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| 1 | Soil Macropore Structure Characterized by X-Ray Computed Tomography Under Different Land Uses in the Qinghai Lake Watershed, Qinghai-Tibet Plateau显示文摘Quantification of soil macropores is important to enhance our understanding of preferential pathways for water, air, and chemical movement in soils. However, the soil architecture of different land uses is not well understood in elusive alpine regions. The objective of this study was to quantify the architecture of soil macropores in a Kobresia meadow, farmland, and sand in the Qinghai Lake watershed of northeastern Qinghai-Tibet Plateau, China using X-ray computed tomography. Nine soil cores at 0–50 cm depth were collected at three sites with three replicates. At each site, the three collected cores were scanned using a GE Hi Speed FX/i medical scanner(General Electric, USA). To analyze soil architecture, the number of macropores, macroporosity, and mean macropore equivalent diameter within the 50 cm soil profile were determined from the X-ray computed tomography. Analysis of variance indicated that land use significantly influenced macroporosity, mean macropore equivalent diameter, and number of macropores. The soils of the Kobresia meadow and farmland had greater macroporosity and developed deeper and longer macropores than that of sand. For the Kobresia meadow, macropores were distributed mainly in the 0–10 cm soil layer, while they were distributed in the 0–20 cm soil layer for the farmland. The large number of macropores observed in the soils of the Kobresia meadow and farmland could be attributed to greater root development. The results of this study provided improved quantitative evaluation of a suite of soil macropore features with significant implications for non-equilibrium flow prediction and chemical transport modeling in soils. | HU Xia LI Zongchao LI Xiaoyan WANG Pei ZHAO Yunduo LIU Lianyou LU Yanli | 2018 | Pedosphere2018，28，3： | 3 |
| 2 | Exhausted local lactate accumulation via injectable nanozyme-functionalized hydrogel microsphere for inflammation relief and tissue regeneration显示文摘Local lactate accumulation greatly hinders tissue repair and regeneration under ischemic condition.Herein,an injectable microsphere(MS@MCL)for local lactate exhaustion was constructed by grafting manganese dioxide(MnO_(2))-lactate oxidase(LOX)composite nanozyme on microfluidic hyaluronic acid methacrylate(HAMA)microspheres via chemical bonds,achieving a long-term oxygen-promoted lactate exhaustion effect and a long half-life in vivo.The uniform and porous microspheres synthesized by microfluidic technology is beneficial to in situ injection therapy and improving encapsulation efficiency.Furthermore,chemical grafting into HAMA microspheres through amide reactions promoted local enzymatic concentration and activity enhancement.It was showed that the MS@MCL eliminated oxidative and inflammatory stress and promoted extracellular matrix metabolism and cell survival when co-cultured with nucleus pulposus cells(NPCs)in vitro.In the rat degenerative intervertebral disc model caused by lactate injection,MS@MCL showed a long-term therapeutic effect in reducing intervertebral height narrowing and preventing extracellular matrix(ECM)degradation as well as inflammatory damage in vivo.Altogether,this study confirms that this nanozyme-functionalized injectable MS@MCL effectively improves the regenerative and reparative effect in ischemic tissues by disposing of enriched lactate in local microenvironment. | Jieliang Shen Ao Chen Zhengwei Cai Zhijie Chen Ruichao Cao Zongchao Liu Yuling Li Jie Hao | 2022 | Bioactive Materials2022，7，6： | 2 |
| 3 | Thermodynamics fundamentals and energy efciency for the separation and high‑valued utilization of Fischer–Tropsch heavy oil显示文摘The development trend of Fischer–Tropsch(F–T)technology is to develop high value-added products.The separation of linearα-olefns with low cost is an efective method.Nevertheless,the lack of thermodynamic data and the huge energy consumption are the two main problems restricting the development of the separation process.The thermodynamic data of the key components(1-dodecene and n-dodecane)in the F–T product were measured.The Wilson binary interaction parameters of the key components were obtained.Next,one traditional distillation column sequence and two dividing wall column(DWC)sequences were designed to separate the F–T heavy oil to obtain narrow fractions with diferent carbon numbers.Then,the obtained fractions of C10 and C12 were simulated to obtain 1-decene and 1-dodecene,respectively.There was a traditional distillation and a diferential pressure thermal coupling distillation process.When separating 95.0%purity 1-decene and 1-octene,the direct DWC process and diferential pressure thermal coupled distillation are an excellent combination,which can reduce the energy by 33.1%(i.e.,11,286 kW)and total annual cost by 15.9%(i.e.,3.96×10^(6)$)compared with traditional distillation. | Zongchao Liu Hong Li Suli Liu Jiuzhou Chen Zisheng Zhang Xingang Li Angui Zhang Wei Yuan Xin Gao | 2022 | International Journal of Coal Science & Technology2022，9，4： | 0 |
