|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | In vitro study of radiosensitization by β-Elemene in A549 cell line from adenocarcinoma of lung显示文摘在 A549 房间由 β-Elemene 探索效果和收音机促进感受性的可能的机制在试管内的目的从肺的腺癌排队。A549 房间从肺的腺癌衬里的方法被选择让学习由使用 MTT 试金决定抑制比率。词法变化,生长曲线,克隆效率,师的索引被观察。房间周期和 apoptosis 率的变化被 FCM 和基因 P53 的表情分析, Bcl-2 被检测。结果在照耀和 β-Elemene 下面的组的繁殖活动显著地被压制,它的克隆的效率和师的索引也衰退了。在照耀和 β-Elemene 下面的组的 apoptosis 率在 48 h 和 72 h 是显著地更高的,它被 FCM 分析。没有 Bcl-2 的 P53 的表达式在照耀和 β-Elemene 下面在这个组被观察,在仅仅在第 48 小时的 β-Elemene 下面的组指,当没有 p53 的 Bcl-2 的表达式仅仅在照耀下面在这个组被观察,控制组织时。结论 β-Elemene 擅长收音机促进感受性,它的机制可能与 P53, Bcl-2 的下面规定和导致的 apoptosis 的起来规定相关。 | Hao Jiang Shenglin Ma Jianguo Feng | 2009 | The Chinese-German Journal of Clinical Oncology2009，8，1： | 17 |
| 2 | Epidermal growth factor receptor (EGFR) T790M mutation identified in plasma indicates failure sites and predicts clinical prognosis in non-small cell lung cancer progression during first-generation tyrosine kinase inhibitor therapy: a prospective observational study显示文摘Introduction:Plasma circulating tumor DNA(ctDNA)is an ideal approach to detecting the epidermal growth factor receptor(EGFR)T790M mutation,which is a major mechanism of resistance to first-generation EGFR-tyrosine kinase inhibitor(TKI)therapy.The present study aimed to explore the association of ctDNA-identified T790M mutation with disease failure sites and clinical prognosis in non-small cell lung cancer(NSCLC)patients.Methods:Patients who progressed on first-generation TKIs were categorized into failure site groups of chest limited(CF),brain limited(BF)and other(OF).Amplification refractory mutation system(ARMS)and droplet digital PCR(ddPCR)were used to identify the T790M mutation in ctDNA.Prognosis was analyzed with Kaplan-Meier methods.Results:Overall concordance between the two methods was 78.3%.According to both ARMS and ddPCR,patients in the OF group had a significantly higher rate of T790M mutation than did patients in the BF and CF groups(P<0.001),and a significantly higher T790M mutation rate was also observed in OF-group patients than in those in the CF and BF groups(P<0.001).AZD9291 was found to be an excellent treatment option and yielded the longest survival for T790M+patients in all groups who had progressed on EGFR-TKIs;for other treatments,the prognosis of T790M−patient subgroups varied.Conclusions:The present study demonstrates that T790M mutation in ctDNA is associated with failure sites for NSCLC patients after EGFR-TKI therapy and indicates that both failure site and T790M mutational status greatly influ-ence treatment selection and prognosis. | Shirong Zhang Lucheng Zhu Bing Xia Enguo Chen Qiong Zhao Xiaochen Zhang Xueqin Chen Xufeng Chen Shenglin Ma | 2018 | Cancer Communications2018，38，1： | 12 |
| 3 | The Late Carboniferous–Early Permian Ocean-Continent Transition in the West Junggar,Central Asian Orogenic Belt: Constraints from Columnar Jointed Rhyolite显示文摘The West Junggar of the western Central Asian Orogenic Belt is one of the typical regions in the term of ocean subduction, contraction and continental growth in the Late Paleozoic. However, it is still controversial on the exact time of ocean-continent transition so far. This study investigates rhyolites with columnar joint in the West Junggar for the first time.Based on zircon U-Pb dating, we determined that the ages of the newly-discovered rhyolites are between 303.6 and 294.5 Ma, belonging to Late Carboniferous–Early Permian, which is the oldest rhyolite with columnar joint preserved in the world at present. Geochemical results show that the characteristics of the major element compositions include a high