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    题名 作者 年代 出处 被引量
1Soil concentrations and soil-air exchange of organochlorine pesticides along the Aba profile, east of the Tibetan Plateau, western China显示文摘MianzhuAba 侧面,西藏的高原的东方,被选择沿着一个高度的坡度学习 organochlorine 杀虫剂(OCP ) 的出现。在表面土壤的 Dichlorodiphenyltrichloroethanes (DDT ) , hexachlorocyclohexanes (HCH ) 和 Aldrin,狄氏剂和 Endrin (Drins ) 在冬季(三月) 和夏天(7 月) 被检测。Hongxia LIU Shihua QI Dan YANG Ying HU Feng LI Jia LIU Xinli XING 2013Frontiers of Earth Science2013,7,4:6
2GLUT1-mediated effective anti-miRNA21 pompon for cancer therapy显示文摘Oncogenic microRNAs are essential components in regulating the gene expression of cancer cells. Especially miR21, which is a major player involved of tumor initiation, progression, invasion and metastasis in several cancers. The delivery of anti-miR21 sequences has significant potential for cancer treatment. Nevertheless, since anti-miR21 sequences are extremely unstable and they need to obtain certain concentration to function, it is intensely difficult to build an effective delivery system for them.The purpose of this work is to construct a self-assembled glutathione(GSH)-responsive system with tumor accumulation capacity for effective anti-miR21 delivery and cancer therapy. A novel drug delivery nanosphere carrying millions of anti-miR21 sequences was developed through the rolling circle transcription(RCT) method. GSH-responsive cationic polymer polyethyleneimine(pOEI) was synthesized to protect the nanosphere from degradation by Dicer or other RNase in normal cells and optimize the pompon-like nanoparticle to suitable size. Dehydroascorbic acid(DHA), a targeting molecule, which is a substrate of glucose transporter 1(GLUT 1) and highly expressed on malignant tumor cells, was connected to pOEI through PEG, and then the polymer was used for contracting a RNA nanospheres into nanopompons. The anti-miR21 nanopompons showed its potential for effective cancer therapy.Qin Guo Chao Li Wenxi Zhou Xinli Chen Yu Zhang Yifei Lu Yujie Zhang Qinjun Chen Donghui Liang Tao Sun Chen Jiang 2019Acta Pharmaceutica Sinica B2019,9,4:5
3Identification and classification of subspecies of Asian cultivated rice and their hybrids显示文摘Having reviewed the major classification systems proposed by various scholars across the world, it is found that \%indica\% and \%japonica\% under \%O.sativa\% L. are two major directions thoroughly differentiated from the Asian cultivated rice, forming the framework of the classification structure. A system with \%indica\% and \%japonica\% as the only two subspecies is therefore reiterated.There are various ways to determine the indica_japonica identity of hybrid rice, but the 'combined morphological trait index'(CMT index) method is more efficient and easier to handle, although the isozyme analysis, molecular marker analysis and grain quality assay methods are also feasible.Xiangkun Wang Renhua Li Chuanqing Sun Zichao Li Hongwei Cai Xinli Sun 1998Chinese Science Bulletin1998,43,22:5
48-hydroxy-2-(di-n-propylamino)tetralin intervenes with neural cell apoptosis following diffuse axonal injury显示文摘Previous studies have reported a neuroprotective effect of 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) against traumatic brain injury. In accordance with the Marmarou method, rat models of diffuse axonal injury were established. 8-OH-DPAT was intraperitoneally injected into model rats 8-OH-DPAT treated rats maintained at constant temperature served as normal temperature controls TUNEL results revealed that neural cell swelling, brain tissue necrosis and cell apoptosis occurred around the injured tissue. Moreover, the number of Bax-, Bcl-2- and caspase-3-positive cells increased at 6 hours after diffuse axonal injury, and peaked at 24 hours. However, brain injury was attenuated, the number of apoptotic cells reduced, Bax and caspase-3 expression decreased, and Bcl-2 expression increased at 6, 12, 24, 72 and 168 hours after diffuse axonal injury in normal temperature control and in 8-OH-DPAT-intervention rats. The difference was most significant at 24 hours. All indices in 8-OH-DPAT-intervention rats were better than those in the constant temperature group. These results suggest that 8-OH-DPAT inhibits Bax and caspase-3 expression, increases Bcl-2 expression, and reduces neural cell apoptosis, resulting in neuroprotection against diffuse axonal injury. This effect is associated with a decrease in brain temperature.Zhenli Mao Zhenquan Song Gang Li Wei Lv Xu Zhao Bin Li Xinli Feng Youli Chen 2013Neural Regeneration Research2013,8,2:3
