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| 1 | 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents显示文摘Syncope belongs to the transient loss of consciousness(TLOC), characterized by a rapid onset, short duration, and spontaneous complete recovery. It is common in children and adolescents, accounting for 1% to 2% of emergency department visits.Recurrent syncope can seriously affect children's physical and mental health, learning ability and quality of life and sometimes cardiac syncope even poses a risk of sudden death. The present guideline for the diagnosis and treatment of syncope in children and adolescents was developed for guiding a better clinical management of pediatric syncope. Based on the globally recent development and the evidence-based data in China, 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents was jointly prepared by the Pediatric Cardiology Society, Chinese Pediatric Society, Chinese Medical Association(CMA)/Committee on Pediatric Syncope, Pediatricians Branch, Chinese Medical Doctor Association(CMDA)/Committee on Pediatric Cardiology, Chinese College of Cardiovascular Physicians, Chinese Medical Doctor Association(CMDA)/Pediatric Cardiology Society, Beijing Pediatric Society, Beijing Medical Association(BMA). The present guideline includes the underlying diseases of syncope in children and adolescents, the diagnostic procedures, methodology and clinical significance of standing test and headup tilt test, the clinical diagnosis vasovagal syncope, postural orthostatic tachycardia syndrome, orthostatic hypotension and orthostatic hypertension, and the treatment of syncope as well as follow-up. | Cheng Wang Yaqi Li Ying Liao Hong Tian Min Huang Xiangyu Dong Lin Shi Jinghui Sun Hongfang Jin Junbao Du Jindou An Jie Chen Mingwu Chen Qi Chen Sun Chen Yonghong Chen Zhi Chen Adolphus Kai-tung Chau Junbao Du Zhongdong Du Junkai Duan Hongyu Duan Xiangyu Dong Lin Feng Lijun Fu Fangqi Gong Yonghao Gui Ling Han Zhenhui Han Bing He Zhixu He Xiufen Hu Yimin Hua Guoying Huang Min Huang Ping Huang Yujuan Huang Hongfang Jin Mei Jin Bo Li Fen Li Tao Li Xiaohui Li Xiaoyan Liu Yan Li Haitao Lv Tiewei Lv Zipu Li Luyi Ma Silin Pan Yusheng Pang Hua Peng Yuming Qin Jie Shen Lin Shi Kun Sun Jinghui Sun Hong Tian Jie Tian Cheng Wang Hong Wang Lei Wang Jinju Wang Wendi Wang Yuli Wang Rongzhou Wu Tianhe Xia Yanyan Xiao Chunhong Xie Yanlin Xing Zhenyu Xiong Baoyuan Xu Yi Xu Hui Yan Shiwei Yang Qijian Yi Xia Yu Xianyi Yu Yue Yuan Hongyan Zhang Huili Zhang Li Zhang Qingyou Zhang Xi Zhang Yanmin Zhang Zhiwei Zhang Cuifen Zhao Bin Zhou Hua Zhu | 2018 | Science Bulletin2018，63，23： | 54 |
| 2 | Age of the Miyun dyke swarm:Constraints on the maximum depositional age of the Changcheng System显示文摘A group of NE-trending(~30°)mafic dykes,termed Miyun swarm herein,are distributed around the Miyun Reservoir,northe China,and have individual widths of over 40 m,and lengths of up to 8000 m.Baddeleyite grains were extracted from a~40 wide dyke.Using an isotope dilution thermal ionization mass spectrometry method,these grains yield an average 207Pb/206Pb a of 1731±4 Ma(n=4;or 1731±1 Ma,n=3).Because this dyke is overlain unconformably by conglomerates of the Changzhoug Formation,the lowermost formation of the Changcheng Group,the maximum depositional age of this group is constrained to no earlier than 1731 Ma.This result also suggests that the Changcheng System,with the Changcheng Group as its standard stra graphic section,is younger than 1731 Ma.The Miyun dykes possibly have distinct petrogenesis from the subsequent anorth site-rapakivi intrusions(1730-1680 Ma),which are thought to be responsible for the opening of the Yan-Liao rift,where Changcheng Group was deposited.Thus it is reasonable to set the initial boundary of the Changchengian Period at 1730 Ma slightly younger. | PENG Peng LIU Fu ZHAI MingGuo GUO JingHui | 2012 | Chinese Science Bulletin2012，57，1： | 40 |
