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| 1 | New guaiane-type sesquiterpenoid dimers from Artemisia atrovirens and their antihepatoma activity显示文摘Leading by cytotoxicity against HepG2 cells,bioactivity-guided fractionation of the EtOAc fraction from Artemisia atrovirens led to the isolation of 18 new guaianolide dimers,artematrolides A-R and lavandiolides A,B,C,H,and J.Eight compounds(1,4,10,12,13,and 19-21) were unambiguously confirmed by the single-crystal X-ray diffraction analyses,and the others were elucidated based on IR,UV,HRESIMS,1 D and 2 D NMR experiments,and comparison of the experimental and calculated ECD data.Structurally,all of them were [4+2] Diels-Alder adducts of two monomeric guaianolides.The isolates were evaluated for their cytotoxicity against three human hepatoma cell lines,and 19 compounds demonstrated cytotoxicity against HepG2,SMMC-7721,and Huh7 cell lines.Especially,compounds 1,12,14,and 15 exhibited cytotoxicity with IC50 values of 4.4,3.8,7.6,and 6.7 μmol/L(HepG2),9.6,4.6,6.6,and 6.0 μmol/L(SMMC-7721),and 7.6,4.5,6.9,and 5.6 μmol/L(Huh7),respectively.Notably,compound 12 showed the most promising activity against three human hepatoma cell lines and dose-dependently inhibited cell migration and invasion,induced G2/M cell cycle arrest and cell apoptosis in HepG2 cells,down-regulated the expression of BCL-2 and PARP-1,and activated PARP-1 to up-regulate the expression of cleaved-PARP-1. | Lihua Su Xintian Zhang Yunbao Ma Changan Geng Xiaoyan Huang Jing Hu Tianze Li Shuang Tang Cheng Shen Zhen Gao Xuemei Zhang Ji-Jun Chen | 2021 | Acta Pharmaceutica Sinica B2021，11，6： | 6 |
| 2 | Optical and Radiative Properties of Aerosols during a Severe Haze Episode over the North China Plain in December 2016显示文摘The optical and radiative properties of aerosols during a severe haze episode from 15 to 22 December 2016 over Beijing, Shijiazhuang, and Jiaozuo in the North China Plain were analyzed based on the ground-based and satellite data, meteorological observations, and atmospheric environmental monitoring data. The aerosol optical depth at 500 nm was < 0.30 and increased to > 1.4 as the haze pollution developed. The ?ngstr?m exponent was > 0.80 for most of the study period. The daily single-scattering albedo was > 0.85 over all of the North China Plain on the most polluted days and was > 0.97 on some particular days. The volumes of fine and coarse mode particles during the haze event were approximately 0.05–0.21 and 0.01–0.43 μm3, respectively—that is, larger than those in the time without haze. The daily absorption aerosol optical depth was about 0.01–0.11 in Beijing, 0.01–0.13 in Shijiazhuang, and0.01–0.04 in Jiaozuo, and the average absorption ?ngstr?m exponent varied between 0.6 and 2.0. The aerosol radiative forcing at the bottom of the atmosphere varied from –23 to –227, –34 to –199, and –29 to –191 W m–2 for the whole haze period, while the aerosol radiative forcing at the top of the atmosphere varied from –4 to –98, –10 to –51,and –21 to –143 W m–2 in Beijing, Shijiazhuang, and Jiaozuo, respectively. Satellite observations showed that smoke,polluted dust, and polluted continental components of aerosols may aggravate air pollution during haze episodes. The analysis of the potential source contribution function and concentration-weighted trajectory showed that the contribution from local emissions and pollutants transport from upstream areas were 190–450 and 100–410 μg m^(–3), respectively. | Yu ZHENG Huizheng CHE Leiku YANG Jing CHEN Yaqiang WANG Xiangao XIA Hujia ZHAO Hong WANG Deying WANG Ke GUI Linchang AN Tianze SUN Jie YU Xiang KUANG Xin LI Enwei SUN Dapeng ZHAO Dongsen YANG Zengyuan GUO Tianliang ZHAO Xiaoye ZHANG | 2017 | Journal of Meteorological Research2017，31，6： | 2 |
| 3 | Home Planting Techniques of Green and Healthy Rape Sprouts显示文摘With the continuous development of society and the continuous improvement of people s income levels,consumers demand for agricultural products has also changed.Rape sprouts as a new type of green and pollution-free health food meet people s needs.In this paper,we summarized a set of home cultivation techniques for green and healthy rape sprouts.The techniques are simple to operate and low in cost.Growers can notonly experience the fun of planting and but also taste green and healthy food. | Nian LIU Tianze TANG Yan ZHU Qixin FAN Daqing MENG Yingchun LI Zhifan LI Jun CHEN | 2021 | Agricultural Biotechnology2021，10，5： | 1 |
