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| 1 | A large-scale flight multi-objective assignment approach based on multi-island parallel evolution algorithm with cooperative coevolutionary显示文摘Due to the rapid increase of air traffic demand, the large-scale flight assignment plays a crucial role in reducing airspace congestion and economic losses via reasonably regulating the air traffic flow of China. In this paper, the large-scale flight assignment problem is formulated as a multi-objective model with consideration of the reduction of airspace congestion and flight delay. However, it is a large-scale combinatorial optimization problem with complex constraints and tightly coupled decision variables, which is difficult to deal with.Hence, an effective multi-objective optimization algorithm is proposed based on the multi-island parallel evolution framework(PEA) with a left-right probability migration topology. Multi-island PEA employs multiple evolution populations for solving the problem simultaneously, and the left-right probability migration topology for exchange individuals among populations to improve the efficiency of the cooperation of populations. Then the cooperative co-evolution(CC) algorithm is introduced for each population to further improve the searching capability. Simulation results using the real traffic data from the China air route network and daily flight plans demonstrate that the proposed approach can improve the solution quality effectively, showing superiority to the existing approaches such as the multi-objective genetic algorithm, the well-known multi-objective evolutionary algorithm based on decomposition, a CC-based multi-objective algorithm as well as other two parallel evolution algorithms with different migration topologies. | Renli LU Xiangmin GUAN Xueyuan LI Inseok HWANG | 2016 | Science China(Information Sciences)2016，59，7： | 4 |
| 2 | Whole-Genome Sequences Analysis Displays Relationship of SARS-CoV-2 Delta Variant Between Four Local Cases and Passengers of a Flight from South Africa—Shenzhen City,Guangdong Province,China,June 2021显示文摘On June 14,2021,a customs officer(Case A)went to the infirmary at Baoan International Airport in Shenzhen due to a runny nose and fever.He was admitted to the Central Hospital of Baoan immediately.This patient preliminarily tested positive for coronavirus disease 2019(COVID-19)infection,caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),using a quantitative realtime reverse transcription polymerase chain reaction(qRT-PCR)method in this hospital.Then,a mixed specimen of nasopharyngeal swab. | Yaqing He Renli Zhang Qiuying Lyu Bo Peng Shujiang Mei Ying Sun Dongfeng Kong Chaoqiong Peng Ziquan Lyu Xinyi Wei Can Zhu Xiaoliang Xiao Shimin Li Qingju Lu Jiancheng Chen Hang Zhang Xuan Zou Tiejian Feng Long Chen | 2021 | China CDC weekly2021，3，50： | 3 |
| 3 | Analysis of terrestrial water storage changes in the Shaan-Gan-Ning Region using GPS and GRACE/GFO显示文摘Both the Global Positioning System(GPS)and Gravity Recovery and Climate Experiment(GRACE)/GRACE Follow-On(GFO)provide effective tools to infer surface mass changes.In this paper,we combined GPS,GRACE/GFO spherical harmonic(SH)solutions and GRACE/GFO mascon solutions to analyze the total surface mass changes and terrestrial water storage(TWS)changes in the Shaan-Gan-Ning Region(SGNR)over the period from December 2010 to February 2021.To improve the reliability of GPS inversion results,an improved regularization Laplace matrix and monthly optimal regularization parameter estimation strategy were employed to solve the ill-posed problem.The results show that the improved Laplace matrix can suppress the edge effects better than that of the traditional Laplace matrix,and the corre-lation coefficient and standard deviation(STD)between the original signal and inversion results from the traditional and improved Laplace matrix are 0.84 and 0.88,and 17.49 mm and 15.16 mm,respectively.The spatial distributions of annual amplitudes and time series changes for total surface mass changes derived from GPS agree well with GRACE/GFO SH solutions and mascon solutions,and the correlation coefficients of total surface mass change time series between GPS and GRACE/GFO SH solutions,GPS and GRACE/GFO mascon solutions are 0.80 and 0.77.However,the obvious differences still exist in local regions.In addition,the seasonal characteristics,increasing and decreasing rate of TWS change time series derived from GPS,GRACE/GFO SH and mascon solutions agree well with the Global Land Data Assimilation System(GLDAS)hydrological model in the studied area,and generally consistent with the precipitation data.Meanwhile,TWS changes derived from GPS and GRACE mascon solutions in the SGNR are more reliable than those of GRACE SH solutions over the period from January 2016 to June 2017(the final operation phase of the GRACE mission). | Xianpao Li Bo Zhong Jiancheng Li Renli Liu | 2022 | Geodesy and Geodynamics2022，13，2： | 2 |
