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| 1 | Blocking the recruitment of naive CD4+ T cells reverses immunosuppression in breast cancer显示文摘渗入肿瘤的 Tregs 的起源,肿瘤免疫力的抑制的批评调停人,是不清楚的。这里,,我们证明在人的乳癌的渗入肿瘤的天真的 CD4 + T 房间和 Tregs 有重叠 TCR 全部剧目几乎别与传播 Tregs 重叠,建议 intratumoral Tregs 主要在 situ 而非从招募的 Tregs 从天真的 T 房间发展。而且,许多天真的 CD4 + T 房间和 Tregs 密切被相关,两个显示的穷人为乳癌病人的预后。天真的 CD4 + T 房间与许多生产 CCL18 巨噬细胞成比例遵守肿瘤片。而且,采纳地转移的人的天真的 CD4 + T 房间以一种 CCL18 依赖的方式渗入人的乳癌 orthotopic 异种皮移植。在在人性化的鼠标的人的乳癌异种皮移植,由将 PITPNM3 的表达式击倒堵住天真的 CD4 + T 房间的招募进肿瘤, CCL18 受体,显著地减少 intratumoral Tregs 并且禁止肿瘤前进。这些调查结果建议那个乳房渗入肿瘤的 Tregs 从在 situ 区分进 Tregs 的传播天真的 CD4 + T 房间的趋化性产生。由防碍 CCL18 的 PITPNM3 识别禁止天真的 CD4 + T 房间招募进肿瘤可以是为 anticancer 免疫疗法的吸引人的策略。 | Shicheng Su Jianyou Liao Jiang Liu Di Huang Chonghua He Fei Chen LinBing Yang Wei Wu Jianing Chen Ling Lin Yunjie Zeng Nengtai Ouyang Xiuying Cui Herui Yao Fengxi Su Jian-dong Huang Judy Lieberman Qiang Liu Erwei Song | 2017 | Cell Research2017，27，4： | 19 |
| 2 | Ubiquitination of Rheb governs growth factor-induced mTORC1 activation显示文摘Mechanistic target of rapamycin mTOR complex 1 (mTORC1)plays a key role in the integration of various environmental signals to regulate cell growth and metabolism,mTORC1 is recruited to the lysosome where it is activated by its interaction with GTP-bound Rheb GTPase.However,the regulatory mechanism of Rheb activity remains largely unknown.Here,we show that ubiquitination governs the nucleotide-bound status of Rheb.Lysosome-anchored E3 ligase RNF152 catalyzes Rheb ubiquitination and promotes its binding to the TSC complex.EGF enhances the deubiquitination of Rheb through AKT-dependent USP4 phosphorylation,leading to the release of Rheb from the TSC complex.Functionally,ubiquitination of Rheb is linked to mTORC1-mediated signaling and consequently regulates tumor growth.Thus,we propose a mechanistic model whereby Rheb-mediated mTORC1 activation is dictated by a dynamic opposing act between Rheb ubiquitination and deubiquitination that are catalyzed by RNF152 and USP4 respectively. | Lu Deng Lei Chen Linlin Zhao Yan Xu Xiaoping Peng Xinbo Wang Lin Ding Jiali Jin Hongqi Teng Yanming Wang Weijuan Pan Fei Yu Lujian Liao Li Li Xin Ge Ping Wang | 2019 | Cell Research2019，29，2： | 16 |
| 3 | Identification of the novel recessive gene pi55(t) conferring resistance to Magnaporthe oryzae显示文摘The elite rice cultivar Yuejingsimiao 2 (YJ2) is characterized by a high level of grain quality and yield, and resistance against Magnaporthe oryzae. YJ2 showed 100% resistance to four fungal populations collected from Guangdong, Sichuan, Liaoning, and Heilongjiang Provinces, which is a higher frequency than that shown by the well-known resistance (R) gene donor cultivars such as Sanhuangzhan 2 and 28zhan. Segregation analysis for resistance with F 2 and F 4 populations indicated the resistance of YJ2 was controlled by multiple genes that are dominant or recessive. The putative R genes of YJ2 were roughly tagged by SSR markers, located on chromosomes 2, 6, 8, and 12, in a bulked-segregant analysis using genome-wide selected SSR markers with F 4 lines that segregated into 3 resistant (R):1 susceptible (S) or 1R:3S. The recessive R gene on chromosome 8 was further mapped to an interval 1.9 cM/152 kb in length by linkage analysis with genomic position-ready markers in the mapping population derived from an F 4 line that segregated into 1R:3S. Given that no major R gene was mapped to this interval, the novel R gene was designated as pi55(t). Out of 26 candidate genes predicted in the region based on the reference genomic sequence of the cultivar Nipponbare, two genes that encode a leucine-rich repeat-containing protein and heavy-metalassociated domain-containing protein, respectively, were suggested as the most likely candidates for pi55(t). | HE XiuYing LIU XinQiong WANG Li WANGLing LIN Fei CHENG YongSheng CHEN ZhaoMing LIAO YaoPing PAN QingHua | 2012 | Science China(Life Sciences)2012，55，2： | 15 |
