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| 1 | Prevalence of Nontraumatic Osteonecrosis of the Femoral Head and its Associated Risk Factors in the Chinese Population: Results from a Nationally Representative Survey显示文摘 | De-Wei Zhao Mang Yu Kai Hu Wei Wang Lei Yang Ben-Jie Wang Xiao-Hong Gao Yong-Ming Guo Yong-Qing Xu Yu-Shan Wei Si-Miao Tian Fan Yang Nan Wang Shi-Bo Huang Hui Xie Xiao-Wei Wei Hai-Shen Jiang Yu-Qiang Zang Jun Ai Yuan-Liang Chen Guang-Hua Lei Yu-Jin Li Geng Tia Zong-Sheng Li Yong Cao Li Ma | 2015 | Chinese Medical Journal2015，，21： | 151 |
| 2 | Ligustrazine monomer against cerebral ischemia/reperfusion injury显示文摘Ligustrazine(2,3,5,6-tetramethylpyrazine) is a major active ingredient of the Szechwan lovage rhizome and is extensively used in treatment of ischemic cerebrovascular disease.The mechanism of action of ligustrazine use against ischemic cerebrovascular diseases remains unclear at present.This study summarizes its protective effect,the optimum time window of administration,and the most effective mode of administration for clinical treatment of cerebral ischemia/reperfusion injury.We examine the effects of ligustrazine on suppressing excitatory amino acid release,promoting migration,differentiation and proliferation of endogenous neural stem cells.We also looked at its effects on angiogenesis and how it inhibits thrombosis,the inflammatory response,and apoptosis after cerebral ischemia.We consider that ligustrazine gives noticeable protection from cerebral ischemia/reperfusion injury.The time window of ligustrazine administration is limited.The protective effect and time window of a series of derivative monomers of ligustrazine such as 2-[(1,1-dimethylethyl)oxidoimino]methyl]-3,5,6-trimethylpyrazine,CXC137 and CXC195 after cerebral ischemia were better than ligustrazine. | Hai-jun Gao Peng-fei Liu Pei-wen Li Zhuo-yan Huang Feng-bo Yu Ting Lei Yong Chen Ye Cheng Qing-chun Mu Hai-yan Huang | 2015 | Neural Regeneration Research2015，10，5： | 48 |
| 3 | Achieving over 16% efficiency for single-junction organic solar cells显示文摘To achieve high photovoltaic performance of bulk hetero-junction organic solar cells(OSCs), a range of critical factors including absorption profiles, energy level alignment, charge carrier mobility and miscibility of donor and acceptor materials should be carefully considered. For electron-donating materials, the deep highest occupied molecular orbital(HOMO) energy level that is beneficial for high open-circuit voltage is much appreciated. However, a new issue in charge transfer emerges when matching such a donor with an acceptor that has a shallower HOMO energy level. More to this point, the chemical strategies used to enhance the absorption coefficient of acceptors may lead to increased molecular crystallinity, and thus result in less controllable phase-separation of photoactive layer. Therefore, to realize balanced photovoltaic parameters, the donor-acceptor combinations should simultaneously address the absorption spectra, energy levels, and film morphologies. Here, we selected two non-fullerene acceptors, namely BTPT-4F and BTPTT-4F, to match with a wide-bandgap polymer donor P2F-EHp consisting of an imidefunctionalized benzotriazole moiety, as these materials presented complementary absorption and well-matched energy levels. By delicately optimizing the blend film morphology, we demonstrated an unprecedented power conversion efficiency of over 16% for the device based on P2F-EHp:BTPTT-4F, suggesting the great promise of materials matching toward high-performance OSCs. | Baobing Fan Difei Zhang Meijing Li Wenkai Zhong Zhaomiyi Zeng Lei Ying Fei Huang Yong Cao | 2019 | Science China Chemistry2019，62，6： | 38 |
