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| 1 | Inactivation of Cryptosporidium by ozone and cell ultrastructures显示文摘The fluorescence staining method and scanning electron microscopy (SEM) were used to study the effect of ozone (O3) inactivating Cryptosporidium in water and cell ultrastructures variation to shed light on the mechanism of inactivation preliminarily.Results indicated that O3 had a stronger inactivating capability.When the concentration of O3 was above 3.0 mg/L and the contact time was up to 7 min,a significant inactivating effect could be achieved.The turbidity on inactivation effects was also found to be statistically significant in artificial water.With increases in turbidity,the inactivating effect decreased.Inactivation rate improved with a temperature increase from 5 to 25°C,but decreased beyond this.The inactivating capability of O3 was found to be stronger under acidic than that under alkalic conditions.When the concentration of organic matter in the reaction system was increased,the competition between Cryptosporidium and organics with O3 probably took place,thereby reducing the inactivation rate.In addition,the cellular morphology of Cryptosporidium varied with different contact times.At zero contact time,cells were rotundity and sphericity,at 60 sec they became folded,underwent emboly,and burst at 480 sec,the cell membrane of Cryptosporidium shrinked and collapsed completely. | Zhilin Ran Shaofeng Li Junli Huang Yixing Yuan Chongwei Cui Craig Denver Williams | 2010 | Journal of Environmental Sciences2010，22，12： | 11 |
| 2 | Profiling the repertoire of T-cell receptor beta-chain variable genes in peripheral blood lymphocytes from subjects who have recovered from acute hepatitis B virus infection显示文摘T 房间受体贝它链的侧面变量(TRBV ) 基因通常与病毒感染或癌症在题目扭曲。融化的基因光谱模式(GMSP ) 能被用来决定 TRBV 基因家庭的侧面。从从尖锐肝炎 B 病毒感染(AHI ) 恢复了的题目在外部血淋巴细胞探索 TRBV 家庭的肖像,外部血 mononuclear 房间(PBMC ) 被分开并且进一步排序 + 和 CD8 +T 房间子集进 CD4。TRBV 的分子的特征补足的决定区域 3 (CDR3 ) 主题用 GMSP 分析被决定。当 GMSP 侧面显示出一座单个山峰时, monoclonally 扩展的 TRBV 基因被克隆并且定序。多重 TRBV 基因的扭曲的扩大在 CD4 + 和 CD8 +T 房间子集和 PBMC 之中被观察。在 CD8 +T 房间子集的 monoclonally 扩展的 TRBV 基因的频率比 CD4 +T 房间子集和 PBMC 的显著地高。比作 TRBV 基因家庭, TRBV11, BV15 和 BV20 的另外的成员主要在恢复 AHI 题目在外部血淋巴细胞的全部剧目被表示。TRBV5.1 和 BV20 CDR3 的相对保存的氨基酸主题也在 CD4 + 和 CD8 +T 房间子集被检测。这些结果在恢复 AHI 题目表明多重偏导的 TRBV 家庭的存在。特别从 CD8 +T 房间子集, TRBV11, BV15 和 BV20 可能与有 AHI 的题目的致病相关。有相对保存的 CDR3 主题的优先地选择的 TRBV5.1 和 BV20 可以是为长期的 HBV 感染的个性化的处理的潜在的目标。 | Jiezuan Yang | 2014 | Cellular & Molecular Immunology2014，11，4： | 6 |
| 3 | Differentiation of Hepatocellular Carcinoma from Hepatic Hemangioma and Focal Nodular Hyperplasia using Computed Tomographic Spectral Imaging显示文摘Background and Aims:Hepatocellular carcinoma(HCC)is the most common primary hepatic malignancy.This study was designed to investigate the value of computed tomography(CT)spectral imaging in differentiating HCC from hepatic hemangioma(HH)and focal nodular hyperplasia(FNH).Methods:This was a retrospective study of 51 patients who underwent spectral multiple-phase CT at 40–140 keV during the arterial phase(AP)and portal venous phase(PP).Slopes of the spectral curves,iodine density,water density derived from iodine-and water-based material decomposition images,iodine uptake ratio(IUR),normalized iodine concentration,and the ratio of iodine concentration in liver lesions between AP and PP were measured or calculated.Results:As energy level decreased,the CT values of HCC(n=31),HH(n=17),and FNH(n=7)increased in both AP and PP.There were significant differences in IUR in the AP,IUR in the PP,normalized iodine concentration in the AP,slope in the AP,and slope in the PP among HCC,HH,and FNH.The CT values in AP,IUR in the AP and PP,normalized iodine concentration in the AP,slope in the AP and PP had high sensitivity and specificity in differentiating HH and HCC from FNH.Quantitative CT spectral data had higher sensitivity and specificity than conventional qualitative CT image analysis during the combined phases.Conclusions:Mean CT values at low energy(40–90 keV)and quantitative analysis of CT spectral data(IUR in the AP)could be helpful in the differentiation of HCC,HH,and FNH. | Weixia Li Ruokun Li Xiangtian Zhao Xiaozhu Lin Yixing Yu Jing Zhang Kemin Chen Weimin Chai Fuhua Yan | 2021 | Journal of Clinical and Translational Hepatology2021，9，3： | 6 |