5Tangnaikang improves insulin resistance and β-cell apoptosis by ameliorating metabolic inflammation in SHR.Cg-Lepr^(cp)/NDmcr rats显示文摘OBJECTIVE: To investigate the effects of Tangnaikang(TNK), a mixture of five herbal plant extracts,on inflammation-mediated insulin resistance andβ-cell apoptosis in SHR.Cg-Leprcp/NDmcr(SHR-cp)rats.METHODS: Seven-week-old SHR-cp rats were randomly divided into a control(CON) group and a TNK(3.24 g/kg) group. Wistar-Kyoto rats at the same age were used as the normal control group.After 7 weeks of continuous intragastric administration of TNK, the glucose metabolic status and insulin sensitivity of the rats were evaluated by assessing fasting serum glucose(FBG), the oral glucose tolerance test(OGTT), fasting serum insulin(FINS),and the insulin sensitivity index(ISI). Serum tumor necrosis factor-α(TNF-α), interleukin-6(IL-6), C-reactive protein(CRP) and adiponectin were measured via enzyme-linked immunosorbent assays.Macrophage infiltration and apoptosis in adipose tissues were detected through F4/80 immunohistochemistry and the terminal deoxynucleotidyl transferase d UTP nick end labeling(TUNEL) assay. Islet morphology and β-cell apoptosis were investigated using double immunofluorescence staining and the TUNEL assay. The expression of cytokine genes in adipose tissue, the liver, and the pancreas was detected in real-time polymerase chain reaction assays. The expression and phosphorylation levels of insulin signaling-, inflammation-, and β-cell survival-related proteins in the liver and pancreas of SHR-cp rats were detected by western blotting.RESULTS: TNK(3.24 g/kg) treatment significantly decreased body weight, FBG and FINS; improved impaired glucose tolerance; increased the ISI; reduced serum levels of TNF-α, CRP and IL-6; and increased serum adiponectin. The m RNA expression of inflammatory markers was markedly reduced in the liver, pancreas, and adipose tissue. F4/80-and TUNEL-positive cells in adipose tissues were decreased, as was the number of TUNEL-positiveβ-cells. The phosphorylation of c-Jun N-terminal kinase and that of insulin receptor substrate-1 at serines 307 and 1101 was significantly decreased.In the pancreas, the expression of nuclear factor kappa-light chain-enhancer of activated B cells-p65 was significantly decreased, and phosphoinositide3-kinase and IRS-2 were significantly increased.CONCLUSION: TNK was able to improve insulin resistance and β-cell apoptosis in SHR-cp rats, which might be associated with its ability to relieve the overall and local metabolic inflammatory responses observed in SHR-cp rats.Li Linyi Hisae Yoshitomi Qin Lingling Wu Xinli Zhou Tian Wang Haiyan Jiang Yueying Wei Ying Xu Tunhai Liu Tonghua Gao Ming 2017Journal of Traditional Chinese Medicine2017,37,3:3
6CPSO-XGBoost segmented regression model for asphalt pavement deflection basin area prediction显示文摘The use of non-destructive testing(NDT) equipment, such as the falling weight deflectometer(FWD), provides important estimates of road health and helps to optimize road management regimes. However, periodic road testing and post-processing of the collected data are cumbersome and require much expertise, a considerable amount of time, money, and other resources. This study attempts to develop a reliable prediction method for estimating the deflection basin area of different asphalt pavements using road temperature, load time, and load pressure as main characteristics. The data are obtained from 19 kinds of asphalt pavements on a 2.038-km-long full-scale fleld accelerated pavement testing track named RIOHTrack(Research Institute of Highway Track) in Tongzhou, Beijing. In addition, a chaotic particle swarm