| 4 | Effect of wastewater COD/N ratio on aerobic nitrifying sludge granulation and microbial population shift显示文摘The effect of COD/N ratio on the granulation process and microbial population succession was investigated.Four identical sequencing batch reactors,R1,R2,R3 and R4,were operated with various initial COD/N ratios ranging from 0/200 to 800/200(m/m).Ethanol was fed as the source of COD.Aerobic granules were successfully cultivated in R2 and R3,operating with the COD/N ratio of 200/200 and 400/200,respectively.Scanning electron microscope observations indicated that short rod-shaped and spherical bacteria were dominant in R2,while granules produced in R3 were surrounded with a large amount of filamentous bacteria.The average specific nitritation rate in R2 and R3 were 0.019 and 0.008 mg N/(mg MLVSS.hr),respectively.Fluorescence in situ hybridization results demonstrated that nitrifying bacteria population was enriched remarkably in R2.It indicated that nitrification ability and nitrifying bacteria population were enriched remarkably at low COD/N ratio.However,no granules were formed in R1 and R4 which might attribute to either limited or excessive extracellular polymeric substances production.This study contributed to a better understanding of the role of COD/N ratio in nitrifying sludge granulation. | Lei Wu Chengyao Peng Yongzhen Peng Lingyun Li Shuying Wang Yong Ma | 2012 | Journal of Environmental Sciences2012，24，2： | 29 |
| 5 | Stenting for symptomatic intracranial arterial stenosis in China:1-year outcome of a multicentre registry study显示文摘background and purpose A multicentre prospective registry study of individually tailored stenting for a patient with symptomatic intracranial atherosclerotic stenosis(ICAS)combined with poor collaterals in China showed that the short-term safety and efficacy of stenting was acceptable.However,it remained uncertain whether the low event rate could be of a long term.We reported the 1-year outcome of this registry study to evaluate the long-term efficacy of individually tailored stenting for patients with severe symptomatic ICAS combined with poor collaterals.Methods Patients with symptomatic ICAS caused by 70%-99% stenosis located at the intracranial internal carotid,middle cerebral,intracranial vertebral or basilar arteries combined with poor collaterals were enrolled.Balloon-mounted stent or balloon plus self-expanding stent were selected based on the ease of vascular access and lesion morphology determined by the operators.The primary outcome was the rate of 30-day stroke,transient ischaemic attack and death,and 12-month ischaemic stroke within the same vascular territory,haemorrhagic stroke and vascular death after stenting.results From September 2013 to January 2015,300 patients(ages 58.3±9.78 years)were recruited.Among them,159 patients were treated with balloon-mounted stent and 141 with balloon plus self-expanding stent.During the 1-year follow-up,25 patients had a primary end point event.The probability of primary outcome at 1 year was 8.1%(95% CI 5.3% to 11.7%).In 76 patients with digital subtraction angiography follow-up,27.6%(21/76)had re-stenosis≥50% and 18.4%(14/76)had re-stenosis≥70%.No baseline characteristic was associated with the primary outcome.Conclusion The event rate remains low over 1 year of individually tailored stenting for patients with severe symptomatic ICAS combined with poor collaterals.Further randomised trial of comparing individually tailored stenting with best medical therapy is needed. | Ning Ma Yong Zhang Jie Shuai Changchun Jiang Qiyi Zhu Kangning Chen Li Liu Baomin Li Xiangqun Shi Lianbo Gao Yajie Liu Feng Wang Yongli Li Tieyan Liu Hongbo Zheng Dapeng Mo Feng Gao Yilong Wang Yongjun Wang Lei Feng Zhongrong Miao | 2018 | Stroke & Vascular Neurology2018，3，3： | 29 |