| 4 | Combination treatment with comprehensive cryoablation and immunotherapy in metastatic hepatocellular cancer显示文摘AIM: To retrospectively assess the effect of comprehensive cryosurgery (ablation of intraand extra-hepatic tumors) plus dendritic cell-cytokine-induced killer cell immunotherapy in metastatic hepatocellular cancer. METHODS: We divided 45 patients into cryo-immunotherapy (21 patients), cryotherapy (n = 12), immunotherapy (n = 5) and untreated (n = 7) groups. Overall survival (OS) after diagnosis of metastatic hepatocellular cancer was assessed after an 8-year follow-up. RESULTS: Median OS was higher following cryo-immu-notherapy (32 mo) or cryotherapy (17.5 mo; P < 0.05) than in the untreated group (3 mo) and was higher in the cryo-immunotherapy group than in the cryotherapy group (P < 0.05). In the cryo-immunotherapy group, median OS was higher after multiple treatments (36.5 mo) than after a single treatment (21 mo; P < 0.05). CONCLUSION: Cryotherapy and, especially, cryoimmunotherapy significantly increased OS in metastatic hepatocellular cancer patients. Multiple cryo-immunotherapy was associated with a better prognosis than single cryo-immunotherapy. | Li-Zhi Niu Jia-Liang Li Jian-Ying Zeng Feng Mu Meng-Tian Liao Fei Yao Li Li Chun-Yan Liu Ji-Bing Chen Jian-Sheng Zuo Ke-Cheng Xu | 2013 | World Journal of Gastroenterology2013，19，22： | 13 |
| 5 | Science Letters:Evaluation of a kinetic uricase method for serum uric acid assay by predicting background absorbance of uricase reaction solution with an integrated method显示文摘A patented kinetic uricase method was evaluated for serum uric acid assay. Initial absorbance of the reaction mixture before uricase action (A0) was obtained by correcting the absorbance at 293 nm measured before the addition of uricase solution, and background absorbance (Ab) was predicted by an integrated method. Uric acid concentration in reaction solution was calcu-lated from ?A, the difference between A0 and Ab, using the absorptivity preset for uric acid. This kinetic uricase method exhibited CV<4.3% and recovery of 100%. Lipids, bilirubin, hemoglobin, ascorbic acid, reduced glutathione and xanthine <0.32 mmol/L in serum had no significant effects. ?A linearly responded to 1.2 to 37.5 μmol/L uric acid in reaction solution containing 15 μl serum. The slope of linear response was consistent with the absorptivity preset for uric acid while the intercept was consistent with that for serum alone. Uric acid concentrations in clinic sera by different uricase methods positively correlated to each other. By Bland-Altman analysis, this kinetic uricase method accorded with that by quantifying the total change of UV absorbance on the completion of uricase reaction. These results demonstrated that this kinetic uricase method is reliable for serum uric acid assay with enhanced resistance to both xanthine and other common errors, wider range of linear response and much lower cost. | LIAO Fei ZHAO Yun-sheng ZHAO Li-na TAO Jia ZHU Xiao-yun LIU Lan | 2006 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2006，7，6： | 12 |
| 6 | A vertical sounding of severe haze process in Guangzhou area显示文摘We detected a severe haze process in Guangzhou area with lidar and microwave radiometer, performed an inversion to get boundary layer height by wavelet covariance transform, and analyzed the correlation between meteorological factors of boundary layer and visibility from the perspective of dynamical and thermodynamic structures. Our results indicate that the boundary layer height shows significant daily changes, consistent with ground visibility variation. During the cleaning process, the boundary layer height exceeded 1 km; during severe haze, the height was