algorithm(CPSO) and a segmented regression strategy are proposed in this paper to optimize the XGBoost model. The experiment results of the proposed method are compared with those of classical machine learning algorithms and achieve an average of mean square error and mean absolute error respectively by 5.80 and 1.59.The experiments demonstrate the superiority of the XGBoost algorithm over classical machine learning methods in dealing with nonlinear problems in road engineering. Signiflcantly, the method can reduce the frequency of deflection tests without affecting its estimation accuracy, which is a promising alternative way to facilitate the rapid assessment of pavement conditions.LI ZhuoXuan SHI XinLi CAO JinDe WANG XuDong HUANG Wei 2022Science China(Technological Sciences)2022,65,7:3
7Doppel-induced cytotoxicity in human neuronal SH-SY5Y cells is antagonized by the prion protein显示文摘Doppel (Dpl ) 由于结构、生物化学的类似是象蛋白质一样的 prion (PrP ) ;然而, Dpl 和 PrP 的自然功能仍然保持不清楚。在这研究,编码 Dpl 蛋白质的一个 531-bp 人 PRND 基因序列从人的外部血白细胞被放大。全身、各种各样的截断的人的 Dpl 和 PrP 蛋白质从 Escherichia 被表示并且净化 coli。全身的 Dpl 的补充导致了显著 cytotoxicity,和负责的区域到人的 neuroblastoma 房间 SH-SY5Y 上因为它的 cytotoxicity 在 Dpl 的中间的片断被印射[氨基酸(aa ) 81122 ] 。有趣地,导致 Dpl 的 cytotoxicity 被全身的野类型的 PrP 的存在反对。PrP 异种的碎片上的分析证明 N 终端碎裂(aa 2390 ) PrP 为保护的活动负责。有 Dpl 在 SH-SY5Y 房间上导致了象 Dpl 一样 cytotoxicity 的类似的第二等的结构的截断的 PrP (PrP32121 ) 。而且,铜离子的绑定能在导致 Dpl 的 cytotoxicity 上提高 PrP 的反对效果。Apoptosis 试金表明 Dpl 导致的 cytotoxicity 通过 apoptotic 机制发生了。这些结果建议 Dpl 的功能对 PrP 而非 synergistic 对抗。Ping Li Chenfang Dong Yanjun Lei Bing Shan Xinli Xiao Huiying Jiang Xin Wang Chen Gao Qi Shi Kun Xu Chan Tian Jun Han Xiaoping Dong 2009Acta Biochimica et Biophysica Sinica2009,41,1:3
8Simultaneous determination of bisphenols, benzophenones and parabens in human urine by using UHPLC-TQMS显示文摘Bisphenols, benzophenones and parabens may alter one or more functions of endocrine system and consequently cause adverse health effects on human. A rapid and sensitive analytical method for the simultaneous determination of six bisphenols, five benzophenones and seven parabens in human urine by using ultra-high performance liquid chromatography coupled with triple quadrupole mass spectrometry was developed and applied for human urine sample analysis. The eighteen targeted compounds were separated within 11 min. Heated-electrospray ionization was operated with multiple reaction monitoring in negative-ion mode. The limit of detection ranged from 0.01 ng/mL to 0.5 ng/mL.Seven isotope-labeled internal standards were used in the quantitative analysis. After the method was validated for sensitivity, linearity, precision, accuracy and matrix effect, it was applied for the analysis of human urine samples to evaluate the profiles of human exposure. Eight of the targeted analytes were detected in more than 50% urine samples.Hongzhi Zhao Jiufeng Li Xinli Ma Wenqian Huo Shunqing Xu Zongwei Cai 2018Chinese Chemical Letters2018,29,1:3
9Porous graphene paper for supercapacitor applications显示文摘Graphene paper shows a great promise for the electrical energy storage. However, the high stability, purity and specific surface area have become stringent requirements for supercapacitor applications. Finding methods to tackle these problems is rather challenging. Here, we develop a facile method to prepare porous graphene papers with a thickness 0.5 mm by a thermal shock to the layer-structure graphene paper self-assembled on Cu foil under nitrogen flowing. The as-prepared porous graphene paper exhibits a large specific capacitance of 100 F g^(-1)at the scan rate of 100 m V s^(-1)with high stability and purity without any residual chemical reagents, showing a promising potential for supercapacitor applications. The high electrochemical properties are mainly attributed to the high-specific area and the improved conductivity of the porous graphene paper performed by the multieffect of reducing, cleaving and expanding to the layer-structure graphene paper by high-energy thermal heating during the thermal shock process. This work paves a pathway to the facile preparation of porous graphene paper for supercapacitor applications.Qi Li Xinli Guo Yao Zhang Weijie Zhang Chuang Ge Li Zhao Xiaojuan Wang Hongyi Zhang Jian Chen Zengmei Wang Litao Sun 2017Journal of Materials Science & Technology2017,33,8:2
