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| 1 | Role of ascites adenosine deaminase in differentiating between tuberculous peritonitis and peritoneal carcinomatosis显示文摘AIM: To investigate the usefulness of tumor markers and adenosine deaminase in differentiating between tuberculous peritonitis (TBP) and peritoneal carcinoma- tosis (PC). METHODS: A retrospective analysis of data was performed on consecutive patients who underwent perito-neoscopic and abdominal computed tomography (CT) evaluations. Among 75 patients at the Seoul National University Hospital from January 2000 to June 2010 who underwent both tests, 27 patients (36.0%) and 25 patients (33.3%) were diagnosed with TBP and PC, respectively. Diagnosis was confirmed by peritoneoscopic biopsy. RESULTS: Serum c-reactive protein (7.88 ± 6.62 mg/ dL vs 3.12 ± 2.69 mg/dL, P = 0.01), ascites adenosine deaminase (66.76 ± 32.09 IU/L vs 13.89 ± 8.95 IU/L, P < 0.01), ascites lymphocyte proportion (67.77 ± 23.41% vs 48.36 ± 18.78%, P < 0.01), and serumascites albumin gradient (0.72 ± 0.49 g/dL vs 1.05 ± 0.50 g/dL, P = 0.03) were significantly different between the two groups. Among tumor markers, serum and ascites carcinoembryonic antigen, serum carbohydrate antigen 19-9 showed significant difference between two groups. Abdominal CT examinations showed that smooth involvement of the parietal peritoneum was more common in the TBP group (77.8% vs 40.7%) whereas nodular involvement was more common in the PC group (14.8% vs 40.7%, P = 0.04). From receiver operating characteristic (ROC) curves ascites adenosines deaminase (ADA) showed better discriminative capability than tumor markers. An ADA cut-off level of 21 IU/L was found to yield the best results of differential diagnosis; sensitivity, specificity, positive predictive value, and negative predictive value were 92.0%, 85.0%, 88.5% and 89.5%, respectively. CONCLUSION: Besides clinical and radiologic findings, ascitic fluid ADA measurement is helpful in the differential diagnosis of TBP and PC. | Seung Joo Kang Ji Won Kim Jee Hyun Baek Se Hyung Kim Byeong Gwan Kim Kook Lae Lee Ji Bong Jeong Yong Jin Jung Joo Sung Kim Hyun Chae Jung In Sung Song | 2012 | World Journal of Gastroenterology2012，18，22： | 15 |
| 2 | Association between Helicobacter pylori status and metachronous gastric cancer after endoscopic resection显示文摘AIM To investigate the effect of Helicobacter pylori(H. pylori) status test and H. pylori eradication on the occurrence of metachronous gastric cancer(MGC) after endoscopic submucosal dissection(ESD) of early gastric cancer(EGC) and risk factors of MGC. METHODS The authors retrospectively reviewed the medical records of 433 patients(441 lesions) who underwent ESD for EGC from January 2005 to January 2015 in Yeungnam University Hospital. Patients were categorized into two groups; the H. pylori tested group(n = 257) and the H. pylori non-tested group(n = 176) based on performance of H. pylori status test after ESD of EGC. The H. pylori tested group was further categorized into three subgroups based on H. pylori status; the H. pylori-eradicated subgroup(n = 120), the H. pylori-persistent subgroup(n = 42), and the H. pylori-negative subgroup(n = 95). Incidences of MGC and risk factors of MGC were identified.RESULTS Median follow-up duration after ESD was 30.00 mo(range, 6-107 mo). Total 15 patients developed MGC during follow-up. MGC developed in 11 patients of the H. pylori tested group(7 in the H. pylori-negative subgroup, 3 in the H. pylori-eradicated subgroup, and 1 