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| 1 | m^6A mRNA methylation sustains Treg suppressive functions显示文摘 | Jiyu Tong Guangchao Cao Ting Zhang Esen Sefik Maria Carolina Amezcua Vesely James P Broughton Shu Zhu Huabin Li Bin Li Lei Chen Howard Y Chang Bing Su Richard A Flavell Hua-Bing Li | 2018 | Cell Research2018，28，2： | 30 |
| 2 | Explicit diagnosis of the local ozone production rate and the ozone-NOx-VOC sensitivities显示文摘In the troposphere, ozone is a harmful gas compound to both human health and vegetation. Ozone is produced from the reaction of NO_x(@NO + NO_2) and VOCs(volatile organic compounds) with light. Due to the highly nonlinear relationships between ozone and its precursors, proper ozone mitigation relies on the knowledge of chemical mechanisms. In this study, an observation-based method is used to simulate ozone formation and elucidate its controlling factors for a rural site on the North China Plain. The instantaneous ozone production rate is calculated utilizing a box model using the dataset obtained from the Wangdu campaign. First, the model was operated in a time-dependent mode to calculate the ozone production rate at each time stamp. The calculated ozone formation rate showed a diurnal average maximum value of 17 ppbv/h(1-h diurnal averaged). The contribution of individual peroxy radicals to ozone production was analyzed. In addition, the functional dependence of calculated P(O_3) reveals that ozone production was in a NO_x-limited regime during the campaign. Furthermore, the missing peroxy radical source will further extend NO_x-limited conditions to earlier in the day, making NO_xlimitation dominate more of a day than the current chemical model predicts. Finally, a multiple scenarios mode,also known as EKMA(empirical kinetic modeling approach), was used to simulate the response of P(O_3) to the imaginary change in precursor concentrations. We found that ozone production was in the NO_x-limited region. However, the use of NO_2 measured by the molybdenum converter and/or the absence of a peroxy radical source in the current chemical model could over-emphasize the VOC-limited effect on ozone production. | Zhaofeng Tan Keding Lu Huabin Dong Min Hu Xin Li Yuhan Liu Sihua Lu Min Shao Rong Su Haichao Wang Yusheng Wu Andreas Wahner Yuanhang Zhang | 2018 | Science Bulletin2018，63，16： | 25 |
| 3 | Ciliary parathyroid hormone signaling activates transforming growth factor-βto maintain intervertebral disc homeostasis during aging显示文摘Degenerative disc disease(DDD) is associated with intervertebral disc degeneration of spinal instability. Here, we report that the cilia of nucleus pulposus(NP) cells mediate mechanotransduction to maintain anabolic activity in the discs. We found that mechanical stress promotes transport of parathyroid hormone 1 receptor(PTH1 R) to the cilia and enhances parathyroid hormone(PTH) signaling in NP cells. PTH induces transcription of integrin α_vβ_6 to activate the transforming growth factor(TGF)-β-connective tissue growth factor(CCN2)-matrix proteins signaling cascade. Intermittent injection of PTH(iPTH) effectively attenuates disc degeneration of aged mice by direct signaling through NP cells, specifically improving intervertebral disc height and volume by increasing levels of TGF-β activity, CCN2, and aggrecan. PTH1 R is expressed in both mouse and human NP cells. Importantly,knockout PTH1 R or cilia in the NP cells results in significant disc degeneration and blunts the effect of PTH on attenuation of aged discs. Thus, mechanical stress-induced transport of PTH1 R to the cilia enhances PTH signaling, which helps maintain intervertebral disc homeostasis, particularly during aging, indicating therapeutic potential of iPTH for DDD. | Liwei Zheng Yong Cao Shuangfei Ni Huabin Qi Zemin Ling Xin Xu Xuenong Zou Tianding Wu Ruoxian Deng Bo Hu Bo Gao Hao Chen Yusheng Li Jianxi Zhu Francis Tintani Shadpour Demehri Amit Jain Khaled M.Kebaish Shenghui Liao Cheryle A.Séguin Janet L.Crane Mei Wan Hongbin Lu Paul D.Sponseller Lee H.RileyIII Xuedong Zhou Jianzhong Hu Xu Cao | 2018 | Bone Research2018，6，3： | 13 |
