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| 1 | Suppression of Jasmonic Acid-Mediated Defense by Viral-Inducible MicroRNA319 Facilitates Virus Infection in Rice显示文摘MicroRNAs (miRNAs ) 是植物开发和主人病毒相互作用的枢轴的调节的人。然而,角色和涉及病毒的感染和主人危险性的特定的 miRNAs 的行动模式仍然保持大部分不清楚。在这研究,我们给那瑞斯看引起 miR319 的增加的累积,但是减少的破旧绝技病毒(RRSV ) 感染调整 miR319 的 TCP (TEOSINTE BRANCHED/CYCLOIDEA/PCF ) 的表示基因,特别 TCP21,在米饭植物。转基因的米饭植物 overexpressing miR319 或 downregulating TCP21 展出了像疾病的显型并且与野类型的植物比较显示出显著地更高的危险性到 RRSV。相反,仅仅温和的疾病症状在感染 RRSV 的线 overexpressing TCP21 并且特别在转基因的植物 overexpressing 被观察 miR319 抵抗的 TCP21。miR319 的 RRSV 感染和 overexpression 在米饭与 JA 生合成和信号相关的基因的 downregulated 表示一起引起了减少的内长的 jasmonic 酸(JA ) 层次。然而,有甲基 jasmonate 的米饭植物的治疗减轻了 RRSV 引起并且减少了病毒累积的疾病症状。一起拿,我们的结果建议由在米饭的 RRSV 感染的 miR319 的正式就职压制调停 JA 的防卫便于病毒感染和症状开发。 | Chao Zhang Zuomei Ding Kangcheng Wu Liang Yang Yang Li Zhen Yang Shan Shi Xiaojuan Liu Shanshan Zhao Zhirui Yang Yu Wang Luping Zheng Juan Wei Zhenguo Du Aihong Zhang Hongqin Miao Yi Li Zujian Wu Jianguo Wu | 2016 | Molecular Plant2016，9，9： | 27 |
| 2 | Curculigoside isolated from Curculigo orchioides prevents hydrogen peroxide-induced dysfunction and oxidative damage in calvarial osteoblasts显示文摘反应的氧种类(ROS ) 包括 H2O2,在骨质疏松症的 pathophysiology 起一个关键作用。因此,能禁止 ROS 生产的代理人或抗氧化剂在骨质疏松症的治疗有高临床的价值。Curculigoside (杂种狗) ,酉分的混合物从 Curculigo orchioides Gaertn 的根茎孤立的主要 bioactive 之一,被报导有有势力抗氧化剂和 anti-osteoporotic 性质。然而,没有直接证据与观察 anti-osteoporotic 效果连接杂种狗的抗氧化剂能力,并且相关分子的机制仍然保持不清楚。因此,我们在 calvarial 造骨细胞对氧化应力调查了杂种狗的保护的效果并且讨论了相关机制。造骨细胞生存能力在 48-h 暴露以后显著地减少了到 H2O2 的 400 M,这被发现,与对待车辆的房间相比,并且 H2O2 的细胞毒素的效果显著地被颠倒什么时候有杂种狗的 0.110 M 的 pretreated (P < 0.05 ) 。有杂种狗的 0.110 M 的预告的处理减少了 ROS 生产和类脂化合物 peroxidation,并且增加了抗氧化剂酶的活动,例如 superoxide,在造骨细胞的 dismutase 和谷胱甘肽 peroxidase 由 H2O2 导致了。另外,象碱的磷酸酶,钙免职,和 Runx2 水平那样的区别标记的导致 H2O2 的减小显著地面对杂种狗被恢复。杂种狗也颠倒了细胞外的调整信号的 kinase 1/2,并且原子 factor-B 发信号和 p38 的抑制的导致 H2O2 的刺激激活 mitogen 的蛋白质 kinase 激活。这些结果通过减少 ROS 的生产提供新卓见进杂种狗的造骨细胞保护的机制,建议那条杂种狗可以作为为骨质疏松症和另外的骨头相关的人的疾病的预防和处理的一个对简历安全的代理人被开发。 | Ying Wang Lu Zhao Yin Wang Jinlong Xu Yah Nie Yuanhui Guo Yongtao Tong Luping Qin Qiaoyan Zhang | 2012 | Acta Biochimica et Biophysica Sinica2012，44，5： | 15 |
| 3 | Effects of lysedEnterococcus faecalis FK-23 on experimental allergic rhinitis in a murine model显示文摘In the current study,we sought to investigate whether lysed Enterococcus faecalis FK-23(LFK),a heat-killed probiotic preparation,attenuated eosinophil influx into the upper airway and had immunomodulatory activity in a murine allergic rhinitis model.Eighteen BALB/c mice were divided into three groups;the ovalbumin(OVA)-sensitized/challenged group,which received saline orally for 6 weeks(OVA group),the OVA-sensitized/challenged group,which received LFK orally for 6 weeks(LFK-fed group),and the non-sensitized group,which received saline for 6 weeks(saline control group).Nasal rubbing and sneezing were monitored during the study.After the final challenge,interleukin(IL)-4,interferon(IFN)-γ,and OVA-specific IgE levels in the sera and splenocyte culture supernatants were determined,eosinophilic infiltrate into the upper airway was quantified,and splenic CD4+CD25+ regulatory T cells(Tregs) were examined by flow cytometry.We found that nasal rubbing was significantly reduced in LFK-fed mice compared to the OVA group on d 27 and 35,and sneezing was significantly inhibited by LFK administration for 35 d.LFK-fed mice had significantly less eosinophil influx into the nasal mucosa than the OVA group.There were no significant differences between the LFK-fed group and OVA group in the serum and splenocyte culture supernatant levels of IL-4,IFN-γ,and OVA-specific IgE.Interestingly,the LFK-fed mice had a significantly greater percentage of splenic CD4+CD25+ Tregs than OVA group.Our results indicate that oral administration of LFK may alleviate nasal symptoms,reduce nasal eosinophilia,and increase the percentage of CD4+CD25+ Tregs in experimental allergic rhinitis. | Luping Zhu Takashi Shimada Ruoxi Chen Meiping Lu Qingzhao Zhang Wenmin Lu Min Yin Tadao Enomoto Lei Cheng | 2012 | The Journal of Biomedical Research2012，26，3： | 11 |