| 4 | Treatment of Sepsis by Hemofiltration Combined with Plasma Exchange in One Case显示文摘Female patients,44 years old,due to'regular peritoneal dialysis5 years,stomach ache 1 week'admission.Previous had 2 times for'Peritoneal dialysis related peritonitis'in hospital,after anti-infection treatment patients symptoms improved and discharged.1 week ago in patients admitted to hospital because of abdominal pain again.Physical:abdominal tenderness,bowel sounds hyperthyroidism.Laboratory inspection index:CRP:172.22 mg/l,WBC:23.26×10~9/L,NEU%:89.23%,D dimer:3 800 ng/ml,PCT:14.86 ng/ml。 | Weilong Li Sibo Huang Shuang Cui Zongchao Yu Shufei Zeng Bo Hu Aiyun Cha Jian Li Huixia Yu Mingming Ma Xiangnan Dong Xiaoyi Chen W.Pommer Chen Yun Lianghong Yin | 2017 | 临床医学工程2017，24，S1： | 0 |
| 5 | Simulation of strong earthquake characteristics of a scenario earthquake(M_(S)7.5)based on the enlightenment of 2022 M_(S)6.9 earthquake in Menyuan显示文摘The Menyuan area is an important transportation hub in the Hexi Corridor.The Menyuan M_(S)6.9 earthquake that occurred on January 8,2022 had a major impact on the local infrastructure and transportation of this region.Due to the high possibility of similar strong earthquakes occurring in this area in the future,preliminary assessment of the seismic intensity characteristics of destructive earthquakes in this region is essential for effective disaster control.This paper uses the empirical Green′s function(EGF)method as a numerical simulation tool to predict the ground motion intensity of Datong Autonomous County under the action of the scenario earthquake(M_(S)7.5).Seismic records of aftershocks of the 2016 Menyuan M_(S)6.4 earthquake were used as Green’s functions for this simulation.The uncertainties associated with various source parameters were considered,and 36possible earthquake scenarios were simulated to obtain 72 sets of horizontal ground motions in Datong County.The obtained peak ground acceleration(PGA)vs.time histories of the horizontal ground motion were screened using the attenuation relationships provided by the fifth-edition of China’s Seismic Ground Motion Parameter Zoning Map and the NGA-West2dataset.Ultimately,32 possible acceleration-time histories were selected for further analysis.The screened PGA values ranged from 78.8 to 153 cm/s^(2).The uncertainty associated with the initial rupture point was found to greatly affect the results of the earthquake simulation.The average acceleration spectrum of the selected acceleration-time history exceeded the expected spectrum of a intermediate earthquake,which means that buildings in Datong County might sustain some damage should the scenario earthquake occur.This research can provide reliable ground motion input for urban earthquake damage simulation and seismic design in Datong County.Growing the dataset of small earthquakes recorded in this region will facilitate the large-scale simulation of ground motions under different earthquake scenarios. | Zhiwei Ji Zongchao Li Mengtan Gao Jize Sun Xiangyun Guo | 2022 | Earthquake Science2022，35，6： | 0 |
| 6 | Design and Prototype Test of 9FQM1000 Branch and Straw Hammer Mill显示文摘[Objectives]To better design and test 9FQM1000 branch and straw hammer mill in view of the problems of large output,low utilization rate,traditional incineration and easily polluting environment of the new agricultural economic organization's straw and waste branches.[Methods]This hammer mill adopts dual-channel feeding method.It adopts the basic working principle of disc shredding and hammer crushing.Besides,it makes design of the structure and driving system of the branch and straw hammer mill.9FQM1000 type branch and straw hammer mill can finely crush the branches and straws.Finally,it makes a trial production of 9FQM1000 type branch and straw hammer mill.[Results]The prototype test showed that the combined crushing structure of 9FQM1000 type branch and straw hammer mill is reliable,and the production capacity is 3000 kg/h.[Conclusions]The automatic feeder makes the crushing operation more stable,the labor intensity is reduced,the structure is simple,and it can be moved by traction.It is environmentally friendly and pollution-free.It has the characteristics of high safety,automation and high production efficiency.Also,crushed materials can be used as edible fungus culture medium,animal feed,organic fertilizer,etc.,and can be further compressed into biomass fuel,and the crushed branches can also be returned to the field. | Xiangquan CUI Hansong LI Feng ZHAO Zongchao ZHANG Dayong GUO Bin WANG | 2020 | Asian Agricultural Research2020，12，5： | 0 |
