mm osteotomy gap stabilized by an external fixator, to examine the impact of various cyclical axial loading protocols(2%, 10%, and 30% strain) on osteotomy healing. We examined the presence of Cx43 in the osteotomy-healing environment and assessed how mechanical strain modulates Cx43 expression patterns in the callus. We demonstrated that increased cyclical axial strain results in increased radiographic and histologic bone formation. In addition, we show by immunohistochemistry that Cx43 is abundantly expressed in the healing callus, with the expression most robust in samples exposed to increased cyclical axial strain. These data are consistent with the concept that an increase in Cx43 expression by mechanical load may be part of the mechanisms by which mechanical forces enhances fracture healing. | Rishi R Gupta Hyunchul Kim Yu-Kwan Chan Carla Hebert Leah Gitajn David J Yoo Robert V O’Toole Adam H Hsieh Joseph P Stains | 2015 | Bone Research2015，3，2： | 2 |
| 2 | The bifunctional x-amylase/subtilisin inhibitor of barley: nucleotide sequence and patterns of seed-specific ex- pression 显示文摘 | Leah R Mundy J | 1989 | Plant Mol Bio1989，12，6： | 1 |
| 3 | Application of genomics and proteomics for identification of bacterial gene products as potential vaccine candidates显示文摘 | Deb N Chakravarti Michael J Fiske Leah D Fletcher Robert J Zagursky | 2001 | Vaccine2001，，6： | 1 |
| 4 | Behavioral activity of catnip (Lamiaceae) essential oil components to the German cockroach (Blattodea:Blattelidae)显示文摘 | Leah M | 2002 | J Econ Entomol2002，95，2： | 1 |
| 5 | High frequency hearing loss correlated with mutations in the GJB2 gene显示文摘 | Stephen A Wilcox Kerryn Saunders Amelia H Osborn Angela Arnold Julia Wunderlich Therese Kelly Veronica Collins Leah J Wilcox RJ McKinlay Gardner Maria Kamarinos Barbara Cone-Wesson Robert Williamson Hans-Henrik M. Dahl | 2000 | Human Genetics2000，，4： | 1 |
| 6 | Identification of a methyl jasmonate-responsive region in the promoter of a lipoxygenase 1 gene expressed in barley grain显示文摘 | Rouster J Leah R Mundy J Cameron-Mills | | 0，，03： | 1 |
| 7 | Lack of energy compensation over 4 days when white button mushrooms are substi- tuted for beef显示文摘 | LAWRENCE J C LISA M D LEAH M L | 2008 | Appetite2008，51，1： | 1 |
| 8 | Identification of a methyl jasmonate-responsive region in the promoter of a lipoxygenase 1 gene expressed in barley grain显示文摘 | ROUSTER J LEAH R MUNDY J | 1997 | The Plant Journal1997，11，3： | 1 |
| 9 | Identifieation of a methyljasmonate -responsive region in the promoter of a lipoxygenase1 gene expressed in barley grain显示文摘 | Rouster J Leah R Mundy J | 1997 | Plant J1997，11，3： | 1 |
| 10 | Identification of a methyl jasmonate-responsive region in the promoter of a lipoxygenase 1 gene expressed in barley grain 显示文摘 | Rouster J Leah R Mundy J | 1997 | The Plant Journal1997，11，3： | 1 |
| 11 | Delp An Overview of Parallel Processing Approaches to Image and Video Compression显示文摘 | Gregory W Cook Leah H Jamieson Edward J | 1994 | Proceedings of SPIE-The International Society for Optical Engineering1994，2186，： | 1 |
| 12 | on-line scheduling of unit time with rejection: minimizing the total completion time显示文摘 | Leah Epstein Join Noga Gerhard J Woeginger | 2002 | Operations Research Letters2002，30，： | 1 |
| 13 | Identification of a methyl jasmonate - responsive region in the promoter of a lipoxygenase 1 gene expressed in barley grain 显示文摘 | Rouster J Leah R Mundy J V | 1997 | Plant J1997，11，3： | 1 |
| 14 | The Registry of the International Society for Heart and Lung Transplantation: Twenty-seventh official adult lung and heart-lung transplant report-2010 显示文摘 | Christie J D Leah B Anna Y | 2010 | J Heart Lung Transplant2010，29，10： | 1 |
| 15 | Accuracy of neural network approximator in simulation-optimization显示文摘 | Virginia M J Leah L R | 2000 | Journal of Water Resources Planning and Management ASCE2000，126，2： | 1 |
| 16 | The coexistence of neuropeptides in feline sensory neurons 显示文摘 | CAMERSON A A LEAH J D SNOW P J | 1988 | Neuroscience1988，，27： | 1 |
| 17 | Association between elevated activity of aryl aeylamidase and propanil resistance in jungle-rice, Echinochloa colona 显示文摘 | Leah J M Caseley J C Riches C R | 1994 | Pesticide Science1994，42，4： | 1 |
| 18 | The bifunctional c-amylase/ subtilisin inhibitor of barley: nucleotide sequence and patterns of seed-specific expression显示文摘 | Leah R Mundy J | 1989 | Plant Molecular Biology1989，12，： | 1 |
| 19 | Age-related mechanisms of propanil tolerance in jungle-rice, Echinochloa colona 显示文摘 | Leah J M Caseley J C Riches C R | 1995 | Pesticide Science1995，43，4： | 1 |
| 20 | Interaction between Spathius agrili(Hymenoptera:Braconidae) and Tetrastichus planipennisi(Hymenoptera; Eulophidae),larval parasitioids of Agrilus planipennis(Coleoptera:Buprestidae)显示文摘 | Michael D Ulyshen Jian J Duan Leah S Bauer | 2010 | Biological Control2010，52，： | 1 |
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