content of SiO_2(75.78–79.20 wt%) and a moderate content of Al_2O_3(12.21–13.19 wt%). The total alkali content(K_2O +Na_2O) is 6.14–8.05 wt%, among which K_2O is 2.09–4.72 wt% and the rate of K_2O/Na_2O is 0.38–3.05. Over-based minerals such as Ne, Lc, and Ac do not appear. The contents of TiO_2(0.09–0.24 wt%), CaO(0.15–0.99 wt%) and MgO(0.06–0.18 wt%) are low. A/CNK=0.91–1.68, A/NK=1.06–1.76, and as such, these are associated with the quasi-aluminum-weak peraluminous high potassium calc-alkaline and some calc-alkaline magma series. These rhyolites show a significant negative Eu anomaly with relative enrichment of LREE and LILE(Rb, Ba, Th, U, K) and depletion of Sr, HREE and HFSE(Nb, Ta, Ti, P). These rhyolites also have the characteristics of an A2-type granite, similar to the Miaoergou batholith,which indicates they both were affected by post-orogenic extension. Combining petrological, zircon U-Pb dating and geochemical characteristics of the rhyolites, we conclude that the specific time of ocean-continent transition of the West Junggar is the Late Carboniferous–Early Permian. | XU Shenglin CHEN Xuanhua LI Tingdong SHI Jianjie DING Weicui LI Bing HUANG Penghui ZHANG Yiping ZHANG Yaoyao MA Feizhou | 2019 | Acta Geologica Sinica(English Edition)2019，93，2： | 9 |
| 4 | P-doped BN nanosheets decorated graphene as the functional interlayer for Li–S batteries显示文摘Lithium–sulfur(Li–S)batteries have attracted much attention due to their ultrahigh theoretical specific capacity.However,serious capacity attenuation caused by shuttle effect still inhibits the performance improvement.Herein,a modified separator consists of the few-layer graphene as a highly conductive network and stable scaffold to support P-doped boron nitride(denoted as BN-P@GO)as the functional interlayer of Li–S batteries.The cell with the interlayer provides an initial discharge capacity as high as1045.3 mAh g^-1,and retains a high reversible capacity of 728.7 mAh g^-1 at 1 C after 500 cycles with a capacity decay of 0.061%per cycle.Moreover,the rate capability is also superior to cells with BN@GO or BN-P interlayers,i.e.reversible capcity of 457.9 mAh g^-1 even at 3 C.The excellent electrochemical performance is ascribed to the synergistic effect of physical barrier and chemical adsorption for dissolved polysulfides provided by the modified layer.Furhtermore,it also mitigates the polarization and promotes kinetic reactions of the cells.This work provides a concise and effective method for commercialization of lithium–sulfur batteries. | Jing Zhang Wenzhe Ma Zhenyu Feng Fangfang Wu Denghu Wei Baojuan Xi Shenglin Xiong | 2019 | Journal of Energy Chemistry2019，28，12： | 7 |
| 5 | s-HBEGF/SIRT1 circuit-dictated crosstalk between vascular endothelial cells and keratinocytes mediates sorafenib-induced hand-foot skin reaction that can be reversed by nicotinamide显示文摘Hand-foot skin reaction(HFSR),among the most significant adverse effects of sorafenib,has been limiting the clinical benefits of this frontline drug in treating various malignant tumors.The mechanism underlying such toxicity remains poorly understood,hence the absence of effective intervention strategies.In the present study,we show that vascular endothelial cells are the primary cellular target of sorafenib-induced HFSR wherein soluble heparin-binding epidermal growth factor(s-HBEGF)mediates the crosstalk between vascular endothelial cells and keratinocytes.Mechanistically,s-HBEGF released from vascular endothelial cells activates the epidermal growth factor receptor(EGFR)on keratinocytes and promotes the phosphorylation of c-Jun N-terminal kinase 2(JNK2),which