| 4 | Assessment of nomadic rice-duck complex ecosystem on energy and economy显示文摘Introduction:Modern intensive rice production has brought a large amount of environmental pollution and do not guarantee the safety of rice quality.Thus,to improve the farmer's rice production model to reduce agro-chemicals is of great importance to decrease pollution and to guarantee the security of food quality.Here,our experiments illustrated that nomadic rice-duck complex ecosystem(RD)could reduce energy input and increase both energy output and the values of the product safety index based on energy(PSI).Results:According to the results of our experiments,RD and rice monoculture production system(RM)were-0.6 and-0.78,respectively,which indicated that the safety potential of products in RD was higher than that of RM.Protein yield based on RD was significantly higher than that of RM.The output/input,gross income,and net income of RD were 15.26%,39.51%,and 44.80%,respectively,higher than that of RM;the data suggest that the economic benefits of RD were greater than that of RM.Conclusions:Consequently,as an intermediate-type technology,RD could become a feasible alternative that could reduce agro-chemical application rate without decreasing rice yield and increasing labor intensity.Furthermore,as an inheritance and development of the Chinese farming culture,RD is a classic Chinese farming technology withstanding more than 700 years of tests. | Huabin Zheng Huang Huang Diqin Li Xumeng Li Zhiqiang Fu Can Chen | 2014 | Ecological Processes2014，3，1： | 5 |
| 5 | Engineering the Coordination Sphere of Isolated Active Sites to Explore the Intrinsic Activity in Single-Atom Catalysts显示文摘Reducing the dimensions of metallic nanoparticles to isolated,single atom has attracted considerable attention in heterogeneous catalysis,because it significantly improves atomic utilization and often leads to distinct catalytic performance.Through extensive research,it has been recognized that the local coordination environment of single atoms has an important influence on their electronic structures and catalytic behaviors.In this review,we summarize a series of representative systems of single-atom catalysts,discussing their preparation,characterization,and structure-property relationship,with an emphasis on the correlation between the coordination spheres of isolated reactive centers and their intrinsic catalytic activities.We also share our perspectives on the current challenges and future research promises in the development of single-atom catalysis.With this article,we aim to highlight the possibility of finely tuning the catalytic performances by engineering the coordination spheres of single-atom sites and provide new insights into the further development for this emerging research field. | Xin Wu Huabin Zhang Shouwei Zuo Juncai Dong Yang Li Jian Zhang Yu Han | 2021 | Nano-Micro Letters2021，13，9： | 4 |
| 6 | Changes in soil carbon sequestration and soil respiration following afforestation on paddy fields in north subtropical China显示文摘Aims Although many studies have reported net gains of soil organic carbon(SOC)after afforestation on croplands,this is uncertain for Chinese paddy rice croplands.Here,we aimed to evaluate the effects of affores-tation of paddy rice croplands on SOC sequestration and soil respiration(R).Such knowledge would improve our understanding of the efctive-ness of various land use options on greenhouse gas mitigation in China.Methods The investigation was conducted on the Chongming Island,north subtropical China.Field sites were reclaimed from coastal salt marshes in the 1960s,and soils were homogeneous with simple land use:histories.SOC stocks and R,levels were monitored over one year in a paddy rice cropland,an evergreen and a deciduous broad-leaved plantation established on previous paddy fields and a reference fal-low land site never cultivated.Laboratory incubation of soil under fast-changing temperatures was used to compare the temperature sensitivity(Q10)of SOC decomposition across land uses.Important Findings After 15-20 years of afforestation on paddy fields,SOC concentra-tion only slightly increased at the depth of 0--5 cm but decreased in deeper layers,which resulted in a net loss of SOC stock in the top 40cm.Seasonal increase of sOC was observed during the rice-growing period in croplands but not in afforested soils,suggest-ing a stronger SOC sequestration by paddy rice cropping.However,SOC sequestered under cropping was more labile,as indicated by its higher contents of dissolved organic carbon and microbial bio-mass.Also,paddy soils had higher annual R,than afforested soils;R,abruptly increased after paddy fields were drained and plowed and remained distinctively high throughout the dry farming period.Laboratory incubation revealed that paddy soils had a much higher Q10 of SOC decomposition than afforested soils.Given that tem-perature was the primary controller of R,in this region,it was con-cluded that despite the stronger SOC sequestration by paddy rice cropping,its SOC was less stable than in afforested systems and might be more easily released into the atmosphere under global warming. | Jun Cui Rongjuan Zhang Naishun Bu Huabin Zhang Boping Tang Zhaolei Li Lifeng Jiang Jiakuan Chen Changming Fang | 2013 | Journal of Plant Ecology2013，6，3： | 4 |