| 4 | An improved phase measurement method of integrated pulse profile for pulsar显示文摘Integrated profile is one of the basic characteristic of X-ray pulsar.Gaussian function fit is used to model the components of X-ray pulsar profile,and it is combined with Poisson distribution model of X-ray pulsar to analyze Cramér-Rao low bound (CRLB) of phase,phase rate estimation and relation between CRLB and profile components.Then,a time domain method us-ing minimum entropy is proposed for profile phase and phase rate estimation,and its effectiveness is explained using simula-tion examples. | ZHANG Hua XU LuPing | 2011 | Science China(Technological Sciences)2011，54，9： | 10 |
| 5 | Modeling and Doppler measurement of X-ray pulsar显示文摘Generally,the Doppler caused by the velocity of the detector leads to distortion of the integrated profile of the X-ray pulsar,on the contrary,if the distortion can be used to measure the Doppler,then the velocity of the detector is easy to be solved.In view of this,the correlation of the periodic error arise from the Doppler and the integrated profile was analyzed,then,based on the Poisson distribution model of the X-ray Pulsar,a new signal model and the concept of the profile entropy was defined.Furthermore,the directly cumulated profile of the signal was modeled with the Doppler as a parameter,and then the Doppler was solved via optimal method.Simultaneously,the performance of phase measurement based on this method was studded.The analysis shows that this method can get rid of the periodic error due to the discrete sampling,and can obtain continuous phase estimation.The experiment verification shows the consistency of the theory and the experiment. | ZHANG Hua | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，6： | 10 |
| 6 | 晚期非小细胞肺癌免疫检查点抑制剂新型生物标志物:血液PD-L1动态检测显示文摘背景免疫检查点抑制剂(immune checkpoint inhibitors,ICIs)具有良好疗效已成为恶性肿瘤治疗领域备受瞩目的翘楚。然而,仅有小部分患者获得长期临床获益。如何选择生物标志物来筛查ICIs治疗优势人群仍是一大热点。方法收集51例晚期恶性肿瘤患者的肿瘤组织和配对血样本,进行PD-L1表达的相关性分析。40例晚期非小细胞肺癌(non-small cell lung cancer,NSCLC)患者接受ICIs治疗,2个月时检测血液PD-L1(bloodPD-L1,bPD-L1)表达的动态变化,包括PD-L1 mRNA、外泌体PD-L1(exosomalPD-L1,exoPD-L1)蛋白和可溶性PD-L1(solublePD-L1,sPD-L1)。应用R软件计算最佳截断值,用于预测最佳客观缓解(best objective response,b OR)、无进展生存期(progression-free survival,PFS)和总生存期(overall survival,OS)。结果51例不同恶性肿瘤患者中,组织PD-L1(tissuePD-L1,tPD-L1)表达阳性患者的PD-L1mRNA表达水平显著升高。40例接受ICIs治疗的晚期NSCLC患者中,bPD-L1 mRNA上调≥2.04的患者b OR、PFS和OS更佳;21例接受ICIs治疗的晚期NSCLC患者中,exoPD-L1上调≥1.86的患者临床获益更大。sPD-L1动态变化与ICIs疗效无显著相关性。PD-L1 mRNA和exoPD-L1联合检测更有利于预测ICIs治疗疗效。结论bPD-L1表达与tPD-L1表达存在正相关;晚期NSCLC患者ICIs治疗初期PD-L1 mRNA和(或)exoPD-L1表达升高,可作为评估临床获益的新型生物标志物。 | Qiao YANG Mingjing CHEN Jiaoyang GU Kai NIU Xianlan ZHAO Linpeng ZHENG Zihan XU Yongxin YU Feng LI Lingxin MENG Zhengtang CHEN Wenlei ZHUO Luping ZHANG Jianguo SUN 杨峤(译) 孙建国(译) | 2021 | 中国肺癌杂志2021，24，12： | 10 |
| 7 | Fast structured illumination microscopy via deep learning显示文摘This study shows that convolutional neural networks(CNNs)can be used to improve the performance of structured illumination microscopy to enable it to reconstruct a super-resolution image using three instead of nine raw frames,which is the standard number of frames required to this end.Owing to the isotropy of the fluorescence group,the correlation between the high-frequency information in each direction of the spectrum is obtained by training the CNNs.A high-precision super-resolution image can thus be reconstructed using accurate data from three image frames in one direction.This allows for gentler super-resolution imaging at higher speeds and weakens phototoxicity in the imaging process. | CHANG LING CHONGLEI ZHANG MINGQUN WANG FANFEI MENG LUPING DU XIAOCONG YUAN | 2020 | Photonics Research2020，8，8： | 8 |