| 7 | Effects of Helicobacter pylori eradication on the profiles of blood metabolites and their associations with the progression of gastric lesions: a prospective follow-up study显示文摘Objective:This study aimed at examining the alterations in metabolomic profiles caused by treatment of H.pylori infection,and the associations between key plasma metabolites and the risk of gastric lesion progression during follow-up after treatment.Methods:An intervention trial was performed in 183 participants,117 of whom were H.pylori positive participants receiving treatment for H.pylori infection.H.pylori positive participants were prospectively followed for 182 to 1,289 days.Untargeted metabolomics assays were conducted on plasma samples collected at baseline,6 months after treatment,and during continued follow-up.Results:We identified 59 metabolites with differential posttreatment changes between participants with successful and failed H.pylori eradication,17 metabolites significantly distinguished participants with successful vs.failed eradication.Two metabolites[PC(18:1(11Z)/14:1(9Z))and(2S)-6-amino-2-formamidohexanamide]showed posttreatment changes positively associated with successful H.pylori eradication,and were inversely associated with the risk of gastric lesion progression among participants with successful eradication.In contrast,9-decenoic acid showed posttreatment changes inversely associated with successful eradication:its level was positively associated with the risk of gastric lesion progression among participants with successful eradication.Although the identified metabolites showed a temporary but significant decline after treatment,the trend generally reversed during continued follow-up,and pretreatment levels were restored.Conclusions:Treatment of H.pylori infection significantly altered plasma metabolic profiles in the short term,and key metabolites were capable of distinguishing participants with successful vs.failed eradication,but might not substantially affect metabolic regulation in the long term.Several plasma metabolites were differentially associated with the risk of gastric lesion progression among participants with successful or failed eradication. | Wenhui Wu Zongchao Liu Zhexuan Li Weidong Liu Lanfu Zhang Yang Zhang Tong Zhou Weicheng You Kaifeng Pan Wenqing Li | 2022 | Cancer Biology & Medicine2022，19，8： | 0 |
| 8 | Health economic evaluation on population-based Helicobacter pylori eradication and endoscopic screening for gastric cancer prevention显示文摘Gastric cancer is a global public health burden, nearly one million new cases are diagnosed per year worldwide, of which 44% of cases occur in China. The prognosis of gastric cancer varies remarkably by the stage of cancer, and most of the patients in China are diagnosed at advanced stages, resulting in poor prognoses. Effective strategies to reduce the burden of gastric cancer include primary prevention through testing and treatment of Helicobacter pylori(H. pylori) and secondary prevention by screening and early detection. Although many countries have issued management guidelines and consensus reports concerning these strategies, the limited availability of healthcare resources often precludes their widespread implementation. Therefore, assessing the costs, benefits, and harms of population-based intervention measures through health economic evaluation is necessary for informed health policy decisions. Accordingly, we synthesize management approaches from different countries on H. pylori eradication and endoscopic screening, and also summarize recent advancements in health economic evaluations on population-based preventive strategies. The goal of the review is to provide empirical evidence supporting optimal resource allocation, maximizing benefits for the population, and ultimately reducing the burden of gastric cancer. | Zhiqiang Hu Zongchao Liu Wenqing Li Weicheng You Kaifeng Pan | 2023 | Chinese Journal of Cancer Research2023，35，6： | 0 |