only 500 m. Temperature gradient of 50–100 m, which was 30 h lag, was remarkably correlated with visibility, with the correlation coefficient of 0.77. High layer visibility(255 m) and low layer stability were significantly anticorrelation, and the maximum anticorrelation coefficient was up to-0.76 in cleaning days and-0.49 in haze days. In the related boundary layer meteorological factors, surface ventilation coefficient was linearly correlated with ground visibility, with the greatest correlation coefficient of 0.88. The correlation coefficients of boundary layer height, ground wind velocity, relative humidity and ground visibility were 0.76, 0.67, and-0.77, respectively. There was a strong correlation between different meteorological factors. The dominant meteorological factor during this haze process was surface ventilation coefficient. In the area without boundary layer height sounding, ground visibility and wind velocity could be used to estimate boundary layer height. | DENG Tao WU Dui DENG XueJiao TAN HaoBo LI Fei LIAO BiTing | 2014 | Science China Earth Sciences2014，57，11： | 10 |
| 7 | Oncogenic AURKA-enhanced N6-methyladenosine modification increases DROSHA mRNA stability to transactivate STC1 in breast cancer stem-like cells显示文摘RNase III DROSHA is upregulated in multiple cancers and contributes to tumor progression by hitherto unclear mechanisms.Here,we demonstrate that DROSHA interacts withβ-Catenin to transactivate STC1 in an RNA cleavage-independent manner,contributing to breast cancer stem-like cell(BCSC)properties.DROSHA mRNA stability is enhanced by N6-methyladenosine(m^(6)A)modification which is activated by AURKA in BCSCs.AURKA stabilizes METTL14 by inhibiting its ubiquitylation and degradation to promote DROSHA mRNA methylation.Moreover,binding of AURKA to DROSHA transcript further strengthens the binding of the m^(6)A reader IGF2BP2 to stabilize m^(6)A-modified DROSHA.In addition,wild-type DROSHA,but not an m^(6)A methylation-deficient mutant,enhances BCSC stemness maintenance,while inhibition of DROSHA m^(6)A modification attenuates BCSC traits.Our study unveils the AURKA-induced oncogenic m^(6)A modification as a key regulator of DROSHA in breast cancer and identifies a novel DROSHA transcriptional function in promoting the BCSC phenotype. | Fei Peng Jie Xu Bai Cui Qilan Liang Sai Zeng Bin He Hong Zou Manman Li Huan Zhao Yuting Meng Jin Chen Bing Liu Shasha Lv Peng Chu Fan An Zifeng Wang Junxiu Huang Yajing Zhan Yuwei Liao Jinxin Lu Lingzhi Xu Jin Zhang Zhaolin Su Zhiguang Li Fangjun Wang Eric W-FLam Quentin Liu | 2021 | Cell Research2021，31，3： | 9 |
| 8 | Expression and distribution of TNF-α and PGE_2 of periodontal tissues in rat periodontitis model显示文摘Objective:To simulate the expression of TNF-α and PGE_2 of periodontal tissues in rat periodontitis model.Methods:40 Wistar rats were randomly divided into the periodontitis group and the control group(n=20).After the successful establishment of periodontitis rat model,raising for six weeks before the animals were sacrificed.The periodontal tissues were obtained and made into slices.Observed the histopathological changes of the periodontal tissues and measured TNF-α,PGE_2 levels change by immunohistochemistry.Western blot analysis and EI.ISA.Results:TNF-α,PGE_2 expression of the periodontitis group was significantly higher than that in the control group,the difference was significant(P<0.0S).Conclusions:The TNF-α.PGE_2expression of the rat periodontal tissue in the periodontitis group was significantly higher than the control group. | Chu-Hang Liao Wei Fei Zhi-Hao Shen Ming-Ping Yin Chen Lu | 2014 | Asian Pacific Journal of Tropical Medicine2014，7，5： | 8 |