10Effect of Phosphorus Grain Boundaries Segregation and Precipitations on Mechanical Properties for Ti-IF Steel after Recrystallization Annealing显示文摘The cold-rolled(75% reduction ratio) Ti-IF(interstitial-free) steels of 1 mm thickness were recrystallized by annealing at 810°C for different times.The microstructure,mechanical properties and phosphorus segregation at grain boundary were investigated by means of optical microscopy(OM),tensile testing and field emission transmission electron microscopy(FE-TEM).It was observed that recrystallization was completed after annealing at 810°C for 180 s.The yield strength and tensile strength decreased as annealing time increased.The FE-TEM observation showed that after the annealing treatment,the grain boundary was broadened and the dislocations with higher density of phosphorus atoms and phosphide at grain boundaries became evident.The amount of phosphorus segregated at grain boundaries increased with annealing time.Xinli Song Zexi Yuan Juan Jia Di Wang Pinghe Li Zhaojun Deng 2010Journal of Materials Science & Technology2010,26,9:2
11Exosome‐Mediated Transfer of miR‐133b from Multipotent Mesenchymal Stromal Cells to Neural Cells Contributes to Neurite Outgrowth显示文摘Hongqi Xin Yi Li Ben Buller Mark Katakowski Yi Zhang Xinli Wang Xia Shang Zheng Gang Zhang Michael Chopp 2012STEM CELLS2012,,7:2
12Chromosome doubling mediates superior drought tolerance in Lycium ruthenicum via abscisic acid signaling显示文摘Plants are continuously affected by unfavorable external stimuli,which influences their productivity and growth.Differences in gene composition and expression patterns lead homologous polyploid plants to exhibit different physiological phenomena,among which enhanced environmental adaptability is a powerful phenotype conferred by polyploidization.The mechanisms underlying the differences in stress tolerance between diploids and autotetraploids at the molecular level remain unclear.In this research,a full-length transcription profile obtained via the singlemolecule real-time(SMRT)sequencing of high-quality single RNA molecules for use as background was combined with next-generation transcriptome and proteome technologies to probe the variation in the molecular mechanisms of autotetraploids.Tetraploids exhibited an increase in ABA content of 78.4%under natural conditions and a superior stress-resistance phenotype under severe drought stress compared with diploids.The substantial differences in the transcriptome profiles observed between diploids and autotetraploids under normal growth conditions were mainly related to ABA biosynthesis and signal transduction pathways,and 9-cis-epoxycarotenoid dioxygenase 1(NCED1)and NCED2,which encode key synthetic enzymes,were significantly upregulated.The increased expression of the ABREbinding factor 5-like(ABF5-like)gene was a pivotal factor in promoting the activation of the ABA signaling pathway and downstream target genes.In addition,ABA strongly induced the expression of osmotic proteins to increase the stress tolerance of the plants at the translational level.We consider the intrinsic mechanisms by which ABA affects drought resistance in tetraploids and diploids to understand the physiological and molecular mechanisms that enhance abiotic stress tolerance in polyploid plants.Shupei Rao Yuru Tian Xinli Xia Yue Li Jinhuan Chen 2020Horticulture Research2020,7,1:2
