|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Nanoscale Ta-based diffusion barrier thin-films and their resistance properties显示文摘Nanoscale Ta-based diffusion barrier thin-films and Cu/barrier/Si multilayer structures were deposited on p-type Si (100) substrates by DC magnetron sputtering. Then the samples were rapidly thermal-annealed (RTA) by tungsten halide lamp. The resistance properties, structure and surface morphology of the thin-films were investigated by four-point probe (FPP) sheet resistance measurement, AFM, SEM-EDS, Alpha-Step IQ Profilers and XRD. The experimental results showed that agglomeration, oxidation and stabilization effects are concurrent. And resistance increasing and decreasing are coexistent after RTA. The formation of high resistance Cu3Si due to inter-diffusion between Cu and Si and more intensive electron scattering resulting from rougher surface caused the sheet resistance to increase abruptly after high temperature RTA. | ZHOU JiCheng CHEN HaiBo LI YouZhen | 2008 | Science China(Technological Sciences)2008，51，7： | 3 |
| 2 | HSP70 alleviates sepsis-induced cardiomyopathy by attenuating mitochondrial dysfunction-initiated NLRP3 inflammasome-mediated pyroptosis in cardiomyocytes显示文摘Background:Sepsis-induced cardiomyopathy(SIC)is an identified serious complication of sepsis that is associated with adverse outcomes and high mortality.Heat shock proteins(HSPs)have been implicated in suppressing septic inflammation.The aim of this study was to investigate whether HSP70 can attenuate cellular mitochondrial dysfunction,exuberated inflammation and inflammasome-mediated pyroptosis for SIC intervention.Methods:Mice with cecal ligation plus perforation(CLP)and lipopolysaccharide(LPS)-treated H9C2 cardiomyocytes were used as models of SIC.The mouse survival rate,gross profile,cardiac function,pathological changes and mitochondrial function were observed by photography,echocardiography,hematoxylin-eosin staining and transmission electron microscopy.In addition,cell proliferation and the levels of cardiac troponin I(cTnI),interleukin-1β(IL-1β)and tumor necrosis factor-α(TNF-α)were determined by Cell Counting Kit-8,crystal violet staining and enzyme-linked immunosorbent assay.Moreover,mitochondrial membrane potential was assessed by immunofluorescence staining,and dynamin-related protein 1 and pyroptosis-related molecules[nucleotide-binding domain,leucine-rich-repeat containing family pyrin domain-containing 3(NLRP3),caspase-1,gasdermin-D(GSDMD),gasdermin-D N-terminal(GSDMD-N)]were measured by western blotting,immunoprecipitation and immunoblotting.Finally,hsp70.1 knockout mice with CLP were used to verify the effects of HSP70 on SIC and the underlying mechanism.Results:Models of SIC were successfully established,as reduced consciousness and activity with liparotrichia in CLP mice were observed,and the survival rate and cardiac ejection fraction(EF)were decreased;conversely,the levels of cTnI,TNF-αand IL-1βand myocardial tissue damage were increased in CLP mice.In addition,LPS stimulation resulted in a reduction in cell viability,mitochondrial destabilization and activation of NLRP3-mediated pyroptosis molecules in vitro.HSP70 treatment improved myocardial tissue damage,survival rate and cardiac dysfunction caused by CLP.Additionally,HSP70 intervention reversed LPS-induced mitochondrial destabiliza-tion,inhibited activation of the NLRP3 inflammasome,caspase-1,GSDMD and GSDMD-N,and decreased