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| 1 | Calcium channel blocker monotherapy versus combination with reninangiotensin system inhibitors on the development of new-onset diabetes mellitus in hypertensive Korean patients显示文摘Background In real practice, two or more antihypertensive drugs are needed to achieve target blood pressure. We investigated the comparative beneficial actions of combination therapy of renin-angiotensin system inhibitors (RASI), with calcium channel blockers (CCB) over CCB monotherapy on the development of new-onset diabetes mellitus (NODM) in Korean patients during four-year follow-up periods. Methods A total of 3208 consecutive hypertensive patients without a history of diabetes mellitus who had been prescribed CCB were retrospectively enrolled from January 2004 to December 2012. These patients were divided into the two groups according to the additional use of RASI (the RASI group, n = 1221 and the no RASI group, n = 1987). Primary endpoint was NODM, defined as a fasting blood glucose ≥ 126 mg/dL or hemoglobin A1c ≥ 6.5%. Secondary endpoint was major adverse cardiac events (MACE) defined as total death, myocardial infarction (MI) and percutaneous coronary intervention (PCI). Results After propensity score-matched (PSM) analysis, two propensity- matched groups (939 pairs, n = 1878, C-statistic = 0.743) were generated. The incidences of NODM (HR = 1.009, 95% CI: 0.700–1.452, P = 0.962), MACE (HR = 0.877, 95% CI: 0.544–1.413, P = 0.589), total death, MI, PCI were similar between the two groups after PSM during four years. Conclusions The use of RASI in addition to CCB showed comparable incidences of NODM and MACE compared to CCB monotherapy in non-diabetic hypertensive Korean patients during four-year follow-up period. However, large-scaled randomized controlled clinical trials will be required for a more definitive conclusion. | Yong Hoon Kim Ae-Young Her Seung-Woon Rha Byoung Geol Choi Se Yeon Choi Jae Kyeong Byun Yoonjee Park Dong Oh Kang Won Young Jang Woohyeun Kim Woong Gil Choi Tae Soo Kang Jihun Ahn Sang-Ho Park Ji Young Park Min-Ho Lee Cheol Ung Choi Chang Gyu Park Hong Seog Seo | 2019 | Journal of Geriatric Cardiology2019，16，6： | 3 |
| 2 | Five-year clinical outcomes of first-generation versus second-generation drug-eluting stents following coronary chronic total occlusion intervention显示文摘Background There are limited data comparing long-term clinical outcomes between first-generation (1G) and second-generation (2G) drug-eluting stents (DESs) in patients who underwent successful percutaneous coronary intervention (PCI) for coronary chronic total occlusion (CTO) lesion. Methods A total of 840 consecutive patients who underwent PCI with DESs for CTO lesion from January 2004 to November 2015 were enrolled. Finally, a total of 324 eligible CTO patients received 1G-DES (Paclitaxel-eluting stent or Sirolimus-eluting stent, n = 157) or 2G-DES (Zotarolimus-eluting stent or Everolimus-eluting stent, n = 167) were enrolled. The clinical endpoint was the occurrence of major adverse cardiac events (MACE) defined as all-cause death, recurrent myocardial infarction (re-MI), total repeat revascularization [target lesion revascularization (TLR), target vessel revascularization (TVR), and non-TVR]. We investigated the 5-year major clinical outcomes between 1G-DES and 2G-DES in patient who underwent successful CTO PCI. Results After propensity score matched (PSM) analysis, two well-balanced groups (111 pairs, n = 222, C-statistic = 0.718) were generated. Up to the 5-year follow-up period, the cumulative incidence of all-cause death, re-MI, TLR, TVR and non-TVR were not significantly different between the two groups. Finally, MACE was also similar between the two groups (HR = 1.557, 95% CI: 0.820–2.959, P = 0.176) after PSM. Conclusions In this study, 2G-DES was not associated with reduced long-term MACE compared with 1G-DES following successful CTO revascularization up to five years. | Yong Hoon Kim Ae-Young Her Seung-Woon Rha Byoung Geol Choi Se Yeon Choi Jae Kyeong Byun Yoonjee Park Dong Oh Kang Won Young Jang Woohyeun Kim Ju Yeol Baek Woong Gil Choi Tae Soo Kang Jihun Ahn Sang-Ho Park Ji Young Park Min-Ho Lee Cheol Ung Choi Chang Gyu Park Hong Seog Seo | 2019 | Journal of Geriatric Cardiology2019，16，8： | 1 |
| 3 | Low-temperature toughening mechanism in thermomechanically processed high-strength low-alloy steels 显示文摘 | Byoungchul Hwang Chang Gil Lee Sung-Joon Kim | 2011 | Metallurgical and Materials Transactions A2011，42，3： | 1 |
| 4 | Composite heddle frame for high-speed looms显示文摘 | Dai Gil Lee Chang Sup Lee etc | 1999 | Composite Structures1999，，47： | 1 |
| 5 | Correlation of microstructure and mechanical properties of thermo mechanically processed low-carbon steels containing boron and copper显示文摘 | Hwang Byoungchul Lee Chang Gil and Lee Tae-Ho | 2010 | Metallurgical and Materials Transactions A2010，41，1： | 1 |
| 6 | Charac- teristcs of Carbon Fiber Phenolic Composite for Journal Bearing Materials 显示文摘 | Kim Seong Su Park Dong Chang Lee Dai Gil | 2004 | Composite Structures2004，66，： | 1 |