| 4 | Effectiveness of Catch-Up Vaccinations after COVID-19 Containment--China,2020显示文摘Introduction:In the early stages of the coronavirus disease 2019(COVID-19)epidemic in China,the highest level of public health emergency response(Level 1 Response)was launched in all province-level administrative divisions(PLADs)across the country.Provision of vaccination services was selectively suspended due to the physical distancing and gathering restrictions required of Level 1 Response.The purpose of this paper is to evaluate the impact of COVID-19 on vaccination services and the effectiveness of selective vaccination service suspension and catch-up vaccinations in China.Methods:Vaccine doses administered,routine vaccination coverage levels,catch-up vaccine doses administered,and coverage levels after the catch-up campaign were determined from individual vaccination records in sampled clinics,standard routine immunization administrative coverage reports,and catch-up vaccination activity reports submitted by PLADs between October 2019 and October 2020.Results:National Immunization Program(NIP)and non-NIP vaccine doses administered in sampled clinics decreased by 80% and 90%,respectively,compared with doses administered before the COVID-19 pandemic.Coverage with the birth dose of hepatitis B vaccine(HepB1)and the Bacillus Calmette-Guérin vaccine(BCG)—two vaccinations recommended to continue throughout the epidemic due to their timecritical nature—were maintained at over 85%,while coverage of other NIP vaccines decreased to below 60%by February 2020.Catch-up vaccination coverage of the 29 PLADs,excluding Xinjiang and Xizang(Tibet),began in April 2020 and exceeded 90%;Hubei catch-up coverage was 95% by October 2020.Conclusions and Implications for Public Health Practice:The COVID-19 pandemic had a great impact on China’s vaccination services.During the epidemic and time of local transmission of the coronavirus,HepB1,BCG,rabies vaccine for postexposure prophylaxis,and tetanus antitoxin(TAT)for wound prophylaxis were maintained at high levels.Of the 69 million vaccine doses postponed during the time of local transmission of the coronavirus,94% were administered in the catch-up campaign.China’s pandemic immunization practices may provide evidence for other countries’immunization programs. | Jing Wu Wenzhou Yu Lei Cao Lingsheng Cao Lance Rodewald Jiakai Ye Yifan Song Li Li Xiaoxue Liu Ning Wen Fuzhen Wang Lixin Hao Yixing Li Hui Zheng Keli Li Chao Ma Dan Wu Yanmin Liu Guomin Zhang Zhijie An Huaqing Wang Zundong Yin | 2020 | China CDC weekly2020，2，50： | 6 |
| 5 | DeST 3.0:A new-generation building performance simulation platform显示文摘Buildings contribute to almost 30%of total energy consumption worldwide.Developing building energy modeling programs is of great significance for lifecycle building performance assessment and optimization.Advances in novel building technologies,the requirements of high-performance computation,and the demands for multi-objective models have brought new challenges for building energy modeling software and platforms.To meet the increasing simulation demands,DeST 3.0,a new-generation building performance simulation platform,was developed and released.The structure of DeST 3.0 incorporates four simulation engines,including building analysis and simulation(BAS)engine,HVAC system engine,combined plant simulation(CPS)engine,and energy system(ES)engine,connected by air loop and water loop balancing iterations.DeST 3.0 offers numerous new simulation features,such as advanced simulation modules for building envelopes,occupant behavior and energy systems,cross-platform and compatible simulation kernel,FMI/FMU-based co-simulation functionalities,and high-performance parallel simulation architecture.DeST 3.0 has been thoroughly evaluated and validated using code verification,inter-program