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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | Engineering properties of fiber reinforced cold asphalt mixes显示文摘 | BUENO B D SILVA W R D LIMA D C | 2003 | Journal of Environmental Engineering2003，129，10： | 1 |
| 3 | A Comprehensive Strategy to Boost the Quantum Yield of Luminescence of Europium Complexes 显示文摘 | Lima N B D Gonqalves S M C Jtnior S A | 2013 | Sci Rep2013，3，： | 1 |
| 4 | Epidemic dynamics on an a- daptive network 显示文摘 | Gross T Lima C J D Blasius B | 2006 | Physical Review Letters2006，96，20： | 1 |
| 5 | Epidemic dynamics on an adaptive network 显示文摘 | Gross T D'Lima C J D Blasius B | 2006 | Physical Review Letters2006，96，20： | 1 |
| 6 | Fundamental rules to construct highly integrated organic nanowires as nanodevices显示文摘 | DE LIMA D B NERO J D | 2008 | J Comput Theor Nanosci2008，5，7： | 1 |
| 7 | IgG fe receptors provide an alternative infection route for murine gamma-herpesvirus-68显示文摘 | Rosa G T Gillet L Smith C M de Lima B D Stevenson P G | 2007 | PLoS ONE2007，2，： | 1 |
| 8 | Epidemic dynamics on an adaptive network显示文摘 | Gross T D'Lima C J D Blasius B | 2006 | Phys Rev Lett2006，96，20： | 1 |
| 9 | Diesel-like fuel obtained by pyrolysis of vegetable oils显示文摘 | Lima D G Soares V C D Ribeiro E B | 2004 | Journal of Analytical and Applied Pyrolysis2004，71，2： | 1 |
| 10 | Knowledge about HPV and screening of cervical cancer among women from the metropolitan region of natal, brazil显示文摘 | Lima E G de Lima D B Miranda C A | 2013 | ISRN Obstet Gynecoh2013，2013，93： | 1 |
| 11 | Physical Characterization and Electrochemical Activity of Bimetallic Platinum- Silver Particles for Oxygen Reduction in Alkaline Electrolyte 显示文摘 | Lima F H B Sanches C D Ticianelli E A | 2005 | J Electrochem Soc2005，152，7： | 1 |
| 12 | Diesel-like fuel obtained by pyrolysis of vegetable oils显示文摘 | Soares V C D Ribeiro E B | 2004 | Anal Appl Pyrolysis2004，71，2： | 1 |
| 13 | Epidemic dynamics on an adaptive network显示文摘 | GROSS T D'LIMA C D J BLASIUS B | 2006 | Physical Review Letters2006，96，20： | 1 |
| 14 | Multifractal IDW interpolationand fractal filtering method in environmental studies:an applicationon regional stream sediments of (Italy),Campania region显示文摘 | Lima A De Vivo B Cicchella D | 2003 | Applied Geochemistry2003，18，12： | 1 |
| 15 | Thermal degradation of biodegradable edible films based on xanthan and starches from different sources显示文摘 | Soares R M D Lima A M F Oliveira R V B | 2005 | Polym Degrad Stab2005，4，7： | 1 |
| 16 | Soybean root growth inhibition and lignification induced by p-coumaric acid显示文摘 | Zanardo D I L Lima R B Ferrarese M L L | 2009 | Environmental and Experimental Botany2009，66，1： | 1 |
| 17 | Epidemic dynamics on anadaptive network 显示文摘 | GROSS T D LIMA C J D BLASIUS B | 2006 | Physical Review Letters2006，96，20： | 1 |
| 18 | Biochar: A Synthesis of Its Agronomic Impact beyond Carbon Sequestration显示文摘 | Spokas Kurt A Cantrell Keri B M Novak Jeffrey Archer David W Ippolito James A Collins Harold P Boateng Akwasi A Lima Isabel M Lamb Marshall C McAloon Andrew J Lentz Rodrick D Nichols Kristine A | 2012 | Journal of Environmental Quality2012，，4： | 1 |
| 19 | Results of proximal arch replacement using deep hypothermia for circulatory arrest : is moderate hypothermia really justifiable? 显示文摘 | LIMA B WILLIAMS J B BHATTACHARYA S D | 2011 | Am Surg2011，77，11： | 1 |
| 20 | Fundamental rules to construct highly integrated organic nanowires as nanodeviees显示文摘 | de Lima D B Nero J D | 2008 | J Comput Theor Nanosei2008，5，7： | 1 |
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