| 3 | SHRIMP zircon U-Pb dating in Jingshan 'migmatitic granite', Bengbu and its geological significance显示文摘The petrographic characteristics of Jingshan 'migmatitic granite' and the occurrence of the magmatic zircons indicate that the granite was formed by normal crystallization of felsic melts. All zircons in the granite have inherited cores and fine-scale oscillatory zoning rims of magmatic origin. It is realized that the granite was formed at 160.2±1.3 Ma through dating magmatic zircons. The generation of the granitic magma could be related to the lithospheric mantle and/or lower crust delamination after the ultrahigh pressure metamorphism (UHPM) in Triassic. Most inherited zircons yield the ages of 217.1±6.6 Ma, which is consistent with the peak UHPM in the Dabie-Sulu orogenic belt. Some of the inherited zircons (433-722 Ma) constitute a discordia line with the upper intercept age of 850+85/-68 Ma and a lower intercept age of 261+100/-140 Ma. These ages imply that the granite could be derived from the partial melting of the crustal materials of the South China Block that was intensively superimposed by the UHPM. The UHPM could be the reason for the major Pb loss at ±220 Ma. | XU Wenliang, WANG Qinghai, YANG Debin, LIU Xiaochun & GUO Jinghui College of Earth Sciences, Jilin University, Changchun 130061, China Institute of Geomechanics, Chinese Academy of Geological Sciences, Beijing 100081, China Institute of Geology & Geophysics, Chinese Academy of Sciences, Beijing 100029, China | 2005 | Science China Earth Sciences2005，48，2： | 32 |
| 4 | Crustal growth at ~2.5 Ga in the North China Craton:evidence from whole-rock Nd and zircon Hf isotopes in the Huai'an gneiss terrane显示文摘Huai'an 片麻岩岩层主要由 TTG 片麻岩和 dioritic 片麻岩组成。在 magmatic 锆石核心标明日期的 situ U-Pb 的激光显示这些片麻岩的 protolith 在 ∼2.5 Ga 被形成。TTG 片麻岩有积极 ε 2.7 ~ 4.3 的 Nd (t) 价值,和大多数 magmatic 锆石有积极 ε 2.0 ~ 8.3 的 Hf (t) 价值。这些积极 ε Nd (t) 和 ε Hf (t) 价值两个都类似于在 2.5 Ga 的同时期的弄空的披风的那些。而且,为 magmatic 锆石的 2.44 ~ 2.73 Ga 的年轻 Hf 模型年龄接近预定锆石生长。整个岩石的 ε Nd (t) 价值由于在它的来源的古老的外壳的参与比在 TTG 片麻岩在 dioritic 片麻岩(0.8 ~ 1.7 ) 是更低的。然而,从 dioritic 片麻岩的许多 magmatic 锆石有类似的 ε Hf (t) 价值(2.0 ~ 7.9 ) 到同时代的弄空的披风的;他们 2.49 ~ 2.75 Ga 的 Hf 模型年龄接近锆石的 U-Pb 年龄。最高的 ε Hf (t) 价值接近弄空的披风,和相对高的 ε Hf (t) 价值对应于相对年轻的 Hf 模型年龄。这些 Nd 和 Hf 同位素特征建议 Huai'an 片麻岩岩层的片麻岩的这二种类型在 ca 从少年外壳发源。2.5 Ga。 | LIU Fu GUO JingHui LU XiaoPing DIWU ChunRong | 2009 | Chinese Science Bulletin2009，54，24： | 24 |
| 5 | Mapping the epigenetic modifications of DNA and RNA显示文摘Over 17 and 160 types of chemical modifications have been identified in DNA and RNA,respectively.The interest in understanding the various biological functions of DNA and RNA modifications has lead to the cutting-edged fields of epigenomics and epitranscriptomics.Developing chemical and biological tools to detect specific modifications in the genome or transcriptome has greatly facilitated their study.Here,we review the recent technological advances in this rapidly evolving field.We focus on high-throughput detection methods and biological findings for these modifications,and discuss questions to be addressed as well.We also summarize third-generation sequencing methods,which enable long-read and single-molecule sequencing of DNA and RNA modification. | Lin-Yong Zhao Jinghui Song Yibin Liu Chun-Xiao Song Chengqi Yi | 2020 | Protein & Cell2020，11，11： | 17 |
