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| 1 | Curative effect of heat-sensitive moxibustion on chronic persistent asthma: a multicenter randomized controlled trial显示文摘OBJECTIVE:To compare the curative effects of heat-sensitive moxibustion with conventional drugs on chronic persistent asthma and seek a valuable therapy to replaceWestern Medicine.METHODS:The participants in this multi-center,randomized,and controlled study were randomly divided into two groups:group A(n=144),treated with heat-sensitive moxibustion(50 sessions)and group B(n=144),treated with Seretide(salmeterol50μg/fluticasone 250μg,twice a day).The scores of asthma control test(ACT),forced expiratory volume in 1 second(FEV1),peak expiratory flow(PEF),and attack frequency were measured after 15,30,60,and 90 days of treatment.Patients followed up3 and 6 months after treatment.RESULTS:There was a significant difference(P=0.0002)in the ACT score and lung function between the two groups after 3 months of treatment and(P=0.000 03)during the follow-up visits.In addition,heat-sensitive moxibustion reduced attack frequency in the period from inclusion to the6-month follow-up visit.CONCLUSION:This study shows that heat-sensitive moxibustion may have a comparable curative effect toSeretide(salmeterol/fluticasone)on asthma. | Rixin Chen Mingren Chen Jun Xiong Zhenhai Chi B0 Zhang Ning Tian Zhenhua Xu Tangfa Zhang Wanyao Li Wei Zhang Xiaofeng Rong Zhen Wang Gang Sun Baohe Ge Guoxiong Yu Nanchang Song | 2013 | Journal of Traditional Chinese Medicine2013，33，5： | 20 |
| 2 | Blocking FSH inhibits hepatic cholesterol biosynthesis and reduces serum cholesterol显示文摘Menopause is associated with dyslipidemia and an increased risk of cardio-cerebrovascular disease.The classic view assumes that the underlying mechanism of dyslipidemia is attributed to an insufficiency of estrogen.In addition to a decrease in estrogen, circulating follicle-stimulating hormone (FSH)levels become elevated at menopause.In this study,we find that blocking FSH reduces serum cholesterol via inhibiting hepatic cholesterol biosynthesis.First,epidemiological results show that the serum FSH levels are positively correlated with the serum total cholesterol levels,even after adjustment by considering the effects of serum estrogen,in addition,the prevalence of hypercholesterolemia is significantly higher in peri-menopausal women than that in premenopausal women.Furthermore,we generated a mouse model of FSH elevation by intraperitoneally injecting exogenous FSH into ovariectomized (OVX)mice,in which a normal level of estrogen (E2)was maintained by exogenous supplementation. Consistently,the results indicate that FSH,independent of estrogen,increases the serum cholesterol level in this mouse model. Moreover,blocking FSH signaling by anti-FSHβ antibody or ablating the FSH receptor (FSHR)gene could effectively prevent hypercholesterolemia induced by FSH injection or high-cholesterol diet feeding.Mechanistically,FSH,via binding to hepatic FSHRs, activates the Gi2α/β-arrestin-2/Akt pathway and subsequently inhibits the binding of FoxO1 with the SREBP-2 promoter,thus preventing FoxO1 from repressing SREBP-2 gene transcription.This effect,in turn,results in the upregulation of SREBP-2,which drives HMGCR nascent transcription and de novo cholesterol biosynthesis,leading to the increase of cholesterol accumulation.This study uncovers that blocking FSH signaling might be a new strategy for treating hypercholesterolemia during menopause, particularly for women in peri-menopause characterized by FSH elevation only. | Yanjing Guo Meng Zhao Tao Bo Shizhan Ma Zhongshang Yuan Wenbin Chen Zhao He Xu Hou Jun Liu Zhenhai Zhang Qiang Zhu Qiangxiu Wang Xiaoyan Lin Zhongli Yang Min Cui Lu Liu Yujie Li Chunxiao Yu Xiaoyi Qi Qian Wang Haiqing Zhang Qingbo Guan Lifang Zhao Shimeng Xuan Huili Yan Yanliang Lin Li Wang Qihang Li Yongfeng Song Ling Gao Jiajun Zhao | 2019 | Cell Research2019，29，2： | 16 |