| 8 | Ultra-broadband on-chip twisted light emitter for optical communications显示文摘On-chip twisted light emitters are essential components of orbital angular momentum(OAM)communication devices1,2.These devices address the growing demand for high-capacity communication systems by providing an additional degree of freedom for wavelength/frequency division multiplexing(WDM/FDM).Although whispering-gallery-mode-enabled OAM emitters have been shown to possess some advantages3–5,such as compactness and phase accuracy,their inherent narrow bandwidths prevent them from being compatible with WDM/FDM techniques.Here,we demonstrate an ultra-broadband multiplexed OAM emitter that utilizes a novel joint path-resonance phase control concept.The emitter has a micron-sized radius and nanometer-sized features.Coaxial OAM beams are emitted across the entire telecommunication band from 1,450 to 1,650 nm.We applied the emitter to an OAM communication with a data rate of 1.2 Tbit/s assisted by 30-channel optical frequency combs(OFCs).The emitter provides a new solution to further increase capacity in the OFC communication scenario. | Zhenwei Xie Ting Lei Fan Li Haodong Qiu Zecen Zhang Hong Wang Changjun Min Luping Du Zhaohui Li Xiaocong Yuan | 2018 | Light(Science & Applications)2018，7，1： | 7 |
| 9 | Dog sciatic nerve gap repaired by artificial tissue nerve graft显示文摘The feasibility of repairing dog sciatic nerve damage by using a biodegradable artificial tissue nerve graft enriched with neuroregenerating factors is investigated. The artificial nerve graft was implanted to a 30 mm gap of the sciatic nerve damage in 7 dogs. The dogs with the same nerve damage that were repaired by interposition of the autologous nerve or were given no treatment served as control group 1 or 2, respectively. The observations include gross and morphological observations, immune reaction, electrophysiological examination, fluorescence tracing of the neuron formation and the number of the neurons at the experimental sites, etc. Results showed that 6 months after the implantation of the graft, the regenerated nerve repaired the damage of the sciatic nerve without occurrence of rejection and obvious inflammatory reaction in all 7 dogs, and the function of the sciatic nerve recovered with the nerve conduction velocity of (23.91±11.35)m/s. The regenerated neurons and the forming of axon could be observed under an electron microscope. This proves that artificial tissue nerve graft transplantation can bridge the damaged nerve ends and promote the nerve regeneration. | GU Xiaosong, ZHANG Peiyun, WANG Xiaodong, DING Fei, PENG Luping and CHENG Hongbing(Nantong Medical College, The Key Laboratory of Neuroregeneration of Jiangsu Province, Nantong 226001, China) | 2003 | Progress in Natural Science:Materials International2003，13，8： | 6 |
| 10 | DCT domain filtering method for multi-antenna code acquisition显示文摘For global navigation satellite system(GNSS) signals in Gaussian and Rayleigh fading channel, a novel signal detection algorithm is proposed. Under the low frequency uncertainty case, after performing discrete cosine transform(DCT) to the outputs of the partial matched filter(PMF) for every antenna, the high order components in the transforming domain will be filtered, then the equalgain(EG) combination for the inverse discrete cosine transform(IDCT) reconstructed signal would be done subsequently. Thus,due to the different frequency distribution characteristics between the noise and signals, after EG combination, the energy of signals has almost no loss and the noise energy is greatly reduced. The theoretical analysis and simulation results show that the detection algorithm can effectively improve the signal-to-noise ratio of the captured signal and increase the probability of detection under the same false alarm probability. In addition, it should be pointed out that this method can also be applied to Rayleigh fading channels with moving antenna. | Xiaojie Li Luping Xu Shibin Song Hua Zhang | 2013 | Journal of Systems Engineering and Electronics2013，24，5： | 6 |