comparison,and case-study calibration.DeST 3.0 has been applied in various aspects throughout the building lifecycle,supporting building design,operation,retrofit analysis,code appliance,technology adaptability evaluation as well as research and education.The new generation building simulation platform DeST 3.0 provides an efficient tool and comprehensive simulation platform for lifecycle building performance analysis and optimization. | Da Yan Xin Zhou Jingjing An Xuyuan Kang Fan Bu Youming Chen Yiqun Pan Yan Gao Qunli Zhang Hui Zhou Kuining Qiu Jing Liu Yan Liu Honglian Li Lei Zhang Hong Dong Lixin Sun Song Pan Xiang Zhou Zhe Tian Wenjie Zhang Ruhong Wu Hongsan Sun Yu Huang Xiaohong Su Yongwei Zhang Rui Shen Diankun Chen Guangyuan Wei Yixing Chen Jinqing Peng | 2022 | Building Simulation2022，15，11： | 5 |
| 6 | Lignin derived multi-doped(N, S, Cl) carbon materials as excellent electrocatalyst for oxygen reduction reaction in proton exchange membrane fuel cells显示文摘Nowadays,hierarchically macro-/meso-/microporous 3D carbon materials have been paid more attention due to their imaginative application potential in specific electrochemistry.Here,we report a dualtemplate strategy using eutectic NaCl/ZnCl2 melt as airtight and swelling agent to obtain 3D mesoporous skeleton structured carbon from renewable lignin.The prepared lignin-derived biocarbon material(LN-3-1)has a high specific surface area(1289 m^2 g^-1),a large pore volume(2.80 cm^3 g^-1),and a well-connected and stable structure.LN-3-1 exhibits extremely high activity and stability in acidic medium for oxygen reduction reaction(ORR),superior to Pt/C catalyst and most non noble-metal catalysts reported in recent literatures.The prepared carbon material was used as a cathode catalyst to assemble a H2-O2 single fuel cell,and its excellent catalytic performance has been confirmed with the maximum power density of 779 mW cm^-2,which is one of the highest power densities among non-metallic catalysts so far.Density functional theory(DFT)calculations indicate that the synergy of chlorine and nitrogen reconciles the intermediate adsorption energies,leading to an appropriate theoretical ORR onset potential.We develop a cost-effective and highly efficient method to prepare biocarbon catalyst for ORR in proton-exchange membrane fuel cells. | Yixing Shen Yuhang Li Guangxing Yang Qiao Zhang Hong Liang Feng Peng | 2020 | Journal of Energy Chemistry2020，29，5： | 5 |
| 7 | Melatonin alleviates alcoholic liver disease via EGFR-BRG1-TERT axis regulation显示文摘Chronic alcohol consumption causes liver steatosis,cell death,and inflammation.Melatonin(MLT)is reported to alleviate alcoholic liver disease(ALD)-induced injury.However,its direct regulating targets in hepatocytes are not fully understood.In the current study,a cell-based screening model and a chronic ethanol-fed mice ALD model were used to test the protective mechanisms of MLT.MLT ameliorated ethanol-induced hepatocyte injury in both cell and animal models(optimal doses of 10μmol/L and 5 mg/kg,respectively),including lowered liver steatosis,cell death,and inflammation.RNA-seq analysis and loss-of-function studies in AML-12 cells revealed that telomerase reverse transcriptase(TERT)was a key downstream effector of MLT.Biophysical assay found that epidermal growth factor receptor(EGFR)on the hepatocyte surface was a direct binding and regulating target of MLT.Liver specific knock-down of Tert or Egfr in the ALD mice model impaired MLT-mediated liver protection,partly through the regulation of nuclear brahma-related gene-1(BRG1).Long-term administration(90 days)of MLT in healthy mice did not cause evident adverse effect.In conclusion,MLT is an efficacious and safe agent for ALD alleviation.Its direct regulating target in hepatocytes is EGFR and downstream BRG1-TERT axis.MLT might be used as a complimentary agent for alcoholics. | Zhaodi Che Yali Song Chengfang Xu Wei Li Zhiyong Dong Cunchuan Wang Yixing Ren Kwok-Fai So George L.Tipoe Fei Wang Jia Xiao | 2023 | Acta Pharmaceutica Sinica B2023，13，1： | 2 |