| 6 | Arsenic removal from contaminated soil using phosphoric acid and phosphate显示文摘实验室批实验被进行学习砷(作为) 从用磷酸(H3PO4 ) 和钾 dihydrogen 磷酸盐(KH2PO4 ) 的自然地污染的土壤的移动。H3PO4 和 KH2PO4 证明了作为内容以土壤减少土壤的毒性,作为在 200 mmol/L 的集中的移动达到超过 20% 。同时,土壤的使发酸和土壤部件(Ca, Mg,和 Si ) 的溶解源于使用这二提炼之物,特别 H3PO4。这二提炼之物的有效性能被归因于代替作为由磷酸盐离子(PO43 ) 。溶解的酸玷污部件的 H3PO4 的功能作为移动穿上小效果。KH2PO4 几乎搬迁了像一样,显示它是更有希望的提炼之物作为 H3PO4,而是它没导致土壤的严重损坏。当移动为土壤部件,特别 Mg 和 Ca 的 360 min,而是溶解在孵化以后到达了平衡,运动研究的结果显示出那,是很快速的。因此如果,土壤部件的溶解将是不可避免的这是进一步的搬迁。Elovich 模型最好描述了运动数据作为在四之中的移动,模型在运动学习用作。 | ZENG Min LIAO Bohan LEI Ming ZHANG Yong ZENG Qingru OUYANG Bin | 2008 | Journal of Environmental Sciences2008，20，1： | 28 |
| 7 | Late Triassic sedimentary records in the northern Tethyan Himalaya:Tectonic link with Greater India显示文摘The Upper Triassic flysch sediments(Nieru Formation and Langjiexue Group)exposed in the Eastern Tethyan Himalayan Sequence are crucial for unraveling the controversial paleogeography and paleotectonics of the Himalayan orogen.This work reports new detrital zircon U-Pb ages and whole-rock geochemical data for clastic rocks from flysch strata in the Shannan area.The mineral modal composition data suggest that these units were mainly sourced from recycled orogen provenances.The chemical compositions of the sandstones in the strata are similar to the chemical composition of upper continental crust.These rocks have relatively low Chemical Index of Alteration values(with an average of 62)and Index of Compositional Variability values(0.69),indicating that they experienced weak weathering and were mainly derived from a mature source.The geochemical compositions of the Upper Triassic strata are similar to those of graywackes from continental island arcs and are indicative of an acidicintermediate igneous source.Furthermore,hornblende and feldspar experienced decomposition in the provenance,and the sediment became enriched in zircon and monazite during sediment transport.The detrital zircons in the strata feature two main age peaks at 225-275 Ma and 500-600 Ma,nearly continuous Paleoproterozoic to Neoproterozoic ages,and a broad inconspicuous cluster in the Tonian-Stenian(800-1200 Ma).The detrital zircons from the Upper Triassic sandstones in the study area lack peaks at 300-325 Ma(characteristic of the Lhasa block)and 1150-1200 Ma(characteristic of the Lhasa and West Australia blocks).Therefore,neither the Lhasa block nor the West Australia blocks likely acted as the main provenance of the Upper Triassic strata.Newly discovered Permian-Triassic basalt and mafic dikes in the Himalayas could have provided the 225-275 Ma detrital zircons.Therefore,Indian and Himalayan units were the main provenances of the flysch strata.The Tethyan Himalaya was part of the northern passive margin and was not an exotic terrane separated from India during the Permian to Early Cretaceous.This evidence suggests that the Neo-Tethyan ocean opened prior to the Late Triassic and that the Upper Triassic deposits were derived from continental crustal fragments adjacent to the northern passive continental margin of Greater India. | Huawen Cao Yong Huang Guangming Li Linkui Zhang Jianyang Wu Lei Dong Zuowen Dai Liu Lu | 2018 | Geoscience Frontiers2018，9，1： | 27 |
