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| 1 | Study of-amyloid adsorption and aggregation on graphite by STM and AFM显示文摘The scanning tunneling microscopy (STM) and the atomic force microscopy (AFM) have been applied to the direct study of the adsorption and aggregation of -amyloid(1-42)(A42) on the hydrophobic graphite surface. It was found that A42 were preferentially adsorbed on graphite defects such as the edges. A42 peptides self-assembled into intermediate protofibrils, which in turn self-associated to form fibrils. Usually, two or more fibrils intertwined to form the helical structure. These results will provide an important clue to studying the aggregation proc-ess of -amyloid. | WANG Zhigang, WAN Lijun, ZHOU Chunqing, FANG Xiaohong, WANG Chen & BAI Chunli Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080, China Correspondence should be addressed to Bai Chunli (e-mail: clbai@ infoc3.icas.ac.cn) | 2003 | Chinese Science Bulletin2003，48，5： | 4 |
| 2 | Formation of domain structure of erythrocyte membrane in Wistar rat fed with CeCl_3per os显示文摘To explore the possibility of absorption of lanthanides via digestive duct and their effects on one membrane structure and permeability of erythrocytes, the fine structure of erythrocyte membrane from Wistar rats, fed for 70 days of daily administration per os with 20 mg CeCl3/kg weight, was imaged by means of atomic force microscopy and FT-IR deconvolution spectra. The results show that, although the erythrocytes maintain the intact shape, the change OT secondary structure, aggregation and crosslinking of the protein particles of membrane surface and the enlarged lipid regions lead to the domain structure formation. This structure might be responsible for the increasing permeability of erythrocyte membrane. | CHENG Yi, LIU Maozi, LI You, LI Rongchang, BAI Chunli & WANG Kui National Research Laboratories of Natural and Biomimetic Drugs, Beijing Medical University, Beijing 100083, China Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080, China Correspondence should be addressed to Wang Kui | 2000 | Chinese Science Bulletin2000，45，5： | 3 |
| 3 | Mechanism for the Nanometer Scale Modification on HOPG Surface by Scanning Tunneling Microscope显示文摘A technique applying voltage across the tunnel junction for wnting permanent features on graphite with lines about 10nm wiidth using our home-built scanning tunneling microscope has been presented.Multiple-tip effects while modifying the surface are often met.The phenomciifi are explained in terms of the strong electric field existing at the junction between the tip an<7 the surface.In addition,the shape of the structure indented by the tip is in agreement with that of the tip. | WANG Zhonghuai DAI Changchun ZHANG Pingchen HUANG Guizhen LI Renli GUO Yi BAI Chunli | 1993 | Chinese Physics Letters1993，10，9： | 2 |
| 4 | Circular dichroism spectroscopic studies on structures formed by telomeric DNA sequences in vitro显示文摘Telomere plays an important role in cellular processes, such as cell aging, death and carcinogenisis. Having special sequences, it can form quadrupiex structure in vitro. Circular dichroism (CD) spectroscopic studies show that TTAGGG, (TTAGGG)2 and (TTAGGG)4 can all form quadrupiex in vitro and exist mainly as parallel quadrupiex without metal ions. Both K+ and Na+ can stabilize the tetrameric structure and facilitate the forming of anti-parallel conformation. Furthermore, the conformations of quadrupiex can also be affected by sequence length, the nature and concentration of metal ions. | ZHANG Xiaoyan CAO Enhua SUN Xueguang BAI Chunli | 2000 | Chinese Science Bulletin2000，45，21： | 1 |
| 5 | Normal zone propagation velocities in Bi-2223/Ag superconducting multifilament tape显示文摘 | Chunli Wu Zhiming Bai | 2003 | Physica C2003，386，： | 1 |
| 6 | Ordered arrays of semi-crown ligands on an Au(111) electrode surface: in situ STM study显示文摘In situ scanning tunneling microscopy (STM) and cyclic voltammetry were employed to investigate the adsorption structures of three semi-crown ligands on an Au(111) surface under the potential control. It is found that all the molecules formed ordered arrays in 0.1 mol/L HClO4 solution, although their geometric structures are complex and asymmetric. The driving force was supposed to come from the balance between intermolecular and molecule-substrate interactions. High resolution STM images revealed internal molecular structures, orientations and packing arrangements in the ordered adlayers. The results are useful for preparing ordered arrays of transition metal-mediated nanostructures. | PAN Gebo LI Huijing YUAN Qunhui CHEN Yongjun WAN Lijun BAI Chunli | 2004 | Science China Chemistry2004，47，4： | 1 |
| 7 | Computational analysis of triplex formation of oligonucleotides: protonated and 5-methylated py-pu-py motif显示文摘 | Imshik Lee Chunli Bai Chen Wang Xinwen Wang | 1997 | Science in China Series B: Chemistry1997，，2： | 1 |