| 9 | Activation of mitogen-activated protein kinases in satellite glial cells of the trigeminal ganglion contributes to substance P-mediated inflammatory pain显示文摘Inflammatory orofacial pain,in which substance P (SP) plays an important role,is closely related to the cross-talk between trigeminal ganglion (TG) neurons and satellite glial cells (SGCs).SGC activation is emerging as the key mechanism underlying inflammatory pain through different signalling mechanisms,including glial fibrillary acidic protein (GFAP) activation,phosphorylation of mitogen-activated protein kinase (MAPK) signalling pathways,and cytokine upregulation.However,in the TG,the mechanism underlying SP-mediated orofacial pain generated by SGCs is largely unknown.In this study,we investigated whether SP is involved in inflammatory orofacial pain by upregulating interleukin (IL)-1β and tumour necrosis factor (TNF)-α from SGCs,and we explored whether MAPK signalling pathways mediate the pain process.In the present study,complete Freund’s adjuvant (CFA) was injected into the whisker pad of rats to induce an inflammatory model in vivo.SP was administered to SGC cultures in vitro to confirm the effect of SP.Facial expression analysis showed that pre-injection of L703,606 (an NK-1 receptor antagonist),U0126 (an inhibitor of MAPK/extracellular signal-regulated kinase [ERK] kinase [MEK] 1/2),and SB203580 (an inhibitor of P38) into the TG to induce targeted prevention of the activation of the NK-1 receptor and the phosphorylation of MAPKs significantly suppressed CFA-induced inflammatory allodynia.In addition,SP promoted SGC activation,which was proven by increased GFAP,p-MAPKs,IL-1β and TNF-α in SGCs under inflammatory conditions.Moreover,the increase in IL-1β and TNF-α was suppressed by L703,606,U0126 and SB203580 in vivo and in vitro.These present findings suggested that SP,released from TG neurons,activated SGCs through the ERK1/2 and P38 pathways and promoted the production of IL-1β and TNF-α from SGCs,contributing to inflammatory orofacial pain associated with peripheral sensitization. | Yanyan Zhang Ning Song Fei Liu Jiu Lin Mengke Liu Chaolan Huang Daqing Liao Cheng Zhou Hang Wang Jiefei Shen | 2019 | International Journal of Oral Science2019，11，3： | 6 |
| 10 | Aptamer-quantum dots and teicoplanin-gold nanoparticles constructed FRET sensor for sensitive detection of Staphylococcus aureus显示文摘The detection of bacterial pathogen such as Staphylococcus aureus(S.aureus) is essential for the regulation of food hygiene and disease diagnosis.Herein,we developed a simple one-step fluorescence resonance energy transfer(FRET)-based sensor for specific and sensitive detection of S.aureus in food and serum samples,in which aptamer-modified quantum dots(aptamer-QDs) was employed as the energy donor and antibiotic of teicoplanin functionalized-gold nanoparticles(Teico-AuNPs) was chosen as the energy acceptor.Within 1 h,the FRET-based sensor showed a linear range of from 10 cfu/mL to 5 × 10^(8) cfu/mL,with the low limit of detection(LOD,2 cfu/mL) for S.aureus in buffer.When further applied to assay S.aureus in real samples,the FRET-based sensor showed good recoveries ranging from 84.5% to 110.0%,with relative standard derivations(RSDs) of 0.01%-0.44% and a LOD of 100 cfu/mL in milk,orange juice and human serum. | Xiaoqi Tao Ziyi Liao Yaqing Zhang Fei Fu Mengqi Hao Yang Song Erqun Song | 2021 | Chinese Chemical Letters2021，32，2： | 5 |