| 3 | EZH2-, CHD4-, and IDH-linked epigenetic perturbation and its association with survival in glioma patients显示文摘Glioma 是有有限治疗选择的复杂疾病。最近的进展在多达 80% 更低的等级 gliomas (LGG ) 并且在 76% 第二等的 glioblastomas (GBM ) 识别了 isocitrate 脱氢酶(IDH ) 变化。IDH 变化也在尖锐 myeloid 白血病(AML ) 的 10%-20% 被看见。在 AML,包含 epigenetic 规定的 IDH 和另外的基因的变化是早事件,这被决定,出现在 pre 白血病的干细胞(最低有效字符前) 上演,而在宣传 oncogenic 信号的基因的变化是在白血病的迟了的事件。IDH 变化也是在 glioma 的早事件,发生在 TP53 变化前, 1p/19q 删除,等等。尽管有在 glioma 研究的这些进展,进另外的分子的改变的研究更加落后。在这研究,我们分析了当前可得到的数据库。我们除了已知的基因 IDH1/2 在 glioma 识别了 EZH2, KMT2C,和 CHD4 同样重要的基因。我们也证明 PIK3CA, CDKN2A, CDK4, FIP1L1,或 FUBP1 的 genomic 改变与 IDH 变化协作否定地在 LGG 影响病人幸存。在有 TP53 变化或 IDH1/2 变化的 LGG 病人,没有如此的改变, EZH2, KMC2C,和 CHD4 的另外的 genomic 改变个别地或在联合比病人与显著地减少的没有疾病的幸存被联系。在基因水平或蛋白质水平的 EZH2, KMT2C,和 CHD4 的改变能使不安 epigenetic 节目,在 glioma 导致恶意的转变。由在可得到的数据集上在 AML 和 glioma 和表现生物信息学分析上考察当前的文学,我们从 premalignant 干细胞在 tumorigenesis 上开发了一个假想模型到 glioma。 | Le Zhang Ying Liu Mengning Wang Zhenhai Wu Na Li Jinsong Zhang Chuanwei Yang | 2017 | Journal of Molecular Cell Biology2017，9，6： | 11 |
| 4 | Preparation,characterization and photocatalytic properties of BiOBr/ZnO composites显示文摘BiOBr/ZnO composite photocatalysts were prepared by a simple hydrothermal method. The as-prepared samples were characterized by X-ray diffraction(XRD), scanning electron microscopy(SEM), transmission electron microscopy(TEM), high-resolution transmission electron microscopy(HRTEM), UV–Vis diffusion reflectance spectroscopy(DRS) and photoluminescence(PL) spectroscopy, respectively. The photocatalytic activities were evaluated by the degradation of methyl blue(MB) under the simulated sunlight irradiation. Among all the samples, the BiOBr/ZnO composite with a mole ratio of 3:1(Bi:Zn) exhibited the best photocatalytic activity. The improvement of photocatalytic activity was mainly attributed to the low recombination ratio of photo-induced electron-hole pairs. The possible photocatalytic mechanism was discussed on the basis of the band structures of BiOBr and ZnO. | Yanling Geng Na Li Jiyan Ma Zhenhai Sun | 2017 | Journal of Energy Chemistry2017，26，3： | 10 |
| 5 | Deep neural network algorithm for estimating maize biomass based on simulated Sentinel 2A vegetation indices and leaf area index显示文摘Accurate estimation of biomass is necessary for evaluating crop growth and predicting crop yield.Biomass is also a key trait in increasing grain yield by crop breeding.The aims of this study were(i)to identify the best vegetation indices for estimating maize biomass,(ii)to investigate the relationship between biomass and leaf area index(LAI)at several growth stages,and(iii)to evaluate a biomass model using measured vegetation indices or simulated vegetation indices of Sentinel 2A and LAI using a deep neural network(DNN)algorithm.The results showed that biomass was associated with all vegetation indices.The three-band water index(TBWI)was the best vegetation index for estimating biomass and the corresponding R2,RMSE,and RRMSE were 0.76,2.84 t ha−1,and 38.22%respectively.LAI was highly correlated with biomass(R2=0.89,RMSE=2.27 t ha−1,and RRMSE=30.55%).Estimated biomass based on 15 hyperspectral vegetation indices was in a high agreement with measured biomass using the DNN algorithm(R2=0.83,RMSE=1.96 t ha−1,and RRMSE=26.43%).Biomass estimation accuracy was further increased when LAI was combined with the 15 vegetation indices(R2=0.91,RMSE=1.49 t ha−1,and RRMSE=20.05%).Relationships between the hyperspectral vegetation indices and biomass differed from relationships between simulated Sentinel 2A vegetation indices and biomass.Biomass estimation from the hyperspectral vegetation indices was more accurate than that from the simulated Sentinel 2A vegetation indices(R2=0.87,RMSE=1.84 t ha−1,and RRMSE=24.76%).The DNN algorithm was effective in improving the estimation accuracy of biomass.It provides a guideline for estimating biomass of maize using remote sensing technology and the DNN algorithm in this region. | Xiuliang Jin Zhenhai Li Haikuan Feng Zhibin Ren Shaokun Li | 2020 | The Crop Journal2020，8，1： | 9 |