| 8 | Three-dimensional hydrodynamic and water quality model for TMDL development of Lake Fuxian,China显示文摘Lake Fuxian is the largest deep freshwater lake in China.Although its average water quality meets Class I of the China National Water Quality Standard(CNWQS),i.e.,GB3838-2002,monitoring data indicate that the water quality approaches the Class II threshold in some areas.Thus it is urgent to reduce the watershed load through the total maximum daily load(TMDL) program.A three-dimensional hydrodynamic and water quality model was developed for Lake Fuxian,simulating flow circulation and pollutant fate and transport.The model development process consists of several steps,including grid generation,initial and boundary condition configurations,and model calibration processes.The model accurately reproduced the observed water surface elevation,spatiotemporal variations in temperature,and total nitrogen(TN),total phosphorus(TP),and chemical oxygen demand(COD) concentrations,suggesting a reasonable numerical representation of the prototype system for further TMDL analyses.The TMDL was calculated using two interpretations of the water quality standards for Class I of the CNWQS based on the maximum instantaneous surface and annual average surface water concentrations.Analysis of the first scenario indicated that the TN,TP and COD loads should be reduced by 66%,68% and 57%,respectively.Water quality was the highest priority;however,local economic development and cost feasibility for load reduction can pose significant issues.In the second interpretation,the model results showed that,under the existing conditions,the average water quality meets the Class I standard and therefore load reduction is unnecessary.Future studies are needed to conduct risk and cost assessments for realistic decision-making. | Lei Zhao Xiaoling Zhang Yong Liu Bin He Xiang Zhu Rui Zou Yuanguan Zhu | 2012 | Journal of Environmental Sciences2012，24，8： | 25 |
| 9 | Application of yolk-shell Fe3O4@N-doped carbon nanochains as highly effective microwave-absorption material显示文摘 | Mingtao Qiao Xingfeng Lei Yong Ma Lidong Tian Xiaowei He Kehe Su Qiuyu Zhang | 2018 | Nano Research2018，11，3： | 26 |
| 10 | Two micron continuous wave laser vaporesection for the treatment of benign prostatic hyperplasia显示文摘 | Wei-Jun Fu Bao-Fa Hong Yong Yang Jiang-Ping Gao Lei Zhang Wei Cai Yao-Fu Chen Xiao-Xiong Wang | 2008 | Asian Journal of Andrology2008，10，2： | 23 |
| 11 | Spectral CT imaging as a new quantitative tool? Assessment of perfusion defects of pulmonary parenchyma in patients with lung cancer显示文摘Objective:This study investigated the capability of dual-energy spectral computed tomography(CT)to quantitatively evaluate lung perfusion defects that are induced by central lung cancer.Methods:Thirty-two patients with central lung cancer underwent CT angiography using spectral imaging.A univariate general linear model was conducted to analyze the variance of iodine concentration/CT value with three factors of lung fields.A paired t-test was used to compare iodine concentrations and CT values between the distal end of lung cancer and the corresponding area in the contralateral normal lung.Results:Iodine concentrations increased progressively in the far,intermediate and near ground sides in the normal lung fields at 0.60±0.28,0.93±0.27 and 1.25±0.38 mg/mL,respectively(P<0.001).The same trend was observed for the CT values[–(840.64±49.08),–(812.66±50.85)and–(760.83±89.17)HU,P<0.001].The iodine concentration(0.70±0.42 mg/mL)of the lung field in the distal end of lung cancer was significantly lower than the corresponding area in the contralateral normal lung(1.19±0.62 mg/mL)(t=–7.23,P<0.001).However,the CT value of lung field in the distal end of lung cancer was significantly higher than the corresponding area in the contralateral normal lung[–(765.29±93.34)HU vs.