in the H. pylori-persistent subgroup) and 4 patients of the H. pylori non-tested group(P > 0.05). The risk factors of MGC were endoscopic mucosal atrophy in the H. pylori tested group and intestinal metaplasia in all patients. CONCLUSION H. pylori eradication and H. pylori status test seems to have no preventive effect on the development of MGC after ESD for EGC. The risk factors of MGC development were endoscopic mucosal atrophy in the H. pylori tested group alone and intestinal metaplasia in all patients. | Sung Bum Kim Si Hyung Lee Seung Il Bae Yo Han Jeong Se Hoon Sohn Kyeong Ok Kim Byung Ik Jang Tae Nyeun Kim | 2016 | World Journal of Gastroenterology2016，22，44： | 8 |
| 3 | Absolute monocyte and lymphocyte count prognostic score for patients with gastric cancer显示文摘AIM:To measure the prognostic significance of absolute monocyte count/absolute lymphocyte count prognostic score(AMLPS) in patients with gastric cancer.METHODS:We retrospectively examined the combination of absolute monocyte count(AMC) and absolute lymphocyte count(ALC) as prognostic variables in a cohort of 299 gastric cancer patients who underwent surgical resection between 2006 and 2013 and were followed at a single institution.Both AMC and ALC were dichotomized into two groups using cut-off points determined by receiving operator characteristic curve analysis.An AMLPS was generated,which stratified patients into three risk groups:low risk(both low AMC and high ALC),intermediate risk(either high AMC or low ALC),and high risk(both high AMC and low ALC).The primary objective of the study was to validate the impact of AMLPS on both disease-free survival(DFS) and overall survival(OS),and the second objective was to assess the AMLPS as an independent prognostic factor for survival in comparison with known prognostic factors.RESULTS:Using data from the entire cohort,the most discriminative cut-off values of AMC and ALC selected on the receiver operating characteristic curve were 672.4/μL and 1734/μL for DFS and OS.AMLPS risk groups included 158(52.8%) patients in the lowrisk,128(42.8%) in the intermediate-risk,and 13(4.3%) in the high-risk group.With a median followup of 37.2 mo(range:1.7-91.4 mo),five-year DFS rates in the low-,intermediate-,and high-risk groups were 83.4%,78.7%,and 19.8%,respectively.And fiveyear OS rates in the low-,intermediate-,and high-risk groups were 89.3%,81.1%,and 14.4%,respectively.On multivariate analysis performed with patient- and tumor-related factors,we identified AMLPS,age,and pathologic tumor-node-metastasis stage as the most valuable prognostic factors impacting DFS and OS.CONCLUSION:AMLPS identified patients with a poor DFS and OS,and it was independent of age,pathologic stage,and various inflammatory markers. | Wan Kyu Eo Da Wun Jeong Hye Jung Chang Kyu Yeoun Won Sung Il Choi Se Hyun Kim Sung Wook Chun Young Lim Oh Tae Hwa Lee Young Ok Kim Ki Hyung Kim Yong Il Ji Ari Kim Heung Yeol Kim | 2015 | World Journal of Gastroenterology2015，21，9： | 6 |
| 4 | Cryptogenic multifocal ulcerous stenosing enteritis: Radiologic features and clinical behavior显示文摘AIM To investigate the characteristic radiologic findings of cryptogenic multifocal ulcerous stenosing enteritis(CMUSE) which can be differentiated from other similar bowel disease and to assess their clinical behavior.METHODS Twenty pathologically and clinically confirmed CMUSE patients(males:females = 8:12; mean age: 40.4 years) between March 2002 and August 2015 from seven academic centers in South Korea were retrospectively reviewed. We