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| 1 | Transplantation of collagen scaffold with autologous bone marrow mononuclear cells promotes functional endometrium reconstruction via downregulating ΔNp63 expression in Asherman's syndrome显示文摘Asherman's syndrome(AS) is a common disease that presents endometrial regeneration disorder. However, little is known about its molecular features of this aregenerative endometrium in AS and how to reconstruct the functioning endometrium for the patients with AS. Here, we report that ΔNp63 is significantly upregulated in residual epithelial cells of the impaired endometrium in AS; the upregulated-ΔNp63 induces endometrial quiescence and alteration of stemness. Importantly, we demonstrate that engrafting high density of autologous bone marrow mononuclear cells(BMNCs) loaded in collagen scaffold onto the uterine lining of patients with AS downregulates ΔNp63 expression, reverses ΔNp63-induced pathological changes, normalizes the stemness alterations and restores endometrial regeneration. Finally, five patients achieved successful pregnancies and live births. Therefore, we conclude that ΔNp63 is a crucial therapeutic target for AS. This novel treatment significantly improves the outcome for the patients with severe AS. | Guangfeng Zhao Yun Cao Xianghong Zhu Xiaoqiu Tang Lijun Ding Haixiang Sun Juan Li Xinan Li Chenyan Dai Tong Ru Hui Zhu Jingjie Lu Caimei Lin Jingmei Wang Guijun Yan Huiyan Wang Lei Wang Yimin Dai Bin Wang Ruotian Li Jianwu Dai Yan Zhou Yali Hu | 2017 | Science China(Life Sciences)2017，60，4： | 39 |
| 2 | Upregulation of CD81 in trophoblasts induces an imbalance of Treg/Th17 cells by promoting IL-6 expression in preeclampsia显示文摘The disturbance of maternal immune tolerance to a semiallogeneic fetus is recognized as one of the key pathologies of preeclampsia(PE),in which an imbalance between the inflammation-limiting regulatory T cells(Tregs)and the inflammationmediating Th17 cells plays an essential role.Previously,we reported that the abnormal upregulation of tetraspannin CD81 in trophoblast cells(fetal component)participated in the pathogenesis of PE.However,as one of the potential immune regulatory molecules,whether CD81 induces PE by interfering with the balance of the maternal immune system has not yet been clarified.Thus,we investigated the relationship between the upregulation of CD81 in trophoblast cells and the imbalance of Treg and Th17 cells in mothers.Here,we demonstrated that upregulation of CD81 in trophoblast cells was accompanied by a decrease in Treg cells and an increase in Th17 cells in both the basal plate(placental maternal side)and peripheral blood of patients with PE.In vitro culture of naïve T cells with medium from the CD81-overexpressing trophoblast cell line HTR-8 resulted in enhanced differentiation of T cells into Th17 cells and decreased the formation of Tregs,which was dependent on the paracrine signaling of IL-6 in trophocytes,induced by CD81.In a CD81-induced PE rat model,we found a significant shift of T cell differentiation towards Th17 cells,and administration of IL-6 antibody mitigated the PE phenotype and the imbalance of the Treg/Th17 cells.These results define a vital regulatory cascade involving trophocyte-derived CD81,IL-6,and maternal Treg/Th17 cells in the pathogenesis of PE and suggests new therapeutic approaches based on CD81 and IL-6 downregulation to prevent human PE. | Hailin Ding Yimin Dai Yi Lei Zhiyin Wang Dan Liu Ruotian Li Li Shen Ning Gu Mingming Zheng Xiangyu Zhu Guangfeng Zhao Yali Hu | 2019 | Cellular & Molecular Immunology2019，16，3： | 15 |
| 3 | Ceramsite Containing Iron Oxide and its Use as Functional Aggregate in Microwave Absorbing Cement-based Materials显示文摘Electromagnetic(EM) wave absorbing cement-based composite has promising applications in protecting civil and military buildings from electromagnetic interferences. A new idea of preparing EM wave absorbing cement-based composite is proposed by using ceramsite containing iron oxide as EM wave absorbing functional aggregate. The ceramsite was synthesized by adding 10 wt% Fe_3O_4 into clay and sintering at 1 200 ℃, which shows obvious dielectric and magnetic loss properties for electromagnetic wave. The maximum reflection loss(RL) of the concrete specimens prepared with the ceramsite is between-10.2--10.7 dB(corresponding to absorption greater than 90% EM energy) in the bandwidth of 8-18 GHz. In addition, the compressive strength at 28 days age of the concrete is 46 MPa, showing the potentiality of being used as structural components in buildings. | 何永佳 LI Guangfeng 李洪斌 Lü Linnü HE Liu | 2018 | Journal of Wuhan University of Technology(Materials Science)2018，33，1： | 5 |