| 11 | Changes in brain activation in stroke patients after mental practice and physical exercise: a functional MRI study显示文摘Mental practice is a new rehabilitation method that refers to the mental rehearsal of motor imagery content with the goal of improving motor performance.However,the relationship between activated regions and motor recovery after mental practice training is not well understood.In this study,15 patients who suffered a first-ever subcortical stroke with neurological deficits affecting the right hand,but no significant cognitive impairment were recruited.10 patients underwent mental practice combined with physical practice training,and 5 patients only underwent physical practice training.We observed brain activation regions after 4 weeks of training,and explored the correlation of activation changes with functional recovery of the affected hands.The results showed that,after 4 weeks of mental practice combined with physical training,the Fugl-Meyer assessment score for the affected right hand was significantly increased than that after 4 weeks of practice training alone.Functional MRI showed enhanced activation in the left primary somatosensory cortex,attenuated activation intensity in the right primary motor cortex,and enhanced right cerebellar activation observed during the motor imagery task using the affected right hand after mental practice training.The changes in brain cortical activity were related to functional recovery of the hand.Experimental findings indicate that cortical and cerebellar functional reorganization following mental practice contributed to the improvement of hand function. | Hua Liu Luping Song Tong Zhang | 2014 | Neural Regeneration Research2014，9，15： | 5 |
| 12 | Discrimination of False Negative Results in RT-PCR Detection of SARS-CoV-2 RNAs in Clinical Specimens by Using an Internal Reference显示文摘Reverse transcription-polymerase chain reaction(RT-PCR)is an essential method for specific diagnosis of SARS-CoV-2 infection.Unfortunately,false negative test results are often reported.In this study,we attempted to determine the principal causes leading to false negative results of RT-PCR detection of SARS-CoV-2 RNAs in respiratory tract specimens.Multiple sputum and throat swab specimens from 161 confirmed COVID-19 patients were tested with a commercialfluorescent RT-PCR kit targeting the ORF1 ab and N regions of SARS-CoV-2 genome.The RNA level of a cellular housekeeping gene ribonuclease P/MRP subunit p30(RPP30)in these specimens was also assessed by RT-PCR.Data for a total of 1052 samples were retrospectively re-analyzed and a strong association between positive results in SARS-CoV-2 RNA tests and high level of RPP30 RNA in respiratory tract specimens was revealed.By using the ROC-AUC analysis,we identified Ct cutoff values for RPP30 RT-PCR which predicted false negative results for SARS-CoV-2 RT-PCR with high sensitivity(95.03%–95.26%)and specificity(83.72%–98.55%)for respective combination of specimen type and ampli-fication reaction.Using these Ct cutoff values,false negative results could be reliably identified.Therefore,the presence of cellular materials,likely infected host cells,are essential for correct SARS-CoV-2 RNA detection by RT-PCR in patient specimens.RPP30 could serve as an indicator for cellular content,or a surrogate indicator for specimen quality.In addition,our results demonstrated that false negativity accounted for a vast majority of contradicting results in SARS-CoV-2 RNA test by RT-PCR. | Yafei Zhang Changtai Wang Mingfeng Han Jun Ye Yong Gao Zhongping Liu Tengfei He Tuantuan Li Mengyuan Xu Luping Zhou Guizhou Zou Mengji Lu Zhenhua Zhang | 2020 | Virologica Sinica2020，35，6： | 5 |