stabilizes sirtuin 1(SIRT1),an essential keratinization inducer,and ultimately gives rise to HFSR.The administration of s-HBEGF in vivo could sufficiently induce hyper-keratinization without sorafenib treatment.Furthermore,we report that HBEGF neutralization antibody,Sirtl knockdown,and a classic SIRTI inhibitor nicotinamide could all significantly reduce the sorafenib-induced HFSR in the mouse model.It is noteworthy that nicotinic acid,a prodrug of nicotinamide,could substantially reverse the sorafenib-induced HFSR in ten patients in a preliminary clinical study.Collectively,our findings reveal the mechanism of vascular endothelial cell-promoted keratinization in keratinocytes and provide a potentially promising therapeutic strategy for the treatment of sorafenib-induced HFSR. | Peihua Luo Hao Yan Xueqin Chen Ying Zhang Ziying Zhao Ji Cao Yi Zhu Jiangxia Du Zhifei Xu Xiaochen Zhang Su Zeng Bo Yang Shenglin Ma Qiaojun He | 2020 | Cell Research2020，30，9： | 5 |
| 6 | Immobilizing VN ultrafine nanocrystals on N-doped carbon nanosheets enable multiple effects for high-rate lithium-sulfur batteries显示文摘The exploitation of new sulfiphilic and catalytic materials is considered as the promising strategy to overcome severe shuttle effect and sluggish kinetics conversion of lithium polysulfides within lithium-sulfur batteries.Herein,we design and fabricate monodisperse VN ultrafine nanocrystals immobilized on nitrogen-doped carbon hybrid nanosheets(VN@NCSs)via an one-step in-situ selftemplate and self-reduction strategy,which simultaneously promotes the interaction with polysulfides and the kinetics of the sulfur conversion reactions demonstrated by experimental and theoretical results.By virtue of the multifunctional structural features of VN@NCSs,the cell with ultrathin VN@NCSs(only 5 pm thickness)modified separator indicates improved electrochemical performances with long cycling stability over 1,000 cycles at 2 C with only 0.041%capacity decay per cycle and excellent rate capability(787.6 mAh g^(-1) at 10 C).Importantly,it delivers an areal reversible capacity of 3.71 mAh cm^(-2) accompanied by robust cycling life. | Ning Song Baojuan Xi Peng Wang Xiaojian Ma Weihua Chen Jinkui Feng Shenglin Xiong | 2022 | Nano Research2022，15，2： | 4 |
| 7 | 第一代酪氨酸激酶抑制剂治疗中发生进展的非小细胞肺癌血浆表皮生长因子受体(EGFR)T790M突变提示了失败部位并预测了临床预后:一项前瞻性观察研究显示文摘背景与目的血浆循环肿瘤DNA(circulating tumor DNA,ctDNA)是检测表皮生长因子受体(epidermal growth factor receptor,EGFR)T790M突变的理想方法。T790M突变是第一代EGFR酪氨酸激酶抑制剂(tyrosine kinase inhibitor,TKI)耐药的主要机制。本研究旨在探讨ctDNA来源的T790M突变与非小细胞肺癌(non-small cell lung cancer,NSCLC)患者疾病失败部位及临床预后的关系。方法第一代TKI治疗发生进展的患者被分为局限胸内进展(chest limited,CF)、局限颅内进展(brain limited,BF)和其他部位进展(other,OF)组。采用扩增阻滞突变系统(amplification refractory mutation system,ARMS)和微滴式数字PCR(droplet digital PCR,ddPCR)对ctDNA中T790M突变进行了检测。采用Kaplan-Meier法分析了预后。结果 2种方法的总体一致性为78.3%。根据ARMS和ddPCR,OF组患者的T790M突变率明显高于BF组和CF组(P <0.001),OF组的T790M突变丰度也明显高于CF组和BF组(P <0.001)。AZD9291是T790M+患者最佳治疗选择,为EGFR-TKI治疗后进展的所有组中T790M+患者提供了最长的生存期;接受其他治疗的T790M-患者亚组的预后各不相同。结论本研究表明ctDNA中T790M突变与NSCLC患者EGFR-TKI治疗失败部位相关,失败部位和T790M突变状态对治疗选择和预后都有很大影响。 | Shirong Zhang Lucheng Zhu Bing Xia Enguo Chen Qiong Zhao Xiaochen Zhang Xueqin Chen Xufeng Chen Shenglin Ma | 2018 | 癌症2018，37，9： | 4 |