| 6 | Vortex genesis over the Bay of Bengal in spring and its role in the onset of the Asian Summer Monsoon显示文摘Physical processes associated with onset of the 1998 Asian summer monsoon were examined in detail using multi-source datasets. We demonstrated that strong ocean-atmosphere-land interaction in the northern Indian Ocean and tropical Asian area during spring is a fundamental factor that induces the genesis and development of a monsoon onset vortex over the Bay of Bengal (BOB), with the vortex in turn triggering onset of the Asian summer monsoon. In spring, strong surface sensible heating over India and the Indochina Peninsula is transferred to the atmosphere, forming prominent in situ cyclonic circulation, with anticyclonic circulations over the Arabian Sea and northern BOB where the ocean receives abundant solar radiation. The corresponding surface winds along the North Indian Ocean coastal areas cause the ocean to produce the in situ offshore currents and upwelling, resulting in sea surface temperature (SST) cooling. With precipitation on the Indochina Peninsula increasing from late April to early May, the offshore current disappears in the eastern BOB or develops into an onshore current, leading to SST increasing. A southwest-northeast oriented spring BOB warm pool with SST >31°C forms in a band from the southeastern Arabian Sea to the eastern BOB. In early May, the Somali cross-equatorial flow forms due to the meridional SST gradient between the two hemispheres, and surface sensible heat over the African land surface. The Somali flow overlaps in phase with the anticyclone over the northern Arabian Sea in the course of its inertial fluctuation along the equator. The convergent cold northerlies on the eastern side of the anticyclone cause the westerly in the inertial trough to increase rapidly, so that enhanced sensible heat is released from the sea surface into the atmosphere. The cyclonic vorticity forced by such sensible heating is superimposed on the inertial trough, leading to its further increase in vorticity strength. Since atmospheric inertial motion is destroyed, the flow deviates from the inertial track in an intensified cyclonic curvature, and then turns northward toward the warm pool in the northern BOB. It therefore converges with the easterly flow on the south side of the anticyclone over the northern BOB, forming a cyclonic circulation center east of Sri Lanka. Co-located with the cyclonic circulation is a generation of atmospheric potential energy, due to lower tropospheric heating by the warm ocean. Eventually the BOB monsoon onset vortex (MOV) is generated east of Sri Lanka. As the MOV migrates northward to the warm pool it develops quickly such that the zonal oriented subtropical high is split over the eastern BOB. Thus, the tropical southwesterly on the southern and eastern sides of the MOV merges into the subtropical westerly in the north, leading to active convection over the eastern BOB and western Indochina Peninsula and onset of the Asian summer monsoon. | WU GuoXiong GUAN Yue WANG TongMei LIU YiMin YAN JingHui MAO JiangYu | 2011 | Science China Earth Sciences2011，54，1： | 16 |
| 7 | Differential stem cell aging kinetics in Hutchinson-Gilford progeria syndrome and Werner syndrome显示文摘Hutchinson-Gilford 早衰症候群(HGPS ) 和沃纳症候群(WS ) 是二最好描绘的人的 progeroid 症候群。HGPS 被一个点变化在 lamin A (LMNA ) 基因引起,导致截断的蛋白质 productprogerin 的生产。WS 被变化在 WRN 基因引起,编码 loss-of-function RecQ DNA helicase。这里,由基因编辑,我们创造了 isogenic 人的胚胎的干细胞(转换字符) 与异质接合(G608G/+) 或同型结合(G608G/G608G ) LMNA 变化和 biallelic WRN 大美人为为 HGPS 和 WS 致病建模,分别地。当转换字符和 endothelial 房间(EC ) 没介绍早熟的老朽的任何特征时, HGPS 间充质、 WS 间充质的干细胞(MSC ) 与不同动力学显示出联系老化的显型。当 HGPS-MSCs 展出了迟了发作的尖锐早衰 characterisitcs 时, WS-MSCs 有早发作的温和早衰显型。一起拿,我们的学习比较并且形成对照不同病理 underpinning 二早衰混乱,并且提供可靠干细胞为病理学、生理的老化识别新治疗学的策略的基于的模型。 | Zeming Wu Weiqi Zhang Moshi Song Wei Wang Gang Wei Wei Li Jinghui Lei Yu Huang Yanmei Sang Piu Chan Chang Chen Jing Qu Keiichiro Suzuki Juan Carlos Izpisua Belmonte Guang-Hui Liu | 2018 | Protein & Cell2018，9，4： | 15 |