–(800.07±76.18)HU,t=3.564,P=0.001].Conclusions:Spectral CT imaging based on the spectral differentiation of iodine is feasible and can quantitatively evaluate pulmonary perfusion and identify perfusion defects that are induced by central lung cancer.Spectral CT seems to be a promising technique for the simultaneous evaluation of both morphological and functional lung information. | Ying-Shi Sun Xiao-Yan Zhang Yong Cui Lei Tang Xiao-Ting Li Ying Chen Xiao-Peng Zhang | 2013 | Chinese Journal of Cancer Research2013，25，6： | 23 |
| 12 | Autoantibody to MOG suggests two distinct clinical subtypes of NMOSD显示文摘We characterized a unique group of patients with neuromyelitis optica spectrum disorder(NMOSD) who carried autoantibodies of aquaporin-4(AQP4) and myelin-oligodendrocyte glycoprotein(MOG). Among the 125 NMOSD patients, 10(8.0%) were AQP4- and MOG-ab double positive, and 14(11.2%) were MOG-ab single positive. The double-positive patients had a multiphase disease course with a high annual relapse rate(P=0.0431), and severe residual disability(P<0.0001). Of the double-positive patients, 70% had MS-like brain lesions, more severe edematous, multifocal regions on spinal magnetic resonance imaging(MRI), pronounced decreases of retinal nerve fiber layer thickness and atrophy of optic nerves. In contrast, patients with only MOG-ab had a higher ratio of monophasic disease course and mild residual disability. Spinal cord MRI illustrated multifocal cord lesions with mild edema, and brain MRIs showed more lesions around lateral ventricles. NMOSD patients carrying both autoantibodies to AQP4 and MOG existed and exhibited combined features of prototypic NMO and relapsing-remitting form of MS, whereas NMOSD with antibodies to MOG only exhibited an 'intermediate' phenotype between NMOSD and MS. Our study suggests that antibodies against MOG might be pathogenic in NMOSD patients and that determination of anti-MOG antibodies maybe instructive for management of NMOSD patients. | Yaping Yan Yujing Li Ying Fu Li Yang Lei Su Kaibin Shi Minshu Li Qiang Liu Aimee Borazanci Yaou Liu Yong He Jeffrey L Bennett Timothy L Vollmer Fu-Dong Shi | 2016 | Science China(Life Sciences)2016，59，12： | 20 |
| 13 | The Role of Fibrocyte in the Pathogenesis of Silicosis显示文摘Exposure to free silica induces silicosis and myofibroblasts are regarded as primary effector cells.Fibrocytes can differentiate into myofibroblast.Therefore,the present study was designed to investigate whether | LI Juan YAO Wu HOU Jian Yong ZHANG Lin BAO Lei CHEN Hui Ting WANG Di YUE Zhong Zheng LI Yi Ping ZHANG Miao YU Xing Hao ZHANG Jian Hui QU Ya Qian HAO Chang Fu | 2018 | Biomedical and Environmental Sciences2018，31，4： | 20 |
| 14 | Single-cell transcriptomics reveals regulators underlying immune cell diversity and immune subtypes associated with prognosis in nasopharyngeal carcinoma显示文摘Nasopharyngeal carcinoma(NPC)is an aggressive malignancy with extremely skewed ethnic and geographic distributions.Increasing evidence indicates that targeting the tumor microenvironment(TME)represents a promising therapeutic approach in NPC,highlighting an urgent need to deepen the understanding of the complex NPC TME.Here,we generated single-cell transcriptome profiles for 7581 malignant cells and 40,285 immune cells from fifteen primary NPC tumors and one normal sample.We revealed malignant signatures capturing intratumoral transcriptional heterogeneity and predicting aggressiveness of malignant cells.Diverse immune cell subtypes were identified,including novel subtypes such as CLEC9A^+dendritic cells(DCs).We further revealed