| 7 | In situ monitoring of atmospheric nitrous acid based on multi-pumping flow system and liquid waveguide capillary cell显示文摘In the last four decades, various techniques including spectroscopic, wet chemical and mass spectrometric methods, have been developed and applied for the detection of ambient nitrous acid(HONO). We developed a HONO detection system based on long path photometry which consists of three independent modules i.e., sampling module, fluid propulsion module and detection module. In the propulsion module, solenoid pumps are applied. With solenoid pumps the pulsed flow can be computer controlled both in terms of pump stroke volume and pulse frequency, which enables the attainment of a very stable flow rate. In the detection module, a customized Liquid Waveguide Capillary Cell(LWCC) is used. The customized LWCC pre-sets the optical fiber in-coupling with the liquid wave guide, providing the option of fast startup and easy maintenance of the absorption photometry. In summer 2014, our system was deployed in a comprehensive campaign at a rural site in the North China Plain. More than one month of high quality HONO data spanning from the limit of detection to 5 ppb were collected. Intercomparison of our system with another established system from Forschungszentrum Juelich is presented and discussed. In conclusion, our instrument achieved a detection limit of 10 ppt V within2 min and a measurement uncertainty of 7%, which is well suited for investigation of the HONO budget from urban to rural conditions in China. | Yuhan Liu Keding Lu Huabin Dong Xin Li Peng Cheng Qi Zou Yusheng Wu Xingang Liu Yuanhang Zhang | 2016 | Journal of Environmental Sciences2016，28，5： | 4 |
| 8 | Label-free detection repeatability of protein microarrays by oblique-incidence reflectivity difference method显示文摘We examine the repeatabilities of oblique-incidence reflectivity difference(OIRD) method for label-free detecting biological molecular interaction using protein microarrays.The experimental results show that the repeatabilities are the same in a given microarray or microarray-microarray and are consistent,indicating that OIRD is a promising label-free detection technique for biological microarrays. | DAI Jun LI Lin WANG JingYi HE LiPing LU HuaBin RUAN KangCheng JIN KuiJuan YANG GuoZhen | 2012 | Science China(Physics,Mechanics & Astronomy)2012，55，12： | 3 |
| 9 | Modifying the Power and Performance of 2-Dimensional MoS_(2)Field Effect Transistors显示文摘Over the past 60 years,the semiconductor industry has been the core driver for the development of information technology,contributing to the birth of integrated circuits,Internet,artificial intelligence,and Internet of Things.Semiconductor technology has been evolving in structure and material with co-optimization of performance–power–area–cost until the state-of-the-art sub-5-nm node.Two-dimensional(2D)semiconductors are recognized by the industry and academia as a hopeful solution to break through the quantum confinement for the future technology nodes.In the recent 10 years,the key issues on 2D semiconductors regarding material,processing,and integration have been overcome in sequence,making 2D semiconductors already on the verge of application.In this paper,the evolution of transistors is reviewed by outlining the potential of 2D semiconductors as a technological option beyond the scaled metal oxide semiconductor field-effect transistors.We mainly focus on the optimization strategies of mobility(μ),equivalent oxide thickness(EOT),and contact resistance(RC),which enables high ON current(Ion)with reduced driving voltage(Vdd).Finally,we prospect the semiconductor technology roadmap by summarizing the technological development of 2D semiconductors over the past decade. | Fulin Zhuo Jie Wu Binhong Li Moyang Li Chee Leong Tan Zhongzhong Luo Huabin Sun Yong Xu Zhihao Yu | 2023 | Research2023，，3： | 2 |