| 8 | Overexpression of potato miR482e enhanced plant sensitivity to Verticillium dahliae infection显示文摘Verticillium wilt of potato is caused by the fungus pathogen Verticillium dahliae. Present s RNA sequencing data revealed that miR482 was in response to V. dahliae infection but the function in potato is elusive. Here, we characterized potato miR482 family and its putative role resistance to Verticillium wilt. Members of the potato mi R482 superfamily are variable in sequence, but all variants target a class of disease-resistance proteins with nucleotide binding site(NBS)and leucine-rich repeat(LRR) motifs. When potato plantlets were infected with V. dahliae, the expression level of miR482e was downregulated, and that of several NBS-LRR targets of miR482e were upregulated. Transgenic potato plantlets overexpressing miR482e showed hypersensitivity to V. dahliae infection. Using s RNA and degradome datasets, we validated that miR482e targets m RNAs of NBS-LRR disease-resistance proteins and triggers the production of trans-acting(ta)si RNAs, most of which target m RNAs of defense-related proteins. Thus, the hypersensitivity of transgenic potato could be explained by enhanced miR482e and miR482e-derived tasi RNA-mediated silencing on NBS-LRR-disease-resistance proteins. It is speculated that a miR482-mediated silencing cascade mechanism is involved in regulating potato resistance against V. dahliae infection and could be a counter defense action of plant in response to pathogen infection. | Liu Yang Xiaoying Mu Chao Liu Jinghui Cai Ke Shi Wenjiao Zhu Qing Yang | 2015 | Journal of Integrative Plant Biology2015，57，12： | 14 |
| 9 | Comparative studies on histological and ultra-structure of the pituitary of different ploidy level fishes显示文摘The histological and ultra-structure of the pituitary in diploid red crucian carp(Carassius auratus red var.),triploid crucian carp and allotetraploid hybrids within and after the breeding season were comparatively studied.The result showed that there were six endocrine cell types in the pituitary of these three kinds of fishes,and there was an obvious difference in cell size among different ploidy level fishes.As for the same type of pituitary cells,the cell size was increased gradually with the in- creasing ploidy level.In the breeding season,the allotetraploid hybrids had higher proportion of go- nadotropin cells(GTH)than triploids,and the triploids had higher proportion of GTH than diploids.The results were related to the earlier sexual maturity of allotetraploid hybrids and sterility of triploid cru- cian carp.On the other hand,among the three kinds of fishes,the proportion of somatotropin(STH) cells in triploids crucian carp was the highest,whereas that in allotetraploid hybrids was the lowest. The results might be connected with the faster growth rate of triploids and slower growth rate of al- lotetraploid hybrids.In addition,in GTH cells of meso-adenohypophysis after the breeding season, there were many endocrine particles in triploids,while those endocrine particles were released from the cells in allotetraploids and diploids.This result showed that the sterility of triploid crucian carp might be related to the hormone which was not released from the GTH cells.In a word,the present study indicated that the differences in the structure of pituitary among different ploidy level fishes contributed to their difference in the growth rate and gonadal development. | LONG Yu LIU Shaojun HUANG Weiren ZHANG Jian SUN Yuandong ZHANG Chun CHEN Song LIU Jinghui LIU Yun | 2006 | Science China(Life Sciences)2006，49，5： | 13 |
