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| 1 | 晚期非小细胞肺癌免疫检查点抑制剂新型生物标志物:血液PD-L1动态检测显示文摘背景免疫检查点抑制剂(immune checkpoint inhibitors,ICIs)具有良好疗效已成为恶性肿瘤治疗领域备受瞩目的翘楚。然而,仅有小部分患者获得长期临床获益。如何选择生物标志物来筛查ICIs治疗优势人群仍是一大热点。方法收集51例晚期恶性肿瘤患者的肿瘤组织和配对血样本,进行PD-L1表达的相关性分析。40例晚期非小细胞肺癌(non-small cell lung cancer,NSCLC)患者接受ICIs治疗,2个月时检测血液PD-L1(bloodPD-L1,bPD-L1)表达的动态变化,包括PD-L1 mRNA、外泌体PD-L1(exosomalPD-L1,exoPD-L1)蛋白和可溶性PD-L1(solublePD-L1,sPD-L1)。应用R软件计算最佳截断值,用于预测最佳客观缓解(best objective response,b OR)、无进展生存期(progression-free survival,PFS)和总生存期(overall survival,OS)。结果51例不同恶性肿瘤患者中,组织PD-L1(tissuePD-L1,tPD-L1)表达阳性患者的PD-L1mRNA表达水平显著升高。40例接受ICIs治疗的晚期NSCLC患者中,bPD-L1 mRNA上调≥2.04的患者b OR、PFS和OS更佳;21例接受ICIs治疗的晚期NSCLC患者中,exoPD-L1上调≥1.86的患者临床获益更大。sPD-L1动态变化与ICIs疗效无显著相关性。PD-L1 mRNA和exoPD-L1联合检测更有利于预测ICIs治疗疗效。结论bPD-L1表达与tPD-L1表达存在正相关;晚期NSCLC患者ICIs治疗初期PD-L1 mRNA和(或)exoPD-L1表达升高,可作为评估临床获益的新型生物标志物。 | Qiao YANG Mingjing CHEN Jiaoyang GU Kai NIU Xianlan ZHAO Linpeng ZHENG Zihan XU Yongxin YU Feng LI Lingxin MENG Zhengtang CHEN Wenlei ZHUO Luping ZHANG Jianguo SUN 杨峤(译) 孙建国(译) | 2021 | 中国肺癌杂志2021，24，12： | 10 |
| 2 | A complete genome assembly of Glaciecola mesophila sp. nov. sequenced by using BIGIS-4 sequencer system显示文摘Using a pyrosequencing-based custom-made sequencer BIGIS-4, we sequenced a Gram-negative bacterium Glaciecola mesophila sp. nov. (Gmn) isolated from marine invertebrate specimens. We generated 152043 sequencing reads with a mean high-quality length of 406 bp, and assembled them using the BIGIS-4 post-processing module. No systematic low-quality data was detected beyond expected homopolymer-derived errors. The assembled Gmn genome is 5144318 bp in length and harbors 4303 annotated genes. A large number of metabolic genes correspond to various nutrients from surface marine invertebrates. Its abundant cold-tolerant and cellular signaling and related genes reveal a fundamental adaptation to low-temperature marine environment. | YUAN LiNa REN LuFeng LI YunTao HAN WeiJing YU Yong CHU YaNan LIU GuiMing YU Dan TENG MingJing WANG Liang WANG XuMin ZHOU XiaoGuang YU YuDe YU Jun | 2011 | Science China(Life Sciences)2011，54，9： | 4 |
| 3 | Strain localization analyses of idealized sands in biaxial tests by distinct element method显示文摘This paper presents a numerical investigation on the strain localization of an idealized sand in biaxial compression tests using the distinct element method(DEM).In addition to the dilatancy and material frictional angle,the principal stress field,and distributions of void ratio,particle velocity,and the averaged pure rotation rate(APR)in the DEM specimen are examined to illustrate the link between microscopic and macroscopic variables in the case of strain localization.The study shows that strain localization of the granular material in the tests proceeds with localizations of void ratio,strain and APR,and distortions of stress field and force chains.In addition,both thickness and inclination of the shear band change with the increasing of axial swain,with the former valued around 10-14 times of mean grain diameter and the later overall described by the Mohr-Coulomb theory. | Mingjing JIANG Hehua ZHU Xiumei LI | 2010 | Frontiers of Structural and Civil Engineering2010，4，2： | 4 |
| 4 | Effects of imazethapyr spraying on plant growth and leaf surface microbial communities in Arabidopsis thaliana显示文摘Imazethapyr (IM) is an acetolactate synthase (ALS)-inhibiting herbicide that has been widely used in recent years.However,IM spraying can lead to the accumulation of herbicide residues in leaves.Here,we determined the effects of IM spraying on the plant growth and leaf surface microbial communities of Arabidopsis thaliana after 7 and 14 days of exposure.The results suggested that IM spraying inhibited plant growth.Fresh weight decreased to 48% and 26% of the control value after 7 and 14 days,respectively,of 0.035 kg/ha IM exposure.In addition,anthocyanin content increased 9.2-fold and 37.2-fold relative to the control content after 7 and 14 days of treatment,respectively.Furthermore,IM spraying destroyed the