| 8 | Cu/ACF adsorbent modified by non-thermal plasma for simultaneous adsorption–oxidation of H_(2)S and PH_(3)显示文摘Non-thermal plasma(NTP)surface modification technology is a new method to control the surface properties of materials,which has been widely used in the field of environmental protection because of its short action time,simple process and no pollution.In this study,Cu/ACF(activated carbon fiber loaded with copper)adsorbent was modified with NTP to remove H_(2)S and PH_(3) simultaneously under low temperature and micro-oxygen condition.Meanwhile,the effects of different modified atmosphere(air,N_(2) and NH_(3)),specific energy input(0–13 J/mL)and modification time(0–30 min)on the removal of H_(2)S and PH_(3) were investigated.Performance test results indicated that under the same reaction conditions,the adsorbent modified by NH_(3) plasma with 5 J/mL for 10 min had the best removal effect on H_(2)S and PH_(3).CO_(2) temperature-programmed desorption and X-ray photoelectron spectroscopy(XPS)analyzes showed that NH_(3) plasma modification could introduce amino functional groups on the surface of the adsorbent,and increase the types and number of alkaline sites on the surface.Brunauer-Emmett-Teller and scanning electron microscopy showed that NH_(3) plasma modification did not significantly change the pore size structure of the adsorbent,but more active components were evenly exposed to the surface,thus improving the adsorption performance.In addition,X-ray diffraction and XPS analysis indicated that the consumption of active components(Cu and Cu_(2)O)and the accumulation of sulfate and phosphate on the surface and inner pores of the adsorbent are the main reasons for the deactivation of the adsorbent. | Xinyu Yang Kai Li Chi Wang Fei Wang Xin Sun Yixing Ma Yuan Li Lei Shi Ping Ning | 2023 | Journal of Environmental Sciences2023，，5： | 2 |
| 9 | The relationship between soil,climate and forest development in the mid-mountain zone of the Sangong River watershed in the northern Tianshan Mountains,China显示文摘The mountainous forests in arid regions, being sensitive to climate change, are one of the key research topics related to the mechanism of interaction between climate and the terrestrial ecosystem. In this study, the spatial distribution of a mid-mountain forest and its environmental factors were investigated by using a combination of remote sensing technology, field survey, climate indices and soil nutrient analysis in the Sangong River watershed of the northern Tianshan Mountains. The forest(Picea schrenkiana) was distributed between 1,510 and 2,720 m asl. Tree height and diameter at breast height(DBH) exhibited a bi-modal pattern with increasing elevation, and rested at 2,450 and 2,250 m asl, respectively. The two maxima of DBH appeared at 2,000 and 2,550 m asl, and the taller trees were observed at 2,100 and 2,600 m asl. For the annual mean temperature, the difference was approximately 5.8°C between the lowest and the highest limits of the forest, and the average decreasing rates per hundred meters were 0.49°C and 0.55°C with increasing altitude between 1,500 and 2,000 m asl and above 2,000 m asl, respectively. The annual precipitation in the forest zone first increased and then decreased with the increase of altitude, and the maximum value was at 2,000 m asl. For per hundred meters, the annual precipitation increased with the rate of 31 mm between 1,500 and 2,000 m asl and decreased by 7.8 mm above 2,000 m asl. The SOM, TN and TP were high between 2,000 and 2,700 m asl and low at the lower and upper forest limits. The minimum Ca CO3 concentration, p H value and EC coincided with the maximum precipitation belt at 2,000 m asl. The SOM, TN and TP were high in the topsoil(0–10 cm) and differed significantly from the values observed in the deep soil layers(>10 cm). The soil nutrients exhibited spatial heterogeneity and higher aggregation in the topsoil. In conclusion, soil and climate are closely related to each other, working synergistically to determine the development and spatial distribution of the mid-mountain forest in the study area. The order of the importance of environmental factors to forest development in this study is as follows: soil nutrients>precipitation>elevation>temperature. | Li DAI YiXing FENG GePing LUO YanZhong LI WenQiang XU | 2015 | Journal of Arid Land2015，7，1： | 2 |