| 4 | Spatial and temporal distribution of the cloud optical depth over China based on MODIS satellite data during 2003–2016显示文摘The cloud optical depth(COD) is one of the important parameters used to characterize atmospheric clouds. We analyzed the seasonal variations in the COD over East Asia in 2011 using cloud mode data from the AERONET(Aerosol Robotic Network) ground-based observational network. The applicability of the MODIS(Moderate Resolution Imaging Spectroradiometer) COD product was verified and compared with the AERONET cloud mode dataset. There was a good correlation between the AERONET and the MODIS. The spatial and temporal distribution and trends in the COD over China were then analyzed using MODIS satellite data from 2003 to 2016. The seasonal changes in the AERONET data and the time sequence variation of the satellite data suggest that the seasonal variations in the COD are significant. The result shows that the COD first decreases and then increases with the season in northern China, and reaches the maximum in summer and minimum in winter.However, the spatial distribution change is just the opposite in southern China. The spatial variation trend shows the COD in China decreases first with time and gradually increases after 2014. And the trend of COD in the western and central China is consistent with that in China. While the trend of COD shows a continuously increasing over time in northeast China and the Pearl River Delta. | Xiaopan Li Huizheng Che Hong Wang Xiang'ao Xia Quanliang Chen Ke Gui Hujia Zhao Linchang An Yu Zheng Tianze Sun Zhizhong Sheng Chao Liu Xiaoye Zhang | 2019 | Journal of Environmental Sciences2019，31，6： | 1 |
| 5 | Diverse structures and antihepatoma effect of sesquiterpenoid dimers from Artemisia eriopoda by AKT/STAT signaling pathway显示文摘Dear Editor,Liver cancer as a common malignant tumor has become a major source of morbidity and mortality worldwide.1 Currently,four synthetic drugs and three monoclonal antibody drugs have been approved for the treatment of hepatocellular carcinoma(HCC)since 2007.Whereas,the disadvantages of the above drugs such as low response rates,severe side effects,and drug resistance hamper their therapeutic effects.Structurally and biologically diverse natural products are a major source in the search for novel antihepatoma agents. | Xiaofeng He Wenjing Ma Jing Hu Tianze Li Changan Geng Yunbao Ma Mengfei Wang Kexin Yang Xuemei Zhang Ji-Jun Chen | 2023 | Signal Transduction and Targeted Therapy2023，8，3： | 1 |
| 6 | Two-dimensional PSD nonlinear correction based on newton interpola- tion algorithm显示文摘 | Li Qian Li Tianze Xie Aizhang | 2015 | Journal of Shandong University of Technology2015，16，3： | 1 |
| 7 | Allelic diversities in rice starch biosynthesis lead to a diverse array of rice eating and cooking qualities 显示文摘 | TianZ Qian Q Liu Q Yan M Liu X Yan C Liu G Gao Z Tang S Zeng D Wang Y Yu J Gu M Li J | 2009 | Proceedings of the National Academy of Sciences2009，106，21： | 1 |
| 8 | 蛇形画廊显示文摘对于2016年的蛇形画廊展厅,我们尝试设计一种包含多个通常意义上的对立面的结构:一种既形态自由又结构严谨、既模块化又具有雕塑感、既透明又不透明、既似盒子又难以名状的结构。我们决定使用建筑最基本的元素之一:砖墙。 | Aaron Powers Alice Cladet Claire Thomas Daniel Sundlin Jakob Lange Kai-Uwe Bergmann Kristian Hindsberg Kristoffer Negendahl Lorenz Krisai Maria Holst Maxwell Moriyama Rune Hansen Tianze Li Tore Banke Wells Barber Iwan Baan Derek Shapton 陈子钰(译) | 2019 | 城市环境设计2019，0，2： | 1 |
| 9 | Molecular Markers and Agronomic Traits of a New Kind of Genic Male Sterile MateriaI Mian 7AB-4-2 in Brassica napus L 显示文摘 | LI Haojie TANG Tianze YUAN Daibin | 2009 | Agricultural Seience&Technology2009，10，63： | 1 |
| 10 | Dynamics and genetic regulation of macronutrient concentrations during grain development in maize显示文摘Nitrogen(N), phosphorus(P), and potassium(K) are essential macronutrients that are crucial not only for maize growth and development, but also for crop yield and quality. The genetic basis of macronutrient dynamics and accumulation during grain filling in maize remains largely unknown. In this study, we evaluated grain N, P, and K concentrations in 206 recombinant inbred lines generated from a cross of DH1M and T877 at six time points after pollination. We then calculated conditional phenotypic values at different time intervals to explore the dynamic characteristics of the N, P, and K concentrations. Abundant phenotypic variations were observed in the concentrations and net changes of these nutrients. Unconditional quantitative trait locus(QTL) mapping revealed 41 