| 7 | Neuroprotective effects of tadalafil on gerbil dopaminergic neurons following cerebral ischemia显示文摘Impairment of dopamine function,which is known to have major effects on behaviors and cognition,is one of the main problems associated with cerebral ischemia.Tadalafil,a long-acting phosphodiesterase type-5 inhibitor,is known to ameliorate neurologic impairment induced by brain injury,but not in dopaminergic regions.We investigated the neuroprotective effects of treatment with tadalafil on cyclic guanosine monophosphate level and dopamine function following cerebral ischemia.Forty adult Mongolian gerbils were randomly and evenly divided into five groups (n=8 in each group):Sham-operation group,cerebral ischemia-induced and 0,0.1,1,and 10 mg/kg tadalafil-treated groups,respectively.Tadalafil dissolved in distilled water was administered orally for 7 consecutive days,starting 1 day after surgery.Cyclic guanosine monophosphate assay and immunohistochemistry were performed for thyrosine hydroxylase expression and western blot analysis for dopamine D 2 receptor expression.A decrease in cyclic guanosine monophosphate level following cerebral ischemia was found with an increase in thyrosine hydroxylase activity and a decrease in dopamine D 2 receptor expression in the striatum and substantia nigra region.However,treatment with tadalafil increased cyclic guanosine monophosphate expression,suppressed thyrosine hydroxylase expression and increased dopamine D 2 receptor expression in the striatum and substantia nigra region in a dose-dependent manner.Tadalafil might ameliorate cerebral ischemia-induced dopaminergic neuron injury.Therefore,tadalafil has the potential as a new neuroprotective treatment strategy for cerebral ischemic injury. | Kwang Taek Kim Kyung Jin Chung Han Sae Lee Il Gyu Ko Chang Ju Kim Yong Gil Na Khae Hawn Kim | 2013 | Neural Regeneration Research2013，8，8： | 1 |
| 8 | Characteristics of Carbon Fiber Phenolic Composite for Journal Bearing Materials显示文摘 | Kim Seong Su Park Dong Chang Lee Dai Gil | 2004 | Composite Structures2004，66，： | 1 |
| 9 | Demonstration of 10 Gbps, all - optical encryption and decryption system utilizing SOA XOR logic gates 显示文摘 | Young Jin Jung Chang Wan Son Seok Lee Sangkeun Gil Hyung Seok Kim and Namkyoo Park | 2008 | Opt Quant Electron2008，40，： | 1 |
| 10 | Fatigue crack propagation behavior of friction stir welded 5083-H32 and 6061-T651 aluminum alloys显示文摘 | Sangshik Kim Chang Gil Lee Sung-Joon Kim | 2008 | Materials Science and Engineering A2008，478，2： | 1 |
| 11 | Effect of tramp elements on formability of low carbon trip-aided muhiphase cold-rolled steel sheets 显示文摘 | LEE Chang Gil KIM Sung-Joon LEE Tae-Ho | 2004 | ISIJ Inter2004，44，4： | 1 |
| 12 | Effect of test temperature on the dynamic torsional deformation behavior of two aluminum-lithium alloys显示文摘 | Chang Gil Lee Ki Jong Kim Sunghak Lee Kyungmox Cho | 1998 | Metallurgical and Materials Transactions A1998，，2： | 1 |
| 13 | Would complex decongestive therapy reveal long term effect and lymphoscintigraphy predict the outcome of lower-limb lymphedema related to gynecologic cancer treatment?显示文摘 | Young Bum Kim Ji Hye Hwang Tae Won Kim Hyun Ju Chang Sang Gil Lee | 2012 | Gynecologic Oncology2012，，3： | 1 |
| 14 | Glass composite vibration isolating structure for the LNG cargo containment system显示文摘 | Jaeheon Choe Ki Hyun Kim Dongyoung Lee Chang Seon Bang Dai Gil Lee | 2014 | Composite Structures2014，，： | 1 |
| 15 | Correlation of microstructure and microfracture mechanism of five work rolls显示文摘 | Gwihwan Byun Seungchan Oh Chang Gil Lee Sunghak Lee | 1999 | Metallurgical and Materials Transactions A1999，，1： | 1 |
| 16 | Observation of adiabatic shear bands formed by ballistic impact in aluminum-lithium alloys显示文摘 | Chang Gil Lee Yeung-Jo Lee | 1995 | Scripta Metallurgica of Materialia1995，32，6： | 1 |
| 17 | Correla- tion of Microstructure and Mechanical Properties of Thermo- mechanically Processed Low-Carbon Steels Containing Boron and Copper显示文摘 | Hwang Byoungchul Lee Chang Gil Lee Tae-Ho | 2010 | Metallurgical and Materials Transactions A2010，41，1： | 1 |
| 18 | Effect of Tramp Elements on Formability of Low carbon TRIP - aided Multiphase Coldrolled Steel Sheets显示文摘 | Lee Chang Gil Kim Sung - Joon Lee Tae - Ho | 2004 | ISIJ International2004，44，4： | 1 |
| 19 | Effects of coiling temperature on mierostrueture and mechanical properties of high-strength hotrolled steel plates containing Cu, Cr and Ni显示文摘 | Kim Sung-joon Lee Chang Gil Lee Tae-ho | 2000 | ISIJ International2000，40，7： | 1 |
| 20 | Rapamycin inhibits both motility through down-regulation of p-STAT3 (S727) by disrupting the mTORC2 assembly and peritoneal dissemination in sarcomatoid cholangiocarcinoma显示文摘 | Sun Mi Hong Chang Wook Park Hyung Jin Cha Jung Hee Kwon Young Sung Yun Nam Gyu Lee Dae-Ghon Kim Hong Gil Nam Kwan Yong Choi | 2013 | Clinical & Experimental Metastasis2013，，2： | 1 |
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