| 4 | Comparative evaluation of the impact of GRAPES and MM5 meteorology on CMAQ prediction over Pearl River Delta, China显示文摘The community multiscale air quality (CMAQ) model was used to forecast air quality over the Pearl River Delta region from December 2013 to January 2014.The pollution forecasting performance of CMAQ coupled with two different meteorological models,i.e.,the global/regional assimilation and prediction system (GRAPES) and the fifth-generation mesoscale model (MM5),was assessed by comparison with observational data.The effects of meteorological factors and physicochemical processes on the forecast results were discussed through process analysis.The results showed that both models exhibited good performance but that of GRAPES-CMAQ was better.GRAPES was superior in predicting the overall variation tendencies of meteorological fields,but it showed large deviations in atmospheric pressure and wind speed.This contributed to the higher correlation coefficients of the pollutants with GRAPES-CMAQ but with greater deviations.The underestimations of nitrate and ammonium salt contributed to the underestimations of both particulate matter and extinction coefficients.Source emissions made the only positive contributions to surface layer SO2,CO,and NO.It was found that O3 originated primarily from horizontal and vertical transport and that its consumption was predominantly via chemical processes.Conversely,NO2 was found derived primarily from chemical production. | Tao Deng Yiang Chen Qilin Wan Yanxia Zhang Xuejiao Deng Yanyan Huang Guangfeng Dai Fei Li | 2018 | Particuology2018，16，5： | 4 |
| 5 | Cooperative effect from cation and anion of pyridine-containing anion-based ionic liquids for catalysing CO_2 transformation at ambient conditions显示文摘Pyridine-containing anion-based ionic liquids(PA-ILs) with two kinds of interaction sites to bind CO_2, e.g., [P4444][2-OP], were found to be highly efficient for catalysing the cycloaddition reactions of atmospheric CO_2 with epoxides at room temperature under metal-and halogen-free conditions, producing a series of cyclic carbonates in high yields. It was demonstrated that the cooperative interaction from two interaction sites in the anions of PA-ILs activated CO_2, while the cation activated the epoxides substrates via coordination to the central P+ unit, thus resulting in the high activity of the IL catalysts. | Guangfeng Yuan Yanfei Zhao Yunyan Wu Ruipeng Li Yu Chen Dongmei Xu Zhimin Liu | 2017 | Science China Chemistry2017，60，7： | 2 |
| 6 | Study of Cracking Mechanism and Wear Resistance in Laser Cladding Coating of Ni-based Alloy显示文摘Nickel-based alloy coatings were widely used for the remanufacturing of dies and moulds by laser cladding,but the crack sensitivity would be increase due to the higher strength and hardness,which reduced the wear resistance of Ni-based alloys.In this paper,Ni-based coatings with the addition of a plastic phase(an austenitic stainless net)were prepared using laser cladding technology,and the CeO_(2)was added in cladding layers.The cracking mechanism,microhardness,microstructure,phase composition,and wear properties were investigated.The relationship between thermal stress and the elastic and plastic fracture had been developed from the standpoint of fracture mechan-ics and thermal elastic fracture mechanics.The fracture criterion of the nickel-based coating was obtained,and the study has shown that the crack sensitivity could be reduced by decreasing the thermal expansion coefficientΔα.Thus,a new method was proposed,which the stainless steel nets were prefabricated on the substrate.It was found that the number of cracks reduced significantly with the addition of stainless steel net.When the stainless steel net with 14 mesh was added in Ni-based coatings,the average microhardness of nickel composite coating was 565 HV_(0.2),which was 2.6 times higher than that of the 45 steel substrate.Although the rare earth oxide 4 wt.%CeO_(2)and stainless steel net were added in the Ni-based coating reducing the microhardness(the average microhardness is 425 HV_(0.2)),the wear resistance of it improved substantially.The wear volume of Ni-based composite coating was 0.56×10^(−5) mm^(3)·N^(−1)·m^(−1),which was 85.1%lower than that of 45 steel.The experiment results have shown that the Nickel-based composite coating is equipped with low crack sensitivity and high abrasive resistance with austenitic stainless net and the rare earth oxide 4 wt.%CeO2.This research offers an efficient solution to produce components with low crack susceptibility and high wear-resistance coatings fabricated by laser cladding. | Zhenglei Yu Lunxiang Li Deqiang Zhang Guangfeng Shi Guang Yang Zezhou Xu Zhihui Zhang | 2021 | Chinese Journal of Mechanical Engineering2021，34，5： | 2 |