| 10 | Salivary microbiota may predict the presence of esophageal squamous cell carcinoma显示文摘The aim is to explore the predictive value of salivary bacteria for the presence of esophageal squamous cell carcinoma (ESCC). Saliva samples were obtained from 178 patients with ESCC and 101 healthy controls, and allocated to screening and verification cohorts, respectively. In the screening phase, after saliva DNA was extracted, 16S rRNA V4 regions of salivary bacteria were amplified by polymerase chain reaction (PCR) with high-throughput sequencing. Highly expressed target bacteria were screened by Operational Taxonomic Units clustering, species annotation and microbial diversity assessment. In the verification phase, the expression levels of target bacteria identified in the screening phase were verified by absolute quantitative PCR (Q-PCR). Receiver operating characteristic (ROC) curves were plotted to investigate the predictive value of target salivary bacteria. LEfSe analysis revealed higher proportions of Fusobacterium, Streptococcus and Porphyromonas, and Q-PCR assay showed significantly higher numbers of Streptococcus salivarius, Fusobacterium nucleatum and Porphyromonas gingivalis in patients with ESCC, when compared with healthy controls (all P < 0.05). The areas under the ROC curves for Streptococcus salivarius, Fusobacterium nucleatum, Porphyromonas gingivalis and the combination of the three bacteria for predicting patients with ESCC were 69%, 56.5%, 61.8% and 76.4%, respectively. The sensitivities corresponding to cutoff value were 69.3%, 22.7%, 35.2% and 86.4%, respectively, and the matched specificity were 78.4%, 96.1%, 90.2% and 58.8%, respectively. These highly expressed Streptococcus salivarius, Fusobacterium nucleatum and Porphyromonas gingivalis in the saliva, alone or in combination, indicate their predictive value for ESCC. | Junmin Wei Ruifeng Li Yanxian Lu Fan Meng Bohong Xian Xiaorong Lai Xiayi Lin Yu Deng Dongyang Yang Huabin Zhang Liangfang Li Xiaosong Ben Guibin Qiao Wanwei Liu Zijun Li | 2022 | Genes & Diseases2022，9，4： | 2 |
| 11 | The Gβy-Src signaling pathway regulates TNF-induced necroptosis via control of necrosome translocation显示文摘 | Lisheng Li Wanze Chen Yaoji Liang Huabin Ma Wenjuan Li Zhenru Zhou Jie Li Yan Ding Junming Ren Juan Lin Felicia Han Jianfeng Wu Jiahuai Han | 2014 | Cell Research2014，24，4： | 2 |
| 12 | Degradation of dyes solutions by the Fenton process 显示文摘 | Xu Xiangrong Li Huabin Wang Wenhua | 2004 | Chemosphere2004，57，7： | 1 |
| 13 | Preparative isolation and purification of lutein from the microalga Chlorella vulgaris by high- speed counter-current chromatography显示文摘 | LI Huabin CHEN Feng ZHANG Tianyou | 2001 | J Chromatogra A2001，905，： | 1 |
| 14 | Isolation and purification of the bioactive carotenoid zeaxanthin from the microalga Microcystis aeruginosa by high-speed counter-current chromatography显示文摘 | CHEN Feng LI Huabin WONG R N S | 2005 | J Chromatogra A2005，1064，： | 1 |
| 15 | Degradation of dyes in aqueous solutions by the Fenton process显示文摘 | Xu Xiangrong Li Huabin Wang Wenhua | 2004 | Chemosphere2004，57，7： | 1 |
| 16 | SHRIMP Zircon U-Pb Dating of the Tongshi Magmatic Complex in Western Shandong and Its Geological Implications显示文摘The SHRIMP U-Pb zircon dating result of the Tongshi magmatic complex in western Shandong is presented in this paper. The Tongshi magmatic complex comprises fine-grained porphyritic diorite and syenitic porphyry. Eighteen analyses for fine-grained porphyritic diorite gave two concordia ages, in which ten analyses constitute the young age group, giving 206Pb/238U ages ranging from 167.9 Ma to 183 Ma with a weighted mean age of 175.7 ± 3.8 Ma, and the other eight yielded 207Pb/206Pb ages of 2502 Ma to 2554 Ma with a weighted mean 2518 ± 11 Ma. Two analyses for syenitic porphyry gave ages of 2485 Ma and 2512 Ma, respectively. The age of 175.7± 3.8 Ma indicates that the crystallization of the Tongshi magmatic complex occurred in the Middle Jurassic, whereas that of 2518 ± 11 Ma is interpreted as the age of inherited magmatic zircons in the Neoarchean Wutai period. | HU Huabin MAO Jingwen LIU Dunyi NIU Shuyin WANG Yanbin LI Yongfeng SHI Ruruo | 2005 | Acta Geologica Sinica(English Edition)2005，79，4： | 1 |
| 17 | Reactivity of Bronsted acid ionic liquids as dual solvent and catalyst for Fischer esterifications 显示文摘 | Wei Zuojun Li Feijin Xing Huabin | 2009 | Korean Journal of Chemical Engineering2009，26，3： | 1 |
| 18 | Degradation of dyes solutions by the Fenton process显示文摘 | Xu Xiangrong Li Huabin Wang Wenhua | 2004 | Chemosphere2004，57，7： | 1 |
| 19 | A systematic survey of antioxidant activity of 30 Chinese Medicinal plants using the ferric reducing antioxidant power assay显示文摘 | WONG Chichun LI Huabin CHENG Kawing | 2006 | Food Chemistry2006，97，4： | 1 |
| 20 | Degradation of dyessolutions by the Fenton process 显示文摘 | Xu Xiangrong Li Huabin Wang Wenhua | 2004 | Chemosphere2004，5，77： | 1 |
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