| 6 | Nitrogen-doped graphene nanosheets as high efficient catalysts for oxygen reduction reaction显示文摘It is of great significance in exploring alternative catalysts to platinum (Pt)-based materials for oxygen reduction reaction (ORR),because this reaction is invariably involved in various fuel cells and metal-air batteries.We herein reported the nitrogen doped graphene nanosheets (NGNSs) with pore volume of as high as 3.42 m 3 /g and investigated their potential application as ORR catalysts,it was demonstrated the NGNSs featured high activity,improved kinetics and excellent long-term stability for ORR.The NGNSs were successfully used as cathode catalysts of microbial fuel cells (MFCs) and performed even better than the commercial Pt/C (Pt 10%) catalysts at the maximum power output. | CI SuQin WU YongMin ZOU JianPing TANG LongHua LUO ShengLian LI JingHong WEN ZhenHai | 2012 | Chinese Science Bulletin2012，57，23： | 7 |
| 7 | Variation analyses of growth and wood properties of Larix olgensis clones in China显示文摘The growth traits(tree height, diameter at breast height, and stem straightness degree) and wood properties[wood density(WD), fiber length, fiber width, ash content(AC), lignin content, cellulose content, hemicellulose content(HEC), and holocellulose content] of 208 26-yearold Larix olgensis clones were analyzed. Except for WD and AC, there were significant differences(p \ 0.01) for all traits among clones. The phenotypic coefficient of variation and repeatability of all traits were 9.34–35.33%and 0.218–0.930, respectively. Tree height and diameter at breast height showed significant positive correlation;however, the correlation coefficients among growth characteristics and wood properties were mostly not significant.Ten clones(L70, L56, L82, L90, L59, L91, L61, L92, L86,and L64) were selected as excellent clones under a selection rate of 5%, using tree height, diameter at breast height,and stem straightness degree as evaluation indexes, providing genetic gains of 28.69, 17.96, and 0.67%, respectively. Ten clones(L88, L305, L59, L66, L253, L304,L277, L298, L248, and L293) were selected as excellent clones using wood properties as an evaluation index, with a selection rate of 5%, providing genetic gains in WD, fiber length, fiber width, cellulose content, and HEC of 4.14,3.64, 9.28, 6.77, and 9.61%, respectively. This study provides a theoretical basis for selecting excellent L. olgensis clones. | Shaopeng Yin Zhenhai Xiao Guohui Zhao Xin Zhao Xiaoyang Sun Ying Zhang Fuwei Wang Shuchun Li Xiyang Zhao Guan-Zheng Qu | 2017 | Journal of Forestry Research2017，28，4： | 6 |
| 8 | Total mesorectal excision with or without preoperative chemoradiotherapy for resectable mid/low rectal cancer: a long-term analysis of a prospective, single-center, randomized trial显示文摘Background:The preliminary results of our phase II randomized trial reported comparable functional sphincter pres-ervation rates and short-term survival outcomes between patients undergoing total mesorectal excision(TME)with or without preoperative concurrent chemoradiotherapy(CCRT).We now report the long-term results after a median follow-up of 71 months.Methods:Between March 23,2008 and August 2,2012,192 patients with T3-T4 or node-positive,resectable,mid/low rectal adenocarcinoma were randomly assigned to receive TME with or without preoperative CCRT.The following endpoints were assessed:cumulative rates of local recurrence and distant metastasis,disease-free survival(DFS),and overall survival(OS).Results:The data of 184 eligible patients were analyzed:94 patients in the TME group and 90 patients in the CCRT+TME group.In the whole cohort,the 5-year DFS and OS rates were 84.8%and 85.1%,respectively.The 5-year DFS rates were 85.2%in the CCRT+TME group and 84.3%in the TME group(P=0.969),and the 5-year OS rates were 83.5%in the CCRT+TME group and 86.5%in the TME group(P=0.719).The 5-year cumulative rates of local recur-rence were 6.3%and 5.0%(P=0.681),and the 5-year cumulative rates of distant metastasis were 15.0%and 15.7%(P=0.881)in the CCRT+TME and TME groups,respectively.No significant improvements in 5-year DFS and OS were observed with CCRT by subgroup analyses.Conclusions:Both treatment strategies yielded similar long-term outcomes.A selective policy towards preoperative CCRT is thus recommended for rectal cancer patients if high-quality TME surgery and enhanced chemotherapy can be performed. | Fulong Wang Wenhua Fan Jianhong Peng Zhenhai Lu Zhizhong Pan Liren Li Yuanhong Gao Hui Li Gong Chen Xiaojun Wu Peirong Ding Zhifan Zeng Desen Wan | 2018 | Cancer Communications2018，38，1： | 6 |