non-redundant QTLs, including 17, 16, and 14 for the N, P, and K concentrations, respectively. Conditional QTL mapping uncovered 39 non-redundant QTLs related to net changes in the N, P, and K concentrations. By combining QTL, gene expression, co-expression analysis, and comparative genomic data, we identified 44, 36, and 44 candidate genes for the N, P, and K concentrations, respectively, including GRMZM2G371058 encoding a Doftype zinc finger DNA-binding family protein, which was associated with the N concentration, and GRMZM2G113967encoding a CBL-interacting protein kinase, which was related to the K concentration. The results deepen our understanding of the genetic factors controlling N, P, and K accumulation during maize grain development and provide valuable genes for the genetic improvement of nutrient concentrations in maize. | Pengcheng Li Shuangyi Yin Yunyun Wang Tianze Zhu Xinjie Zhu Minggang Ji Wenye Rui Houmiao Wang Chenwu Xu Zefeng Yang | 2024 | Journal of Integrative Agriculture2024，23，3： | 0 |
| 11 | RESEARCH ON THE MOIRE CHROMATOGRAPHY TECHNIQUE AND ITS APPLICATION显示文摘This paper explains the Moire chromatography technique and the optical characteristics when the light crosses the 3D air flow field.Based on this,taking grating,CCD camera,optical filter and diaphragm as the main device,a multi-direction Moire chromatography optical system was designed.The system consists of five detective light paths,in each detective light path there is parallel and same periodic grating and filtering minipore placed on the lens’focal length plane;the grating is used to adjust the space length and angle between the two gratings,and the filtering minipore is used to remove the unorderly high frequency intermix in the Moire fringe.Utilizing the computer escalator method to convert the tested value,the vivid interference fringe of tested parameter can be obtained.The application of this system in precision measurement and medicine is also analyzed and discussed. | TIANZE LI SHUYUN WANG | 2009 | Journal of Innovative Optical Health Sciences2009，2，2： | 0 |
| 12 | Green High Yield and Efficient Cultivation Technique of Rape for Both Vegetable and Oilseed Utilization显示文摘This paper introduces a set of green,high-yield and high-efficiency cultivation technique of rape for both vegetable and oilseed utilization,including selection of suitable varieties and sowing methods,seedling raising,timely transplanting,field management,pest and disease control,timely harvest,drying rapeseed into storage and so on.The technique not only improves the yield of rape,but also enriches the citizens’vegetable basket and farmers’pocketbook. | Nian LIU Tianze TANG Yan ZHU Qixin FAN Daqing MENG Yingchun LI Zhifan LI Jun CHEN | 2022 | Plant Diseases and Pests2022，13，1： | 0 |
| 13 | Gadolinium-based contrast agents built of DO3A-pyridine scaffold:Precisely tuning carboxylate group for enhanced magnetic resonance imaging显示文摘It is greatly desired to develop novel gadolinium-based contrast agents(GBCAs)as improved platforms for magnetic resonance imaging(MRI).Herein,we report the syntheses of a series of nonionic cyclenbased GBCAs by precisely tuning carboxylate group on DO3A-pyridine scaffold.[Gd-DO3A-4cp]is isolated which adopts an octadentate coordination mode with a free carboxylate group at 4-position of pyridine.It shows the r_(1)relaxivity of 5.8(mmol/L)^(-1)s^(-1)(3 T,25℃),which is 75%higher than 3.3(mmol/L)^(-1)s^(-1)of the clinic used[Gd-DOTA].The possible mechanisms behind the enhanced relaxivity are investigated and proposed by structure-property relationship studies.After validation of low cytotoxicity and considerable kinetic inertness,in-vivo studies are further examined,demonstrating its good MRI performance,biodistribution as well as the way of excretion. | Yongyin Geng Tianze Wu Qiuyue Han Yongtai Yang Zhenxia Chen Xuanxuan Li Bo Yin Yaming Zhou Yun Ling | 2023 | Chinese Chemical Letters2023，34，6： | 0 |