| 4 | Mechanism for the Nanometer Scale Modification on HOPG Surface by Scanning Tunneling Microscope显示文摘A technique applying voltage across the tunnel junction for wnting permanent features on graphite with lines about 10nm wiidth using our home-built scanning tunneling microscope has been presented.Multiple-tip effects while modifying the surface are often met.The phenomciifi are explained in terms of the strong electric field existing at the junction between the tip an<7 the surface.In addition,the shape of the structure indented by the tip is in agreement with that of the tip. | WANG Zhonghuai DAI Changchun ZHANG Pingchen HUANG Guizhen LI Renli GUO Yi BAI Chunli | 1993 | Chinese Physics Letters1993，10，9： | 2 |
| 5 | Four COVID-19 Cases of New Variant B.1.351 First Emerging in South Africa in Chinese Passengers on Same Flight-Shenzhen,China,January 2021显示文摘At 04∶50 on January 1,2021,a 36-year-old Chinese project manager(Case A),a 29-year-old Chinese worker(Case B),and a 53-year-old Chinese businessman(Case C)returned from Africa(Case A and B from South Africa and Case C from Lesotho)on the same flight and tested coronavirus disease 2019(COVID-19)RNA positive by real-time polymerase chain reaction(PCR)by Baoan District People’s Hospital.Shenzhen CDC received their oral nasopharyngeal swabs packages from the hospital and retested COVID-19 RNA positive at 09∶50.Meanwhile,Case D. | Cong Cheng Lei Wang Ziquan Lyu Bo Peng Yinghui Li Dongfeng Kong Le Zuo Xiaomin Zhang Chao Yang Weiwen Liu Jia Wan Yijun Tang Junjia He Ying Wen Shule Xu Weihua Wu Ying Chen Guangnan Liu Junjie Xia Xuan Zou Renli Zhang Qinghua Hu Shujiang Mei Tiejian Feng | 2021 | China CDC weekly2021，3，8： | 2 |
| 6 | The Lipid-regulating Effects of Ator- vastatin on Type 2 Elder Diabetes Patients with Hyperlipidemia显示文摘 | Tu Ling Liu Xiaoqing Li Renli etc | 2004 | Jour- nal of Huazhong University of Science and Technology2004，24，2： | 1 |
| 7 | Analysis of atrial fibrillation after implantation of VVI pacemaker long-term observation of 154patients 显示文摘 | Yao Jihua | 2000 | J Tongji Medical University2000，20，2： | 1 |
| 8 | Effects of Ketamine on Basal Gamma Band Oscillation and Sensory Gating in Prefrontal Cortex of Awake Rats显示文摘Gamma band oscillation(GBO) and sensory gating(SG) are associated with many cognitive functions.Ketamine induces deficits of GBO and SG in the prefrontal cortex(PFC). However, the time-courses of the effects of different doses of ketamine on GBO power and SG are poorly understood. Studies have indicated that GBO power and SG have a common substrate for their generation and abnormalities. In this study, we found that(1) ketamine administration increased GBO power in the PFC in rats differently in the low-and high-dose groups;(2) auditory SG was significantly lower than baseline in the 30 mg/kg and 60 mg/kg groups, but not in the 15 mg/kg and 120 mg/kg groups; and(3) changes in SG and basal GBO power were significantly correlated in awake rats. These results indicate a relationship between mechanisms underlying auditory SG and GBO power. | Renli Qi Jinghui Li Xujun Wu Xin Geng Nanhui Chen Hualin Yu | 2018 | Neuroscience Bulletin2018，34，3： | 1 |
| 9 | A baicalin-loaded coaxial nanofiber scaffold regulated inflammation and osteoclast differentiation for vascularized bone regeneration显示文摘We demonstrate a simple,effective and feasible method to address the shrinkage of Poly(lactic-co-glycolic acid)(PLGA)through a core-shell structure fiber strategy.The results revealed that introducing size-stable poly-caprolactone(PCL)as the core fiber significantly improved the PLGA-based fibrous scaffold’s dimensional maintenance.We further utilized fish collagen to modify the PLGA shell layer(PFC)of coaxial fibers and loaded baicalin(BA)into the PCL core layer(PCL-BA)to endow fibrous scaffold with more functional biological cues.The PFC/PCL-BA fibrous scaffold promoted the osteogenic differentiation of bone mesenchymal stem cells and stimulated the RAW264.7 cells to polarize into a pro-reparative phenotype.Importantly,the in vivo study demonstrated that the PFC/PCL-BA scaffold could regulate inflammation and osteoclast differentiation,favor neovascularization and bone formation.This work tactfully combined PLGA and PCL to establish a drug release platform based on the core-shell fibrous scaffold for vascularized bone regeneration. | Shue Jin Jing Gao Renli Yang Chen Yuan Ruili Wang Qin Zou Yi Zuo Meifang Zhu Yubao Li Yi Man Jidong Li | 2022 | Bioactive Materials2022，7，2： | 1 |