| 11 | Unraveling a genetic roadmap for improved taste in the domesticated apple显示文摘Although taste is an important aspect of fruit quality, an understanding of its genetic control remains elusive in apple and other fruit crops. In this study, we conducted genomic sequence analysis of 497 Malus accessions and revealed erosion of genetic diversity caused by apple breeding and possible independent domestication events of dessert and cider apples. Signatures of selection for fruit acidity and size, but not for fruit sugar content, were detected during the processes of both domestication and improvement. Furthermore, we found that single mutations in major genes affecting fruit taste, including Ma1, MdTDT, and MdSOT2, dramatically decrease malate, citrate, and sorbitol accumulation, respectively, and correspond to important domestication events. Interestingly, Ma1 was identified to have pleiotropic effects on both organic acid content and sugar:acid ratio, suggesting that it plays a vital role in determining fruit taste. Fruit taste is unlikely to have been negatively affected by linkage drag associated with selection for larger fruit that resulted from the pyramiding of multiple genes with minor effects on fruit size. Collectively, our study provides new insights into the genetic basis of fruit quality and its evolutionary roadmap during apple domestication, pinpointing several candidate genes for genetic manipulation of fruit taste in apple. | Liao Liao Weihan Zhang Bo Zhang Ting Fang Xiao-Fei Wang Yarning Cai Collins Ogutu Lei Gao Gang Chen Xiaoqing Nie Jinsheng Xu Quanyan Zhang Yiran Ren Jianqiang Yu Chukun Wang Cecilia H.Deng Baiquan Ma Beibei Zheng Chun-Xiang You Da-Gang Hu Richard Espley Kui Lin-Wang Jia-Long Yao Andrew C.Allan Awais Khan Schuyler S.Korban Zhangjun Fei Ray Ming Yu-Jin Hao Li Li Yuepeng Han | 2021 | Molecular Plant2021，14，9： | 5 |
| 12 | Characteristics of dust distributions and dust control measures around road-header drivers in mining excavation roadways显示文摘In the present study,a numerical simulation method was adopted in order to examine the characteristics of dust dispersion during continuous dust release periods(CRP)and stop dust release periods(SRP).The purpose was to analyze the dust distributions and migration actions around road-header drivers in excavation roadways,and then determine effective dust control measures for underground coal mines.This study’s simulation results showed that the dust concentrations continuously increased,and then gradually reached a stability level during the CRP.During that time,the locations of the drivers were always at the intersection of the original migration dust and the backflow dust,and the drivers were invaded by these two strands dust.However,during the SRP,the dust concentrations gradually decreased under the actions of the roadway ventilation.Besides,obvious backflow phenomena were observed around the road-header during the SRP.The locations of the drivers were still within the backflow paths of the high dust concentrations.At the present time,dust separation and extraction systems have been implemented in coal mines,including vacuuming and air knife devices,which are designed to control the dust around the road-header drivers.The field applications of these systems were conducted in the 26 mechanized excavation faces of the Zhangcun Coal Mine.The results revealed that the use of these dust removal systems could effectively reduce the dust concentrations around the road-header drivers.In the present study,the dust removal rates during the CRP and SRP were determined to reach up to 88.7% and 94.6%,respectively.Therefore,the results of this research study provided effective theoretical guidance of the characteristics of dust distributions in coal mines,and introduced effective control methods for the hazardous dust concentrations around road-header drivers during the excavation process. | Shengyong Hu Yang Gao Guorui Feng Yisheng Huang He Shaoa Qi Liao Fei Hu | 2021 | Particuology2021，19，5： | 4 |
