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| 1 | Effect of Protein Kinase C on Proliferation and Apoptosis of T Lymphocytes in Idiopathic Thrombocytopenic Purpura Children显示文摘It is well-documented that T lymphocyte proliferation and apoptosis are abnormal in idiopathic thrombocytopenic purpura (ITP) children. However, the underlying regulation mechanisms especially in terms of signal transduction remain unknown. In this paper, we reported the changes of protein kinase C (PKC) activity in peripheral blood T lymphocytes and the effect of PKC on T lymphocyte proliferation and apoptosis. We demonstrated that in ITP children, the activator (PMA) and inhibitor (H-7) of PKC affected on T lymphocyte proliferation and apoptosis dramatically, but they altered little in healthy children. PKC activity was significantly enhanced in ITP children together with an increased expression of FasL on CD3+ T, CD4+ T and CD8+T cells, resulting in a positive correlation between PKC activity and the expression of FasL on T cells. While the PKC activity and the platelet count were negatively correlated. Taken together, our findings suggest that the PKC activation may enhance T lymphocytes activity, suppress T cell apoptosis and be involve in thrombocytes damage as a mechanism related to immune pathogenesis of ITP. | Changlin Wu~(1,2) Fang Liu~1 Xuemin Zhou~1 Zhengwei Cheng~1 Xiaomeng Yang~1 Hong Xiao~1 Qun Chen~1 Kangrong Cai~1 ~1Department of Microbiology and Immunology,Guangdong Medical College,Zhanjiang,Guangdong,524023,China ~2Corresponding to:Dr.Changlin Wu,Department of Microbiology and Immunology,Guangdong Medical College,2 Wen-Ming East Road,Zhanjiang,Guangdong,524023,China. | 2005 | Cellular & Molecular Immunology2005，2，3： | 12 |
| 2 | Lead Isotopic Steep-Dipping Zone and Mineralization—An Example from Mineral Deposits Concentrated Area in East Qinling,China显示文摘Lead isotopic geochemical steep-dipping zone usually exists on inhomogeneous boundaries of earth blocks. Its crossing with the geophysical gradient zone often convergently occurs at giant deposits. Deep structures or concealed structural planes obviously have the coupling relationship with the convergent area of mineral deposits. The geochemical steep-dipping zone is usually distributed along the boundary of ancient continental blocks. Its crossing effect with geophysical gradient zone is usually presented as depression or swell of Moho discontinuity on the crossing direction with the ancient continental margin, which would lead to form deep fractures of earth crust at block margins or lead to adjustment of earth crust texture. The deep hydrothermal liquid would rise up along the structural planes to form the convergent areas of mineral deposits. For example, Luonan- Luanchuan area in east Qinling is a typical crossed area of the geochemical steepdipping zone and geophysical gradient zone. The mineral deposit belt extends along EW direction. It was controlled by the geochemical steepdipping zone equidistantly distributed along NE direction like a string of beads controlled by a gravity gradient zone in NE direction and a mantle depression slope. Along a plunging mantle syncline on EW plunging direction, from the east to the west, checkform was distributed which controls synergic crustmantle granoporphyry rocks. Therefore, a convergent mineralization area of Mo, W, Zn and Au giant deposits occurred. | Zhang Zhengwei Zhu Bingquan Guangzhou Institute of Geochemistry, China Academy of Science, Guangzhou 510640 Cai Keqin Deng Jun Department of Earth and Mineral Resources, China University of Geosciences, Beijing 100083 Wang Wei Qiang Lizhi Henan | 2000 | Journal of Earth Science2000，19，1： | 5 |
| 3 | Black phosphorus-based 2D materials for bone therapy显示文摘Since their discovery,Black Phosphorus(BP)-based nanomaterials have received extensive attentions in the fields of electromechanics,optics and biomedicine,due to their remarkable properties and excellent biocompatibility.The most essential feature of BP is that it is composed of a single phosphorus element,which has a high degree of homology with the inorganic components of natural bone,therefore it has a full advantage in the treatment of bone defects.This review will first introduce the source,physicochemical properties,and degradation products of BP,then introduce the remodeling process of bone,and comprehensively summarize the progress of BP-based materials for bone therapy in the form of hydrogels,polymer membranes,microspheres,and three-dimensional(3D)printed scaffolds.Finally,we discuss the challenges and prospects of BP-based implant materials in bone immune regulation and outlook the future clinical application. | Liang Cheng Zhengwei Cai Jingwen Zhao Fei Wang Min Lu Lianfu Deng Wenguo Cui | 2020 | Bioactive Materials2020，5，4： | 4 |
