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| 1 | Signaling networks in immunometabolism显示文摘Adaptive immunity is essential for pathogen and tumor eradication,but may also trigger uncontrolled or pathological inflammation.T cell receptor,co-stimulatory and cytokine signals coordinately dictate specific signaling networks that trigger the activation and functional programming of T cells.In addition,cellular metabolism promotes T cell responses and is dynamically regulated through the interplay of serine/threonine kinases,immunological cues and nutrient signaling networks.In this review,we summarize the upstream regulators and signaling effectors of key serine/threonine kinase-mediated signaling networks,including PI3K-AGC kinases,mTOR and LKB1-AMPK pathways that regulate metabolism,especially in T cells.We also provide our perspectives about the pending questions and clinical applicability of immunometabolic signaling.Understanding the regulators and effectors of immunometabolic signaling networks may uncover therapeutic targets to modulate metabolic programming and T cell responses in human disease. | Jordy Saravia Jana L.Raynor Nicole M.Chapman Seon Ah Lim Hongbo Chi | 2020 | Cell Research2020，30，4： | 9 |
| 2 | Cryptogenic multifocal ulcerous stenosing enteritis: Radiologic features and clinical behavior显示文摘AIM To investigate the characteristic radiologic findings of cryptogenic multifocal ulcerous stenosing enteritis(CMUSE) which can be differentiated from other similar bowel disease and to assess their clinical behavior.METHODS Twenty pathologically and clinically confirmed CMUSE patients(males:females = 8:12; mean age: 40.4 years) between March 2002 and August 2015 from seven academic centers in South Korea were retrospectively reviewed. We evaluated small bowel series(SBS; n = 25), computed tomography(CT) enterography(n = 21), magnetic resonance(MR) enterography(n = 2), and abdominopelvic CT(n = 18) images, focusing on enteric and perienteric manifestations. Any change in radiologic features during followup period was recorded. We evaluated clinical data including presenting symptoms, laboratory finding and presence of relapse from electronic medical records. Histopathologic findings were also evaluated. RESULTS The main symptoms were abdominal pain(n = 12) and anemia(n = 10). All patients showed small bowel strictures(n = 52, mean: 2.6 per patient) on initial CT/MR, located in the ileum(n = 47) or jejunum(n = 5). Strictures showed short-length(mean: 10.44 mm) and circumferential bowel wall thickening(mean: 5.56 mm) with layered enhancement(n = 48) that were also noted on initial SBS(n = 36) with shallow ulcers(n = 10). Some ulcerative lesions or wall thickening progressed into strictures on follow-up SBS/CT, and some strictures revealed recurrent ulceration on followup SBS. There were no penetrating disease features like fistula or abscess and no gastrointestinal tract involvement except the small bowel. Nine patients experienced disease recurrence(median relapse-free period: 32 mo) even post-operatively. Histopathologic features of surgically resected specimens were characterized as multiple superficial ulcerations confined to mucosa or submucosa and multiple strictures.CONCLUSION Under characteristic radiologic findings with multiple short-segmental strictures and/or shallow ulcers of the small intestine, CMUSE should be considered when assessing patients with recurrent abdominal pain and anemia. | Jiyoung Hwang Jin Sil Kim Ah Young Kim Joon Seok Lim Se Hyung Kim Min Ju Kim Mi Sung Kim Kyoung Doo Song Ji Young Woo | 2017 | World Journal of Gastroenterology2017，23，25： | 4 |