| 10 | Land Surface Displacement Geohazards Monitoring Using Multi-temporal InSAR Techniques显示文摘China has been affected by some of the world’s most serious geological disasters and experiences high economic damage every year.Geohazards occur not only in remote areas but also in highly populated cities.In the framework of the Dragon-432365 Project,this paper presents the main results and the major conclusions derived from an extensive exploitation of Sentinel-1,ALOS-2(Advanced Land Observing Satellite 2),GF-3(Gao Fen Satellite 3),and latest launched SAR(Synthetic Aperture Radar),together with methods that allow the evaluation of their importance for various geohazards.Therefore,in the scope of this project,the great benefits of recent remote sensing data(wide spatial and temporal coverage)that allow a detailed reconstruction of past displacement events and to monitor currently occurring phenomena are exploited to study different areas and geohazards problems,including:surface deformation of mountain slopes;identification and monitoring of ground movements and subsidence;landslides;ground fissure;and building inclination studies.Suspicious movements detected in the different study areas were cross validated with different SAR sensors and truth data. | Guang LIU Perski ZBIGNIEW Salvi STEFANO Thiebes BENNI Lixin WU Jinghui FAN Shibiao BAI Lianhuan WEI Shiyong YAN Rui SONG Bignami CHRISTIAN Tolomei CRISTIANO Stefan SCHNEIDERBAUER Joao Sousa JOAQUIM 无 | 2021 | Journal of Geodesy and Geoinformation Science2021，4，1： | 13 |
| 11 | Characterization of Basic Nitrogen Aromatic Species Obtained during Fluid Catalytic Cracking by Fourier Transform Ion Cyclotron Resonance Mass Spectrometry显示文摘The basic-nitrogen aromatic compounds in feedstocks and liquid products from the micro-reactor and soluble components of coke obtained during fluid catalytic cracking (FCC) process were analyzed by the micro-electrospray ionization (ESI) 9.4T Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS) with an average mass resolving power of 300 000 at a mass range of 100-1 200. The analytical results revealed that the coker gas oil (CGO) contained a higher abundance of basic-nitrogen aromatic compounds with the type of -5N to -9N compared with those in deasphalted oil (DAO) and mixed FCC feedstock. After catalytic cracking, the abundance of lowly condensed basic-nitrogen aromatic compounds was much less than those of highly condensed aromatics in the liquid products, with the carbon number mainly ranging from 6 to 25 and the average carbon number of the side-chains equating to 1-5. On the contrary, with respect to the soluble components of coke, the abundance of lowly condensed basic-nitrogen aromatic compounds was more than those of highly condensed aromatics, and the carbon number ranged from 12 to 30, which was much smaller than that of the mixed FCC feedstock but slightly larger than that of the cracked liquid products. These results have provided some fundamental information on FCC process. | Liu Yingrong Wang Wei Hu Qiuling Zhu Yuxia Deng Jinghui Tian Songbai | 2012 | China Petroleum Processing & Petrochemical Technology2012，14，2： | 8 |
| 12 | Clinical features and the traditional Chinese medicine therapeutic characteristics of 293 COVID-19 inpatient cases显示文摘Coronavirus disease 2019 (COVID-19) is now pandemic worldwide and has heavily overloaded hospitals in Wuhan City, China during the time between late January and February. We reported the clinical features and therapeutic characteristics of moderate COVID-19 cases in Wuhan that were treated via the integration of traditional Chinese medicine (TCM) and Western medicine. We collected electronic medical record (EMR) data, which included the full clinical profiles of patients, from a designated TCM hospital in Wuhan. The structured data of symptoms and drugs from admission notes were obtained through an information extraction process. Other key clinical entities were also confirmed and normalized to obtain information on the diagnosis, clinical