evaluated small bowel series(SBS; n = 25), computed tomography(CT) enterography(n = 21), magnetic resonance(MR) enterography(n = 2), and abdominopelvic CT(n = 18) images, focusing on enteric and perienteric manifestations. Any change in radiologic features during followup period was recorded. We evaluated clinical data including presenting symptoms, laboratory finding and presence of relapse from electronic medical records. Histopathologic findings were also evaluated. RESULTS The main symptoms were abdominal pain(n = 12) and anemia(n = 10). All patients showed small bowel strictures(n = 52, mean: 2.6 per patient) on initial CT/MR, located in the ileum(n = 47) or jejunum(n = 5). Strictures showed short-length(mean: 10.44 mm) and circumferential bowel wall thickening(mean: 5.56 mm) with layered enhancement(n = 48) that were also noted on initial SBS(n = 36) with shallow ulcers(n = 10). Some ulcerative lesions or wall thickening progressed into strictures on follow-up SBS/CT, and some strictures revealed recurrent ulceration on followup SBS. There were no penetrating disease features like fistula or abscess and no gastrointestinal tract involvement except the small bowel. Nine patients experienced disease recurrence(median relapse-free period: 32 mo) even post-operatively. Histopathologic features of surgically resected specimens were characterized as multiple superficial ulcerations confined to mucosa or submucosa and multiple strictures.CONCLUSION Under characteristic radiologic findings with multiple short-segmental strictures and/or shallow ulcers of the small intestine, CMUSE should be considered when assessing patients with recurrent abdominal pain and anemia. | Jiyoung Hwang Jin Sil Kim Ah Young Kim Joon Seok Lim Se Hyung Kim Min Ju Kim Mi Sung Kim Kyoung Doo Song Ji Young Woo | 2017 | World Journal of Gastroenterology2017，23，25： | 4 |
| 5 | Oleanolic acid attenuates MK-801-induced schizophrenia-like behaviors in mice显示文摘 | Se Jin Park Younghwa Lee Hee Kyong Oh Hyung Eun Lee Younghwan Lee Sang Yoon Ko Boseong Kim Jae Hoon Cheong Chan Young Shin Jong Hoon Ryu | 2014 | Neuropharmacology2014，，： | 2 |
| 6 | Immunomodulatory effect of caffeic acid phenethyl ester in Balb/c mice显示文摘 | Jae Hyun Park Jong Kwon Lee Hyung Soo Kim Seung Tae Chung Juno H. Eom Kyung A. Kim Se Jin Chung Soon Young Paik Hye Young Oh | 2004 | International Immunopharmacology2004，，3： | 2 |
| 7 | An observational study suggesting clinical benefit for adjuvant postoperative chemoradiation in a population of over 500 cases after gastric resection with D2 nodal dissection for adenocarcinoma of the stomach显示文摘 | Sung Kim Do Hoon Lim Jeeyun Lee Won Ki Kang John S. MacDonald Chan Hyung Park Se Hoon Park Se-Hoon Lee Kihyun Kim Joon Oh Park Won Seog Kim Chul Won Jung Young Suk Park Young-Hyuck Im Tae Sung Sohn Jae Hyung Noh Jin Seok Heo Yong Il Kim Chul Keun Park Keu | 2005 | International Journal of Radiation Oncology Biology Physics2005，，5： | 1 |
| 8 | Lymphoepithelial cyst of the pancreas: comparison of CT findings with other pancreatic cystic lesions显示文摘 | Won Hwa Kim Jae Young Lee Hee Sun Park Hyung Jin Won Young Hun Kim Jin Young Choi Se Hyung Kim Joon Koo Han Byung Ihn Choi | 2013 | Abdominal Imaging2013，，2： | 1 |
| 9 | Numerical and experimental investigations on the gas temperature deviation in a large scale, advanced low NOx, tangentially fired pulverized coal boiler显示文摘 | Ho Young Park Se Hyun Baek Young Ju Kim Tae Hyung Kim Dong Soo Kang Dong Woong Kim | 2013 | Fuel2013，，： | 1 |