| 4 | Shear-responsive boundary-lubricated hydrogels attenuate osteoarthritis显示文摘Lipid-based boundary layers formed on liposome-containing hydrogels can facilitate lubrication.However,these boundary layers can be damaged by shear,resulting in decreased lubrication.Here,a shear-responsive boundary-lubricated drug-loaded hydrogel is created by incorporating celecoxib(CLX)-loaded liposomes within dynamic covalent bond-based hyaluronic acid(HA)hydrogels(CLX@Lipo@HA-gel).The dynamic cross-linked network enables the hydrogel to get restructured in response to shear,and the HA matrix allows the accumulation of internal liposome microreservoirs on the sliding surfaces,which results in the formation of boundary layers to provide stable lubrication.Moreover,hydration shells formed surrounding the hydrogel can retard the degradation process,thus helping in sustaining lubrication.Furthermore,in vitro and in vivo experiments found that CLX@Lipo@HA-gels can maintain anabolic-catabolic balance,alleviate cartilage wear,and attenuate osteoarthritis progression by delivering CLX and shear-responsive boundary lubrication.Overall,CLX@Lipo@HA-gels can serve as shear-responsive boundary lubricants and drug-delivery vehicles to alleviate friction-related diseases like osteoarthritis. | Yiting Lei Xingkuan Wang Junyi Liao Jieliang Shen Yuling Li Zhengwei Cai Ning Hu Xiaoji Luo Wenguo Cui Wei Huang | 2022 | Bioactive Materials2022，7，10： | 4 |
| 5 | The landscape of aging显示文摘Aging is characterized by a progressive deterioration of physiological integrity,leading to impaired functional ability and ultimately increased susceptibility to death.It is a major risk factor for chronic human diseases,including cardiovascular disease,diabetes,neurological degeneration,and cancer.Therefore,the growing emphasis on “healthy aging” raises a series of important questions in life and social sciences.In recent years,there has been unprecedented progress in aging research,particularly the discovery that the rate of aging is at least partly controlled by evolutionarily conserved genetic pathways and biological processes.In an attempt to bring full-fledged understanding to both the aging process and age-associated diseases,we review the descriptive,conceptual,and interventive aspects of the landscape of aging composed of a number of layers at the cellular,tissue,organ,organ system,and organismal levels. | Yusheng Cai Wei Song Jiaming Li Ying Jing Chuqian Liang Liyuan Zhang Xia Zhang Wenhui Zhang Beibei Liu Yongpan An Jingyi Li Baixue Tang Siyu Pei Xueying Wu Yuxuan Liu Cheng-Le Zhuang Yilin Ying Xuefeng Dou Yu Chen Fu-Hui Xiao Dingfeng Li Ruici Yang Ya Zhao Yang Wang Lihui Wang Yujing Li Shuai Ma Si Wang Xiaoyuan Song Jie Ren Liang Zhang Jun Wang Weiqi Zhang Zhengwei Xie Jing Qu Jianwei Wang Yichuan Xiao Ye Tian Gelin Wang Ping Hu Jing Ye Yu Sun Zhiyong Mao Qing-Peng Kong Qiang Liu Weiguo Zou Xiao-Li Tian Zhi-Xiong Xiao Yong Liu Jun-Ping Liu Moshi Song Jing-Dong J.Han Guang-Hui Liu | 2022 | Science China(Life Sciences)2022，65，12： | 4 |
| 6 | Exhausted local lactate accumulation via injectable nanozyme-functionalized hydrogel microsphere for inflammation relief and tissue regeneration显示文摘Local lactate accumulation greatly hinders tissue repair and regeneration under ischemic condition.Herein,an injectable microsphere(MS@MCL)for local lactate exhaustion was constructed by grafting manganese dioxide(MnO_(2))-lactate oxidase(LOX)composite nanozyme on microfluidic hyaluronic acid methacrylate(HAMA)microspheres via chemical bonds,achieving a long-term oxygen-promoted lactate exhaustion effect and a long half-life in vivo.The uniform and porous microspheres synthesized by microfluidic technology is beneficial to in situ injection therapy and improving encapsulation efficiency.Furthermore,chemical grafting into HAMA microspheres through amide reactions promoted local enzymatic concentration and activity enhancement.It was showed that the MS@MCL eliminated oxidative and inflammatory stress and promoted extracellular matrix metabolism and cell survival when co-cultured with nucleus pulposus cells(NPCs)in vitro.In the rat degenerative intervertebral disc model caused by lactate injection,MS@MCL showed a long-term therapeutic effect in reducing intervertebral height narrowing and preventing extracellular matrix(ECM)degradation as well as inflammatory damage in vivo.Altogether,this study confirms that this nanozyme-functionalized injectable MS@MCL effectively improves the regenerative and reparative effect in ischemic tissues by disposing of enriched lactate in local microenvironment. | Jieliang Shen Ao Chen Zhengwei Cai Zhijie Chen Ruichao Cao Zongchao Liu Yuling Li Jie Hao | 2022 | Bioactive Materials2022，7，6： | 2 |