| 8 | Ticagrelor inhibits the NLRP3 inflammasome to protect against inflammatory disease independent of the P2Y_(12 ) signaling pathway显示文摘Ticagrelor is the first reversibly binding oralP2Y_(12) receptor antagonist to inhibit platelet activation and has been approved by the Food and Drug Administration for the treatment of coronary artery disease. At present, the other pharmacological functions of ticagrelor remain poorly understood. The NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasome plays a critical role in the innate immune system, but its excessive activation also contributes to the pathogenesis of complex diseases. In this study, we systematically examined the effects of ticagrelor on the NLRP3 inflammasome and found that ticagrelor inhibits NLRP3 inflammasome activation in macrophages independent of its classic inhibitory effect on theP2Y_(12) signaling pathway. Further mechanistic studies demonstrate that ticagrelor attenuates the oligomerization of apoptosis-associated speck-like protein containing a CARD (ASC) by blocking chloride efflux, an effect achieved through the degradation of chloride intracellular channel proteins (CLICs) and blockade of the translocation of CLICs to the plasma membrane. Moreover, experiments on lipopolysaccharide-induced sepsis and alum-induced peritonitis in mice confirmed that ticagrelor mitigates the severity of systemic inflammation independent ofP2Y_(12) receptor antagonism. Importantly, oral administration of ticagrelor rapidly and strongly inhibited NLRP3 inflammasome activation in peripheral blood mononuclear cells from patients with acute coronary syndrome. Overall, our study reveals a novel pharmacological function of ticagrelor in addition to its classic antiplatelet properties, which suggests that ticagrelor may serve as a potential therapeutic agent for use in NLRP3-associated diseases. | Bo Huang Yufeng Qian Shujun Xie Xianhua Ye Hanwen Chen Zhifeng Chen Lihuan Zhang Jinming Xu Hu Hu Shenglin Ma Paul Héroux Di Wang Han-Ming Shen Yihua Wu Dajing Xia | 2021 | Cellular & Molecular Immunology2021，18，5： | 3 |
| 9 | N-doped carbon nanotubes formed in a wide range of temperature and ramping rate for fast sodium storage显示文摘Herein,nickel@nitrogen-doped carbon nanotubes(Ni@NCNTs)are prepared by a simple and reliable method with Ni-based complex as single-source precursor.Significantly,the formation of CNTs is not susceptible to the calcination temperature and ramping rate and Ni@NCNTs can be attained from 430 to 900℃in an inert atmosphere.Then they are the first time to be applied as the anode material for sodium-ion batteries.The presence of Ni nanoparticles(NPs)facilitates the solid electrolyte interface film over the anode surface and improves the capacity retention of the host material,especially at the high rates.Furthermore,Na+diffusion is reinforced after the introduction of Ni NPs.Ni@NCNTs obtained at 500℃(Ni@NCNTs-500)exhibit the best capacity retention and rate capability.Kinetics analyses demonstrate the faster electron transportation and ion diffusion than others prepared at other temperatures.The surficial capacitance storage favors the fast electrochemistry kinetics.It delivers a high specific capacity(192 mA h g^−1 at 0.5 A g^−1),excellent cycling stability(103 mA h g^−1 after 10,000 cycles at 10 A g^−1),and outstanding high-rate capability up to 20 A g^−1(118 mA h g^−1).The related full cells confirm a high energy density of 140 Wh kg^−1 at 38.16 W kg^−1 and 44.27 W h kg^−1 at 762 W kg^−1. | Ruchao Wei Man Huang Wenzhe Ma Baojuan Xi Zhenyu Feng Haibo Li Jinkui Feng Shenglin Xiong | 2020 | Journal of Energy Chemistry2020，29，10： | 3 |