| 9 | Progress of Apple Rootstock Breeding and Its Use显示文摘Apple rootstock breeding has achieved great progress worldwide.In this review,we first summarize the rootstock breeding targets and utilization in main apple-producing countries.Furthermore,we discuss the focus and important research areas of apple rootstock breeding through five aspects:parent selection and setting of crosses,target genes and marker-assisted breeding,root configuration-guided breeding,apomictic resource utilization,and the application of genetic engineering.Finally,we propose an apple rootstock division plan for China,which has a large potential to provide guidance for apple rootstock breeding and utilization in different apple-producing areas of China. | Yi Wang Wei Li Xuefeng Xu Changpeng Qiu Ting Wu Qinping Wei Fengwang Ma Zhenhai Han | 2019 | Horticultural Plant Journal2019，5，5： | 6 |
| 10 | The Kinetics for Electrochemical Removal of Ammonia in Coking Wastewater显示文摘Electrochemical removal of ammonia is a new and effective method in coking wastewater.The reaction mechanism of ammonia removal was proved by stable polarization curve in this paper.First,the supposing of reaction steps of the electrode were proposed.And then reaction parameter of the electrode was measured by Tafel curve.Finally,the reaction mechanism was determined by quasi-equilibrium approach.The results showed that Cl2+H2O→HOCl+H++Cl was the rate-determining step,the calculated apparent transfer coefficient was uniform to the experimental value. | LIANG Zhenhai LI Su GUO Wenqian FAN Caimei | 2011 | Chinese Journal of Chemical Engineering2011，19，4： | 5 |
| 11 | Performance of the Wind Farm Parameterization Scheme Coupled with the Weather Research and Forecasting Model under Multiple Resolution Regimes for Simulating an Onshore Wind Farm显示文摘We use the Wind Farm Parameterization(WFP) scheme coupled with the Weather Research and Forecasting model under multiple resolution regimes to simulate turbulent wake dynamics generated by a real onshore wind farm and their influence at the local meteorological scale. The model outputs are compared with earlier modeling and observation studies. It is found that higher vertical and horizontal resolutions have great impacts on the simulated wake flow dynamics. The corresponding wind speed deficit and turbulent kinetic energy results match well with previous studies. In addition, the effect of horizontal resolution on near-surface meteorology is significantly higher than that of vertical resolution. The wake flow field extends from the start of the wind farm to downstream within 10 km, where the wind speed deficit may exceed 4%. For a height of 150 m or at a distance of about 25 km downstream, the wind speed deficit is around 2%. This indicates that, at a distance of more than 25 km downstream, the impact of the wind turbines can be ignored. Analysis of near-surface meteorology indicates a night and early morning warming near the surface, and increase in near-surface water vapor mixing ratio with decreasing surface sensible and latent heat fluxes. During daytime, a slight cooling near the surface and decrease in the near-surface water vapor mixing ratio with increasing surface sensible and latent heat fluxes is noticed over the wind farm area. | Rajabu J.MANGARA Zhenhai GUO Shuanglin LI | 2019 | Advances in Atmospheric Sciences2019，36，2： | 5 |
| 12 | Research progress in electrospinning engineering for all-solid-state electrolytes of lithium metal batteries显示文摘Owing to safety issue and low energy density of liquid lithium-ion batteries(LIBs),all-solid-state lithium metal batteries(ASLMBs)with unique all-solid-state electrolytes(SEs)have attracted wide attentions.This arises mainly from the advantages of the SEs in the suppression of lithium dendrite growth,long cycle life,and broad working temperature range,showing huge potential applications in electronic devices,electric vehicles,smart grids,and biomedical devices.However,SEs suffer from low lithiumion conductivity and low mechanical integrity,slowing down the development of practical ASLMBs.Nanostructure engineering is of great efficiency in tuning the structure and composition of the SEs with improved lithium-ion conductivity and