| 13 | Synthesis of nitrogen-doped carbon nanotubes-FePO_4 composite from phosphate residue and its application as effective Fenton-like catalyst for dye degradation显示文摘Phosphate residue is regarded as a hazardous waste, which could potentially create significant environmental and health problems if it is not properly treated and disposed of. In this study, nitrogen-doped carbon nanotubes-FePO_4(NCNTs-FePO_4) composite was successfully synthesized from phosphate residue, and its application as an effective catalyst was explored. Firstly, an effective method was developed to recover FePO_4 from phosphate residue, achieving an impressive FePO_4 mass recovery rate of 98.14%. Then, the NCNTsFePO_4 catalyst was synthesized from the recovered FePO_4 by two main reactions, including surface modification and chemical vapor deposition. Finally, the synthesized NCNTs-FePO_4 was applied to photo-degrade 15 mg/L Rhodamine B(RhB) in a Fenton-like system. The results showed that 98.9% of RhB could be degraded in 60 min, closely following the pseudofirst-order kinetics model. It was found that even after six consecutive cycles, NCNTs-FePO_4 still retained a high catalytic capacity(>50%). Moreover, ·OH radicals participating in the RhB degradation process were evidenced using quenching experiments and electron paramagnetic resonance analysis, and a rational mechanism was proposed. It was demonstrated that the materials synthesized from hazardous phosphate residue can be used as an effective catalyst for dye removal. | Lianmei Wei Yi Zhang Shengwen Chen Luping Zhu Xiaoyu Liu Lingxue Kong Lijun Wang | 2019 | Journal of Environmental Sciences2019，31，2： | 4 |
| 14 | On-chip photonic Fourier transform with surface plasmon polaritons显示文摘The Fourier transform(FT),a cornerstone of optical processing,enables rapid evaluation of fundamental mathematical operations,such as derivatives and integrals.Conventionally,a converging lens performs an optical FT in free space when light passes through it.The speed of the transformation is limited by the thickness and the focal length of the lens.By using the wave nature of surface plasmon polaritons(SPPs),here we demonstrate that the FT can be implemented in a planar configuration with a minimal propagation distance of around 10 mm,resulting in an increase of speed by four to five orders of magnitude.The photonic FT was tested by synthesizing intricate SPP waves with their Fourier components.The reduced dimensionality in the minuscule device allows the future development of an ultrafast on-chip photonic information processing platform for large-scale optical computing. | Shan Shan Kou Guanghui Yuan Qian Wang Luping Du Eugeniu Balaur Daohua Zhang Dingyuan Tang Brian Abbey Xiao-Cong Yuan Jiao Lin | 2016 | Light(Science & Applications)2016，5，1： | 4 |
| 15 | Exploring New City Building Types,Weaving Urban Context:A Case Study on Old City of Jinan显示文摘1. The loss of identities and context: not just a story for one city Located at the north foot of Mount Lishan and to the south of Xiaoqinghe River and Huanghe (Yellow) River, the ' | ZHANG Jie,Professor,School of Architecture,Tsinghua University,Beijing,China DENG Xiangyu,PhD candidate,School of Architecture,Tsinghua University,Beijing,China YUAN Luping,Postgraduate student,School of Architecture,Tsinghua University,Beijing,China.LI Caige | 2006 | China City Planning Review2006，15，2： | 4 |