pyroptosis.Finally,knockout of hsp70.1 mice with CLP aggravated cardiac dysfunction and upregulated NLRP3 inflammasome activity,and exogenous HSP70 significantly rescued these changes.It was further confirmed that HSP70 plays a protective role in SIC by attenuating mitochondrial dysfunction and inactivating pyroptotic molecules.Conclusions:Our study demonstrated that mitochondrial destabilization and NLRP3 inflammasome activation-mediated pyroptosis are attributed to SIC.Interestingly,HSP70 ameliorates sepsis-induced myocardial dysfunction by improving mitochondrial dysfunction and inhibiting the acti-vation of NLRP3 inflammasome-mediated pyroptosis,and such a result may provide approaches for novel therapies for SIC. | Chenlu Song Yiqiu Zhang Qing Pei Li Zheng Meiyu Wang Youzhen Shi Shan Wu Wei Ni Xiujun Fu Yinbo Peng Wen Zhang Min Yao | 2022 | Burns & Trauma2022，10，1： | 2 |
| 3 | Balancing sub‐reaction activity to boost electrocatalytic urea synthesis using a metal‐free electrocatalyst显示文摘Electrocatalytic urea synthesis via coupling of nitrate with CO_(2)is considered as a promising alternative to the industrial urea synthetic process.However,the requirement of sub-reaction(NO_(3)RR and CO_(2)RR)activities for efficient urea synthesis is not clear and the related reaction mechanisms remain obscure.Here,the construction,breaking,and rebuilding of the sub-reaction activity balance would be accompanied by the corresponding regulation in urea synthesis,and the balance of sub-reaction activities was proven to play a vital role in efficient urea synthesis.With rational design,a urea yield rate of 610.6 mg h−1 gcat.−1 was realized on the N-doped carbon electrocatalyst,superior to that of noble-metal electrocatalysts.Based on the operando SRFTIR measurements,we proposed that urea synthesis arises from the coupling of^(*)NO and^(*)CO to generate the key intermediate of^(*)OCNO.This work provides new insights and guidelines into urea synthesis from the aspect of activity balance. | Chen Chen Shuang Li Xiaorong Zhu Shuowen Bo Kai Cheng Nihan He Mengyi Qiu Chao Xie Dezhong Song Youzhen Liu Wei Chen Yafei Li Qinghua Liu Conggang Li Shuangyin Wang | 2023 | Carbon Energy2023，5，10： | 2 |
| 4 | 显示文摘 | Zhou Jicheng Luo Ditian Li Youzhen | 2009 | Trans Nonferrous Met Soc China2009，19，： | 1 |
| 5 | Influence of Plasma Modified Carbon Nanotubes on the Resistance Sensitiveness of Cement显示文摘The surface of carbon nanotubes(CNTs)was modified by plasma to improve the dispersion,conductivity and adsorption properties of carbon nanotubes.Cement-based composites made with plasmatreated carbon nanotubes(P-CNTs)at different perntages were tested under repeated cyclic axial compressive stress by four electrode methods to measure the electric resistance.Those made with CNTs without plasma treatment as controls were tested also.The results showed that electric resistance change values of the cement mortar with P-CNT and CNT were all monatomic corresponding to the cyclic loading.When the water-cement ratio of the mortar was fixed,increasing of the P-CNT/CNT content would increase the resistance change value of the mortars added with P-CNT/CNT,and the sensitivity performance.It has certain engineering application value. | 朱远恒 孙敏 LI Zhendong LIU Yangyang FANG Youzhen | 2023 | Journal of Wuhan University of Technology(Materials Science)2023，38，1： | 1 |