treatments, laboratory tests, and outcomes of the patients. A total of 293 COVID-19 inpatient cases, including 207 moderate and 86 (29.3%) severe cases, were included in our research. Among these cases, 238 were discharged, 31 were transferred, and 24 (all severe cases) died in the hospital. Our COVID-19 cases involved elderly patients with advanced ages (57 years on average) and high comorbidity rates (61%). Our results reconfirmed several well-recognized risk factors, such as age, gender (male), and comorbidities, as well as provided novel laboratory indications (e.g., cholesterol) and TCM-specific phenotype markers (e.g., dull tongue) that were relevant to COVID-19 infections and prognosis. In addition to antiviral/antibiotics and standard supportive therapies, TCM herbal prescriptions incorporating 290 distinct herbs were used in 273 (93%) cases. The cases that received TCM treatment had lower death rates than those that did not receive TCM treatment (17/273= 6.2% vs. 7/20= 35%, P = 0.0004 for all cases;17/77= 22% vs. 7/9= 77.7%, P = 0.002 for severe cases). The TCM herbal prescriptions used for the treatment of COVID-19 infections mainly consisted of Pericarpium Citri Reticulatae, Radix Scutellariae, Rhizoma Pinellia, and their combinations, which reflected the practical TCM principles (e.g., clearing heat and dampening phlegm). Lastly, 59% of the patients received treatment, including antiviral, antibiotics, and Chinese patent medicine, before admission. This situation might have some effects on symptoms, such as fever and dry cough. By using EMR data, we described the clinical features and therapeutic characteristics of 293 COVID-19 cases treated via the integration of TCM herbal prescriptions and Western medicine. Clinical manifestations and treatments before admission and in the hospital were investigated. Our results preliminarily showed the potential effectiveness of TCM herbal prescriptions and their regularities in COVID-19 treatment. | Zixin Shu Yana Zhou Kai Chang Jifen Liu Xiaojun Min Qing Zhang Jing Sun Yajuan Xiong Qunsheng Zou Qiguang Zheng Jinghui Ji Josiah Poon Baoyan Liu Xuezhong Zhou Xiaodong Li | 2020 | Frontiers of Medicine2020，14，6： | 7 |
| 13 | A SYBR-Green I quantitative Real-time Reverse Transcription-PCR assay for rabies viruses with different virulence显示文摘Dear Editor,To establish a more specific diagnostic assay than thecurrent methods for rabies virus(RABV)infection in ca-nines and wildlife species,we developed a SYBR-GreenI quantitative real-time reverse transcription-PCR(RT-PCR).Three primers were designed and synthesized:oneof which,located within the leader sequences and target-ed for the whole viral genome amplification to obtain | Lindong Wang Ye Liu Shoufeng Zhang Ying Wang Jinghui Zhao Fuchun Miao Rongliang Hu | 2014 | Virologica Sinica2014，29，2： | 6 |
| 14 | Efficient Carbon-Based CsPbBr_3 Inorganic Perovskite Solar Cells by Using Cu-Phthalocyanine as Hole Transport Material显示文摘Metal halide perovskite solar cells(PSCs) have attracted extensive research interest for next-generation solution-processed photovoltaic devices because of their high solar-to-electric power conversion efficiency(PCE)and low fabrication cost. Although the world's best PSC successfully achieves a considerable PCE of over 20% within a very limited timeframe after intensive efforts, the stability, high cost, and up-scaling of PSCs still remain issues. Recently, inorganic perovskite material, CsPbBr_3, is emerging as a promising photo-sensitizer with excellent durability and thermal stability, but the efficiency is still embarrassing. In this work, we intend to address these issues by exploiting CsPbBr_3 as light absorber, accompanied by using Cu-phthalocyanine(CuPc) as hole transport material(HTM) and carbon as