13Verticillium dahliae Secretory Effector PevD1 Induces Leaf Senescence by Promoting ORE1-Mediated Ethylene Biosynthesis显示文摘Leaf senescence,the final stage of leaf development,is influenced by numerous internal and environmental signals.So far,how biotic stresses such as pathogen infection regulate leaf senescence is unclear.Here,we found that the premature leaf senescence caused by a soil-borne vascular fungus Verticillium dahliae in Arabidopsis was impaired by the mutation of a protein elicitor from V.dahliae 1(PevD1).Constitutive or inducible overexpression of PevD1 accelerated Arabidopsis leaf senescence.A senescence-associated NAC transcription factor,ORE1,was targeted by PevD1.PevD1 interacted with and stabilized ORE1 protein by disrupting its interaction with the RING-type ubiquitin E3 ligase NLA.Mutation of ORE1 suppressed the premature senescence caused by overexpressing PevD1.Overexpression of ORE1 or PevD1 led to enhanced ethylene production,and ORE1 mediated PevD1-induced ethylene biosynthesis by directly binding to the ACS6 promoter.Loss-of-function of ACSs suppressed V.dahliae-induced leaf senescence in ORE1-overexpressing plants.Interestingly,PevD1 also interacted with Gossypium hirsutum ORE1(GhORE1),and virus-induced gene silencing of GhORE1 delayed V.dahliae-triggered leaf senescence in cotton,indicative of the existence of a conserved mechanism in plants.Altogether,our study demonstrates that V.dahliae induces leaf senescence by secreting the effector PevD1 to regulate the ORE1-ACS6 cascade,providing new insight into biotic stress-induced senescence in plants.Yi Zhang Yuhan Gao Hou-Ling Wang Chengcheng Kan Ze Li Xiufen Yang Weilun Yin Xinli Xia Hong Gil Nam Zhonghai Li Hongwei Guo 2021Molecular Plant2021,14,11:2
14On the Development of an Effective Pressure Driving System for Ultra-Low Permeability Reservoirs显示文摘Given its relevance to the exploitation of ultra-low permeability reservoirs,which account for a substantial proportion of the world’s exploited and still unexploited reserves,in the present study the development of an adequate water injection system is considered.Due to the poor properties and weak seepage capacity of these reservoirs,the water injection pressure typically increases continuously during water flooding.In this research,the impact on such a process of factors as permeability,row spacing,and pressure gradient is evaluated experimentally using a high-pressure large-scale outcrop model.On this basis,a comprehensive evaluation coefficient is introduced able to account for the effective driving pressure.Yapu Zhang Zhengming Yang Dajian Li Xuewei Liu Xinli Zhao 2021Fluid Dynamics & Materials Processing2021,17,6:2
15Late Triassic bivalves associated with a hydrothermal vent system in the Yidun Island Arc (SW China) of the eastern Tethys显示文摘The Yidun Island Arc in the Three Rivers (Jinsha River, Lancang River, Nujiang River) region of southwestern China is one of the most important Kuroko-type volcanogenic massive sulfide deposits (VMS) in China. Intra-arc rifting of Yidun Island occurred during the Late Carnian-Norian when VMS deposits such as the Gacun Pb-Zn-Cu deposit were formed. A bivalve fauna was found in fine-grained tuffaceous slate and in mineralized tuffaceous siltstone containing very high contents of Pb (45.01-103.37 ppm) and Zn (135.78-300.03 ppm) of the upper Tumugou Formation in the Changtai-Gacun volcanic-sedimentary rift basin. Stratigraphically, the bivalve-bearing beds are equivalents of the Gacun Pb-Zn-Cu deposits. The diversity of this bivalve fauna is very low. It consists mainly of the thin-shelled, epibyssate suspension-feeding bivalves Pergamidia eumenea and Parapergamidia changtaiensis, the burrowing large, elongated, suspension-feeding Trigonodus keuperinus and Unionites? sp., and occasional specimens of the endobyssate suspension-feeding Trigonodus? sp. and the deep burrowing suspension-feeding Pleuromya markiamensis. Individuals of the first four taxa are so abundant that the specimens are sometimes concentrated in shell beds, probably indicating a gregarious habit. This bivalve fauna is associated with internal moulds of cylindrical, slightly conical tubes most likely produced by a worm-shaped organism. Composition, morphology, diversity, and high abundance of this fauna, chemical features of the surrounding sediment, and the tectonic setting all suggest that this bivalve fauna lived in a deep-water environment in or around a hydrothermal vent system.LIN Li ZHU LiDong PANG YanChun SHA JinGeng Franz T. FURSICH FU XiuGen WANG XinLi 2011Science China Earth Sciences2011,54,12:2