| 7 | Evidence for a Dirac nodal-line semimetal in SrAs_3显示文摘Dirac nodal-line semimetals with the linear bands crossing along a line or loop, represent a new topological state of matter. Here, by carrying out magnetotransport measurements and performing first-principle calculations, we demonstrate that such a state has been realized in high-quality single crystals of SrAs_3.We obtain the nontrivial ∏ Berry phase by analysing the Shubnikov-de Haas quantum oscillations. We also observe a robust negative longitudinal magnetoresistance induced by the chiral anomaly.Accompanying first-principles calculations identifies that a single hole pocket enclosing the loop nodes is responsible for these observations. | Shichao Li Zhaopeng Guo Dongzhi Fu Xing-Chen Pan Jinghui Wang Kejing Ran Song Bao Zhen Ma Zhengwei Cai Rui Wang Rui Yu Jian Sun Fengqi Song Jinsheng Wen | 2018 | Science Bulletin2018，63，9： | 2 |
| 8 | Capturing dynamic biological signals via bio-mimicking hydrogel for precise remodeling of soft tissue显示文摘Soft tissue remodeling is a sophisticated process that sequentially provides dynamic biological signals to guide cell behavior.However,capturing these signals within hydrogel and directing over time has still been unrealized owing to the poor comprehension of physiological processes.Here,a bio-mimicking hydrogel is designed via thiol-ene click reaction to capture the early physical signal triggered by inflammation,and the chemical signals provided with chemokine and natural adhesion sites,which guaranteed the precise soft tissue remodeling.This bio-mimicking hydrogel efficiently facilitated cell anchoring,migration,and invasion in the 3D matrix due to the permissive space and the interaction with integrin receptors.Besides,the covalently grafted chemokine-like peptide is optimal for colonization and functional differentiation of endothelial cells through a HIF-1αdependent signal pathway.Furthermore,the early polarization of macrophages,collagen deposition and angiogenesis in rat acute wound model,and the increased blood perfusion in mouse skin flap model have confirmed that the bio-mimicking hydrogel realized precise soft tissue remodeling and opens new avenues for the phased repair of different tissues such as nerve,myocardium,and even bone. | Zhengwei Cai Qimanguli Saiding Liang Cheng Liucheng Zhang Zhen Wang Fei Wang Xinliang Chen Gang Chen Lianfu Deng Wenguo Cui | 2021 | Bioactive Materials2021，6，12： | 2 |
| 9 | NSOM/QD-based nanoscale immunofluorescence imaging of antigen-specific T-cell receptor responses during an in vivo clonal Vγ 2V δ 2 T-cell expansion显示文摘 | CHEN Yong SHAO Lingyun ALI Z CAI Jiye CHEN Zhengwei | 2008 | Blood2008，111，8： | 1 |
| 10 | Serum spleen tyrosine kinase and vascular endothelial growth factor-C levels predict lymph node metastasis of oesophageal squamous cell carcinoma显示文摘 | Lincan Duan Lianhua Ye Guangqiang Zhao Zhengwei Wu Congguo Jin Xinyi Cai Gaofeng Li | 2013 | European Journal of Cardio-Thoracic Surgery2013，，： | 1 |
| 11 | Brain injury induced by intracerebral injection of interleukin-lbeta and tumor necrosis factor-alpha in the neonatal rat显示文摘 | CAI Zhengwei LIN Shoying PANG Yi | 2004 | Pediatr Res2004，56，6： | 1 |
| 12 | Disturbance of oligodendrocyte development, hypomyelination and white matter injury in the neonatal rat brain after intracerebral injection of lipopolysaccharide显示文摘 | Yi Pang Zhengwei Cai Philip G Rhodes | 2002 | Developmental Brain Research2002，，2： | 1 |
| 13 | Interleukin-1 receptor antagonist ameliorates neonatal lipopolysaccharide-induced long-lasting hyperalgesia in the adult rats显示文摘 | Kuo-Ching Wang Su-Jane Wang Lir-Wan Fan Zhengwei Cai Philip G. Rhodes Lu-Tai Tien | 2010 | Toxicology2010，，1： | 1 |
| 14 | Effects of dif- ferent pretreatments on dynamic eountercurrent extraction of pol- ysaccharides from Ganoderma 显示文摘 | Cui Zhengwei Cai Min Qi Song Chunfang | 2012 | Separation and Purification Technology2012，85，： | 1 |
| 15 | Evaluation of the Mechanism of Vascular Endothelial Growth Factor Improvement of Ischemic Flap Survival in Rats显示文摘 | Yi Pang William C. Lineaweaver Man-Ping Lei Tanya Oswald Susan Shamburger Zhengwei Cai Feng Zhang | 2003 | Plastic and Reconstructive Surgery2003，，2： | 1 |