counter electrode. The optimal device acquires a decent PCE of 6.21%, over 60% higher than those of the HTM-free devices. The systematic characterization and analysis reveal a more effective charge transfer process and a suppressed charge recombination in PSCs after introducing CuPc as hole transfer layer. More importantly, our devices exhibit an outstanding durability and a promising thermal stability, making it rather meaningful in future fabrication and application of PSCs. | Zhiyong Liu Bo Sun Xingyue Liu Jinghui Han Haibo Ye Tielin Shi Zirong Tang Guanglan Liao | 2018 | Nano-Micro Letters2018，10，2： | 5 |
| 15 | Mex3a promotes oncogenesis through the RAP1/MAPK signaling pathway in colorectal cancer and is inhibited by hsa-miR-6887-3p显示文摘Background:Although Mex3 RNA-binding family member A(Mex3a)has demonstrated an important role in multiple cancers,its role and regulatory mechanism in CRC is unclear.In this study,we aimed to investigate the role and clinical significance of Mex3a in CRC and to explore its underlying mechanism.Methods:Western blotting and quantitative real-time polymerase chain reaction(qRT-PCR)were performed to detect the expression levels of genes.5-Ethynyl-2’-deoxyuridine(EDU)and transwell assays were utilized to examine CRC cell proliferation and metastatic ability.The R software was used to do hierarchical clustering analysis and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway analysis.Overexpression and rescue experiments which included U0126,a specific mitogen activated protein kinase kinase/extracellular regulated protein kinase(MEK/ERK)inhibitor,and PX-478,a hypoxia-inducible factor 1 subunit alpha(HIF-1α)inhibitor,were used to study the molecularmechanisms of Mex3a in CRC cells.Co-immunoprecipitation(Co-IP)assay was performed to detect the interaction between two proteins.Bioinformatics analysis including available public database and Starbase software(starbase.sysu.edu.cn)were used to evaluate the expression and prognostic significance of genes.TargetScan(www.targetscan.org)and the miRDB(mirdb.org)website were used to predict the combination site between microRNA and target mRNA.BALB/c nude micewere used to study the function of Mex3a and hsa-miR-6887-3p in vivo.Results:Clinicopathological and immunohistochemical(IHC)studies of 101 CRC tissues and 79 normal tissues demonstrated that Mex3a was a significant prognostic factor for overall survival(OS)in CRC patients.Mex3a knockdown substantially inhibited the migration,invasion,and proliferation of CRC cells.Transcriptome analysis and mechanism verification showed that Mex3a regulated the RAP1 GTPase activating protein(RAP1GAP)/MEK/ERK/HIF-1αpathway.Furthermore,RAP1GAP was identified to interact with Mex3a in Co-IP experiments.Bioinformatics and dual-luciferase reporter experiments revealed that hsa-miR-6887-3p could bind to the 3’-untranslated regions(3’-UTR)of the Mex3amRNA.hsa-miR-6887-3p downregulated Mex3a expression and inhibited the tumorigenesis of CRC both in vitro and in vivo.Conclusions:Our study demonstrated that the hsa-miR-6887-3p/Mex3a/RAP1GAP signaling axis was a key regulator of CRC and Mex3a has the potential to be a new diagnostic marker and treatment target for CRC. | Haixia Li Jinghui Liang Jiang Wang Jingyi Han Shuang Li Kai Huang Chuanyong Liu | 2021 | Cancer Communications2021，41，6： | 5 |