| 14 | Effect of periodic wide atmospheric pressure change on CO emission in closed goaf显示文摘Atmospheric pressure fuctuation is one of the most important factors afecting the climate environment and gas emission in the fre area.To obtain the infuence rule of the surface atmospheric pressure change on the gas sampling and abnormal emission in the mine closed goaf,the No.1 coal mine in Dananhu was taken as the research object.Using Fourier transform and Fisher harmonic analysis and other statistical methods,the infuence of the periodic variation of atmospheric pressure on the gas leakage and outfow in the closed goaf was studied.The results showed that there were three atmospheric pressure periods of 15.2 d,1 d and 182.2 d,and the probability was greater than 95%.The time period with the highest number of atmospheric pressure peaks was 7:00–8:00,which accounted for 20.2%of total occurrence number in a day.And the time periods with the highest number of atmospheric pressure trough were 2:00,15:00 and 16:00,accounting for 27.4%.The peak-to-trough transition time was mainly concentrated around 6 h,and the diurnal variation curve of atmospheric pressure was mainly bimodal.The atmospheric pressure change rate was mostly concentrated in 10–50 Pa/h.It was determined that the distance that the gas sampling pipe was pre-laid into the inner side of the closed wall should be greater than 44.4 m,and the CO concentration and atmospheric pressure in the closed goaf were both periodic and negative with atmospheric pressure.The research results have important guiding signifcance for the monitoring,early warning and environmental protection of the goaf. | Zhuangzhuang Shao Bo Tan Ruili Hu Xiaozhen Song Yan Guo Tianze Li Shuhui Fu Chaohuan Chen Haiyan Wang | 2023 | International Journal of Coal Science & Technology2023，10，4： | 0 |
| 15 | Artemdubinoids A-N:novel sesquiterpenoids with antihepatoma cytotoxicity from Artemisia dubia显示文摘In pursuit of effective agents for hepatocellular carcinoma derived from the Artemisia species,this study built upon initial findings that an ethanol(EtOH)extract and ethyl acetate(EtOAc)fraction of the aerial parts of Artemisia dubia Wall.ex Bess.exhibited cytotoxicity against HepG2 cells with inhibitory rates of 57.1%and 84.2%(100μg·mL−1),respectively.Guided by bioactivity,fourteen previously unidentified sesquiterpenes,artemdubinoids A–N(1–14),were isolated from the EtOAc fraction.Their structural elucidation was achieved through comprehensive spectroscopic analyses and corroborated by the comparison between the experimental and calculated ECD spectra.Single crystal X-ray diffraction provided definitive structure confirmation for artemdubinoids A,D,F,and H.Artemdubinoids A and B(1–2)represented unique sesquiterpenes featuring a 6/5-fused bicyclic carbon scaffold,and their putative biosynthetic pathways were discussed;artemdubinoid C(3)was a novel guaianolide derivative that might be formed by the[4+2]Diels–Alder reaction;artemdubinoids D and E(4–5)were rare 1,10-seco-guaianolides;artemdubinoids F–K(6–11)were chlorinecontaining guaianolides.Eleven compounds exhibited cytotoxicity against three human hepatoma cell lines(HepG2,Huh7,and SKHep-1)with half-maximal inhibitory concentration(IC50)values spanning 7.5−82.5μmol·L^(−1).Artemdubinoid M(13)exhibited the most active cytotoxicity with IC50 values of 14.5,7.5 and 8.9μmol·L^(−1)against the HepG2,Huh7,and SK-Hep-1 cell lines,respectively,which were equivalent to the positive control,sorafenib. | GAO Zhen LI Tianze MA Yunbao HUANG Xiaoyan GENG Changan ZHANG Xuemei CHEN Jijun | 2023 | Chinese Journal of Natural Medicines2023，21，12： | 0 |
| 16 | Supplementation of alanine improves biomass accumulation and lipid production of Chlorella pyrenoidosa by increasing the respiratory and metabolic processes显示文摘The function of exogenous alanine(Ala)in regulating biomass accumulation,lipid production,photosynthesis,and respiration in Chlorella pyrenoidosa was studied.Result shows that the supplementation of Ala increased C.pyrenoidosa biomass and lipid production in an 8-d batch culture.The concentration of 10 mmol/L of Ala was optimum and increased the microalgal cell biomass and lipid content by 39.3%and 21.4%,respectively,compared with that in the control(0-mmol/L Ala).Ala supplementation reduced photosynthetic activity while boosting respiratory activity and pyruvate levels,indicating that C.pyrenoidosa used exogenous Ala for biomass accumulation through the respiratory metabolic process.The accelerated respiratory metabolism due to Ala supplementation elevated the substrate pool and improved the lipogenic gene expression,promoting lipid production at last.This study provided a novel method for increasing biomass accumulation and lipid production and elucidated the role of Ala in regulating lipid production. | Yongfu LI Tianze ZHAO Wei SUN Ruiwen GAO Guangyuan MA | 2024 | Journal of Oceanology and Limnology2024，42，2： | 0 |
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