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| 1 | Effect of hypnotherapy and educational intervention on brain response to visceral stimulus in the irritable bowel syndrome显示文摘 | M. B. O. Lowén E. A. Mayer M. Sj?berg K. Tillisch B. Naliboff J. Labus P. Lundberg M. Str?m M. Engstr?m S. A. Walter | 2013 | Aliment Pharmacol Ther2013，，12： | 4 |
| 2 | Effects of cutoff thresholds for minor allele frequencies on HapMap resolution: A real dataset-based evaluation of the Chinese Han and Tibetan populations显示文摘Genomic variation is the genetic basis of phenotypic diversity among individuals, including variation in disease susceptibility and drug response. The greatest promise of the International HapMap is to provide roadmaps for identifying genetic variants predisposing to complex diseases. Single nucleotide polymorphism (SNP) is the fundamental element of the HapMap. Allele frequency of SNPs is one of the major factors affecting the resulting HapMap, being the factor upon which linkage disequilibrium (LD) is calculated, haplotypes are constructed, and tagging SNPs (tagSNPs) are selected. The cutoff thresholds for the frequency of minor alleles used in the making of the map therefore have profound effects on the resolution of that map. To date most researchers have adopted their own cutoff thresholds, and there has been little real dataset-based evaluation of the effects of different cutoff thresholds on HapMap resolution. In an attempt to assess the implications of different cutoff values, we analyzed our own data for the centromeric genes on Chromosome 15 in Chinese Han and Tibetan populations, with respect to minor allele frequency cutoff values of ≥0.01 (0.01 group), ≥0.05 (0.05 group), and ≥0.10 (0.10 group), and constructed HapMaps from each of the datasets. The resolution, study power and cost-effectiveness for each of the maps were compared. Our results show that the 0.01 threshold pro- vides the greatest power (P = 0.019 in Han and P = 0.029 in Tibetan for 0.01 vs. 0.05 threshold) and detects most population-specific haploypes (P = 0.012 for 0.01 vs. 0.05 threshold). However, in the regions studied, the 0.05 cutoff threshold did not significantly increase power above the 0.10 threshold (P = 0.191 in Han; 1.000 in Tibetans), and did not improve resolution over the 0.10 value for population-specific haplotypes (P = 0.592) neither. Furthermore the 0.05 and 0.10 values produced the same figures for tagging efficiency, LD block number, LD length, study power and cost-savings in the Tibetan population. These results suggest that a lower cutoff value is more appropriate for studies in which population-specific haplotypes are crucial, and that the most appropriate cutoff value may differ between populations. Due to the limited genes studied in this project more studies should be conducted to further address this important issue. | XIONG ShiYi HAO YuanTao RAO ShaoQi HUANG WeiJun HU Bin Labu Pubuzhuoma Gesangzhuogab WANG YiMing | 2009 | Chinese Science Bulletin2009，54，12： | 3 |
| 3 | Quantitative Meta-analysis Identifies Brain Regions Activated During Rectal Distension in Irritable Bowel Syndrome显示文摘 | Kirsten Tillisch Emeran A. Mayer Jennifer S. Labus | 2011 | Gastroenterology2011，，1： | 3 |
| 4 | Evidence for alterations in central noradrenergic signaling in irritable bowel syndrome显示文摘 | Steven Berman Brandall Suyenobu Bruce D. Naliboff Joshua Bueller Jean Stains Heng Wong Mark Mandelkern Leah Fitzgerald Gordon Ohning Arpana Gupta Jennifer S. Labus Kirsten Tillisch Emeran A. Mayer | 2012 | Neuroimage2012，，4： | 3 |
| 5 | Diffusion tensor imaging (DTI) detects microstructural reorganization in the brain associated with chronic irritable bowel syndrome (IBS)显示文摘 | Benjamin M. Ellingson Emeran Mayer Robert J. Harris Cody Ashe-McNally Bruce D. Naliboff Jennifer S. Labus Kirsten Tillisch | 2013 | Pain2013，，： | 2 |
| 6 | Consumption of Fermented Milk Product With Probiotic Modulates Brain Activity显示文摘 | Kirsten Tillisch Jennifer Labus Lisa Kilpatrick Zhiguo Jiang Jean Stains Bahar Ebrat Denis Guyonnet Sophie Legrain–Raspaud Beatrice Trotin Bruce Naliboff Emeran A. Mayer | 2013 | Gastroenterology2013，，7： | 2 |
| 7 | The HTR3A Polymorphism c. -42C>T Is Associated With Amygdala Responsiveness in Patients With Irritable Bowel Syndrome显示文摘 | Lisa A. Kilpatrick Jennifer S. Labus Kristen Coveleskie Christian Hammer Gudrun Rappold Kirsten Tillisch Joshua A. Bueller Brandall Suyenobu Johana M. Jarcho Jim A. McRoberts Beate Niesler Emeran A. Mayer | 2011 | Gastroenterology2011，，7： | 2 |