| 16 | In Situ Observation of Crystalline Silicon Growth from SiO_(2) at Atomic Scale显示文摘The growth of crystalline Si(c-Si)via direct electron beam writing shows promise for fabricating Si nanomaterials due to its ultrahigh resolution.However,to increase the writing speed is a major obstacle,due to the lack of systematic experimental explorations of the growth process and mechanisms.This paper reports a systematic experimental investigation of the beaminduced formation of c-Si nanoparticles(NPs)from amorphous SiO_(2) under a range of doses and temperatures by in situ transmission electron microscopy at the atomic scale.A three-orders-of-magnitude writing speed-up is identified under 80 keV irradiation at 600℃ compared with 300 keV irradiation at room temperature.Detailed analysis reveals that the self-organization of c-Si NPs is driven by reduction of c-Si effective free energy under electron irradiation.This study provides new insights into the formation mechanisms of c-Si NPs during direct electron beam writing and suggests methods to improve the writing speed. | Kaihao Yu Tao Xu Xing Wu Wen Wang Hui Zhang Qiubo Zhang Luping Tang Litao Sun | 2019 | Research2019，，1： | 3 |
| 17 | Protective effects of Buyinqianzheng Formula on mitochondrial morphology by PINK1/Parkin pathway in SH-SY5Y cells induced by MPP^(+)显示文摘Objective:Buyinqianzheng Formula(BYQZF)is clinically employed in traditional Chinese medicine to treat Parkinson's disease(PD)by improving mitochondrial dysfunction.However,the underlying mechanisms by which BYQZF affects mitochondrial morphology remain unknown.Therefore,we observed the effects of BYQZF on mitochondria from the perspective of the PINK1/Parkin pathway.Methods:Cell survival rates were assessed by Cell Counting Kit-8 assay.Expression levels of PINK1 and Parkin mRNA were examined by qRT-PCR.Protein expression levels of PINK1,PINK1-Ser228,Parkin,Parkin-Ser65,Drp1,and Drp1-Ser637 were examined by western blotting.PINK1,Parkin,and MitoTracker?Red CMXRos(MTR)were stained by triple-labeled immunofluorescence,and observed under laser confocal microscopy.Results:Cell survival rate,mitochondrial form factor,mean length and number of mitochondrial network branches,mitochondrial activity,m RNA expression levels of PINK1 and Parkin,and protein expression levels of PINK1,Parkin,and Drp1-Ser637 were reduced after 1-methyl-4-phenylpyridinium(MPP^(+))intervention.In contrast,Pearson's correlation coefficients between PINK1 and Parkin,and between Parkin and MTR,as well as protein expression levels of PINK1-Ser228,Parkin-Ser65,and Drp1 increased significantly after MPP^(+) intervention.Treatment with BYQZF increased cell survival rate,mitochondrial form factor,mean length and number of mitochondrial network branches,mitochondrial activity,m RNA expression levels of PINK1 and Parkin,and expression of PINK1,Parkin,and Drp1-Ser637 proteins.Pearson's correlation coefficients between PINK1 and Parkin,and between Parkin and MTR,as well as protein expression levels of PINK1-Ser228,Parkin-Ser65,and Drp1 decreased after BYQZF treatment.Conclusion:These results demonstrate that BYQZF has a protective effect on mitochondrial molecular mechanisms in the PD cell model,and the mechanism is related to the PINK1/Parkin pathway. | Haojie Ma Zhenyu Guo Cong Gai Cuicui Cheng Jinkun Zhang Yuxin Zhang Luping Yang Wandi Feng Yushan Gao Hongmei Sun | 2020 | Journal of Traditional Chinese Medical Sciences2020，7，3： | 3 |
| 18 | Detailed resume of RNA m^(6)A demethylases显示文摘N6-Methyladenosine(m^(6)A) is the most abundant internal modification in eukaryotic mRNA,playing critical role in various bioprocesses. Like other epigenetic modifications, m^(6)A modification can be catalyzed by the methyltransferase complex and erased dynamically to maintain cells homeostasis. Up to now, only two m^(6)A demethylases have been reported, fat mass and obesity-associated protein(FTO)and alkylation protein AlkB homolog 5(ALKBH5), involving in a wide range of mRNA biological progress, including mRNA shearing, export, metabolism and stability. Furthermore, they participate in many significantly biological signaling pathway, and contribute to the progress and development of cancer along with other diseases. In this review, we focus on the studies about structure, inhibitors development and biological function of FTO and ALKBH5. | Dandan Shen Bo Wang Ya Gao Lijuan Zhao Yaping Bi Jinge Zhang Ning Wang Huiqin Kang Jingru Pang Ying Liu Luping Pang Zhe-Sheng Chen Yi-Chao Zheng Hong-Min Liu | 2022 | Acta Pharmaceutica Sinica B2022，12，5： | 3 |