| 13 | The research on boundary layer evolution characteristics of Typhoon Usagi based on observations by wind profilers显示文摘Vertically exploring the characteristics of the typhoon boundary layer(TBL) plays an important role in recognizing typhoon structure. The boundary layer radial direction and tangential wind characteristics of Typhoon Usagi based on the observational data of three boundary layer wind profiler stations along the route of Typhoon Usagi(No. 1319) and by combining with sounding data. The results show that:(1) maximum tangential wind appears in the vicinity of the eye area of Usagi, and it basically maintains a height of around 1 800 m when Usagi keeps a strong typhoon level, with the rapidly decreasing strength of Usagi after it lands, the speed of the maximum tangential wind and its vertical range both decrease;(2) the height of the maximum tangential wind is close to that of the inflow layer top of the typhoon, and is greater than that of the boundary layer estimated on the basis of Richardson number or potential temperature gradient, while the height of mixed layer judged on the basis of the signal-to-noise ratio(SNR) or its gradient is usually low;(3) the the boundary layer height can reach higher than2 100 m before Usagi lands. When the typhoon level or above is achieved, the boundary layer height observed by various stations does not change much, basically staying at between 1 200 and 1 600 m. With the decreasing strength of Usagi after its landfall, the boundary layer height rapidly drops. | LIAO Fei DENG Hua GAO Zhiqiu CHAN Pak-wai | 2017 | Acta Oceanologica Sinica2017，36，9： | 3 |
| 14 | 5-Amino-4-oxopentanoic acid photodynamic diagnosis guided microsurgery and photodynamic therapy on VX2 brain tumour implanted in a rabbit model显示文摘背景完全的瘤切除术为改进大脑瘤病人的预后是重要的。然而,因为瘤边缘是困难的与包围大脑织物被区分开来,广泛的切除术仍然保持争论。它被建立了那 5-amino-4-oxopentanoic 酸(5-aminolevulinic 酸,翼) 能在大脑瘤的外科的治疗为光力学的治疗被用作一个光力学的诊断标记和 photosensitizer。我们调查了 VX2 大脑瘤上的 microsurgery 和光力学的治疗在与 VX2 大脑瘤植入的八十只新西兰兔子随机被分到五个组的兔子 model.Methods 植入的光力学地指导的翼的功效:在哪个指导了 microsurgery 的控制,常规白轻 microsurgery,一个光力学的治疗组,一个光力学地指导的 microsurgery 组和一个组被光力学的治疗跟随。VX2 瘤是在一台外科的显微镜下面的 resected。瘤切除术与组织学的分析被证实。所有动物为任何剩余瘤织物的存在与 MRI 被检验。每只兔子的幸存时间 group.Photodynamically 与控制相比是所有处理组显示出的 recorded.Results 一显著地扩大的幸存时间显著地与光力学的治疗相结合的指导 microsurgery 独自延长了幸存时间,与指导 microsurgery 相比。 MRI 和尸体结果证实了那个光力学地指导的手术和光力学的治疗显著地减少,增加激进的切除术的有效性并且延长瘤适用的幸存时间的我们的结果建议的 tumours.Conclusions 的大多数或延期本地人复发的移动兔子,他们的联合有潜力被用作变形大脑瘤的一个快速、高度有效的处理。 | XIAO Hong LIAO Qiong CHENG Ming LI Fei XIE Bing LI Mei FENG Hua | 2009 | Chinese Medical Journal2009，，11： | 3 |
| 15 | Diagnosis of intellectual disability/global developmental delay via genetic analysis in a central region of China显示文摘Background:Advanced technology has become a valuable tool in etiological studies of intellectual disability/global developmental delay(ID/GDD).The present study investigated the role of genetic analysis to confirm the etiology in ID/GDD patients where the cause of the disease was uncertain in central China.Methods:We evaluated 1051 ID/GDD children aged 6 months to 18 years from March 2009 to April 2017.Data concerning basic clinical manifestations were collected,and the method of etiology confirmation was recorded.Genome-wide copy number variations(CNVs)detection and high-throughput sequencing of exons in the targeted regions was performed to identify genetically-based etiologies.We compared the incidence of different methods used to confirm ID/GDD etiology among groups with differing degrees of ID/GDD using the Chi-square or Fisher exact probability test.Results:We recruited 1051 children with mild(367,34.9%),moderate(301,28.6%),severe(310,29.5%),and profoundly severe(73,6.9%)ID/GDD.The main causes of ID/GDD in the children assessed were perinatal factors,such as acquired brain injury,as well as single gene imbalance and chromosomal gene mutation.We identified karyotype and/or CNVs variation in 46/96(47.9%)of cases in severe ID/GDD patients,which was significantly higher than those with mild and moderate ID/GDD of 34/96(35.4%)and 15/96(15.6%),respectively.A total of 331/536(61.8%)patients with clear etiology have undergone genetic analysis while 262/515(50.9%)patients with