| 10 | The microstructure and dielectric properties of titanium oxide doped with nano CuO显示文摘The TiO_(2) ceramics doped with nano CuO were fabricated by the conventional solid-state reaction method.The crystal structure,microstructure,microwave dielectric properties and lattice vibrations of TiO_(2) ceramics doped with nano CuO have been investi-gated.Nano CuO with higher sintering capability worked as flux former and effectively improved the sintering process of TiO_(2) ceramics.The microwave dielectric properties of TiO_(2) doped with nano CuO were much better than that doped with micron CuO at the same doping content.Raman spectra showed that the full width at half maximum of E_(g) mode of TiO_(2) doped with micron CuO was larger than nano CuO doped ones,which indicated a poor crystalline and a short phonon lifetime.TiO_(2) doped with 1wt.% nano CuO,sintered at 950℃ for 2h had compact and homogeneous microstructure and possessed the following dielectric properties:ε_(r)=106,Q×f=24808,τf=371ppm/℃. | Juan Li Renli Fu Yue Xu Zhenxiao Fu Hongjuan Su | 2014 | Journal of Advanced Dielectrics2014，4，3： | 1 |
| 11 | Clinical observation of pegylated interferon a-2a therapy for HBeAg-positive chronic hepatitis B 显示文摘 | NIE Renli YANG Wendong LI Aiqian | 2008 | Journal of Clinical Reseach2008，25，8： | 1 |
| 12 | Construction of the first high-density genetic map for growth related QTL analysis in Ancherythroculter nigrocauda显示文摘Ancherythroculter nigrocauda is a fish endemic to the upper areas of the Changjiang(Yangtze)River in China.Quantitative trait locus(QTL)mapping is a powerful tool to identify potential genes affecting traits of economic importance in domestic animals.In this study,a high-density genetic map was constructed with 5901 single nucleotide polymorphism(SNP)makers by sequencing 92 individual fish from a F1 family using the specific-locus amplified fragment sequencing approach.Initially,48 QTLs for total length,body length,body height,and body weight were identified according to the high density of the genetic map with 24 LGs,a total length of 3839.4 cM,and marker spacing of about 0.82 cM.These QTLs explained 27.1%-49.9%of phenotypic variance.The results of this study suggest that major QTLs are responsible for the growth of A.nigrocauda,and these are potentially useful in comparative genomics research,genome assembly,and marker-assisted breeding programs for this species. | Yanhong SUN Pei LI Guiying WANG Renli SUN Jian CHEN Qi ZHOU Jingou TONG Qing LI | 2021 | Journal of Oceanology and Limnology2021，39，3： | 1 |
| 13 | Studies on the Relationship Between the Structure and Anticonvulsant Activity of Cinnamamides and Their Analogs显示文摘On the basis of systematic modification of the structure of componds of antiepilepsirine type, more than 200 cinnamamides were synthesized and tested by animal assay (maximal electroshock seizure, MES). Pharmacological evaluation showed that the configuration and the substituents on the phenyl ring and the nitrogen of amides, and substituents on the double bond displayed an important effect on the anticonvulsant activity.For studying the effect of the modification of structure to anticonvulsant activity, Hansch approach was employed to study the QSAR among 38 cinnamamides, and Hopfinger’ s MSA was employed to study the MSA-QSAR among 26 cinnamamides. | Wang Shuyu, Li Renli and Liu Weichin (School of Pharmaceutical Sciences, Beijing Medical University, Beijing) | 1989 | Chemical Research in Chinese Universities1989，5，2： | 0 |
| 14 | Genome Characterization of COVID-19 Lineage B.1.1.7 Detected in the First Six Patients of a Cluster Outbreak——Shenzhen City,Guangdong Province,China,May 2021显示文摘Screening for coronavirus disease 2019(COVID-19)virus,also known as SARS-CoV-2,infection every seven days was performed for high-risk populations who worked at the Yantian Port in Yantian District,Shenzhen City,Guangdong Province.On May 20,2021,an oropharyngeal swab from a 44-year-old male(Case A)tested preliminarily positive for COVID-19 by a quantitative real-time reverse transcription polymerase chain reaction(RT-qPCR)method in a third-party laboratory. | Yaqing He Peihua Niu Bo Peng Ying Sun Ziquan Lyu Renli Zhang Xiang Zhao Yang Song Yenan Feng Xiujuan Tang Dongfeng Kong Xinyi Wei Can Zhu Qingju Lu Shimin Li Xiaoliang Xiao Weiwen Liu Junjia He Junjie Xia Long Chen Xuan Zou Tiejian Feng | 2021 | China CDC weekly2021，3，25： | 0 |
