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| 1 | Stenting for symptomatic intracranial arterial stenosis in China:1-year outcome of a multicentre registry study显示文摘background and purpose A multicentre prospective registry study of individually tailored stenting for a patient with symptomatic intracranial atherosclerotic stenosis(ICAS)combined with poor collaterals in China showed that the short-term safety and efficacy of stenting was acceptable.However,it remained uncertain whether the low event rate could be of a long term.We reported the 1-year outcome of this registry study to evaluate the long-term efficacy of individually tailored stenting for patients with severe symptomatic ICAS combined with poor collaterals.Methods Patients with symptomatic ICAS caused by 70%-99% stenosis located at the intracranial internal carotid,middle cerebral,intracranial vertebral or basilar arteries combined with poor collaterals were enrolled.Balloon-mounted stent or balloon plus self-expanding stent were selected based on the ease of vascular access and lesion morphology determined by the operators.The primary outcome was the rate of 30-day stroke,transient ischaemic attack and death,and 12-month ischaemic stroke within the same vascular territory,haemorrhagic stroke and vascular death after stenting.results From September 2013 to January 2015,300 patients(ages 58.3±9.78 years)were recruited.Among them,159 patients were treated with balloon-mounted stent and 141 with balloon plus self-expanding stent.During the 1-year follow-up,25 patients had a primary end point event.The probability of primary outcome at 1 year was 8.1%(95% CI 5.3% to 11.7%).In 76 patients with digital subtraction angiography follow-up,27.6%(21/76)had re-stenosis≥50% and 18.4%(14/76)had re-stenosis≥70%.No baseline characteristic was associated with the primary outcome.Conclusion The event rate remains low over 1 year of individually tailored stenting for patients with severe symptomatic ICAS combined with poor collaterals.Further randomised trial of comparing individually tailored stenting with best medical therapy is needed. | Ning Ma Yong Zhang Jie Shuai Changchun Jiang Qiyi Zhu Kangning Chen Li Liu Baomin Li Xiangqun Shi Lianbo Gao Yajie Liu Feng Wang Yongli Li Tieyan Liu Hongbo Zheng Dapeng Mo Feng Gao Yilong Wang Yongjun Wang Lei Feng Zhongrong Miao | 2018 | Stroke & Vascular Neurology2018，3，3： | 29 |
| 2 | Optical observations of LIGO source GW 170817 by the Antarctic Survey Telescopes at Dome A,Antarctica显示文摘The LIGO detection of gravitational waves(GW) from merging black holes in 2015 marked the beginning of a new era in observational astronomy. The detection of an electromagnetic signal from a GW source is the critical next step to explore in detail the physics involved. The Antarctic Survey Telescopes(AST3),located at Dome A, Antarctica, is uniquely situated for rapid response time-domain astronomy with its continuous night-time coverage during the austral winter. We report optical observations of the GW source(GW 170817) in the nearby galaxy NGC 4993 using AST3. The data show a rapidly fading transient at around 1 day after the GW trigger, with the i-band magnitude declining from 17:23 ± 0:13 magnitude to 17:72 ± 0:09 magnitude in ~1:8 h. The brightness and time evolution of the optical transient associated with GW 170817 are broadly consistent with the predictions of models involving merging binary neutron stars. We infer from our data that the merging process ejected about ~10^(-2) solar mass of radioactive material at a speed of up to 30% the speed of light. | lei hu xuefeng wu igor andreoni michael c.b.ashley jeff cooke xiangqun cui fujia du zigao dai bozhong gu yi hu haiping lu xiaoyan li zhengyang li ensi liang liangduan liu bin ma zhaohui shang tianrui sun n.b.suntzeff charling tao syed a.uddin lifan wang xiaofeng wang haikun wen di xiao jin xu ji yang shihai yang xiangyan yuan hongyan zhou hui zhang jilin zhou zonghong zhu | 2017 | Science Bulletin2017，62，21： | 6 |
| 3 | A quantum algorithm for the dihedral hidden subgroup problem based on lattice basis reduction algorithm显示文摘To optimize the algorithms for the dihedral hidden subgroup problem,we present a new algorithm based on lattice basis reduction algorithm.For n\120,we reduce the dihedral hidden subgroup problem to shortest vector problem.A subroutine is given to get a transition quantum state by constructing a phase filter function,and then the measurement basis are derived based on the lattice basis reduction algorithm for solving low density subset sum problem.Finally,the parity of slope s is revealed by the measurement.This algorithm needs preparing mn quantum states,m qubits to store and O(n2)classical space,which is superior to existing algorithms. | Fada Li Wansu Bao Xiangqun Fu | 2014 | Chinese Science Bulletin2014，59，21： | 5 |