| 6 | Germline Competent Embryonic Stem Cells Derived from Rat Blastocysts显示文摘 | Ping Li Chang Tong Ruty Mehrian-Shai Li Jia Nancy Wu Youzhen Yan Robert E. Maxson Eric N. Schulze Houyan Song Chih-Lin Hsieh Martin F. Pera Qi-Long Ying | 2008 | Cell2008，，7： | 1 |
| 7 | Germline Competent Embryonic Stem Cells Derived from Rat Blastocysts显示文摘 | Ping Li Chang Tong Ruty Mehrian-Shai Li Jia Nancy Wu Youzhen Yan Robert E. Maxson Eric N. Schulze Houyan Song Chih-Lin Hsieh Martin F. Pera Qi-Long Ying | 2008 | Cell2008，，7： | 1 |
| 8 | Increased GSK-3β expression in DRG microglia in response to sciatic nerve crush显示文摘Neuronal 损失和 apoptosis 经常发生在外部神经损害,它与煽动性的分子的版本和 microglia/macrophages 的激活被联系[1 ] 。过多的煽动性的反应由房间能加重的 glial 调停了许多神经病学的条件和原因 allodynia,痛觉过敏,神经病的疼痛,和 opioid 忍耐[2 ] 。在受伤的背面的根中心(DRG ) 的 Iba1-immunoreactive (红外) 房间能是内在的 microglia 或导出单核白血球的巨噬细胞,哪个是肿瘤坏死因素的主要来源 -- 并且另外的煽动性的 cytokines 在神经病的疼痛症候群含有。因此,煽动性的调整可以为这些上述的疾病的治疗提供一个治疗学的答案。作为在神经系统的主要居民免疫者房间, microglia 和星形细胞在外部神经损害期间为对损坏神经原的煽动性的回答是关键的[3 ] 。在外部神经损坏以后, microglial 细胞开始增殖并且在 ipsilateral 在受伤神经原的细胞身体附近形成稠密的簇针的绳索和 DRG [4 ] 。GSK-3 是参予蛋白质合成,房间增长,区别,和煽动性的反应的规定的无所不在的 serine/threonine kinase。最近的证据表明了 GSK-3 是在在 vitro 系统和动物模型的两个的有免疫力的回答的一个有势力管理者[5 ] 。在神经系统, GSK-3 活动能在星形细胞调整煽动性的回答, microglia 的迁居,煽动性的忍耐,和促进感受性[6 ] 。然而,我们的以前的学习表明 GSK-3 没在正常条件下面在 microglia 被表示[7 ] 。尽管 GSK-3 禁止者的应用程序能稀释支持 inflammatory cytokines 和减少的版本,这被显示出在鼠标的神经病的疼痛[8 ] ,在 DRG 后面的外部神经损害的 GSK-3 的表达式尚待被探索。在现在的学习,我们在 DRG 检验了 GSK-3 | Wenjie Tang Bing Li Sheng Chen Ying Lu Ning Han Xia Li Zengchun Li Youzhen Wei | 2016 | Acta Biochimica et Biophysica Sinica2016，48，6： | 1 |
| 9 | NSD2 Is Recruited through Its PHD Domain to Oncogenic Gene Loci to Drive Multiple Myeloma显示文摘 | Zheng Huang Haiping Wu Shannon Chuai Fiona Xu Feng Yan Nathan Englund Zhaofu Wang Hailong Zhang Ming Fang Youzhen Wang Justin Gu Man Zhang Teddy Yang Kehao Zhao Yanyan Yu Jingquan Dai Wei Yi Shaolian Zhou Qian Li Jing Wu Jun Liu Xu Wu Homan Chan Chris Lu | 2013 | Cancer Research2013，，20： | 1 |
| 10 | 显示文摘 | Zhou Jicheng Chen Haibo Li Youzhen | 2007 | Transactions of Nonferrous Metals Society of China2007，17，4： | 1 |
| 11 | A Novel Linear Relationship for Calculating Dynamic Shear Modulus of Geomaterials显示文摘The dynamic shear modulus G of soil was determined using a dynamic triaxial test system(DTTS) together with a fitting method.First,a novel linear relationship between G and damping ratio λ was proposed,which was used to select the appropriate G.Then,a hyperbolic model was constructed using the optimized parameters a and b representing the intercept and slope,respectively,from the linear regression of 1/G and dynamic shear strain γd.Finally,the differences between the tested and predicted results for G were analyzed for different soil types.The experimental results show that this linear relationship can overcome the shortcomings of the nonlinear relationship found in the large deformation stage and can predict λ in the hysteresis loop that is not closed case.In addition to Baoji loess,G was slightly larger(10%) than the experimental curve in the elasto-plastic stage;however,the experimental results show that the attenuation curve of G for Baoji loess is greater than the calculated value in the elasto-plastic stage.The test and analysis results will improve the knowledge of the dynamic properties of soils and also provide reliable values of G for further evaluation of seismic safety at engineering sites. | 马文国 王兰民 LI Xuefeng YANG Youzhen | 2016 | Journal of Wuhan University of Technology(Materials Science)2016，31，4： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员