| 8 | Irritable bowel syndrome in female patients is associated with alterations in structural brain networks显示文摘 | Jennifer S. Labus Ivo D. Dinov Zhiguo Jiang Cody Ashe-McNalley Alen Zamanyan Yonggang Shi Jui-Yang Hong Arpana Gupta Kirsten Tillisch Bahar Ebrat Sam Hobel Boris A. Gutman Shantanu Joshi Paul M. Thompson Arthur W. Toga Emeran A. Mayer | 2014 | Pain2014，，1： | 2 |
| 9 | Advances in Imaging the Brain–Gut Axis: Functional Gastrointestinal Disorders显示文摘 | Kirsten Tillisch Jennifer S. Labus | 2011 | Gastroenterology2011，，2： | 2 |
| 10 | Sex differences in emotion-related cognitive processes in irritable bowel syndrome and healthy control subjects显示文摘 | Jennifer S. Labus Arpana Gupta Kristen Coveleskie Kirsten Tillisch Lisa Kilpatrick Johanna Jarcho Natasha Feier Joshua Bueller Jean Stains Suzanne Smith Brandall Suyenobu Bruce Naliboff Emeran A. Mayer | 2013 | Pain2013，，： | 2 |
| 11 | Genetic and structural analyses suggest that a novel SPG3A mutation causes severe phenotypes of hereditary spastic paraplegia显示文摘Hereditary spastic paraplegia (HSP) is a group of neurodegenerative diseases. The genotypes and phenotypes of HSP are extremely heterogenous. SPG3A is one of the identified genes underlying HSP, and codes for a GTPase, atlastin. Mutations in SPG3A are currently believed to be associated with early onset and mild phenotypes. And most structura predictions could not detect gross changes in the mutant protein. However, in a severely affected HSP family we have identified a novel SPG3A mutation, c.1228G>A (p.G410R), in a Tibetan kindred. The mutation occurred at the highly conserved nucleotide and co-segregated with the disease, and was absent in the control subjects. Structural predictions showed that the Tibetan mutation occurred at the linking part between the guanylate-binding protein domain (GB, the ball region) and the transmembrane helices (TM, the rod region) at the start point of an α-helix, which may disrupt the helix, and cause changes in the overall structure of the transmembrane region of the molecule. Our results indicate that severe pheno- types can also arise from SPG3A mutations and the linking part of the guanylate-binding protein domainand the transmembrane helices might be crucial in determining the severity of the disease. This paper not only presents the first SPG3A mutational report from the Chinese population, but also provides po- tential evidence for a possible correlation between the severity of the phenotypes of HSP with the ex- tension of the changes in the protein structures of atlastin. | CHEN Suqin ZHOU Yan LI Xunhua Labu HUANG Shuang HUANG Weijun ZHOU Chunlong MAXWELL Patrick H WANG Yiming | 2006 | Chinese Science Bulletin2006，51，16： | 2 |
| 12 | Regional Gray Matter Density Changes in Brains of Patients With Irritable Bowel Syndrome显示文摘 | David A. Seminowicz Jennifer S. Labus Joshua A. Bueller Kirsten Tillisch Bruce D. Naliboff M. Catherine Bushnell Emeran A. Mayer | 2010 | Gastroenterology2010，，1： | 2 |
| 13 | Genome fingerprinting by simple sequence repeart (SSR) an hored polymerase chain reaction amplification 显示文摘 | ZIE DEWIEZ E RAFALSKI A LABU DAD | 1994 | Genomics1994，20，： | 1 |
| 14 | Genome fingerprintingby simple sequence repeart(SSR)an hored polymerase chain reactionamplification 显示文摘 | ZIE DEWIEZ E RAFALSKI A LABU DA D | 1994 | Genomics1994，20，： | 1 |
| 15 | Wheat yield estimates using multi temporal NDVI satellite imagery 显示文摘 | Labus M P Nielsen G Lawarence R L | 2002 | International Journal of Remote Sensing2002，23，20： | 1 |
| 16 | Interleukin - lbeta induces an inflammatory response and the breakdown of the endothelial cell layer in an improved human THBMEC - based in vitro blood -brain balker model 显示文摘 | Labus J Haekel S Lucka L | 2014 | J Neurosci Methods2014，228，： | 1 |
| 17 | Impaired emotional learn- ing and involvement of the corticotropin-releasing factor signaling system in patients with irritable bowel syndrome 显示文摘 | Labus JS Hubbard CS Bueller J | 2013 | Gastroenterolo- gy2013，145，6： | 1 |
| 18 | Conversion from cyclosporine to tacrolimus improves renal function an d lipid profile after cardiac transplantation显示文摘 | Garlicki M Czub P Labus K | 2006 | Ann Transplant2006，11，1： | 1 |
| 19 | Neurokinin-I-receptor antagonism decreases anxiety and emotional arousal circuit response to noxious visceral distension in women with irritable bowel syndrome: a pilot study 显示文摘 | Tillisch K Labus J Nam B | 2012 | Aliment Pharmacol Ther2012，35，3： | 1 |
| 20 | General coming ability of six genotypes of spring wheat (Triticum aestium) for biscuit Quality Characteristic显示文摘 | Coetzee M C B Van-Deventer C S | 1996 | Planting-breeding1996，115，： | 1 |
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