mechanical integrity.Among various available technologies for nanostructure engineering,electrospinning is a promising technique because of its simple operation,cost-effectiveness,and efficient integration with different components.In this review,we will first give a simple description of the electrospinning process.Then,the use of electrospinning technique in the synthesis of various SEs is summarized,for example,organic nanofibrous matrix,organic/inorganic nanofibrous matrix,and inorganic nanofibrous matrix combined with other components.The current development of the advanced architectures of SEs through electrospinning technology is also presented to provide references and ideas for designing high-performance ASLMBs.Finally,an outlook and further challenges in the preparation of advanced SEs for ASLMBs through electrospinning engineering are given. | Manxi Wang Yaling Wu Min Qiu Xuan Li Chuanping Li Ruiling Li Jiabo He Ganggang Lin Qingrong Qian Zhenhai Wen Xiaoyan Li Ziqiang Wang Qi Chen Qinghua Chen Jinhyuk Lee Yiu-Wing Mai Yuming Chen | 2021 | Journal of Energy Chemistry2021，30，10： | 4 |
| 13 | Determining the optimal time for bortezomib-based induction chemotherapy followed by autologous hematopoietic stem cell transplant in the treatment of multiple myeloma显示文摘In our study, we determined the efficacy of bortezomib-based induction therapy followed by autologous stem cell transplant (ASCT) in newly diagnosed and relapsed/refractory (R/R) multiple myeloma (MM) patients and compared the advantages of early versus late transplant. We used a retrospective analysis to examine 62 patients, including 46 cases of newly diagnosed MM (early transplant group) and 16 cases of relapsed/refractory MM (late transplant group). All of these patients received bortezomib-based induction therapy followed by ASCT. The efficacy and side effects of the treatment regimen were analyzed. Patients' overall survival (OS) and progression-free survival (PFS) times were determined. The ratio of complete remission to near-complete remission (CR/nCR) was 69.5% versus 56.2% (P=0.361), respectively, for the early transplant group versus the late transplant group, respectively, after receiving bortezomib-based induction therapy; the overall response rates of the two group were 91.3% and 81.2%, respectively (P=0.369). After receiving ASCT, the CR/nCR of the two groups increased to 84.8% and 81.3%, respectively. The median time required for neutrophil engraftment of the early transplant group and the late transplant group was 11 and 14.5 days, respectively (P=0.003); the median time required for platelet engraftment was 13 and 21.5 days (P=0.031), respectively. There were no significant differences in the toxic side effects observed during induction therapy and ASCT between the two groups. The OS of the two groups was not statistically different (P=0.058). The PFS of the early transplant group and the late transplant group was 41.6 and 26.5 months, respectively (P=0.008). Multivariate analysis demonstrated that the time of receiving ASCT, the types of M protein, and the International Staging System (ISS) stage were all independent factors that influenced PFS. In conclusion, patients in a suitable condition for ASCT should be recommended to have an early ASCT immediately after diagnosis. | Junru Liu Juan Li Beihui Huang Dong Zheng Mei Chen Zhenhai Zhou Duorong Xu Waiyi Zou | 2013 | Chinese Journal of Cancer Research2013，25，2： | 4 |
| 14 | Regularization method with two parameters for nonlinear ill-posed problems显示文摘This paper is devoted to the regularization of a class of nonlinear ill-posed problems in Banach spaces. The operators involved are multi-valued and the data are assumed to be known approximately. Under the assumption that the original problem is solvable, a strongly convergent approximation procedure is designed by means of the Tikhonov regularization method with two pa- rameters. | LIU ZhenHai LI Jing LI ZhaoWen | 2008 | Science China Mathematics2008，51，1： | 4 |