| 8 | Oral nano-antioxidants improve sleep by restoring intestinal barrier integrity and preventing systemic inflammation显示文摘Sleep deprivation(SD)is a severe public health threat that can cause systemic inflammation and nerve damage.Few effective and side-effect-free drugs are available to address SD.However,the bidirectional communications between the brain and gut provide new strategies for anti-SD therapeutics.Here we explored oral delivery of fullerene nano-antioxidants(FNAO)in the SD model to improve sleep by regulating abnormal intestinal barrier and systemic inflammation via the brain-gut axis.SD caused excessive reactive oxygen species(ROS)production and hyperactive inflammatory responses in the intestines of zebrafish and mouse models,leading to disturbed sleep patterns and reduced brain nerve activity.Of note,based on the property of the conjugatedπbond of the C_(60)structure to absorb unpaired electrons,oral FNAO efficiently reduced the excessive ROS in the intestines,maintained redox homeostasis and intestinal barrier integrity,and ameliorated intestinal and systemic inflammation,resulting in superior sleep improvement.Our findings suggest that maintaining intestinal homeostasis may be a promising avenue for SD-related nerve injury therapy. | Zhanfeng Wu Lei Liu Lei Li Xinran Cao Wang Jia Xiaodan Liao Zhongpu Zhao Hedong Qi Guoqiang Fan Huiqiang Lu Chunying Shu Mingming Zhen Chunru Wang Chunli Bai | 2023 | National Science Review2023，10，12： | 1 |
| 9 | Scanning tunneling microscopy imaging of doped poliyaniline显示文摘 | Bai Chunli Zhu Chuanfeng Huang Guizhen Yang Jing Wan Meixi ang Chen Runs heng | 1992 | Ultramic roscopy1992，4244，： | 1 |
| 10 | Ascent of Nanoscience in China显示文摘 | Chunli Bai | | 0，，5731： | 1 |
| 11 | Morphology of single-chain polystyrene glass by tapping mode atomic f orce microscopy显示文摘 | Qian Renyuan Shen Jingshu Bei Nianjiong Bai Chunli Zhu Chuanfeng Wang Xinwen | 1996 | Micromolecular Chemistry and Physics1996，197，： | 1 |
| 12 | Development of a novel platform for recombinant protein production in Corynebacterium glutamicum on ethanol显示文摘Corynebacterium glutamicum represents an emerging recombinant protein expression factory due to its ideal features for protein secretion,but its applicability is harmed by the lack of an autoinduction system with tight regulation and high yield.Here,we propose a new recombinant protein manufacturing platform that leverages ethanol as both a delayed carbon source and an inducer.First,we reanalysed the native inducible promoter PICL from the acetate uptake operon and found that its limited capacity is the result of the inadequate translation initial architecture.The two strategies of bicistronic design and ribozyme-based insulator can ensure the high activity of this promoter.Next,through transcriptional engineering that alters transcription factor binding sites(TFBSs)and the first transcribed sequence,the truncated promoter PA256 with a dramatically higher transcription level was generated.When producing the superfolder green fluorescent protein(sfGFP)under 1%ethanol conditions,PA256 exhibited substantially lower protein accumulation in prophase but an approximately 2.5-fold greater final yield than the strong promoter PH36.This superior expression mode was further validated using two secreted proteins,camelid antibody fragment(VHH)and endoxylanase(XynA).Furthermore,utilizing CRISPRi technology,ethanol utilization blocking strains were created,and PA256 was shown to be impaired in the phosphotransacetylase(PTA)knockdown strains,indicating that ethanol metabolism into the tricarboxylic acid cycle is required for PA256 upregulation.Finally,this platform was applied to produce the“de novo design”protein NEO-2/15,and by introducing the N-propeptide of CspB,NEO-2/15 was effectively secreted with the accumulation 281 mg/L obtained after 24 h of shake-flask fermentation.To the best of our knowledge,this is the first report of NEO-2/15 secretory overexpression. | Xinyu Yu Xiuxia Liu Xiong Gao Xunxun Luo Yankun Yang Ye Li Chunli Liu Chong Zhang Zhonghu Bai | 2022 | Synthetic and Systems Biotechnology2022，7，2： | 1 |
| 13 | Intermolecular forces between acetylcholine and acetylcholinesterases studied with atomic force microscopy显示文摘 | Yingge Zhang Chunli Bai Chen Wang Delu Zhao Ming Su Zhang Lin Fang Tian | 1999 | Science in China Series B: Chemistry1999，，5： | 1 |
| 14 | Towards a China-based flagship international journal显示文摘Trudged through my scientific career,I have published key research works in Chinese Science Bulletin.As one of the loyal readers and authors of this prestigious academic journal,I was thrilled when I first published in Chinese Science Bulletin and I believe that numerous | Chunli Bai | 2015 | Science Bulletin2015，60，1： | 1 |
| 15 | The development and applications of atomic force microscope显示文摘 | Bai Chunli | 1995 | Journal of Beijing Institute of Technology1995，4，1： | 1 |
| 16 | Theoretical studies on intratriplex DNA with 5-bromocytosine显示文摘 | Linjing Yang Maozi Liu Qing Li Chen Wang Chunli Bai | 1998 | Science in China Series B: Chemistry1998，，6： | 1 |
| 17 | Atomic force microscopy observation of the condensates of the spermidine-DNA complexes显示文摘 | Zhang Lin Chen Wang Ming Su Fang Tian Jin Ma Chunli Bai | 1998 | Science in China Series B: Chemistry1998，，4： | 1 |
| 18 | Ascent of Nanoseience in China 显示文摘 | Chunli Bai | 2005 | Science2005，309，5731： | 1 |
| 19 | Computational analysis of triplex formation of oligonucleotides: protonated and 5-methylated py-pu-py motif显示文摘 | Imshik Lee Chunli Bai Chen Wang Xinwen Wang | 1997 | Science in China Series B: Chemistry1997，，2： | 1 |
| 20 | Effect of alkyl substitutions on self-assembly显示文摘The self-assemblies of 4-hexadecyloxybenzoic acid and 3,4,5-trihexadecyloxybenzoic acid have been studied by using scanning tunneling microscopy (STM). The well-ordered assemblies with different arrangement have been investigated. The structural change is attributed to the different number of substituted alkyl chains on periphery. | Peng Wu Guojun Deng Sailong Xu Qinghua Fan Lijun Wan Chen Wang Chunli Bai | 2002 | Chinese Science Bulletin2002，47，18： | 1 |
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