| 7 | Placenta-derived IL-32β activates neutrophils to promote preeclampsia development显示文摘Immune activation at the maternal-fetal interface is a main pathogenic factor of preeclampsia(PE).Neutrophils(PMNs)are activated in PE patients,but the mechanism and consequences of PMN activation need to be further explored.Here,we demonstrated that interleukin-32(IL-32)expression was significantly upregulated in syncytiotrophoblasts(STBs)and that IL-32β was the major isoform with increased expression in the placenta of severe PE(sPE)patients.Furthermore,the level of IL-32 expression in the placenta was correlated with its level in the serum of sPE patients,indicating that IL-32 in the serum is derived mainly from the placenta.Then,in vitro experiments showed that IL-32β could highly activate PMNs and that these IL-32β-activated PMNs were better able to adhere to endothelial cells(HUVECs)and enhance the expression of vascular cell adhesion molecule-1(VCAM-1)and intercellular cell adhesion molecule-1(ICAM-1)in HUVECs,which could be reversed by preincubation with the NADPH oxidase inhibitor VAS 2870.In addition,we showed that IL-32β mainly activated PMNs by binding to proteinase 3.Finally,IL-32β administration induced a PE-like phenotype in a pregnant mouse model.This study provides evidence of the involvement of IL-32β in the pathogenesis of PE. | Dan Liu Qiang Li Hailin Ding Guangfeng Zhao Zhiyin Wang Chenrui Cao Yimin Dai Mingming Zheng Xiangyu Zhu Qianwen Wu Ya Wang Honglei Duan Huirong Tang Xianyan Lu Yayi Hou Yali Hu | 2021 | Cellular & Molecular Immunology2021，18，4： | 2 |
| 8 | Twenty-seven continental ancestry-informative SNP analysis of bone remains to resolve a forensic case显示文摘We employed our previously developed 27-plex ancestry-informative single nucleotide polymorphism(SNP)panel to infer the ancestral components of bone remains of a possible foreign pilot found in south-western China.For ancestry assignment of this unknown individual,we first obtained the 27-SNP genotype of the individual.Then,based on a reference database of 3081 individuals from 33 populations,we calculated the match probability and likelihood ratio using the self-developed software program Forensic Intelligence.Inferred ancestral components of this individual were calculated by structure at K=3.A complete profile was obtained for the individual using our multiplexed SNP assay.The European population was within one order of magnitude of the highest likelihood.The major ancestral component of this individual was 97.6%European. | Qifan Sun Li Jiang Guangfeng Zhang Jing Liu Lei Zhao Wenting Zhao Caixia Li | 2019 | Forensic Sciences Research2019，4，4： | 1 |
| 9 | Investigation on properties of a novel ceria–zirconia–praseodymia solid solution and its application in Pd-only three-way catalyst for gasoline engine emission control显示文摘 | Qiuyan Wang Guangfeng Li Bo Zhao Renxian Zhou | 2011 | Fuel2011，，： | 1 |
| 10 | Unified Geometric Approach to Modelling and Control of Constrained Mechanical Systems显示文摘 | Liu Guangfeng Li Zexiang | 2002 | IEEE Transactions on Robotics and Automation2002，18，4： | 1 |
| 11 | A novel way to isolate MSC s from umbilical cords显示文摘 | Liu Liu Xiaoyin Zhao Pengfei Li Guangfeng Zhao Yaping Wang Yali Hu Yayi Hou | 2012 | Eur J Immunol2012，，8： | 1 |
| 12 | Changes of proteins in the Antarctic ice microalga Chlamydomonas sp. cultured under UV-B radiation stress显示文摘Antarctic ice microalga Chlamydomonas sp. can thrive undisturbed under high UV radiation in the Antarctic ice layer. However, it is unknown that the initial adaptation mechanisms in protein level occurring in response to high UV radiation. Global-expression profiling of proteins in response to stress was analyzed by two-dimensional electrophoresis (2-DE) and image analysis. In the 2-DE analysis, protein preparation is the key step. Three different protein extract methods were compared, and the results showed that the trichloroacetic acid (TCA)-acetone fractional precipitation method was the fittest one. At the same time, the proteins in Chlamydomonas sp. were compared in 2-DE way, and the synthesis of seven protein spots was found disappeared and 18 decreased after exposed to UV-B radiation. In addition, 14 protein spots were enhanced or induced, among which two new peptides (20 and 21 kDa) appeared whose isoelectric point (pI) was 7.05 and 4.60 respectively. These changed proteins might act as key role in the acclimation of Antarctic ice microalga to UV-B | KAN Guangfeng MIAO Jinlai SHI Cuijuan LI Guangyou | 2006 | Acta Oceanologica Sinica2006，25，2： | 1 |