| 4 | Stable interfaces constructed by concentrated ether electrolytes to render robust lithium metal batteries显示文摘Lithium metal batteries(LMBs)are highly considered as promising candidates for next-generation energy storage systems.However,routine electrolytes cannot tolerate the high potential at cathodes and low potential at anodes simultaneously,leading to severe interfacial reactions.Herein,a highly concentrated electrolyte(HCE)region trapped in porous carbon coating layer is adopted to form a stable and highly conductive solid electrolyte interphase(SEI)on Li metal surface.The protected Li metal anode can potentially match the high-voltage cathode in ester electrolytes.Synergistically,this ingenious design promises high-voltage-resistant interfaces at cathodes and stable SEI with abundance of inorganic components at anodes simultaneously in high-voltage LMBs.The feasibility of this interface-regulation strategy is demonstrated in Li|LiFePO_(4) batteries,realizing a lifespan twice as long as the routine cells,with a huge capacity retention enhancement from 46.4%to 88.7%after 100 cycles.This contribution proof-ofconcepts the emerging principles on the formation and regulation of stable electrode/electrolyte interfaces in the cathode and anode simultaneously towards the next-generation high-energy-density batteries. | He Liu Tao Li Xiangqun Xu Peng Shi Xueqiang Zhang Rui Xu Xinbing Cheng Jiaqi Huang | 2021 | Chinese Journal of Chemical Engineering2021，34，9： | 5 |
| 5 | Lattice Boltzmann Method used for the aircraft characteristics computation at high angle of attack显示文摘Traditional Finite Volume Method(FVM)and Lattice Boltzmann Method(LBM)are both used to compute the high angle attack aerodynamic characteristics of the benchmark aircraft model named CT-1.Even though the software requires flow on the order of Ma<0.4,simulation at Ma=0.5 is run in PowerFLOW after theoretical analysis.The consistency with the wind tunnel testing is satisfied,especially for the LBM which can produce perfect results at high angle attack.PowerFLOW can accurately capture the detail of flows because it is inherently time-dependent and parallel and suits large-scale computation very well. | DU TeZhuan,LI XiangQun,ZHANG XiaLing&WANG YiWei College of Engineering,Peking University,Beijing 100871,China | 2010 | Science China(Technological Sciences)2010，53，8： | 4 |
| 6 | Joint Toxicity of Beauveria bassiana and Two Insect Growth Regulators on Beet Armyworm,Spodoptera exigua(Hübner)显示文摘Joint toxicity of Beauveria bassiana and two insect growth regulators,methoxyfenozide and hexaflumuron,on beet armyworm larvae,Spodoptera exigua(Hübner),were investigated.An obvious synergism effect of the two insect growth regulators with B.beauveria was observed.When the insect growth regulators at LC_(50) concentrations(25×10^(-6)g/L for methoxyfenozide and 1 000×10^(-6) g/L for hexaflumuron)were mixed with B.bassiana at the volume ratio of 4∶1,the mixtures achieved the best efficacy.The co-toxicity co-efficient(CTC)of methoxyfenozide and B.bassiana was 285,and that of hexaflumuron and B.bassiana was 208.Scanning electron microscope observation of the longitudinal section of S.exigua revealed obviously different patterns of integument in different treatment groups. | Hu Anling Tian Zhaofeng Gao Xiwu Nong Xiangqun Li Yongdan | 2016 | Plant Diseases and Pests2016，7，5： | 2 |
| 7 | A Markov decision problem in a risk model with interest rate and Markovian environment显示文摘We consider the compound binomial model in a Markovian environment presented by Cossette et al.(2004). We modify the model via assuming that the company receives interest on the surplus and a positive real-valued premium per unit time, and introducing a control strategy of periodic dividend payments. A Markov decision problem arises and the control objective is to maximize the cumulative expected discounted dividends paid to the shareholders until ruin minus a discounted penalty for ruin. We show that under the absence of a ceiling of dividend rates the optimal strategy is a conditional band strategy given the current state of the environment process. Under the presence of a ceiling for dividend rates, the character of the optimal control strategy is given. In addition, we offer an algorithm for the optimal strategy and the optimal value function.Numerical results are provided to illustrate the algorithm and the impact of the penalty. | TAN JiYang YANG XiangQun LI ZiQiang CHENG YangJin | 2016 | Science China Mathematics2016，59，1： | 2 |