| 9 | Clinical Application of PES Membrane Dialyzer显示文摘Objective The dialysate membrane can be classified into acetate membrane and synthetic membrane,while the latter can be further divided into polysulfone,polyacrylonitrile,etc.Polyethersulfone membrane is high molecular membrane material with excellent biocompatibility,stable mechanical properties,high temperature and pressure resistance,and good cleaning performance,which has been applied for more than 10 years.This trial is to assess the safety and efficacy of hollow polysulfone membrane fiber dialyzer with pattern number Enttex^(TM)-16LF(E60)for hemodialysis in patients with acute or chronic renal failure due to multiple factors.Methods Totally 76 patients receiving maintenance hemodialysis were included in a two-site,random,open label,two-stage,positive crossover and non inferiority validation study.The clinical efficacy and safety of the test device were observed,which was a hollow fiber dialyzer produced by Guangzhou Enttex Medical Products Co.,Ltd.,with polyethersulfone membrane imported from Germany.It was a low flux dialyzer with the pattern number of EnttexTM-16LF(E60).Inclusion criteria:①patients with acute or chronic renal failure due to various reasons who needed hemodialysis;②18 to 80 years old,gender unlimited;③patients who received stable dialysis for more than 3 months,regular hemodialysis 3 times a week,4 h at each time,blood flow rate of 200~350ml/min;④using bicarbonate dialysate at a flow rate of 500ml/min;⑤patients with arteriovenous fistula or who received artificial blood vessel puncture dialysis;received anticoagulation by heparin or low molecular weight heparin.Exclusion criteria:①patients needing heparin free dialysis for severe anemia,tumor and active bleeding;②patients with severe cardiac(gradeⅢcardiac function),hepatic(severe hepatitis and cirrhosis)and pulmonary diseases(severe respiratory failure).Results Comparison of parameters,including the changes of Kt/V,general creatinine and urea clearance rates and URR(urea reduction rate)shows no statistical significance in differences between the two devices,indicating that the test and control devices can equally and effectively eliminate toxins including creatinine and urea,etc.PPP and MITTP results are consistent.Comparison of ultrafiltration rates between two groups of patients shows no statistical difference.PPP and MITTP results are consistent,indicating that both the test device and control device can effectively eliminate water.In MITTP,electrolytes including K^+,Na^+,Cl^-,Ca^2+,HCO3^-,etc.show no statistical significance in difference between the test and control devices before and after dialysis(P>0.05).After treating by using test and control devices,body weight,serum potassium and phos-phorus all significantly decrease(P<0.001);serum Ca^2+,PO2,PCO2and HCO3^-all significantly increase(P<0.001).These results indicate that both the test and control devices can effectively eliminate serum potassium and phosphorus,and eliminate excess water in body,maintain the balance between liquid and electrolytes in patients.PPP and MITTP results are consistent.Conclusion This clinical trial confirms that hollow polyethersulfone membrane fiber dialyzer can be safely and effectively used in hemodialysis therapy. | YUN Chen YANG Peidian LIANG Wenxue CHEN Yu CHEN Gangyi LIU Hongping OUYANG Zihua SONG Huifeng LI Yunyi YU Zongchao GUAN Baozhang DONG Xiangnan LIU Huanhuan Cao Rui ZHANG Zeyu FAN Lijing HU Bo HE Yongcheng SHI Mingjie XU Jun Yang Lifeng TANG Shuifu | 2019 | 临床医学工程2019，26，S01： | 0 |
| 10 | Experimental Design and Clinical Observation of Modialysis Apparatus显示文摘Objective To evaluate the clinical safety and efficacy of polyethersulfone membrane hollow fiber dialyzer Enttex^(TM)-16LF(E60)in treating patients with end stage renal disease caused by a variety of reasons.Methods This clinical trialwas designed as a randomized,open,two-phase crossover and positive control,non-inferiority study.To evaluate the indicators of blood routine test,serum biochemical indexes,blood gas analysis,vital signsbefore and after hemodialysis,and the adverse events were recorded indetail.Results There was no significant difference in creatinine,urea,creatinine clearance and electrolytes between Enttex TM-16LF dialyzer and control dialyzer before and after hemodialysis,no adverse event associated with the Enttex^(TM)-16LF dialyzer was found during the study.Conclusions The Enttex^(TM)-16LF dialyzeris effective and safe for hemodialysis in patients with end stage renal disease. | Yunyi Li Zongchao Yu Sibo Huang Mingming Ma Huanhuan Liu Taksui Wong Fanna Liu Huifeng Song Chen Yun Hongwei Hu Yu Chen Fanna Liu Yongpin Lu Huanhuan Liu Aiyun Cha Guanmin Wu Jie Shu Gangyi Chen Shuifu Tang Lianghong Yin | 2017 | 临床医学工程2017，24，S1： | 0 |
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