| 13 | Study on digital image watermark algorithm based on chaos mapping and DWT显示文摘 | Gu Zhifeng Li Guangfeng Yang Zongxiao | | 0，，： | 1 |
| 14 | A geometric theory for analysis and synthesis of sub-6 DOF parallel manipulators显示文摘 | MENG Jian LIU Guangfeng LI Zexiang | 2007 | IEEE Transactions on Robotics2007，，： | 1 |
| 15 | Salen Type Sandwich Triple-Decker Tri- and Di-nuclear Lanthanide Complexes显示文摘 | Quan Li Pengfei Yan Peng Chen Guangfeng Hou Guangming Li | 2012 | Journal of Inorganic and Organometallic Polymers and Materials2012，，5： | 1 |
| 16 | Randomized, three‐arm study to optimize lamivudine efficacy in hepatitis B e antigen‐positive chronic hepatitis B patients显示文摘 | Xieer Liang Jun Cheng Yongtao Sun Xinyue Chen Tong Li Hao Wang Jianning Jiang Xiaoping Chen Hui Long Hong Tang Yanyan Yu Jifang Sheng Shijun Chen Junqi Niu Hong Ren Junping Shi Xiaoguang Dou Mobin Wan Jiaji Jiang Qing Xie Guangfeng Shi Qin Ning Chengwei C | 2015 | J Gastroenterol Hepatol2015，，4： | 1 |
| 17 | Experimental re-search on passive millimeter wave radiometric stealth technologyof metal objects 显示文摘 | Zhang Guangfeng Lou Guowei Li Xingguo | 2012 | J Infrared Milli Terahz Waves2012，33，： | 1 |
| 18 | Hybrid Hydrogels Toughened by Chemical Covalent Bonding and Physical Electrostatic Interactions显示文摘 | LIU Li PAN Ge WANG Licheng PEN Xiuyan ZHANG Xinyue WU Guangfeng | 2018 | Chemical Research in Chinese Universities2018，34，3： | 1 |
| 19 | Light-emitting self-assembled metallacages显示文摘Coordination-driven self-assembly of metallacages has garnered significant interest because of their 3 D layout and cavity-cored nature. The well-defined, highly tunable metallacage structures render them particularly attractive for investigating the properties of luminophores, as well as for inducing novel photophysical characters that enable widespread applications. In this review, we summarize the recent advances in synthetic methodologies for light-emitting metallacages, and highlight some representative applications of these metallacages. In particular, we focus on the favorable photophysical properties—including high luminescence efficiency in various physical states, good modularity in photophysical properties and stimulus responsiveness—that have resulted from incorporating ligands displaying aggregation-induced emission(AIE) into metallacages. These features show that the synergy between carrying out coordination-driven self-assembly and using luminophores with novel photophysical characteristics like AIE could stimulate the development of supramolecular luminophores for applications in fields as diverse as sensing, biomedicine and catalysis. | Jun Zhao Zhixuan Zhou Guangfeng Li Peter J.Stang Xuzhou Yan | 2021 | National Science Review2021，8，6： | 0 |
| 20 | Topological effect on fluorescence emission of tetraphenylethylene-based metallacages显示文摘Herein,we describe the selective formation of a barrel-shaped or a ball-shaped fluorescent metallacage by controlling the shape and stoichiometry of the building blocks.Specifically,the tetraphenylethylene-based donor and two acceptors with different numbers of Pt(Ⅱ)centers were combined via coordination-driven self-assembly.Owing to the differences in the shapes of the assemblies,the resultant ball-shaped metallacage displayed stronger and blue-shifted fluorescence compared to the barrel-shaped one in dilute solutions,while a reversal of fluorescence intensities was observed in the aggregation process.Overall,this work demonstrates that the photophysical properties of supramolecular coordination complexes can be affected by subtle geometrical factors,which can be controlled precisely at the molecular level. | Yuhang Liu Zhewen Guo Yuchen Gu Guangfeng Li Shengbing Yang Xuzhou Yan Yi Shen Jinbing Wang | 2023 | Chinese Chemical Letters2023，34，12： | 0 |
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