| 10 | Synthesis and Photocatalytic Activity of Fe-doped TiO_2 Supported on Hollow Glass Microbeads显示文摘In this paper, Fe-doped TiO_2 photocatalyst supported on hollow glass microbeads(Fe-TiO_2 /beads)is prepared by dip-coating method, which uses hollow glass microbeads as the carriers and tetrabutylorthotitanate [Ti(OC_4H_9)_4] as the raw material. The phase structure, ingredient, morphologies, particle size and shell thickness of the products are characterized by X-ray powder diffraction(XRD), energy-dispersive spectroscopy(EDS) and field emission scanning electron microscope(FESEM). The feasibility of photocatylic degradation of Rhodamine B(Rh B) under illumination of UV-vis light is studied. The results show that the core-shell structure catalyst is composed of Fe-doped anatase TiO_2 and hollow glass microbeads, and the catalytic activity of the TiO_2 is markedly enhanced by Fe ion doping. The optimum concentration of Fe ion is 0.1%(molecular fraction) in the precursor and the photocatalytic activity can be increased to 98% compared with that of the undoped one. The presence of ferrum elements neither influences the transformation of anatase to rutile, nor creates new crystal phases. The possible mechanism of photocatalytic oxidation is also discussed. | Wenyan Zhao Wuyou Fu Haibin Yang Chuanjin Tian Minghui Li Juan Ding Wei Zhang Xiaoming Zhou Hui Zhao Yixing Li | 2011 | Nano-Micro Letters2011，3，1： | 1 |
| 11 | The Estimation and Control of the Electroslag Remelting Melt Rate by Mechanism-Based Modeling显示文摘 | Wanzhou Li Weiyu Wang Yuechen Hu Yixing Chen | 2012 | Metallurgical and Materials Transactions B2012，，2： | 1 |
| 12 | High-entropy-alloy nanoparticles with 21 ultra-mixed elements for efficient photothermal conversion显示文摘Multi-metallic nanoparticles have been proven to be an efficient photothermal conversion material, for which the optical absorption can be broadened through the interband transitions(IBTs), but it remains a challenge due to the strong immiscibility among the repelling combinations. Here, assisted by an extremely high evaporation temperature, ultra-fast cooling and vapor-pressure strategy, the arc-discharged plasma method was employed to synthesize ultra-mixed multi-metallic nanoparticles composed of 21 elements(FeCoNiCrYTiVCuAlNbMoTaWZnCdPbBiAgInMnSn), in which the strongly repelling combinations were uniformly distributed. Due to the reinforced lattice distortion effect and excellent IBTs, the nanoparticles can realize an average absorption of >92% in the entire solar spectrum(250 to 2500 nm). In particular, the 21-element nanoparticles achieve a considerably high solar steam efficiency of nearly 99%under one solar irradiation, with a water evaporation rate of 2.42 kg mh, demonstrating a highly efficient photothermal conversion performance. The present approach creates a new strategy for uniformly mixing multi-metallic elements for exploring their unknown properties and various applications. | Yijun Liao Yixing Li Rongzhi Zhao Jian Zhang Lizhong Zhao Lianze Ji Zhengyu Zhang Xiaolian Liu Gaowu Qin Xuefeng Zhang | 2022 | National Science Review2022，9，6： | 1 |
| 13 | ROS is essential for initiation of energy deprivation-induced autophagy显示文摘Autophagy is a highly conserved degradation process in which intracellular components are engulfed into a double membrane structure,known as the autophagosomes,and then delivered to lysosomes/vacuoles for degradation(Ohsumi,2014).Recently,autophagy has been found to be responsible for maintaining glucose homeostasis in adult animals(Karsli-Uzunbas et al.,2014).However,the molecular mechanism underlying energy deprivation-induced autophagy remains relatively unclear. | Choufei Wu Yixing Li Shu Zhong Yingcong Chen Yu Xie Yuyao Feng Weijing Yao Suping Fu Yanlan Zhu Liefeng Wang Yuting Chen Liqin Zhang Jingjing Tong Cong Yi | 2021 | Journal of Genetics and Genomics2021，48，6： | 1 |