| 10 | Frequent RNF43 mutation contributes to moderate activation of Wnt signaling in colorectal signet-ring cell carcinoma显示文摘Dear Editor,Signet-ring cell carcinoma(SRCC)is a rare subtype of colorectal cancer(CRC)characterized histologically by the accumulation of mucins in the cytoplasm and displacement of nuclei to the cellular periphery,accounting for about 1%CRC(Fig.S1A)(Borger et al.,2007).Compare to common subtypes of CRC,such as adenocarcinoma(AC)and mucinous adenocarcinoma(MAC),SRCC is associated with aggressive behaviors and younger age at presentation(Kang et al.,2005;Sung et al.,2008;Nitsche et al.,2013;Hugen et al.,2014;Inamura et al.,2015).A retrospective analysis of CRC patient's data at Fudan University Shanghai Cancer Center(FUSCC)also indicated a worse overall and disease-free survival of SRCC patients(Fig.S1B and S1C,Table S1). | Yaqi Li Jian Li Renjie Wang Long Zhang Guoxiang Fu Xueying Wang Yebin Wang Chuantao Fang Dandan Zhang Duo Du Xiaoji Ma Mengxue Pan Qiang Guo Xiaoya Xu Xiang Hu Yi Zhou Shaobo Mo Huijun Wang Jianjun Gao Shenglin Huang Yun Liu Sanjun Cai Guoqiang Hua Junjie Peng Fa-Xing Yu | 2020 | Protein & Cell2020，11，4： | 2 |
| 11 | Late Paleozoic Element Migration and Accumulation under Intracontinental Sinistral Strike-slip Faulting in the West Junggar Orogenic Belt, NW China显示文摘The migration,accumulation and dispersion of elements caused by tectonic dynamics have always been a focus of attention,and become the basis of tectono-geochemistry.However,the effects of faulting,especially strike-slip faulting,on the adjustment of geochemical element distribution,are still not clear.In this paper,we select the West Junggar Orogenic Belt(WJOB),NW China,as a case study to test the migration behavior of elements under tectonic dynamics.The WJOB is dominated by NE-trending large-scale sinistral strike-slip faults such as the Darabut Fault,the Mayile Fault,and the Baerluke Fault,which formed during the intracontinental adjustment under N-S compression during ocean-continental conversion in the Late Paleozoic.Geochemical maps of 13 elements,Al,W,Sn,Mo,Cu,Pb,Zn,As,Sb,Hg,Fe,Ni,and Au,are analyzed for the effects of faulting and folding on element distribution at the regional scale.The results show that the element distribution in the WJOB is controlled mainly by two mechanisms during tectonic deformation:first is the material transporting mechanism,where the movement of geological units is consistent with the direction of tectonic movement;second is the diffusion mechanism,especially by tectonic pressure dissolution driven by tectonic dynamics,where the migration of elements is approximately perpendicular or opposite to the direction of tectonic movement.We conclude that the adjustment of element distributions has been determined by the combined actions of transporting and diffusion mechanisms,and that the diffusion mechanism plays an important role in the formation of geochemical Au blocks in the WJOB. | WANG Ye CHEN Xuanhua NIE Lanshi DING Weicui WANG Xueqiu XU Shenglin MA Feizhou HAN Lele | 2020 | Acta Geologica Sinica(English Edition)2020，94，6： | 1 |
| 12 | Standardization Framework of Marine Sustainable Development Evaluation System显示文摘The core concepts of standardization framework of marine sustainable development evaluation systemare fairness and justice and the aim of sustainable development is to pursue development beneficial bothfor the current and future generations.Scientific evaluation of sustainable marine development is importantfor ensuring an accurate level of marine development.Establishing a scientific evaluation system is of greatimportance in the planning of marine development.Standardization of such an evaluation system needs tobe based on comprehensive work and must be founded on both marine science and modern managementprinciples.This paper analyses the current marine standards situation and looks at the assessment systemfor marine sustainable development.It also lists the main reasons for the standardization of a sustainablemarine development evaluation system and analyses five existing marine standardization problems whichare a constraint to this standardization.Finally a framework of marine sustainable development evaluationsystem standardization is established.The conclusion incorporates some advice on how to promote thisstandardization. | Ye Shenglin,Ma Chun and Ju Meiting | 2009 | China Standardization2009，54，6： | 1 |