transcriptional regulators underlying immune cell diversity,and cell–cell interaction analyses highlighted promising immunotherapeutic targets in NPC.Moreover,we established the immune subtype-specific signatures,and demonstrated that the signatures of macrophages,plasmacytoid dendritic cells(pDCs),CLEC9A^+DCs,natural killer(NK)cells,and plasma cells were significantly associated with improved survival outcomes in NPC.Taken together,our findings represent a unique resource providing in-depth insights into the cellular heterogeneity of NPC TME and highlight potential biomarkers for anticancer treatment and risk stratification,laying a new foundation for precision therapies in NPC. | Yu-Pei Chen Jian-Hua Yin Wen-Fei Li Han-Jie Li Dong-Ping Chen Cui-Juan Zhang Jia-Wei Lv Ya-Qin Wang Xiao-Min Li Jun-Yan Li Pan-Pan Zhang Ying-Qin Li Qing-Mei He Xiao-Jing Yang Yuan Lei Ling-Long Tang Guan-Qun Zhou Yan-Ping Mao Chen Wei Ke-Xu Xiong Hong-Bo Zhang Shi-Da Zhu Yong Hou Ying Sun Michael Dean Ido Amit Kui Wu Dong-Ming Kuang Gui-Bo Li Na Liu Jun Ma | 2020 | Cell Research2020，30，11： | 19 |
| 15 | Self-healing superhydrophobic polyvinylidene fluoride/ Fe3O4@polypyrrole fiber with core-sheath structures for superior microwave absorption显示文摘Self-healing superhydrophobic polyvinylidene fluoride/Fe 3 O 4@polypyrrole (F-PVDF/Fe 3 有核心鞘结构的 O 4@PPy x ) 纤维被 PVDF/Fe 3 O 4 混合并且在 situ 吡咯的化学氧化聚合,与 fluoroalkyl silane 由化学蒸汽免职列在后面。F-PVDF/Fe 3 当表面化学上被损坏时, O 4@PPy0.075 纤维电影与 self-healing 行为生产 superhydrophobic 表面,它能重复地并且自动地恢复 superhydrophobicity。而且,最大的思考损失(R F-PVDF/Fe 3)> O 4@PPy0.075 纤维电影在 16.8 GHz 和 R 在 10 dB 下面的 L 在有 2.5 公里的厚度的 10.6-16.5 GHz 的频率范围。微波吸收表演被归因于在从 PPy, PVDF 和 Fe 3 O 4 。作为后果,准备如此的 F-PVDF/Fe 3 以这种方式的 O 4@PPy x 纤维提供一条简单、有效的线路开发为实际应用程序吸收材料的多功能的微波。 | Yunan Li Yong Zhao Xianyong Lu Ying Zhu Lei Jiang | 2016 | Nano Research2016，9，7： | 18 |
| 16 | Hemodynamic variables and clinical features correlated with serum uric acid in patients with pulmonary arterial hypertension显示文摘背景浆液尿酸(UA ) ,嘌呤降级的最后的产品,被建议了是为严厉和在有肺的动脉的高血压的病人的死亡的一个可能的预言者的一个标记(哼) 。这研究的目的是阐明浆液 UA 水平是否在中国病人与临床的特征和血液动力学的变量相关与哼并且与不同病原学联系了在病人比较相互关联的差别。方法浆液 UA 与三种类型在 228 个病人被估计哼(自发哼(IPAH ) ,联系的先天的心疾病哼(CHD 哼) 并且联系的结缔组织疾病哼(CTD 哼)) 和另外的临床的特征。在为至少 6 个月的个性化的治疗以后, UA 层次和临床的特征在 88 个病人被重新估计。结果浆液 UA 显著地在病人被提高与与匹配年龄的控制题目相比哼((350.40 ???????? 僚 ?????? 隸??????? 丨吗?? | JIANG Xin HAN Zhi-yan WANG Yong XU Xi-qi MA Chuan-rong WU Yan PAN Lei JING Zhi-cheng | 2008 | Chinese Medical Journal2008，，24： | 17 |
| 17 | Correlation of burial organic carbon and paleoproductivity in the Mesoproterozoic Hongshuizhuang Formation, northern North China显示文摘In general, total organic carbon (TOC) is directly used as a proxy for paleoproductivity, however, it is not only affected by paleoproductivity, but also controlled by redox conditions and terrigenous detrital matter influx. Major and trace elements were analysed with the purpose of investigating the redox potential and paleoproductivity during deposition of the Hongshuizhuang Formation. In the present study, C-S relationship, V/Cr ratio and Mo concentration indicate that the dolomites were deposited in oxic environments, however, most of the black shales were accumulated in euxinic environments. P/Ti values in the Hongshuizhuang samples can be compared with those in the Japanese Ubara Permian-Triassic section which were regarded to be deposited under a moderate to high paleoproductivity. Ba/Al values are slightly lower than that of the laminated sediments from the continental margins of Central California (CCAL) which were thought to be accumulated under a high paleoproductivity. These results indicate that the paleoproductivity was