| 10 | Diagnostic Accuracy of Multi-/Single-Detector Row CT and Contrast-Enhanced MRI in the Detection of Hepatocellular Carcinomas Meeting the Milan Criteria before Liver Transplantation显示文摘 | Kim Se Hyung Choi Byung Ihn Lee Jae Young Kim Soo Jin So Young Ho Eun Hyo Won Lee Jeong Min Han Joon Koo | 2008 | Intervirology2008，，： | 1 |
| 11 | Biliary Complications in Living Donor Liver Transplantation: Imaging Findings and the Roles of Interventional Procedures显示文摘 | Jung Min Chang Jeong Min Lee Kyung Suk Suh Nam Joon Yi Yong Tae Kim Se Hyung Kim Joon Koo Han Byung Ihn Choi | 2005 | CardioVascular and Interventional Radiology2005，，6： | 1 |
| 12 | Appropriate diagnosis of biliary cystic tumors: comparison with atypical hepatic simple cysts显示文摘 | Jeong Kyun Seo Su Hyun Kim Sang Hyub Lee Joo Kyung Park Sang Myung Woo Ji Bong Jeong Jin-Hyeok Hwang Ji Kon Ryu Jin-Wook Kim Sook-Hyang Jeong Yong-Tae Kim Yong Bum Yoon Kuhn Uk Lee Se Hyung Kim Min A. Kim | 2010 | European Journal of Gastroenterology & Hepatology2010，，8： | 1 |
| 13 | Intermodality comparison between 3D perfusion CT and 18F-FDG PET/CT imaging for predicting early tumor response in patients with liver metastasis after chemotherapy: Preliminary results of a prospective study显示文摘 | Dong Hyun Kim Se Hyung Kim Seock-Ah Im Sae-Won Han Jin Mo Goo Jürgen K. Willmann Eun Seong Lee Jae Seon Eo Jin Chul Paeng Joon Koo Han Byung Ihn Choi | 2012 | European Journal of Radiology2012，，11： | 1 |
| 14 | Elevated circulating level of osteopontin is associated with advanced disease state of non-small cell lung cancer显示文摘 | Yoon Soo Chang Hyung Jung Kim Joon Chang Chul Min Ahn Sung Kyu Kim Se Kyu Kim | 2007 | Lung Cancer2007，，3： | 1 |
| 15 | Differentiation of large (≥5<ce:hsp sp='0.25'/>cm) gastrointestinal stromal tumors from benign subepithelial tumors in the stomach: Radiologists’ performance using CT显示文摘 | Ye Ra Choi Se Hyung Kim Sun-Ah Kim Cheong-il Shin Hyung Jin Kim Seong Ho Kim Joon Koo Han Byung Ihn Choi | 2014 | European Journal of Radiology2014，，2： | 1 |
| 16 | Betulinic acid, a bioactive pentacyclic triterpenoid, inhibits skeletal-related events induced by breast cancer bone metastases and treatment显示文摘 | Se Young Park Hyung Jeong Kim Ki Rim Kim Sun Kyoung Lee Chang Ki Lee Kwang-Kyun Park Won-Yoon Chung | 2014 | Toxicology and Applied Pharmacology2014，，： | 1 |
| 17 | Pigmented villonodular synovitis of the temporomandibular joint:MR findings in four cases显示文摘 | Kyoung Won Kima Moon Hee Han Sun-Won Park Se Hyung Kim Hyun Ju Lee Hwan Jun Jae Joon Won Kang Kee Hyun Chang | 2004 | European Journal of Radiology2004，49，： | 1 |
| 18 | CT imaging spectrum of pancreatic serous tumors: Based on new pathologic classification显示文摘 | Hye Young Sun Se Hyung Kim Min A. Kim Jae Young Lee Joon Koo Han Byung Ihn Choi | 2009 | European Journal of Radiology2009，，2： | 1 |
| 19 | The Morphological Classification of a Serous Cystic Tumor (SCT) of the Pancreas and Evaluation of the Preoperative Diagnostic Accuracy of Computed Tomography显示文摘 | Seung Eun Lee MD Yujin Kwon MD Jin-Young Jang MD PhD Young-Hun Kim MD Dae Wook Hwang MD Min A. Kim MD PhD Se Hyung Kim MD PhD Sun-Whe Kim MD PhD | 2008 | Annals of Surgical Oncology2008，，8： | 1 |
| 20 | Differentiation of large (≥5cm) gastrointestinal stromal tumors from benign subepithelial tumors in the stomach: Radiologists’ performance using CT显示文摘 | Ye Ra Choi Se Hyung Kim Sun-Ah Kim Cheong-il Shin Hyung Jin Kim Seong Ho Kim Joon Koo Han Byung Ihn Choi | 2014 | European Journal of Radiology2014，，2： | 1 |
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