cell structures of the leaves,as evidenced by increases in the number of starch granules and the stomatal closure rate.Reductions in photosynthetic efficiency and antioxidant enzyme activity were observed after IM spraying,especially after 14 days of exposure.The diversity and evenness of the leaf microbiota were not affected by IM treatment,but the composition of community structure at the genus level was altered by IM spraying.Imazethapyr application increased the abundance of Pseudomonas,a genus that includes species pathogenic to plants and humans,indicating that IM potentially increased the abundance of pathogenic bacteria on leaves.Our findings increase our understanding of the relationships between herbicide application and the microbial community structures on plant leaves,and they provide a new perspective for studying the ecological safety of herbicide usage. | Wanyue Liu Mingjing Ke Zhenyan Zhang Tao Lu Youchao Zhu Yan Li Xiangliang Pan Haifeng Qian | 2019 | Journal of Environmental Sciences2019，31，11： | 2 |
| 5 | Preparation of Spherical Microfine Silicon Powder显示文摘Under certain conditions of proper temperature and pH value, sodium silicate was hydrolyzed in liquid ammonia chloride, and spherical microfine SiO2 powder in micrometer-size was prepared. In this experiment, the relationship between needed time and proper pH value, temperature, density of the solution, and its current capacity were found .The optimum conditions are pH 8.5, 70 ℃, and the concentration of sodium silicate is 0.6 mol/L for the density of the solution. The structure of spherical microfi ne silicon was charactetized by SEM and XRD. | SHENG Yong ZOU Jun LI Bing TU Mingjing | 2008 | Journal of Wuhan University of Technology(Materials Science)2008，23，4： | 2 |
| 6 | A novel specimen preparation method for TJ-1 lunar soil simulant in hollow cylinder apparatus显示文摘Conventional methods for hollow cylinder apparatus (HCA) specimen preparation are not applicable for TJ-1 lunar soil simulant due to its wide particle size distribution. A novel method to prepare uniform TJ-1 specimen for HCA tests is put forward. The method is a combination of the multi-layering dry-rodding method and a new under-compaction criterion in the multi-layer with under-compaction method (UCM). In the novel method, the specimen is prepared with 5 layers by dry-rodding and the UCM is used to determine the height after each layer is compacted. The density uniformity of specimen is evaluated by the freezing method to find out the best under-compaction criterion. Two HCA specimens with the same target density are prepared by the novel method and examined in the tests of pure rotation of the principal stresses. Their conformable mechanical behaviors ascertain the effectiveness of the method to produce uniform and reproducible HCA specimens. Four groups of HCA tests are carried out to investigate the anisotropic and non-coaxial behaviors of TJ-1 lunar soil simulant. The results indicate that the principal stress direction, the deviator stress ratio, the stress level and the coefficient of the intermediate principal stress significantly influence the strength and deformation properties of TJ-1 lunar soil simulant. | Mingjing Jiang Zhifu Shen Liqing Li Jiaxing Su | 2012 | Journal of Rock Mechanics and Geotechnical Engineering2012，4，4： | 2 |
| 7 | Preparation of isotropic Sm_2Fe_(17)N_x magnetic powders and their bonded magnets显示文摘The isotropic Sm2Fe17Nx magnetic powders were prepared by Hydrogenation-Disproportion-Desorption-Recombination (HDDR) process. The phase and microstructure evolutionary process of Sm-Fe alloy during the solidification, homogenization, HDDR and nitration processes were investigated by means of XRD, SEM, EDX and AFM. The results show that the homogeneous Sm2Fe17 alloy was successfully obtained and the impurity phases and residual stress were well removed by heated at 1050 ℃ for 24 h. When heated at 800 ℃ for 1h in H2 of 0.1 MPa, the alloy turns into SmHx and α-Fe with plenty of nanocrystals. After vacuumized at 800 ℃ for 2 h the alloy recombines into Sm2Fe17 with a crystal grain size of about 85 nm. The lattice constant of the alloy increases and the expanding of the crystal cell reaches 6.28% after nitrified at 500 ℃ for 5 h. The magnetic property of isotropic bonded Sm2Fe17Nx magnets is Br=0.6704 T, Hcj=1015 kA·m-1, (BH)max=73.7 kJ·m-3 with a density of 6.04 g·cm-3. | YE Jinwen LIU Ying LI Meng SONG Dayu GAO Shengji TU Mingjing | 2006 | Rare Metals2006，25，z1： | 2 |