| 13 | Recent progress,mechanisms,and perspectives for crystal and interface chemistry applying to the Zn metal anodes in aqueous zinc-ion batteries显示文摘The need for large-scale electrochemical energy storage devices in the future has spawned several new breeds of batteries in which aqueous zinc ion batteries(AZIBs)have attracted great attention due to their high safety,low cost,and excellent electrochemical performance.In the current research,the dendrite and corrosion caused by aqueous electrolytes are the main problems being studied.However,the research on the zinc metal anode is still in its infancy.We think it really needs to provide clear guidelines about how to reasonably configure the system of AZIBs to realize high-energy density and long cycle life.Therefore,it is worth analyzing the works on the zinc anode,and several strategies are proposed to improve the stability and cycle life of the battery in recent years.Based on the crystal chemistry and interface chemistry,this review reveals the key factors and essential causes that inhibit dendrite growth and side reactions and puts forward the potential prospects for future work in this direction.It is foreseeable that guiding the construction of AZIBs with high-energy density and long cycle life in various systems would be quite possible by following this overview as a roadmap. | Zhengchunyu Zhang Baojuan Xi Xiaojian Ma Weihua Chen Jinkui Feng Shenglin Xiong | 2022 | SusMat2022，2，2： | 1 |
| 14 | Immobilization of Ag nan- oparticles/FGF-2 on a modified titanium implant surfaceand im- proved human gingival fibroblasts behavior 显示文摘 | Qianli Ma Shenglin Mei Kun Ji | 2011 | Journal of Bio- medical Materials Research2011，98，2： | 1 |
| 15 | Gefitinib versus placebo as maintenance therapy in patients with locally advanced or metastatic non-small-cell lung cancer(INFORM;C-TONG 0804):a multicentre,double-blind randomised phase 3 trial显示文摘 | Zhang Li Ma Shenglin Song Xiangqun | 2012 | Lancet Oncology2012，13，5： | 1 |
| 16 | Induction of a tumour-specific CTL response by exosomes isolated from heat-treated malignant ascites of gastric cancer patients显示文摘 | Haijun Zhong Yunshan Yang Shenglin Ma Fangming Xiu Zhijian Cai Hongguang Zhao Linbin Du | 2011 | International Journal of Hyperthermia2011，，6： | 1 |
| 17 | Gefitinib versus placebo as maintenance therapy in patients with locally advanced or metastatic non-small-cell lung cancer (INFORM; C-TONG 0804 ): a multicentre, double-blind randomised phase 3 trial显示文摘 | Zhang Li Ma ShengLin Song XiangQun | 2012 | Lancet Oneol2012，13，5： | 1 |
| 18 | Antibacterial effects and biocompatibility of titanium surfaces with graded silver incorporation in titania nanotubes显示文摘 | Shenglin Mei Huaiyu Wang Wei Wang Liping Tong Haobo Pan Changshun Ruan Qianli Ma Mengyuan Liu Huiling Yang Liang Zhang Yicheng Cheng Yumei Zhang Lingzhou Zhao Paul K. Chu | 2014 | Biomaterials2014，，： | 1 |
| 19 | Rare Metal Materials and Engineering显示文摘 | Liu Shenglin Ma Qiuhua Lii Heng | 2014 | 43(1 ): 61 (in Chinese)2014，43，1： | 1 |
| 20 | Rare Metal Ma- terials and Engineering显示文摘 | Liu Shenglin Ma Qiuhua Zheng Xueping | 2014 | 43(2): 287 (in Chinese)2014，43，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员