| 15 | Synthesis and Structure-Antitumor Activity of 4,6-Diamino-1,2-Dihydro-2 ,2-Dimethyl-1-(Substituted-Naphthyl- 2)-1,3,5-Triazines显示文摘Introduction 4,6-Diamino-1,2-dihydro-2,2-dimethyl-1-substituted-1,3,5-triazines (Ⅰ) are dihydrofolate reductase(DHFR) inhibitors, hence they possess the inhibition to the growth of bacteria and cancer cells. Baker’s antifolate (Ⅱ) has shown promise as an antitumor agertt in clinical trials. The study of the structure-activity relationships of I shows that the inhibition to vertebrate DHFR is significantly influenced by the hydrophobicity of 1-substituent, i.e., the stronger the hydrophobicity of the 1-substituent, the more potent the inhibition of the compound to vertebrate DHFR. | Li Renli, Sun Guogang and Dai Huacheng (Department of Medicinal Chemistry, Beijing Medical University, Beijing)Yin Jianlin (Institute of Haematology, Chinese Academy of Medical Sciences, Tianjin) | 1991 | Chemical Research in Chinese Universities1991，7，3： | 0 |
| 16 | Targeted genome engineering in human induced pluripotent stem cells by penetrating TALENs显示文摘Background:Zinc-finger nucleases(ZFNs)and transcription activator-like effector nucleases(TALENs)have been successfully used to knock out endogenous genes in stem cell research.However,the deficiencies of current gene-based delivery systems may hamper the clinical application of these nucleases.A new delivery method that can improve the utility of these nucleases is needed.Results:In this study,we utilized a cell-penetrating peptide-based system for ZFN and TALEN delivery.Functional TAT-ZFN and TAT-TALEN proteins were generated by fusing the cell-penetrating TAT peptide to ZFN and TALEN,respectively.However,TAT-ZFN was difficult to purify in quantities sufficient for analysis in cell culture.Purified TAT-TALEN was able to penetrate cells and disrupt the gene encoding endogenous human chemokine(C-C motif)receptor 5(CCR5,a co-receptor for HIV-1 entry into cells).Hypothermic treatment greatly enhanced the TAT-TALENmediated gene disruption efficiency.A 5%modification rate was observed in human induced pluripotent stem cells(hiPSCs)treated with TAT-TALEN as measured by the Surveyor assay.Conclusions:TAT-TALEN protein-mediated gene disruption was applicable in hiPSCs and represents a promising technique for gene knockout in stem cells.This new technique may advance the clinical application of TALEN technology. | Renli Ru Yongchao Yao Songlin Yu Benpeng Yin Wanwan Xu Siting Zhao Li Qin Xiaoping Chen | 2013 | Cell Regeneration2013，2，1： | 0 |
| 17 | Development of localized interictal epileptiform discharges following vagus nerve stimulation for lennox-gastaut syndrome: a case report显示文摘Background Lennox-gastaut syndrome(LGS)is an epileptic encephalopathy often associated with behavioral and psychiatric disorders.Vagus nerve stimulation(VNS)has been approved effective for LGS treatment.Surgical resection is also an option for LGS patients with focal pathology,offering a high probability of seizure control.However,it is challenging to accurately localize the seizure focus.Case presentation The case presented here is a 19-year-old male with a 16-year history of epilepsy with comorbid severe cognitive and psychiatric disorders.He was diagnosed with LGS due to generalized slow spike-wave discharges and multiple seizure types.He was treated with VNS in 2017 at the age of 15.After that,the frequency of the short tonic seizures decreased from 4–5 times per day to 2–5 times per year,and the generalized tonic–clonic seizure pattern did not recur,which had a frequency of 2–4 times per month before the surgery.In 2019,the generalized abnormal interictal epileptiform discharges changed to be localized in the right frontal–temporal lobe at the age of 17 years(2019).Conclusions This case report suggested that the generalized epileptiform discharges evolve into localized discharges after VNS treatment,which may help reveal the primary seizure focus for resection surgery in patients with LGS. | Renli Qi Wei Wang Yaoduan Xu Zongling Shen Xin Geng Na Li Jinghui Li Hualin Yu | 2022 | Acta Epileptologica2022，5，4： | 0 |
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