| 14 | Efficient removal of Cr(Ⅲ)-carboxyl complex from neutral and high-salinity wastewater by nitrogen doped biomass-based composites显示文摘Heavy metals usually exist stably as the species of organic complexes in high-salinity wastewater.Therefore,their effective removal is challenging,especially when the initial p H is neutral.Herein,a novel nitrogen doped biomass-based composite(N-CMCS)was synthesized to remove the complexed heavy metal of Cr(Ⅲ)-carboxyl.The maximum adsorption capacity of Cr(Ⅲ)-Citrate(Cr-Cit)by N-CMCS under neutral p H(7.0)and high-salinity(200 mmol/L NaCl)condition was up to 2.50 mmol/g.And the removal performance remained stable after 6 times of regeneration.Combined with species and characterizations analysis,electrostatic attraction and hydrogen bonding were the main mechanisms for N-CMCS to remove Cr(Ⅲ)-carboxyl complexes.Dynamic adsorption indicated N-CMCS column could treat about 1300BV simulated wastewater and 350 BV actual wastewater with the concentration of effluent lower than1.0 mg/L.Furthermore,N-CMCS could remove a variety of complexed heavy metal ions under neutral p H,indicating the great potential in practical application. | Li Song Shichao Jing Yixing Qiu Fuqiang Liu Aimin Li | 2023 | Chinese Chemical Letters2023，34，1： | 1 |
| 15 | Association of elevated GRP78 expression with increased lymph node metastasis and poor prognosis in patients with gastric cancer显示文摘 | Jun Zhang Yixing Jiang Zhiliang Jia Qiang Li Weida Gong Liwei Wang Daoyan Wei James Yao Shengyun Fang Keping Xie | 2006 | 2006 (7-8)2006，，7： | 1 |
| 16 | Experimental investigation on humidifying performance of counter flow spray saturator for humid air turbine cycle显示文摘 | WANG Yuzhang LI Yixing WENG Shilie | 2007 | Energy Conversion & Management2007，48，3： | 1 |
| 17 | Wood polymer composites prepared by in-situ polymerization of monomers within wood显示文摘 | LI Yongfeng LIU Yixing WANG Xiangming et at | 2011 | Journal of Applied Polymer Sci- ence2011，119，6： | 1 |
| 18 | Novel SnO 2 hierarchical nanostructures: Synthesis and their gas sensing properties显示文摘 | Xiaoming Zhou Wuyou Fu Haibin Yang Yanyan Zhang Minghui Li Yixing Li | 2013 | Materials Letters2013，，： | 1 |
| 19 | A sequence variant in the phospholipase C epsilon C2 domain is associated with esophageal carcinoma and esophagitis显示文摘 | Li‐Dong Wang Xiuli Bi Xin Song Nicole M. Pohl Yulan Cheng Yixing Zhou Stephen Shears Emmanuel Ansong Mengtao Xing Shaomeng Wang Xiao‐Chun Xu Peng Huang Liyan Xu Liang Wang Zongmin Fan Xueke Zhao Huali Dong Stephen J. Meltzer Ivan Ding Wancai Yang | 2013 | Mol Carcinog2013，，1： | 1 |
| 20 | Variations regularity of microorganisms and corrosion of cast iron in water distribution system显示文摘Corrosion, one of the most common problems of metal pipe for water supply, generally leads to poor water quality, bacteria proliferation, water capacity decrease and other problems. As microorganisms affect corrosion by changing the characteristics of metal surface, the mechanism of microbial corrosion still remains unclear. The corrosion behavior of ductile cast iron is implemented in the dynamic flow and static conditions, in which variations of water quality and microbial community are analyzed in details. The results show that if the corrosion rate of ductile cast iron decreases, the corrosion of cast iron will result in a lower DO and a higher total iron in bulk water. The number of microorganisms is not a decisive factor of corrosion, even though the counts of bacteria had a close relationship with DO. On the basis of the detection of the 10 kinds of nitratereducing bacteria by Miseq sequencing, NRB of the biofilm biomass accounts for 18.3% on the 30 th day and 20.5% on the 55 th day. Even though aerobic NRBs go into the biofilm later than the facultative anaerobic NRBs, the growth of the anaerobic NRBs is not affected. | Wei Qiu Weiyu Li Junguo He Hongyu Zhao Xiuming Liu Yixing Yuan | 2018 | Journal of Environmental Sciences2018，30，12： | 1 |
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