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| 1 | Comparison of Postoperative Pain Following Laser-assisted Subepithelial Keratectomy and Transepithelial Photorefractive Keratectomy:a Prospective,Random Paired Bilateral Eye Study显示文摘Purpose:To compare postoperative pain following laser-assisted subepithelial keratectomy(LASEK) and transepithelial photorefractive keratectomy(T-PRK, two-step surgery) and alleviate postoperative subjective pain.Methods:.Thirty patients(60 eyes) with myopia or myopic astigmatism were consecutively recruited into this prospective,randomized paired study..Patients underwent LASEK in one eye,and T-PRK in the other. The degree of pain was rated on a scale of 0-10 on postoperative days 1,2 and 3..Uncorrected visual acuity(UCVA) and subepithelial corneal haze were assessed at postoperative 1 and 3 months.Results:.The pain was relieved on the 4th postoperative day in all patients,.healing of corneal epithelium was observed at4-5 days after surgery and contact lenses were removed promptly.At postoperative 1 day,.the mean subjective pain score in the LASEK group was 3.2±1.88 and 4.43±1.61 in TPRK group(P=0.008).No significant difference was found between two groups on postoperative 2 and 3 days. At postoperative 3 months, the percentage of UCVA ≥0.8 in the LASEK group was 100% and 96.7% in the T-PRK group.(P =0.24),93.3% of patients in the LASEK with UCVA ≥1.0 and 90%in the T-PRK group(P=0.64). In the LASEK group, the value of corneal haze was 0.26 ±0.21 and 0.27 ±0.25 in the T-PRK group(P=0.877).Conclusion:.Good visual acuity was obtained in both groups at postoperative 3 months. Compared with those in the T-PRKgroup, patients undergoing had less discomfort in the LASEK group, which may be associated with corneal epithelial activity. The changing curve of subjective pain in the T-PRK group was relatively flat and stable at postoperative 3 days. | Dongmei Wang Guangsheng Chen Liusong Tang Qiaoling Li | 2014 | Eye Science2014，29，3： | 14 |
| 2 | Developing gene-tagged molecular markers for evaluation of genetic association of apple SWEET genes with fruit sugar accumulation显示文摘Sugar content is an important component of fruit quality.Although sugar transporters are known to be crucial for sugar accumulation,the role of genes encoding SWEET sugar transporters in fruit sugar accumulation remains elusive.Here we report the effect of the SWEET genes on fruit sugar accumulation in apple.A total of 25 MdSWEET genes were identified in the apple genome,and 9 were highly expressed throughout fruit development.Molecular markers of these 9 MdSWEET genes were developed and used for genotyping of 188 apple cultivars.The association of polymorphic MdSWEET genes with soluble sugar content in mature fruit was analyzed.Three genes,MdSWEET2e,MdSWEET9b,and MdSWEET15a,were significantly associated with fruit sugar content,with MdSWEET15a and MdSWEET9b accounting for a relatively large proportion of phenotypic variation in sugar content.Moreover,both MdSWEET9b and MdSWEET15a are located on chromosomal regions harboring QTLs for sugar content.Hence,MdSWEET9b and MdSWEET15a are likely candidates regulating fruit sugar accumulation in apple.Our study not only presents an efficient way of implementing gene functional study but also provides molecular tools for genetic improvement of fruit quality in apple-breeding programs. | Qiaoling Zhen Ting Fang Qian Peng Liao Liao Li Zhao Albert Owiti Yuepeng Han | 2018 | Horticulture Research2018，5，1： | 12 |