| 15 | Suburbanization and Subcentering of Population in Beijing Metropolitan Area:A Nonparametric Analysis显示文摘This study focuses on the suburbanization and subcentering of population and examines the nature of spatial restructuring in terms of the population distribution in the Beijing metropolitan area.Instead of the classic density function approach,we employ the nonparametric analysis to characterize the spatial pattern of population densities in the Beijing metropolitan area and identify the suburban subcenters.Our findings suggest that the population has spread with rapid urban growth in the Beijing metropolitan area,and the compact urban form has been replaced by a more dispersed polycentric spatial distribution.However,compared with the decentralization of western cities,the spatial extent of the decentralization of population in the Beijing metropolitan area is quite limited.The rapid growth of population in the near suburbs has expedited the sprawl of the central city,with a larger central agglomeration of population dominating the metropolitan area.In this sense,the spatial pattern of the Beijing metropolitan area is still characterized by the continuous compactness.However,our findings do provide the evidence that the city has been turning to a polycentric structure.We find significant population subcenters have emerged in the suburbs of Beijing since the 1980s.But the polycentricity emerged in the Beijing metropolitan area is very different by nature from that observed in Western cities.The subcenters emerged are adherent to the development scheme planned for the city,so it can be referred to as the so called 'planned polycentricity'. | SUN Tieshan HAN Zhenhai WANG Lanlan LI Guoping | 2012 | Chinese Geographical Science2012，22，4： | 3 |
| 16 | Statistically designed enzymatic hydrolysis of an icariin/b-cyclodextrin inclusion complex optimized for production of icaritin显示文摘This study focuses on the preparation and enzymic hydrolysis of an icariin/bcyclodextrin inclusion complex to efficiently generate icaritin.The physical characteristics of the inclusion complex were evaluated by differential scanning calorimetry(DSC).Enzymatic hydrolysis was optimized for the conversion of icariin/b-cyclodextrin complex to icaritin by Box–Behnken statistical design.The inclusion complex formulation increased the solubility of icariin approximately 17-fold,from 29.2 to 513.5 mg/mL at 60℃.The optimum conditions were predicted by Box–Behnken statistical design as follows:60℃,pH 7.0,the ratio of enzyme/substrate(1:1.1)and reaction time 7 h.Under the optimal conditions the conversion of icariin was 97.91%and the reaction time was decreased by 68%compared with that without b-CD inclusion.Product analysis by melting point,ESI-MS,UV,IR,1H NMR and 13C NMR confirmed the authenticity of icaritin with a purity of 99.3%and a yield of 473 mg of icaritin from 1.1 g icariin. | Xin Jin Zhenhai Zhang E.Suna Songlin Li Xiaobin Jia | 2012 | Acta Pharmaceutica Sinica B2012，2，1： | 3 |
| 17 | Molecular and physiological characterization of the effects of auxin-enriched rootstock on grafting显示文摘Grafting is a highly useful technique,and its success largely depends on graft union formation.In this study,we found that root-specific expression of the auxin biosynthetic gene iaaM in tobacco,when used as rootstock,resulted in more rapid callus formation and faster graft healing.However,overexpression of the auxin-inactivating iaaL gene in rootstocks delayed graft healing.We observed increased endogenous auxin levels and auxin-responsive DR5::GUS expression in scions of WT/iaaM grafts compared with those found in WT/WT grafts,which suggested that auxin is transported upward from rootstock to scion tissues.A transcriptome analysis showed that auxin enhanced graft union formation through increases in the expression of genes involved in graft healing in both rootstock and scion tissues.We also observed that the ethylene biosynthetic gene ACS1 and the ethylene-responsive gene ERF5 were upregulated in both scions and rootstocks of the WT/iaaM grafts.Furthermore,exogenous applications of the ethylene precursor ACC to the junction of WT/WT grafts promoted graft union formation,whereas application of the ethylene biosynthesis inhibitor AVG delayed graft healing in WT/WT grafts,and the observed delay was less pronounced in the WT/iaaM grafts.These results demonstrated that elevated auxin levels in the iaaM rootstock in combination with the increased auxin levels in scions caused by upward transport/diffusion enhanced graft union formation and that ethylene was partially responsible for the effects of auxin on grafting.Our findings showed that grafting success can be enhanced by increasing the auxin levels in rootstocks using transgenic or gene-editing techniques. | Longmei Zhai Xiaomin Wang Dan Tang Qi Qi Huseyin Yer Xiangning Jiang Zhenhai Han Richard McAvoy Wei Li Yi Li | 2021 | Horticulture Research2021，8，1： | 3 |