| 8 | Synthesis, structure and properties of carbon nanotubo/poly (p-phenylene benzobisoxazole) composite fibres 显示文摘 | Li Jinhuan Chen Xiangqun Li Xia | 2006 | Polymer International2006，55，4： | 1 |
| 9 | Binding characteristics of the Lactobacillus brevis ATCC 8287 surface layer to extracellular matrix proteins显示文摘 | LEEUW E LI Xiangqun LU Wuyuan | 2006 | Federation of European Microbiological Societies2006，260，2： | 1 |
| 10 | Design and Synthesis of Proteolysis Targeting Chimeras for Inducing BRD4 Protein Degradation显示文摘 | WANG Shihui LI Haiyan WANG Yue GAO Yang YU Shanshan ZHAO Qianqian JIN Xiangqun LU Haibin | 2018 | Chemical Research in Chinese Universities2018，34，2： | 1 |
| 11 | Binding characteristics of the Lactobacillus brevis ATCC8287 surface layer to extracellular matrixproteins显示文摘 | de LEEUW E LI Xiangqun LU Wuyuan | 2006 | FEMS Microbiol Lett2006，260，2： | 1 |
| 12 | Gefitinib versus placebo as maintenance therapy in patients with locally advanced or metastatic non-small-cell lung cancer(INFORM;C-TONG 0804):a multicentre,double-blind randomised phase 3 trial显示文摘 | Zhang Li Ma Shenglin Song Xiangqun | 2012 | Lancet Oncology2012，13，5： | 1 |
| 13 | A highly Conductive Proton Exchange Membrane for High Temperature Fuel Ceils Based on Poly (5-vinyl tetrazole) and Sulfonated polystyrene显示文摘 | Li Jinhuan Wang Jianxin Chen Xiangqun | 2014 | Solid State Ionics2014，，255： | 1 |
| 14 | Gefitinib versus placebo as maintenance therapy in patients with locally advanced or metastatic non-small-cell lung cancer (INFORM; C-TONG 0804 ): a multicentre, double-blind randomised phase 3 trial显示文摘 | Zhang Li Ma ShengLin Song XiangQun | 2012 | Lancet Oneol2012，13，5： | 1 |
| 15 | Clarithromycin-loaded liposomes offering high drug loading and less irritation显示文摘 | Xiaona Liu Wei Sun Bo Zhang Bin Tian Xing Tang Na Qi Haibing He Huifang Li Xiangqun Jin | 2013 | International Journal of Pharmaceutics . 2013 (1-2)2013，，： | 1 |
| 16 | Tetrahydroxy stilbene glucoside improved the behavioral disorders of APP695V717l transgenic mice by inhibiting the expression of Beclin-1 and LC3-Ⅱ显示文摘OBJECTIVE:To observe the effect of tetrahydroxy stilbene glucoside(TSG) on the behavior of APP695V717 I transgenic mouse models and the expression of autophagy-associated proteins Beclin-1and LC3-Ⅱ.METHODS:Forty 3-month-old APP695V717 I transgenic mice were randomized equally into either a TSG group(n = 20) or a model group(n = 20).A normal control group consisted of C57BL/6J mice of the same age and background(n = 20).The TSG group received TSG intragastric administration for1 month.Behavior was measured using the Morris water maze and the Y-maze tests.Changes in protein expression and mRNA of autophagy-associated Beclin-1 and LC3-Ⅱ in mice hippocampus were detected by western blot and Reverse Transcription-Polymerase Chain Reaction(RT-PCR) analyses.RESULTS:The number of electric-stimulus escapes significantly increased and the Morris water maze test showed prolonged escape latency,greater swimming distance,less time taken to cross the exact former platform location in the model group,and increased mRNA and protein expressions of Beclin-1 and LC3-Ⅱ compared with the control group(P < 0.05).The TSG group showed a decrease in the number of electric-stimulus escapes,shorter escape latency and swimming distance,greater time taken to cross the exact former platform location,and decreased mRNA and protein expressions of Beclin-1 and LC3-Ⅱ compared with the model group(P< 0.05).CONCLUSION:These results indicate that tetrahydroxy stilbene glucoside can decrease expressions of Beclin-1 and LC3-Ⅱ in the autophagy pathway.It can attenuate injury to endoplasmic reticulum functions caused by Ab neurotoxicity,improving learning,memorizing,and spatial orientation behavior in mice. | Luo Hongbo Li Yun Guo Jiankui Liu Zunjing Zhang Zhiqiang Wang Yong Liu Zhao Shi Xiangqun | 2015 | Journal of Traditional Chinese Medicine2015，35，3： | 1 |