| 3 | Notoginsenoside Ft1 acts as a TGR5 agonist but FXR antagonist to alleviate high fat diet-induced obesity and insulin resistance in mice显示文摘Obesity and its associated complications are highly related to a current public health crisis around the world.A growing body of evidence has indicated that G-protein coupled bile acid(BA) receptor TGR5(also known as Gpbar-1) is a potential drug target to treat obesity and associated metabolic disorders.We have identified notoginsenoside Ftl(Ftl) from Panax notoginseng as an agonist of TGR5 in vitro.However,the pharmacological effects of Ftl on diet-induced obese(DIO) mice and the underlying mechanisms are still elusive.Here we show that Ftl(100 mg/100 diet) increased adipose lipolysis,promoted fat browning in inguinal adipose tissue and induced glucagon-like peptide-1(GLP-1) secretion in the ileum of wild type but not Tgr5^(-/-) obese mice.In addition,Ftl elevated serum free and taurineconjugated bile acids(BAs) by antagonizing Fxr transcriptional activities in the ileum to activate Tgr5 in the adipose tissues.The metabolic benefits of Ftl were abolished in Cyp27 al^(-/-) mice which have much lower BA levels.These results identify Ftl as a single compound with opposite activities on two key BA receptors to alleviate high fat diet-induced obesity and insulin resistance in mice. | Lili Ding Qiaoling Yang Eryun Zhang Yangmeng Wang Siming Sun Yingbo Yang Tong Tian Zhengcai Ju Linshan Jiang Xunjiang Wang Zhengtao Wang Wendong Huang Li Yang | 2021 | Acta Pharmaceutica Sinica B2021，11，6： | 10 |
| 4 | Effect of size and crystalline phase of TiO2 nanotubes on cell behaviors: A high throughput study using gradient TiO2 nanotubes显示文摘The research of TiO2 nanotubes(TNTs)in the field of biomedicine has been increasingly active.However,given the diversity of the nanoscale dimension and controversial reports,our understanding of the structure-property relationships of TNTs is not yet complete.In this paper,gradient TNTs with a wide diameter range of 20-350 nm were achieved by bipolar electrochemistry and utilized for a thorough high-throughput study of the effect of nanotube dimension and crystalline phase on protein adsorption and cell behaviors.Results indicated that protein adsorption escalated with nanotube dimension whereas cell proliferation and differentiation are preferred on small diameter(<70 nm)nanotubes.Large diameter anatase nanotubes had higher adsorption of serum proteins than as-prepared ones.But only as-prepared small diameter nanotubes presented slightly higher cell proliferation than corresponding annealed nanotubes whereas there was no discernible difference between as-prepared and annealed nanotubes on cell differentiation for the entire gradient.Those findings replenish previous research about how cell responses to TNTs with a wide diameter range and provide scientific guidance for the optimal design of biomedical materials. | Yanran Li Si Wang Yuanjun Dong Ping Mu Yun Yang Xiangyang Liu Changjian Lin Qiaoling Huang | 2020 | Bioactive Materials2020，5，4： | 3 |
| 5 | A super pan-genomic landscape of rice显示文摘Pan-genomes from large natural populations can capture genetic diversity and reveal genomic complexity.Using de novo longread assembly,we generated a graph-based super pan-genome of rice consisting of a 251-accession panel comprising both cultivated and wild species of Asian and African rice.Our pan-genome reveals extensive structural variations(SVs)and gene presence/absence variations.Additionally,our pan-genome enables the accurate identification of nucleotide-binding leucine-rich repeat genes and characterization of their inter-and intraspecific diversity.Moreover,we uncovered grain weight-associated SVs which specify traits by affecting the expression of their nearby genes.We characterized genetic variants associated with submergence tolerance,seed shattering and plant architecture and found independent selection for a common set of genes that drove adaptation and domestication in Asian and African rice.This super pan-genome facilitates pinpointing of lineage-specific haplotypes for trait-associated genes and provides insights into the evolutionary events that have shaped the genomic architecture of various rice species. | Lianguang Shang Xiaoxia Li Huiying He Qiaoling Yuan Yanni Song Zhaoran Wei Hai Lin Min Hu Fengli Zhao Chao Zhang Yuhua Li Hongsheng Gao Tianyi Wang Xiangpei Liu Hong Zhang Ya Zhang Shuaimin Cao Xiaoman Yu Bintao Zhang Yong Zhang Yiqing Tan Mao Qin Cheng Ai Yingxue Yang Bin Zhang Zhiqiang Hu Hongru Wang Yang Lv Yuexing Wang Jie Ma Quan Wang Hongwei Lu Zhe Wu Shanlin Liu Zongyi Sun Hongliang Zhang Longbiao Guo Zichao Li Yongfeng Zhou Jiayang Li Zuofeng Zhu Guosheng Xiong Jue Ruan Qian Qian | 2022 | Cell Research2022，32，10： | 3 |
