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| 1 | microRNA-21a-5p/PDCD4 axis regulates mesenchymal stem cell-induced neuroprotection in acute glaucoma显示文摘间充质的干细胞(MSC ) 被表明了为许多神经病学的疾病有有希望的治疗学的好处;然而,内在的机制糟糕被理解。这里,我们显示出 MSC 的那 intravitreal 注入在尖锐绿内障的一个老鼠模型的支持的网膜的中心细胞(RGC ) 幸存与 microglial 激活的重要抑制, TNF- , IL-1,和反应的氧种类的生产,以及 caspase-8 和 caspase-3 激活。在 vitro, MSC 禁止了两 caspase-8-mediated RGC apoptosis 和 microglial 激活,部分经由 stanniocalcin 的行动 1 (STC1 ) 。而且,我们发现了那 microRNA-21a-5p (miR-21 ) 和它的目标, PDCD4,为 STC1 生产和在 vitro 并且在 vivo 的 MSC 的 neuroprotective 性质是必要的。重要地, miR-21 overexpression 或 PDCD4 尖锐绿内障上的击倒的扩充调停 MSC 的 neuroprotective 效果。miR-21/PDCD4 轴由导致 MSC 分泌施加 neuroprotective 的 STC1 和另外的因素的以前未被认出的 neuroprotective 机制完成的这些数据热点。因此, modulating miR-21/PDCD4 轴可能是为尖锐绿内障和另外的神经病学的疾病的临床的处理的有希望的策略。 | Wenru Su Zuohong Li Yu Jia Yingting Zhu Wenjia Cai Peixing Wan Yingying Zhang Song Guo Zheng Yehong Zhuo | 2017 | Journal of Molecular Cell Biology2017，9，4： | 5 |
| 2 | Generation of time-varying orbital angular momentum beams with space-time-coding digital metasurface显示文摘The recently proposed extreme-ultraviolet beams with time-varying orbital angular momentum(OAM)realized by high-harmonic generation provide extraordinary tools for quantum excitation control and particle manipulation.However,such an approach is not easily scalable to other frequency regimes.We design a space-time-coding digital metasurface operating in the microwave regime to experimentally generate time-varying OAM beams.Due to the flexible programmability of the metasurface,a higher-order twist in the envelope wavefront structure of time-varying OAM beams can be further designed as an additional degree of freedom.The time-varying OAM field patterns are dynamically mapped by developing a two-probe measurement technique.Our approach in combining the programmability of space-time-coding digital metasurfaces and the two-probe measurement technique provides a versatile platform for generating and observing time-varying OAM and other spatiotemporal excitations in general.The proposed time-varying OAM beams have application potentials in particle manipulation,time-division multiplexing,and information encryption. | Jingxin Zhang Peixing Li Ray C.C.Cheung Alex M.H.Wong Jensen Li | 2023 | Advanced Photonics2023，5，3： | 1 |
| 3 | High resolution linkage disequilibrium and haplotype maps for the genes in the centromeric region of chromosome 15 in Tibetans and comparisons with Han population显示文摘Genetic variations and their functional implications have been one of the focuses in recent genome research. With the release of the HapMap by the International Consortium, and the availability of the ultra-high-volume genotyping platform, it will soon be possible to use genome-wide association ap- proach to identify genetic variations responsible for complex traits/diseases. While the power of this ap- proach is generally agreed, it is a debated issue as to how much population difference should be exploited, and how best it should be applied. To address this issue we have sequenced 7 genes in the centromeric region of chromosome 15, investigated their SNPs, SNP frequencies, tagSNPs, LD structures, and hap- lotypes in 50 Tibetan subjects, and compared them with those from the Han population. Genetic diversi- ties between the two populations were also quantified. Our results show that the overall genetic variation between the two populations is very little, but there are differences, primarily in allele frequencies, which is a dominating factor for haplotypes and tagSNPs. In general Tibetans have longer LD and less diversity inthe region studied. These data provide genetic evi- dence for the close relationship between the two populations, and support the idea that all populations are fundamentally the same, but also indicate popu- lation variations, particularly in allele frequency, should be taken into account in complex traits/ dis- eases analysis. Data obtained in this investigation not only help us understand the genome region, but also provide road maps for variation study in the genes/ region in Tibetan population. | HUANG Weijun LI Caixia Labu ZHOU Yan LI Peixing HU Bin Pubuzhuoma Gesangzhuogab FANG Jiqian WANG Yiming | 2006 | Chinese Science Bulletin2006，51，5： | 1 |
| 4 | The Design of Control System for Auto-Packing Pantyhose Machine显示文摘 | Peixing LI Zhijun SUN Helei ZHU Yize SUN | | 0，，： | 1 |
| 5 | Evaluation of Water Transfer Capacity of Poplar with Pectinase Treated under the Solar Interface Evaporation显示文摘Poplar wood,which was used as the absorption material for the solar-driven interfacial evaporation,was treated for 3 days,6 days and 9 days with the pectinase,and then was simulated for photothermal evaporation test at one standard solar radiation intensity(1 kW⋅m^(−2)).The effects of pectinase treatment on cell passage and water migration capacity of poplars were analyzed by the mercury intrusion porosimetry,the scanning electron microscope and fractal theory.It was found that the pit membrane and the ray parenchyma cells of poplar wood were degraded and destroyed after pectinase treatment.Compared with the untreated poplar wood,the evaporation rate of three sections of the specimen was changed.Especially the evaporation rate of radial and tangential direction was significantly increased.At the same time,based on the experimental data and fractal dimension deduction,fractal characteristics could be found in that the structure of poplars treated with pectinase.The porosity decreased with the increase of the fractal dimension in a certain range.It was shown that it is feasible to evaluate solar-driven water migration capacity by using fractal theory. | Wei Xiong Dagang Li Peixing Wei Lin Wang Qian Feng | 2023 | Journal of Renewable Materials2023，11，5： | 0 |