| 8 | A memory learning framework for effective image retrieval 显示文摘 | Han Junwei Ngan K N Li Mingjing | 2005 | IEEE Transactions on2005，14，4： | 1 |
| 9 | Unsupervised extraction of visual attention objects in color images 显示文摘 | Han J Ngan K N Li Mingjing | 2006 | IEEE Transactions on Circuits and Systems for Video Technology2006，16，1： | 1 |
| 10 | Generalized Manifold-Ranking-Based Image Retrieval显示文摘 | He Jingrui Li Mingjing Zhang Hongjiang | 2006 | IEEE Trans Image Process2006，15，10： | 1 |
| 11 | Multi-view face detection with floatboost显示文摘 | Zhang Zhenqiu Li Mingjing | 2002 | WACV2002，，： | 1 |
| 12 | Unsupervised Extraction of Visual Attention Objects in Color Images显示文摘 | Han Junwei Ngan K N Li Mingjing | 2006 | IEEETransactions on Circuits and Systems for Video Technology2006，16，1： | 1 |
| 13 | The nurses of operation room patients with preoperative visit effect显示文摘 | Hu Mingjing Ma Yongqing Li Xiaoyan | 2010 | Journal of practical medicine2010，21，12： | 1 |
| 14 | Factors Affecting Transformation Temperatures in Fe-Mn-Si-Cr-Ni Shape Memory Alloy显示文摘The effects of prestrain and annealing temperature on phase transformation temperatures in Fe14Mn5Si8Cr4Ni shape memory alloy have been Studied. The results showed that when the annealing temperature was 673 K, both the Af and the Ms temperatures increased appreciably as the prestrain increased, the A. temperature increased slightly with increasing prestrain; the resistivity difference at 303 K between the heating and cooling curve also increased with increasing prestrain, which agreed with the recovery strain. The shape memory effect in Fe-Mn-Si-Cr-Ni shape memory alloy is caused by the stress-inducedγ→ε martensite transformation and its reverse transformation. When the prestrain was 10%, the Ms temperature decreased remarkably as the annealing temperature increased. | Yuhua WEN+, ding LI and Mingjing TU (Department of Materials Shaping and Controlling Engineering, Sichuan University, Chengdu 610065, China) | 2000 | Journal of Materials Science & Technology2000，16，5： | 1 |
| 15 | A memory learning framework for effective image retrieval显示文摘 | Han J Ngan K N Li Mingjing | 2005 | IEEE Transactions on Image Processing2005，14，4： | 1 |
| 16 | Manifold-Ranking-Based Keyword Propagation for Image Retrieval显示文摘 | Tong Hanghang He Jingrui Li Mingjing | 2009 | EURASIP Journal on Applied Signal Processing2009，2006，： | 1 |
| 17 | A unified framework for image retrieval using keyword and visual features显示文摘 | Jing Feng Li Mingjing Zhang Hongjiang | 2005 | IEEE Transactions on Image Processing2005，14，7： | 1 |
| 18 | Unsupervised extraction of visual attention objects in color images显示文摘 | Han Junwei Ngan K N Li Mingjing | | 0，，01： | 1 |
| 19 | Comparison of two in vitro angiogenesis assays for evaluating the effects of netrin-1 on tube formation显示文摘Netrin-1 是也调整脉管的开发的神经指导暗示。然而,争论结果在 vivo 并且在 vitro 在脉管的开发有关 netrin-1 的角色被获得了。在现在的学习,二在 vitro angiogenesis 试金与相比评估藏匿由的 netrin-1 的效果 retrovirally 试管形成上的 transduced 黑瘤房间(Mel2a-netrin1 ) 。结果证明在调节媒介(厘米) 在 matrigel 试金从控制, Mel2a-netrin1 和 Mel2a 房间导致的试管形成没有明显的差别。在哪个 endothelial 房间然而与人的成纤维细胞是 co 有教养的,在 vitro 试金的另外一个的结果证明那 Mel2a-netrin1 厘米禁止了试管形成,据说通过堵住人的脐的静脉 endothelial 房间(HUVEC ) 的延伸和结合。这些结果证实 matrigel 试金不能表明 netrin-1 的 anti-angiogenic 角色。 | Hui Guo Yin Jia Min Shang Yuan Zhang Fu'an Xie Heng Wang Mingjing Yuan Li Yuan Jura Ye | 2014 | Acta Biochimica et Biophysica Sinica2014，46，9： | 1 |
| 20 | Statistical Correlation Analysis in Image Retrieval显示文摘 | CHEN Zheng ZHANG Hong-jiang | 2002 | Pattern Recognition2002，35，12： | 1 |
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