16Au nanoparticles decorated graphene/nickel foam nanocomposite for sensitive detection of hydrogen peroxide显示文摘The Au nanoparticles decorated graphene(AuNPs@Gr)/nickel foam(Gr/NiF) nanocomposite(AuNPs@Gr/NiF) was prepared by chemical vapor deposition followed by electrophoretic deposition of AuNPs on Gr/NiF. The morphology, microstructure and sensing performance of the as-prepared AuNPs@Gr/NiF nanocomposite were characterized and measured, respectively by scanning electron microscope, transmission electron microscope, ultraviolet visible spectroscopy and chemical workstation. The asprepared AuNPs@Gr/NiF nanocomposite was used as the electrode to construct a chemical sensor for the detection of hydrogen peroxide(H_2O_2). The results showed that the AuNPs distributed homogenously and stably on the surface of Gr/NiF. The chemical sensor exhibits a sensitive and selective performance to the detection of H_2O_2.Xiaojuan Wang Xinli Guo Jian Chen Chuang Ge Hongyi Zhang Yuanyuan Liu Li Zhao Yao Zhang Zengmei Wang Litao Sun 2017Journal of Materials Science & Technology2017,33,3:2
17Advances and perspectives in catalytic oxidation of hydrocarbons in liquid phase显示文摘This review article summarizes recent advances in catalytic oxidation of hydrocarbons,especially presents two strategies for activation of C-H bonds or molecular oxygen.Based on our own research results,the applications of the two methods in the oxidation of cyclohexane,toluene and ethyl benzene,etc.are introduced,and the perspectives of the two methods are also discussed.Zhou Lipeng Yang Guanyu Zhang Wei Sun Zhiqiang Gao Jin Miao Hong Chen Chen Ma Hong Li Xiaoqiang Zhang Qiaohong Wang Feng Tong Xinli Xu Jie 2007Progress in Natural Science:Materials International2007,17,9:2
18Direct growth of graphene on vertically standing glass by a metal-free chemical vapor deposition method显示文摘A new method to directly grow graphene on quartz glass substrate by atmospheric-pressure chemical vapor deposition(CVD) without using any catalyst was developed. The prime feature of this method is to build a vertical-glass model in the quartz tube to significantly increase the collision probability of the carbon precursors and reactive fragments between each other with the glass surface. The growth rate of high-quality graphene on glass remarkably increases compared with the conventional gas flow CVD technique. The optical transmittance and sheet resistance of the graphene glass can be readily adjusted by regulating growth time. When growth time is 35 min, the graphene glass presents an intriguing sheet resistance of about 1.48 kΩ sq^(-1) at a transmittance of 93.08% and exhibits an excellent hydrophobic performance. The method is simple and scalable, and might stimulate various potential applications of transparent and conductive graphene glass in practical fields.Zhongtao Chen Xinli Guo Long Zhu Long Li Yuanyuan Liu Li Zhao Weijie Zhang Jian Chen Yao Zhang Yuhong Zhao 2018Journal of Materials Science & Technology2018,34,10:2
19Positioning taxonomic research for the future显示文摘Why do taxonomists matter? The work of taxonomists is often understated if not completely misunderstood. Without taxonomists, organisms cannot be accurately identified, neither can these organisms be given universally accepted names, and reliably positioned in the phylogenetic tree of life. Thanks to the work of taxonomists over the last 269 years since Carl Linnaeus established the binomial system, we can now measure the health and wealth of our biodiversity in a refined, science-based inventory prescribed by stringent nomenclatural rules.Deyuan Hong Wenying Zhuang Min Zhu Keping Ma Xiaoquan Wang Dawei Huang Yalin Zhang Guodong Ren Wenjun Bu Wanzhi Cai Dong Ren Ding Yang Aiping Liang Fengyan Bai Runzhi Zhang Fumin Lei Shuqiang Li Hongzhi Kong Lei Cai Yucheng Dai Chaodong Zhu Qisen Yang Jun Chen Zhongli Sha Jianping Jiang Jing Che Donghui Wu Jiatang Li Qiang Wang Xinli Wei Ming Bai Xingyue Liu Xuexin Chen Gexia Qiao 2022Zoological Systematics2022,47,3:2
20An efficient catalytic dehydration of fructose and sucrose to 5-hydroxymethylfurfural with protic ionic liquids 显示文摘Tong Xinli Ma Yang Li Yongdan 2010Carbohydrate Research2010,345,12:1
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