| 6 | Cartilage-targeting and inflammatory-responsive nanocarriers for effective osteoarthritis treatment via reactive oxygen species scavenging and anti-angiogenesis显示文摘Osteoarthritis(OA),a common disabling joint disease,is highly associated with microenvironmental changes in the cartilage and subchondral bone.Elevated reactive oxygen species(ROS)in the cartilage and subchondral bone angiogenesis accelerate articular cartilage erosion.New cartilage-targeting drug deliv-ery systems that are aimed at preventing ROS production and angiogenesis may be of clinical significance for OA treatment.Herein,an ROS scavenger and an inflammatory-responsive nanocarrier are designed by immobilizing the natural polyphenol(curcumin)in chitosan-catechol nanoformulations(Cur-CS-C NPs)via boronate ester.The robust cartilage-targeting effects and ROS scavenging capacities of Cur-CS-C NPs were respectively determined in cartilage explants and chondrocytes.Intra-articular injection of Cur-CS-C NPs in OA rat models efficiently suppressed angiogenesis and cartilage degradation partially via the ROS-mediated NF-κB/PI3K-Akt signaling pathway.The developed curcumin-functionalized nanocarriers can significantly delay OA progression and provide a promising therapeutic strategy for other inflamma-tory diseases that are characterized by oxidative stress and angiogenesis. | Sixiang Wang Yan Gao Lili Dong Peixing Chen Wanqian Liu Li Yang | 2023 | Journal of Materials Science & Technology2023，，12： | 0 |
| 7 | Multi-functionalized nanofibers with reactive oxygen species scavenging capability and fibrocartilage inductivity for tendon-bone integration显示文摘The presence of excessive reactive oxygen species(ROS)after injuries to the enthesis could lead to cellular oxidative damage,high inflammatory response,chronic inflammation,and limited fibrochondral inductivity,making tissue repair and functional recovery difficult.Here,a multifunctional silk fibroin nanofiber modified with polydopamine and kartogenin was designed and fabricated to not only effectively reduce inflammation by scavenging ROS in the early stage of the enthesis healing but also enhance fibrocartilage formation with fibrochondrogenic induction in the later stages.The in vitro results confirmed the antioxidant capability and the fibrochondral inductivity of the functionalized nanofibers.In vivo studies showed that the multifunctional nanofiber can significantly improve the integration of tendon-bone and accelerate the regeneration of interface tissue,resulting in an excellent biomechanical property.Thus,the incorporation of antioxidant and bio-active molecules into extracellular matrix-like biomaterials in interface tissue engineering provides an integrative approach that facilitates damaged tissue regeneration and functional recovery,thereby improving the clinical outcome of the engineered tissue. | Peixing Chen Sixiang Wang Zhi Huang Yan Gao Yu Zhang Chunli Wang Tingting Xia Linhao Li Wanqian Liu Li Yang | 2021 | Journal of Materials Science & Technology2021，，11： | 0 |
| 8 | Cross-laminated Timber(CLT)in China:A State-of-the-Art显示文摘As a new type of green low-carbon engineered wood product,cross-laminated timber(CLT)is widely used in various types of wooden buildings in Europe and North America,and the number of high-rise wood construction is also increasing.Based on the introduction of the structural characteristics of the CLT and the development status of the CLT in developed countries,this paper focused on the review of the status of research and development of the CLT in China,with an emphasis on the breakthrough technologies of new bamboo-wood composite CLT developed.Finally,the prospects of the CLT in China were discussed. | Hao LI Brad Jianhe WANG Peixing WEI Libin WANG | 2019 | Journal of Bioresources and Bioproducts2019，4，1： | 0 |
| 9 | Corrigendum to‘microRNA-21a-5p/PDCD4 axis regulates mesenchymal stem cell-induced neuroprotection in acute glaucoma’显示文摘Journal of Molecular Cell Biology(2017),9(4),289‒301,http://gffzzd3cc09b8251d45dfs0bkwp0cow5056bv5.ffgz.tsg.suse.edu.cn/10.1093/jmcb/mjx022 In this article,there were errors in Figures 4D(western blotting analysis),3E and F,5G and H,and 5J and K(flow cytometry analysis).Iba1 band in Figure 4D was the same as Cleaved caspase-3 band in Figure 2F.This was caused by carelessly mistaking the latter(Cleaved caspase-3,#1)for Iba1 band due to the high similarity between images(raw blot images of these bands from three experiments are provided in the Supplementary material).The corrected Figure 4D with updated Iba1 band(#1)and quantitation graph is shown below. | Wenru Su Zuohong Li Yu Jia Yingting Zhu Wenjia Cai Peixing Wan Yingying Zhang Song Guo Zheng Yehong Zhuo | 2023 | Journal of Molecular Cell Biology2023，15，4： | 0 |
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