| 6 | Dynamic monitoring of menopause hormone therapy and defining the cut-off value of endometrial thickness during uterine bleeding显示文摘The aim of this study was to evaluate the effects of low-dose tibolone therapy on ovarian area,uterine volume and endometrial thickness,and define the cut-off value of endometrial thickness for curettage during uterine bleeding.We followed 619 postmenopausal women,aged 40-60 years,for two years.There were 301 subjects in the low-dose tibolone treatment group and 318 subjects in the control group.The ovarian area,uterine volume and endometrial thickness in all participants were measured by transvaginal ultrasound prior to,one and two years post enrollment,respectively.Endometrial specimens were collected from all subjects with abnormal uterine bleeding during the follow-up period.We found that the uterine volume in the treatment group was greater than that in the control group,and the difference was significant(P<0.05),but there were no significant differences in ovarian area and endometrial thickness between the two groups(P>0.05).When the cut-off value for endometrial thickness was 7.35 mm,the sensitivity and specificity were 100%and 79.07%,respectively,and 85.71%and 93.02%when 7.55 mm was set as the cut-off during tibolone therapy.The results indicate that low-dose tibolone therapy may postpone uterine atrophy and the cut-off value of endometrial thickness may be appropriately adjusted for curettage. | Qiu Sheng Jun Yang Qiaoling Zhao Fen Li | 2016 | The Journal of Biomedical Research2016，30，3： | 3 |
| 7 | Effects of cultivation of Osr HSA transgenic rice on functional diversity of microbial communities in the soil rhizosphere显示文摘With the widespread cultivation of transgenic crops, there is increasing concern about unintended effects of these crops on soil environmental quality. In this study, we used the Biolog method and ELISA to evaluate the possible effects of Osr HSA transgenic rice on soil microbial utilization of carbon substrates under field conditions. There were no significant differences in average well-color development(AWCD) values, Shannon–Wiener diversity index(H), Simpson dominance indices(D) and Shannon–Wiener evenness indices(E) of microbial communities in rhizosphere soils at eight samplings between Osr HSA transgenic rice and its non-transgenic counterpart. The main carbon sources utilized by soil microbes were carbohydrates, carboxylic acids, amino acids and polymers. The types,capacities and patterns of carbon source utilization by microbial communities in rhizosphere soils were similar throughout the detection period. We detected no Osr HSA protein in the roots of Osr HSA transgenic rice. We concluded that Osr HSA transgenic rice and the r HSA protein it produced did not alter the functional diversity of microbial communities in the rhizosphere. | Xiaobing Zhang Xujing Wang Qiaoling Tang Ning Li Peilei Liu Yufeng Dong Weimin Pang Jiangtao Yang Zhixing Wang | 2015 | The Crop Journal2015，3，2： | 3 |
| 8 | Dispersion Performance of Methanol-Diesel Emulsified Fuel Prepared by High Gravity Technology显示文摘A new continuous process for preparing methanol-diesel emulsified fuel with an Impinging Stream-Rotating Packed Bed is proposed. The droplet size of dispersed phase(methanol) of the emulsified fuel has a significant effect on the combustion of methanol-diesel emulsified fuel. In this paper, the methanol-diesel emulsified fuel uses diesel as the continuous phase and methanol as the dispersed phase. The Sauter mean diameter of the dispersed phase of methanol-diesel emulsified fuel was characterized with microphotography and arithmetic method. The experimental result showed that the Sauter mean diameter of the dispersed phase, which was decreased with the augmentation of the high gravity factor, liquid flow rate and emulsifier dosage, was inversely proportional to the methanol content. The Sauter mean diameter of the dispersed phase can be controlled and adjusted in the range of 12—40 μm through the change of operating conditions. The correlative expressions of the Sauter mean diameter of emulsified fuel were obtained and the calculated values agreed well with the experimental values. | Jiao Weizhou Li Jing Liu Youzhi Zhang Qiaoling Liu Wenli Xu Chengcheng Guo Liang | 2014 | China Petroleum Processing & Petrochemical Technology2014，16，1： | 2 |