| 16 | Interlayer gap widened TiS_(2) for highly efficient sodium-ion storage显示文摘As an alternative for lithium-ion batteries(LIBs),sodium-ion batteries(SIBs)have lately received tremendous interest due to their abundant reserves as well as low cost.Nevertheless,the lack of suitable anode materials severely hinders the application of sodium-ion batteries.TiS_(2)is elected as a representative material owing to its unique layered structure.But it always suffers from capacity fade due to poor electrochemical kinetics and structural stability.In this work,we fabricate a pre-potassiated TiS_(2)as a host material for sodium storage by an electrochemical pre-potassiation strategy.The intercalation/extraction mechanism,structural changes and reaction kinetics are completely investigated to reveal the outstanding electrochemical property of pre-potassiated TiS_(2)electrode.It turns out that the large interlayer space of pre-potassiated TiS_(2)is conducive to the diffusion of sodium ions,inducing the reduction of entropic barrier for the electrochemical reactions.In addition,the pre-potassiated host structure is still firmly maintained upon repeated cycles.Therefore,the pre-potassiated TiS_(2)presents superior rate capability(165.9 mA h g^(−1) at 1 C and 132.1 mA h g^(−1) at 20 C)and long-term cycling stability(85.3%capacity retention at 5 C after 500 cycles)for SIBs.This research provides an avenue to construct long-life sodium energy storage systems based on pre-potassiated TiS_(2). | Chengcheng Huang Yiwen Liu Runtian Zheng Zhengwei Yang Zhonghao Miao Junwei Zhang Xinhao Cai Haoxiang Yu Liyuan Zhang Jie Shu | 2022 | Journal of Materials Science & Technology2022，，12： | 1 |
| 17 | Retinoic acid-induced lumbosacral neural tube defects: myeloschisis and hamartoma显示文摘 | WeiSong Cai HongYu Zhao JunBin Guo Yong Li ZhengWei Yuan WeiLin Wang | 2007 | Child’s Nervous System2007，，： | 1 |
| 18 | Brain injury induced by intracerebral injection of interleukin-1beta and tumor necrosis factor-alpha in the neonatal rat显示文摘 | Zhengwei Cai Shoying Lin Yi Pang | 2004 | Pediair Res2004，56，6： | 1 |
| 19 | Experimental and Numerical Studies of a Linear Synchronous Motor with the Secondary Made of Coated Superconductor显示文摘Thrust tests of a linear synchronous motor(LSM)with its secondary made of coated superconducting coils were conducted via the built prototype over the traditional copper windings.A numerical model of the superconducting LSM was made and the measured data of experiment validate its reliability.The nonlinear resistivity of coated superconductor was electromagnetically modeled by resorting to the power law in conjunction with the constitutive relationship of conductor.Based on the numerical model,we carried out a set of transient studies to make a forecast about the superiority of the proposed high temperature superconducting(HTS)LSM,such as magnetic field distribution and the time evolution of thrust together with the speed in different loads and frequencies.The achieved results clearly confirm that the proposed HTS LSM has the advantages to work as a candidate for developing the high-thrust LSM with a large air gap. | Kang Liu Xingtian Li Yao Cai Tianyong Gong Zhengwei Zhao Jing Li Guangtong Ma | 2019 | CES Transactions on Electrical Machines and Systems2019，3，3： | 0 |
| 20 | Model free optimization of building cooling water systems with refined action space显示文摘Deep Q Network(DQN)is an efficient model-free optimization method,and has the potential to be used in building cooling water systems.However,due to the high dimension of actions,this method requires a complex neural network.Therefore,both the required number of training samples and the length of convergence period are barriers for real application.Furthermore,penalty function based exploration may lead to unsafe actions,causing the application of this optimization method even more difficult.To solve these problems,an approach to limit the action space within a safe area is proposed in this paper.First of all,the action space for cooling towers and pumps are separated into two sub-regions.Secondly,for each type of equipment,the action space is further divided into safe and unsafe regions.As a result,the convergence speed is significantly improved.Compared with the traditional DQN method in a simulation environment validated by real data,the proposed method is able to save the convergence time by 1 episode(one cooling season).The results in this paper suggest that,the proposed DQN method can achieve a much quicker learning speed without any undesired consequences,and therefore is more suitable to be used in projects without pre-learning stage. | Qiaofeng Xiong Zhengwei Li Wenxia Cai Zhechao Wang | 2023 | Building Simulation2023，16，4： | 0 |
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