unclear etiology have undergone genetic analysis(x^2=12.645,P<0.001).Gene structure variation via karyotype analysis and CNV detection increased the proportion of children with confirmed etiology from 51.0%to 56.3%,and second-generation high-throughput sequencing dramatically increased this to 78.9%.Ten novel mutations were detected,recessive mutations in X-linked genes(ATPase copper transporting alpha and bromodomain and WD repeat domain containing 3)and dominant de novo heterozygous mutations in X-linked genes(cyclin-dependent kinase like 5,protocadherin 19,IQ motif and Sec7 domain 2,and methyl-CpG binding protein 2)were reported in the study.Conclusions:The present study indicates that genetic analysis is an effective method to increase the proportion of confirmed etiology in ID/GDD children and is highly recommended,especially in ID/GDD children with uncertain etiology. | Li-Hong Liao Chen Chen Jing Peng Li-Wen Wu Fang He Li-Fen Yang Ci-Liu Zhang Guo-Li Wang Pan Peng Yu-Ping Ma Pu Miao Fei Yin | 2019 | Chinese Medical Journal2019，，13： | 3 |
| 16 | Structural topology optimization under stationary random base acceleration excitations显示文摘Structural topology optimization subjected to stationary random base acceleration excitations is investigated in this paper. In the random response analysis, the Large Mass Method(LMM) which attributes artificial large mass values at each driven nodal Degree Of Freedom(DOF) to transforming the base acceleration excitations into force excitations is proposed. The Complete Quadratic Combination(CQC) which is commonly used to calculate the random responses in previous optimization has been proven to be computationally expensive especially for large-scale problems. In order to conquer this difficulty, the Pseudo Excitation Method(PEM) and the combined method of PEM and Mode Acceleration Method(MAM) are adopted into the dynamic topology optimization, and random responses are calculated using these two methods to ascertain a high efficiency over the CQC. A density-based topology optimization method minimizing dynamic responses is then formulated based on the integration of LMM and PEM or the combined method of PEM and MAM. Numerical examples are presented to verify the accuracy of the proposed schemes in dynamic response analysis and the quality of the optimized design in improving dynamic performance. | Fei HE Hongqiang LIAO Jihong ZHU Zhongze GUO | 2019 | Chinese Journal of Aeronautics2019，32，6： | 3 |
| 17 | Out-of-step oscillation splitting criterion based on bus voltage frequency显示文摘Under the background of complicated interconnected network,the splitting criterion for accurately capturing the electrical center in real time is the prerequisite of power grid splitting.This paper studies the features of electric quantity in the electrical center in aspect of the instantaneous frequency,and proposes the out-of-step splitting criterion for power systems based on bus voltage frequency.Firstly,through the establishment and solution to the out-of-step model of the power grid,the analytical expression of the voltage frequency at any position is obtained in the out-of-step oscillation,and the voltage frequency features of electrical center and non-electrical center are analyzed in details.Then,this paper constructs the typical scene of migration of electrical center to study the change rules of voltage frequency.Finally,the splitting criterion based on bus voltage frequency is proposed as well as the instruction for use.This criterion is easy to be realized and can adapt to the migration of electrical center.Also it is free from the limits of power network structure and operational mode.Simulation results of CEPRI-36 system and interconnected network example of one actual region verify the accuracy and the effectiveness of the proposed criterion. | Fei TANG Jian YANG Qingfen LIAO Yifei WANG Jun JIA | 2015 | Journal of Modern Power Systems and Clean Energy2015，3，3： | 3 |