| 3 | Transbuccal perme ation of a nucleoside analo g, dideoxycytidine: effects of menthol as a permeation enhancer 显示文摘 | Khan M Lim G | 1999 | Int J Pha rm1999，192，： | 1 |
| 4 | Feedback effects in erbium-doped fiber amplifier/source for open-loop fiber optic gyroscope显示文摘 | Hee Gap Park Kyoung Ah Lim Young-Jun Chin | 1997 | Journal of Lightwave Technology1997，15，8： | 1 |
| 5 | Cutting edge:direct suppression of B cells by CD4+ CD25+ Regulatory T cells显示文摘 | Lim HW Hillsamer P Banham AH | | 0，，： | 1 |
| 6 | Effect of Presoaking on Textural, Thermal, and Digestive Properties of Cooked Brown Rice 显示文摘 | Jung Ah Han Seung Taik Lim | 2009 | Cereal Chemistry2009，86，1： | 1 |
| 7 | Cutting edge:Direct suppression of B cells by CD4+ CD25+ regulatory T cells显示文摘 | Lim HW Hillsamer P Banham AH | 2005 | J Immunol2005，175，7： | 1 |
| 8 | Temozolomide-associat- ed organizing pneumonitis 显示文摘 | Maldonado F Limper AH Lim KG | 2007 | Mayo Clin Proc2007，82，6： | 1 |
| 9 | Extreme learning machine terrain-based navigation for unmanned aerial vehicles显示文摘 | Ee May Kan Meng Hiot Lim Yew Soon Ong Ah Hwee Tan Swee Ping Yeo | 2013 | Neural Computing and Applications2013，，3： | 1 |
| 10 | Pathogenesis of primary varicose veins 显示文摘 | Lim CS Davies AH | 2009 | Br J Surg2009，96，11： | 1 |
| 11 | Cleaved c-FLIP mediates the antiviral effect of TNF-α against hepatitis B virus by dysregulating hepatocyte nuclear factors显示文摘 | Yong Kwang Park Eun-Sook Park Doo Hyun Kim Sung Hyun Ahn Seung Hwa Park Ah Ram Lee Soree Park Hong Seok Kang Ji-Hyun Lee Jong Man Kim Suk-Koo Lee Keo-Heun Lim Nathalie Isorce Shuping Tong Fabien Zoulim Kyun-Hwan Kim | 2015 | Journal of Hepatology2015，，： | 1 |
| 12 | Cutting edge:direct suppression of B cells by CD4+CD25+regulatory T cells显示文摘 | Lim HW Hillsamer P Banham AH | 2005 | J Immunol2005，175，7： | 1 |
| 13 | Pneumocystis jirovecii pneumonia 13 years post renal transplant following a recurrent cytomegalovirus infection显示文摘 | Muhammad Iqbal AH Lim SK Ng KP | 2012 | Transpl Infect Dis2012，14，4： | 1 |
| 14 | Extraction optimisation and isolation oftriterpenoids from Ganoderma lucidum and theireffect on human carcinoma cell growth 显示文摘 | RUAN W LIM AH HUANG LG | 2014 | NatProd Res2014，28，24： | 1 |
| 15 | Resting-state regional homogeneity as a biological marker for patients with Internet gaming disorder: A comparison with patients with alcohol use disorder and healthy controls显示文摘 | Heejung Kim Yu Kyeong Kim Ah Reum Gwak Jae-A Lim Jun-Young Lee Hee Yeon Jung Bo Kyung Sohn Sam-Wook Choi Dai Jin Kim Jung-Seok Choi | 2015 | Progress in Neuropsychopharmacology & Biological2015，，： | 1 |
| 16 | Thermal performance study of two-pass solar air heaters 显示文摘 | Wueysundera N E Ah Lee Lee Tjioe Lim Ek | 1982 | Solar Energy1982，28，5： | 1 |
| 17 | Pathogenesis of primary varicose veins显示文摘 | Lim CS Davies AH | | 0，，11： | 1 |
| 18 | Bowel Wall Thickening in Patients with Crohn’s Disease: CT Patterns and Correlation with Inflammatory Activity显示文摘 | Dongil Choi Soon Jin Lee Young Ah Cho Hyo K Lim Seung Hoon Kim Won Jae Lee Jae Hoon Lim Haewon Park Young Rae Lee | 2003 | Clinical Radiology2003，，1： | 1 |
| 19 | Impulse control and related disorders in Parkinson' s disease:review显示文摘 | Lim SY Evans AH Miyasaki JM | | 0，，： | 1 |
| 20 | Cutting edge:direct suppression of B cells by CD4^+ CD25^+ regulatory T cells显示文摘 | Lim HW Hillsamer P Banham AH | 2005 | J Immunol2005，175，： | 1 |
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