moderate to high during deposition of the Hongshuizhuang Formation. Burial organic carbon shows positive correlations with V/Cr and Mo, but shows only weakly or no correlation with P/Ti and Ba/Al, respectively, suggesting that although the paleoproductivity was moderate to high during deposition of the Hongshuizhuang Formation, its organic-rich sediments were predominantly controlled by redox conditions and had no direct relationship with paleoproductivity. | LUO QingYong ZHONG NingNing ZHU Lei WANG YanNian QIN Jing QI Lin ZHANG Yi MA Yong | 2013 | Chinese Science Bulletin2013，58，11： | 17 |
| 18 | Probabilistic stability analyses of undrained slopes by 3D random fields and finite element methods显示文摘A long slope consisting of spatially random soils is a common geographical feature. This paper examined the necessity of three-dimensional(3 D) analysis when dealing with slope with full randomness in soil properties. Although 3 D random finite element analysis can well reflect the spatial variability of soil properties, it is often time-consuming for probabilistic stability analysis. For this reason, we also examined the least advantageous(or most pessimistic) cross-section of the studied slope. The concept of'most pessimistic' refers to the minimal cross-sectional average of undrained shear strength. The selection of the most pessimistic section is achievable by simulating the undrained shear strength as a 3 D random field. Random finite element analysis results suggest that two-dimensional(2 D) plane strain analysis based the most pessimistic cross-section generally provides a more conservative result than the corresponding full 3 D analysis. The level of conservativeness is around 15% on average. This result may have engineering implications for slope design where computationally tractable 2 D analyses based on the procedure proposed in this study could ensure conservative results. | Yong Liu Wengang Zhang Lei Zhang Zhiren Zhu Jun Hu Hong Wei | 2018 | Geoscience Frontiers2018，9，6： | 17 |
| 19 | An R2R3-type transcription factor gene AtMYB59 regulates root growth and cell cycle progression in Arabidopsis显示文摘MYB 蛋白质在真核细胞的有机体起重要作用。在植物, R1R2R3 类型 MYB 蛋白质在房间周期控制工作。然而, R2R3 类型 MYB 蛋白质是否也涉及房间部门过程,仍然保持未知。这里,我们报导那 R2R3 类型抄写因素基因, AtMYB59,涉及房间周期前进和根生长的规定。AtMYB59 蛋白质在洋葱的原子核是局部性的表皮的房间并且 transactivation 活动。在酵母房间的 AtMYB59 的表示压制房间增长,和 transformants 与更长的房间有更多的原子核和更高的 aneuploid DNA 内容。在 AtMYB59 的保存领域的变化在酵母细胞生长上废除它的效果。在同步 Arabidopsis 房间暂停, AtMYB59 基因明确地在房间周期前进期间在 S 阶段被表示。表示和 promoter-GUS 分析表明 AtMYB59 基因富有地在根被表示。转基因的植物 overexpressing AtMYB59 更短的根与野类型的植物(Arabidopsis 就职 Col-0 ) 相比,并且在在根尖端的有丝分裂的房间的一半附近在中期。相反地,空变异的 myb59-1 比关口在中期让更长的根和更少有丝分裂的房间,建议那 AtMYB59 可以由扩大有丝分裂的房间的中期禁止根生长。AtMYB59 调整许多下游的基因,包括 CYCB1; 1 基因,可能通过到 MYB 应答的元素的绑定。这些结果在细胞周期规定和植物根生长为 AtMYB59 支持一个角色。 | Rui-Ling Mu Yang-Rong Cao Yun-Feng Liu Gang Lei Hong-Feng Zou Yong Liao Hui-Wen Wang Wan-Ke Zhang Biao Ma Ji-Zhou Du Ming Yuan Jin-Song Zhang Shou-Yi Chen | 2009 | Cell Research2009，19，11： | 16 |
| 20 | Combined Influence of Insulin Resistance and Inflammatory Biomarkers on Type 2 Diabetes:A Population-based Prospective Cohort Study of Inner Mongolians in China显示文摘This prospective study was designed to examine the combined influence of insulin resistance(IR)and inflammatory biomarker levels on type 2 diabetes mellitus(T2DM)among 1,903Inner Mongolians.During follow-up,205(10.77%)participants developed T2DM,and the incidence | QIU Qiao Yan ZHANG Bei Lei ZHANG Ming Zhi WU Jia Hui ZHOU Jing Wen LIANG Zhu ZHANG Yong Hong ZHANG Shao Yan | 2018 | Biomedical and Environmental Sciences2018，31，4： | 15 |
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