| 18 | 对可切除的中/低位直肠癌是/否进行术前放化疗的全直肠系膜切除术研究:一项前瞻性、单中心、随机试验的长期分析显示文摘背景与目的我们的Ⅱ期随机试验的初步研究结果显示,对进行全直肠系膜切除术(total mesorectal excision,TME)的患者是/否进行术前同步放化疗(concurrent chemoradiotherapy,CCRT),二者的功能性括约肌保留率和短期生存结局相近。在经过中位71个月的随访后,现报告这一长期试验的结果。方法在2008年3月23日至2012年8月2日期间,192例患有T3–T4或淋巴结阳性、可切除的中/低直肠腺癌患者被随机分为接受或不接受术前CCRT组,之后均进行TME。评估以下终点:局部复发和远处转移的累积率、无病生存(disease?free survival,DFS)和总生存(overall survival,OS)。结果对入组的184例患者资料进行分析,其中TME组有94例,CCRT+TME组有90例。在整个队列中,5年DFS和OS率分别为84.8%和85.1%。CCRT+TME组的5年DFS率为85.2%,TME组为84.3%(P=0.969);CCRT+TME组的5年OS率为83.5%,TME组为86.5%(P=0.719)。在CCRT+TME和TME组中,局部复发的5年累积率分别为6.3%和5.0%(P=0.681),远处转移的5年累积率分别为15.0%和15.7%(P=0.881)。通过亚组分析,接受CCRT未观察到5年DFS和OS的显著改善。结论两种治疗方案的长期结局相近。因此,如果可以进行高质量的TME手术和强化化疗,建议选择性地对直肠癌患者进行术前CCRT。 | Fulong Wang Wenhua Fan Jianhong Peng Zhenhai Lu Zhizhong Pan Liren Li Yuanhong Gao Hui Li Gong Chen Xiaojun Wu Peirong Ding Zhifan Zeng Desen Wan | 2019 | 癌症2019，38，5： | 2 |
| 19 | Modeling of Earth’s Gravity Fields Visualization Based on Quad Tree显示文摘The problems of the earth's gravity fields' visualization are both focus and puzzle currently. Aiming at multiresolution rendering, modeling of the Earth's gravity fields' data is discussed in the paper by using LOD algorithm based on Quad Tree. First, this paper employed the method of LOD based on Quad Tree to divide up the regional gravity anomaly data, introduced the combined node evaluation system that was composed of viewpoint related and roughness related systems, and then eliminated the T-cracks that appeared among the gravity anomaly data grids with different resolutions. The test results demonstrated that the gravity anomaly data grids' rendering effects were living, and the computational power was low. Therefore, the proposed algorithm was a suitable method for modeling the gravity anomaly data and has potential applications in visualization of the earth's gravity fields. | LUO Zhicai LI Zhenhai ZHONG Bo | 2010 | Geo-Spatial Information Science2010，13，3： | 2 |
| 20 | ERF4 affects fruit ripening by acting as a JAZ interactor between ethylene and jasmonic acid hormone signaling pathways显示文摘The regulation of apple(Malus domestica)fruit texture during ripening is complex and a fundamental determinant of its commercial quality.In climacteric fruit,ripening-related processes are regulated by ethylene(ET),and jasmonate(JA)is also involved in the ethylene biosynthesis pathway,mainly through the transcription factor MYC2.However,the molecular genetic mechanism for fruit ripening processes between the JA and ET signaling pathways still needs to be elucidated.In order to explore how JA regulates apple fruit ripening through ERF4,we used’Gala’and’Ralls Janet’fruit at different developmental stages as experimental materials to determine the fruit firmness and related gene expression analysis.Meanwhile,we carried out different hormone treatments on’Gala’fruit at ripening stage.Here,we show that ERF4 is a core JA signaling hub protein JASMONATE ZIM-DOMAIN(JAZ)interactor that affects ethylene signaling pathways.During fruit development,ERF4 represses the expression of ACS1 and ACO1 by interacting with JAZ,as well as with the JA-activated transcription factor MYC2.Ripening is promoted in JAZ-suppressed apples.Thus,ERF4 acts as a molecular link between ethylene and JA hormone signals,and the natural variation of the ERF4Ethylene-responsive binding factor-associated amphiphilic repression(EAR)motif decreases repression of ethylene biosynthesis genes. | Yanan Hu Hualin Sun Zhenyun Han Shuai Wang Ting Wang Qiqi Li Ji Tian Yi Wang Xinzhong Zhang Xuefeng Xu Zhenhai Han Ting Wu | 2022 | Horticultural Plant Journal2022，8，6： | 2 |
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