| 17 | Polysaccharides from Inonotusobliquus sclerotia and cultured mycelia stimulate cytokine productionof human peripheral blood mononuclear cells in vitro and theirchemical characterization显示文摘 | XU Xiangqun LI Juan HU Yan | 2014 | International Immunopharmacology2014，21，： | 1 |
| 18 | Highly dispersed silver nanoparticles for performance-enhanced lithium oxygen batteries显示文摘Aprotic lithium-oxygen batteries possess ultrahigh energy density but suffer from the sluggish decomposition of discharge product,quick depletion of Li anode and cleavage of electrolyte,in close association with oxygen reduction reaction at the cathode.Herein,highly dispersed silver nanoparticles are used to enhance the lithium-oxygen battery with 1.0 M lithium perchlorate in dimethyl sulfoxide.It is observed that film-like amorphous lithium peroxide is formed through surface pathway instead of bulk crystals,due to the incorporation of silver nanoparticles dispersed in the electrolyte,which subsequently accelerates the decomposition of the discharge product by offering more active sites and improved conductivity.The released silver nanoparticles after battery charging can be re-used in the following cycles.Experiments and theoretical calculation further indicate that the suspended silver nanoparticles can adsorb the soluble oxygen reduction intermediates,which are responsible for the alleviation of oxidative cleavage of electrolyte and corrosion of lithium anode.The lifespan of lithium oxygen batteries is therefore significantly extended from 55 to 390 cycles,and the rate performance and full-discharge capacity are also largely enhanced.The battery failure is attributed to the coalescence and growth of silver nanoparticles in the electrolyte,and further improvement on colloid stability is underway. | Zhihong Luo Fujie Li Chengliang Hu Liankun Yin Degui Li Chenhao Ji Xiangqun Zhuge Kui Zhang Kun Luo | 2021 | Journal of Materials Science & Technology2021，，14： | 0 |
| 19 | Spatial distribution of bacterial resistance towards antibiotics of rural sanitation system in China and its potential link with diseases incidence显示文摘Chinese government is vigorously promoting toilet renovation in rural areas to reduce the risk of human feces exposure,which would cause infectious diseases,especially antibiotic resistance genes(ARGs)and pathogens.However,the distribution of ARGs in human feces from different regions of China remained ill-defined.It is not yet known how the survival of ARGs after toilet treatment is associated with the regional infection rates.Here,we investigated the prevalence of ARGs in human feces in rural areas of China and their potential relationship with infectious diseases for the first large-scale.The results showed that there were still high ARGs residues in human feces after rural toilet treatment,especially tetM-01 and ermB with average relative abundance as high as 1.21×10^(−1)(Eastern)and 1.56×10^(−1)(Northern),respectively.At a large regional scale,the significant differences in human feces resistomeswere mainly shaped by the toilet types,TN,NH_(3)-N,and the bacterial community.A critical finding was that toilets still cannot effectively decrease the pathogenicity risk in human feces.The significant positive relationship(P<0.05)between infectious diseases and ARGs can infer that ARGs in human feces exposure might be a critical path for enhancing the incidence of diseases,as these ARGs hinder the effectiveness of antibiotics. | Houyu Li Lu Tan Chunxue Zhang Xiaocheng Wei Qiang Wang Qian Li Xiangqun Zheng Yan Xu | 2023 | Journal of Environmental Sciences2023，，5： | 0 |
| 20 | Overview of the LAMOST survey in the first decade显示文摘The Large Sky Area Multi-Object Fiber Spectroscopic Telescope(LAMOST),also known as the Guoshoujing Telescope,is a major national scientific facility for astronomical research located in Xinglong,China.Beginning with a pilot survey in 2011,LAMOST has been surveying the night sky for more than 10 years.The LAMOST survey covers various objects in the Universe,from normal stars to peculiar ones. | Hongliang Yan Haining Li Song Wang Weikai Zong Haibo Yuan Maosheng Xiang Yang Huang Jiwei Xie Subo Dong Hailong Yuan Shaolan Bi Yaoquan Chu Xiangqun Cui Licai Deng Jianning Fu Zhanwen Han Jinliang Hou Guoping Li Chao Liu Jifeng Liu Xiaowei Liu Ali Luo Jianrong Shi Xuebing Wu Haotong Zhang Gang Zhao Yongheng Zhao | 2022 | The Innovation2022，3，2： | 0 |
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