| 19 | The progress and prospect of assessment measures of uterine cavity function for infertility patients显示文摘Objective:To explore the progress and prospect of evaluation methods for infertility patients.Methods:From September 2017 to December 2020,199 cases of infertility patients who have accepted mini-hysteroscopy examination in the Department of Gynecological Endocrinology,Beijing Obstetrics and Gynecology Hospital,Capital Medical University.The patients who had primary ovary insufficiency,tubal infertility were excluded;patients with hysteroscopy contradiction,such as acute or sub-acute vaginal tract inflammation,endometrium lesion or endometrium carcinoma,severe cardiovascular,liver or kidney insufficiency were excluded.40 patients were excluded and 15 patients lost follow up,144 patients were eventually included in the analysis.The patient’s age,body mass index,infertility etiology,preoperative and postoperative stimulate ovulation cycle,pregnancy state and pregnancy time were recorded.The effect of mini-hysteroscopy on ovulation induction cycle was analyzed in pregnant patients.Results:The average age of 144 patients was 32.10±4.67 years old.96(66.67%)patients were found to have intrauterine abnormalities,while 48(33.33%)patients were found to have normal intrauterine cavity.48 cases of pregnancy,accounting for 33.33%;the median and interquartile ranges[M(Q1,Q3)]of ovulation induction cycles before and after surgery were respectively[3(0,5)],[2(1,3)],the difference was statistically significant(P<0.05).Among the 48 pregnant patients,32 of them had no structural lesions in hysteroscopy,the ovulation induction cycle of these patients before and after hysteroscopy were respectively[5(0,9)],[1(0,3)],the difference was statistically significant(P<0.05).Conclusion:Uterine cavity evaluation is important for the assessments of fertility.As an advanced diagnosis instrument,mini-hysteroscopy can not only timely detect the intrauterine abnormalities of patients,hut also with great application value in shorten the ovulation cycle in infertility patients and increase the pregnancy rate. | Luping Zhang Rui Ju Xiangyan Ruan Yinmei Dai Husheng Wang Fengyu Jin Jing Jin Muqing Gu Jiaojiao Cheng Yu Yang Xin Xu Thomas Roemer | 2021 | Global Health Journal2021，5，2： | 3 |
| 20 | Japanese Encephalitis Virus NS1' Protein Antagonizes Interferon Beta Production显示文摘Japanese encephalitis virus(JEV) is a mosquito-borne virus and the major cause of viral encephalitis in Asia. NS1', a52-amino acid C-terminal extension of NS1, is generated with a-1 programmed ribosomal frameshift and is only present in members of the Japanese encephalitis serogroup of flaviviruses. Previous studies demonstrated that NS1' plays a vital role in virulence, but the mechanism is unclear. In this study, an NS1' defected(rG66A) virus was generated. We found that rG66A virus was less virulent than its parent virus(pSA14) in wild-type mice. However, similar mortality caused by the two viruses was observed in an IFNAR knockout mouse model. Moreover, we found that rG66A virus induced a greater type Ⅰ interferon(IFN) response than that by pSA14, and JEV NS1' significantly inhibited the production of IFN-b and IFN-stimulated genes. Taken together, our results reveal that NS1' plays a vital role in blocking type I IFN production to help JEV evade antiviral immunity and benefit viral replication. | Dengyuan Zhou Fan Jia Qiuyan Li Luping Zhang Zheng Chen Zikai Zhao Min Cui Yunfeng Song Huanchun Chen Shengbo Cao Jing Ye | 2018 | Virologica Sinica2018，33，6： | 3 |
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