| 9 | TiO_2–SA–Arg nanoparticles stabilized Pickering emulsion for photocatalytic degradation of nitrobenzene in a rotating annular reactor显示文摘Pickering emulsions stabilized by salicylic acid and arginine modified titanium dioxide(Ti O2–SA–Arg) nanoparticles were prepared in this study for photocatalytic degradation of nitrobenzene in a rotating annular reactor,and the effects of various design parameters of the rotating annular reactor, initial nitrobenzene concentration,catalyst amount, and solution p H on the degradation rate of nitrobenzene were investigated. Meanwhile, the degradation mechanism of nitrobenzene was proposed. The results show that increasing the aeration rate, the rotational speed, and light intensity results in a higher photocatalytic degradation rate of nitrobenzene owing to the effective clearance of electrons and a high quantity of oxidative free radicals. The degradation of nitrobenzene in the rotating annular reactor follows the pseudo first-order kinetics, but it is not well described by the Langmuir–Hinshelwood equation. Aeration has a significant effect on the photocatalytic degradation pathway of nitrobenzene. Because nitrobenzene can undergo reduction reaction as electron acceptors and oxidative degradation initiated by hydroxyl free radicals, the photocatalytic degradation of nitrobenzene follows the reduction mechanism under no aeration, but the oxidation mechanism under aeration. | Shiguang Zhang Lei Li Youzhi Liu Qiaoling Zhang | 2017 | Chinese Journal of Chemical Engineering2017，25，2： | 2 |
| 10 | Generating Giant Membrane Vesicles from Live Cells with Preserved Cellular Properties显示文摘Biomimetic giant membrane vesicles,with size and lipid compositions comparable to cells,have been recognized as an attractive experimental alternative to living systems.Due to the similarity of their membrane structure to that of body cells,cell-derived giant plasma membrane vesicles have been used as a membrane model for studying lipid/protein behavior of plasma membranes.However,further application of biomimetic giant membrane vesicles has been hampered by the side-efects of chemical vesiculants and the utilization of osmotic bufer.We herein develop a facile strategy to derive giant membrane vesicles(GMVs)from mammalian cells in biofriendly medium with high yields.Tese GMVs preserve membrane properties and adaptability for surface modifcation and encapsulation of exogenous molecules,which would facilitate their potential biological applications.Moreover,by loading GMVs with therapeutic drugs,GMVs could be employed for drug transport to tumor cells,which represents another step forward in the biomedical application of giant membrane vesicles.Tis study highlights biocompatible GMVs with biomimicking membrane surface properties and adaptability as an ideal platform for drug delivery strategies with potential clinical applications. | Qiaoling Liu Cheng Bi Jiangling Li Xuejiao Liu Ruizi Peng Cheng Jin Yang Sun Yifan Lyu Hui Liu Huijing Wang Can Luo Weihong Tan | 2019 | Research2019，，1： | 2 |