| 18 | Prescreening teratogenic potential of chlorinated drinking water disinfection by-products by using Hydra regeneration assay显示文摘PrescreeningteratogenicpotentialofchlorinateddrinkingwaterdisinfectionbyproductsbyusingHydraregenerationasayJiYuantangDepar... | Ji Yuan tang Department of Preventive Medicine, Anhui Medical University, Hefei 230032, China Chen Qin yao, Wei Xiao fei, Li Yi, Liao Hong mei Department of Biology, Anhui University, Hefei 230039, China | 1998 | Journal of Environmental Sciences1998，10，1： | 2 |
| 19 | A novel 4H-SiC trench MOSFET with double shielding structures and ultralow gate-drain charge显示文摘A new ultralow gate–drain charge(Q_(GD)) 4 H-SiC trench MOSFET is presented and its mechanism is investigated by simulation. The novel MOSFET features double shielding structures(DS-MOS): one is the grounded split gate(SG), the other is the P+shielding region(PSR). Both the SG and the PSR reduce the coupling effect between the gate and the drain, and transform the most part of the gate–drain capacitance(C_(GD)) into the gate–source capacitance(C_(GS)) and drain–source capacitance(C_(DS)) in series.Thus the C_(GD) is reduced and the proposed DS-MOS obtains ultralow Q_(GD). Compared with the double-trench MOSFET(DT-MOS)and the conventional trench MOSFET(CT-MOS), the proposed DS-MOS decreases the Q_(GD) by 85% and 81%, respectively.Moreover, the figure of merit(FOM), defined as the product of specific on-resistance(R_(on, sp)) and Q_(GD)(R_(on, sp)Q_(GD)), is reduced by 84% and 81%, respectively. | Xiaorong Luo Tian Liao Jie Wei Jian Fang Fei Yang Bo Zhang | 2019 | Journal of Semiconductors2019，40，5： | 2 |
| 20 | Life History Recorded in the Vagino-cervical Microbiome Along with Multi-omes显示文摘The vagina contains at least a billion microbial cells,dominated by lactobacilli.Here we perform metagenomic shotgun sequencing on cervical and fecal samples from a cohort of 516 Chinese women of reproductive age,as well as cervical,fecal,and salivary samples from a second cohort of 632 women.Factors such as pregnancy history,delivery history,cesarean section,and breastfeeding were all more important than menstrual cycle in shaping the microbiome,and such information would be necessary before trying to interpret differences between vagino-cervical microbiome data.Greater proportion of Bifidobacterium breve was seen with older age at sexual debut.The relative abundance of lactobacilli especially Lactobacillus crispatus was negatively associated with pregnancy history.Potential markers for lack of menstrual regularity,heavy flow,dysmenorrhea,and contraceptives were also identified.Lactobacilli were rare during breastfeeding or post-menopause.Other features such as mood fluctuations and facial speckles could potentially be predicted from the vagino-cervical microbiome.Gut and salivary microbiomes,plasma vitamins,metals,amino acids,and hormones showed associations with the vagino-cervical microbiome.Our results offer an unprecedented glimpse into the microbiota of the female reproductive tract and call for international collaborations to better understand its long-term health impact other than in the settings of infection or pre-term birth. | Zhuye Jie Chen Chen Lilan Hao Fei Li Liju Song Xiaowei Zhang Jie Zhu Liu Tian Xin Tong Kaiye Cai Zhe Zhang Yanmei Ju Xinlei Yu Ying Li Hongcheng Zhou Haorong Lu Xuemei Qiu Qiang Li Yunli Liao Dongsheng Zhou Heng Lian Yong Zuo Xiaomin Chen Weiqiao Rao Yan Ren Yuan Wang Jin Zi Rong Wang Na Liu Jinghua Wu Wei Zhang Xiao Liu Yang Zong Weibin Liu Liang Xiao Yong Hou Xun Xu Huanming Yang Jian Wang Karsten Kristiansen Huijue Jia | 2022 | Genomics, Proteomics & Bioinformatics2022，20，2： | 2 |
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