| 11 | Preparation and magnetic properties of Fe_2O_3 microtubules prepared by sol-gel template method显示文摘Fe(OH)3 precursor sol was prepared by a sol-gel method.The precursor sol was dipped onto the absorbent cotton,and gel was formed on the absorbent cotton template after the volatilization of moisture.Fe2O3 microtubules were synthesized after the process of self-propagation or calcination.The phase,morphology,and particle diameter of the samples were examined by X-ray diffraction(XRD) and scanning electron microscopy(SEM),and the magnetic properties of the samples were measured using a vibrating sample magnetometer(VSM).The external diameters of Fe2O3 microtubules ranged between 8 and 13 μm,and the wall thicknesses ranged between 0.5 and 2 μm.The type of the calcination method plays a significant role in developing the Fe2O3 phase and the variation in the magnetic properties in the sol-gel template complexing method.γ-Fe2O3 was synthesized by a self-propagation method.However,α-Fe2O3 was synthesized after calcination at 400 °C for 2 h.The coercivity of the samples synthesized by calcination at 400°C for 2 h after self-propagation was found to increase significantly,thereby presenting hard magnetic properties. | CHANG Chuanbo ZHANG Cunrui WANG Wenyan LI Qiaoling | 2010 | Rare Metals2010，29，5： | 2 |
| 12 | The behaviors of ultra-low-gold-loaded catalysts (Au/ Ce02) for CO oxidation in the presence of water on the catalysts显示文摘The catalytic behavior of ultra-low-gold-loaded Au/CeO2 during CO oxidation was studied using HRTEM, TGA, in-situ FTIR, CO--TPD, O2-TPD, and O2-TPO. Herein, water, which facilitates CO oxidation, is present on the catalyst rather than obtained from the reactant gas. The experimental results show that the presence of water on the catalyst enhances the adsorption and activation of 02 to produce Oact on the catalyst surface, resulting in excellent catalytic activity. Different reaction pathways for CO oxidation over Au/CeO2 may be present; however, the dominant pathway is influenced by the species on the catalyst surface. | Qiaoling Li Wei Xie Guoqin Chen Yuefeng Li Yanjun Huang Xiaodong Chen | 2015 | Nano Research2015，8，9： | 2 |
| 13 | Variation in Chromosome Constitution of the Xiaoyan Series Partial Amphiploids and Its Relationship to Stripe Rust and Stem Rust Resistance显示文摘The wild relatives of wheat(Triticum aestivum L.)contain tremendous amounts of potentially useful genes and represent a promising source of genetic diversity for wheat improvement(Bommineni and Jauhar,1997).Thinopyrum ponticum(Popd.)Barkworth and D.R.Dewey[syn.Agropyron | Qi Zheng Qiaoling Luo Zhixia Niu Hongwei Li Bin Li Steven S.Xu Zhensheng Li | 2015 | Journal of Genetics and Genomics2015，42，11： | 2 |
| 14 | Effect of MWCNTs content on the magnetic and wave absorbing properties of ferrite-MWCNTs composites显示文摘 | Wenting Wang Qiaoling Li Chuanbo Chang | 2010 | Synthetic Metals2010，，1： | 1 |
| 15 | Existence and multiplicity of positive solutions to elliptic systems in- volving critical exponents 显示文摘 | WANG LI WEI QIAOLING KANG DONGSHENG | 2011 | Journal of Mathematical Analysis and Applications2011，383，2： | 1 |
| 16 | Fabri- cation and thermal stability studies of polyamide 66 con- taining triaryl phosphine oxide 显示文摘 | Yang Xiaofeng Li Qiaoling Chen Zhiping | 2009 | Bulletin of Materials Science2009，32，4： | 1 |
| 17 | Preparation and Characterization of Biodegradable Chitosan/hydroxyapatite Nanocomposite Rods via in situ Hybridization :a Potential Material as Internal Fixation of Bone Fracture显示文摘 | Hu Qiaoling Li Baoqiang Wang Mang | 2004 | Biomaterials2004，25，： | 1 |
| 18 | Preparation and characterization of biodegradable chitosan/hydroxyapatite nanocomposite rods via in situ hybridization: a potential material as internal fixation of bone fracture显示文摘 | Qiaoling Hu Baoqiang Li Mang Wang Jiacong Shen | 2003 | Biomaterials2003，，5： | 1 |
| 19 | Molecular phylogeny of the domesticated silkworm,Bombyx mori, based on the sequences of mitochondrialcytochrome b genes显示文摘 | Ailing Li Qiaoling Zhao Shunming Tang Zhifang Zhang Shenyuan Pan Guifang Shen | 2005 | Journal of Genetics2005，，2： | 1 |
| 20 | Preparation and characterization of biodegradable chitosan/hydroxyapatite nanocomposite rods via in situ hybridization:a potential material as internal fixation of bone fracture显示文摘 | BAOQIANG LI MANG WANG | 2004 | Biomaterials2004，25，： | 1 |
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