| 16 | Polyethyleneimine modified AuPd@PdAu alloy nanocrystals as advanced electrocatalysts towards the oxygen reduction reaction显示文摘Designing the low cost, active, durable, and alcohol-tolerant cathode catalysts towards the oxygen reduction reaction(ORR) is significant for the large-scale commercialization of direct alcohol fuel cells.Recently, Pd-based nanocrystals have attracted attention as Pt-alternative cathode catalysts towards the ORR in the alkaline electrolyte. Unfortunately, the pristine Pd-based nanocrystals lack the selectivity towards the ORR due to their inherent activity for the alcohol molecule oxidation reaction in the alkaline electrolyte. In this work, polyethyleneimine(PEI) modified Au Pd alloy nanocrystals with Au-rich Au Pd alloy cores and Pd-rich Pd Au alloy shells(AuPd@PdAu-PEI) are successfully synthesized using a traditional chemical reduction method in presence of PEI. The rotating disk electrode(RDE) technique is applied to evaluate the ORR performance of AuPd@PdAu-PEI nanocrystals. Compared with commercial Pd black,AuPd@PdAu-PEI nanocrystals show significantly enhanced activity and durability towards the ORR, and simultaneously exhibit particular alcohol tolerance towards the ORR in the alkaline electrolyte. | Qi Xue Guangrui Xu Rundong Mao Huimin Liu Jinghui Zeng Jiaxing Jiang Yu Chen | 2017 | Journal of Energy Chemistry2017，26，6： | 5 |
| 17 | Aerodynamic characteristics of rigid coaxial rotor by wind tunnel test and numerical calculation显示文摘Focusing on aerodynamic characteristics of rigid coaxial rotor of a high-speed helicopter in hover and forward flight, a wind tunnel test is conducted in the 8 m ? 6 m low-speed straightflow wind tunnel of China Aerodynamics Research and Development Center. In the experiment,a 4 m diameter composite model rigid coaxial rotor is designed and manufactured, and firstorder flapping frequency ratio of the blade is 1.796 to ensure sufficient stiffness at the blade root.Rotor aerodynamic performance is measured under hovering and high advance ratio conditions.Also, the numerical method is used to calculate aerodynamic characteristics in typical states of the rigid coaxial rotor for analysis purpose. The rotor lift-drag ratio and lateral lift offset in the experiment are emphatically analyzed for the rigid coaxial rotor. The results indicate that in forward flight condition, the rotor lift-drag ratio first increases and then decreases with the increment of advance ratio and lift offset. When advance ratio remains constant, with the increment of lift offset, the lift-drag ratio of rigid coaxial rotor first increases and then decreases. | Jinghui DENG Feng FAN Ping'an LIU Shuilin HUANG Yongfeng LIN | 2019 | Chinese Journal of Aeronautics2019，32，3： | 5 |
| 18 | Combination of hydrophobically modified γ-poly(glutamic acid)and trehalose achieving high cryosurvival of RBCs显示文摘Trehalose is expected to be an alternative for toxic glycerol as a biocompatible cryoprotectant of red blood cells(RBCs).In this work,γ-poly(glutamic acid)(PGA)is modified by grafting hydrophobic phenethylamine,3,4-dimethoxyphenylethylamine and dodecylamine,respectively.The graft-modified PGA can significantly enhance cryosurvival of RBCs in combination with trehalose.Analyses of dynamic light scattering,hemolysis assay,atomic force microscope and confocal laser scanning microscope suggest that the modified PGA polymers can self-assemble into nanoparticles in phosphate buffer saline solutions at the pH range of 6.0–7.4,and exhibit membrane-disruptive activity due to hydrogen bond,conjugation and hydrophobic interactions with cell membranes.It is assumed that the modified PGA polymers can improve the cryosurvival of RBCs by promoting membrane permeability of trehalose.Among the three graft-modified polymers,phenethylamine-grafted PGA(PGA-g-PEA)can significantly increase the intracellular trehalose-loading content to 11.3±2.4 m M at pH 7.4,much higher than the value0.17±0.66 m M when trehalose is used without any polymers.In view of the aforementioned merit,the cryosurvival rate of sheep RBCs is increased to about 90%by incubation with 1.0 mg mL-1 PGA-g-PEA and 0.36 M trehalose.In vitro cell culture of L929 fibroblasts demonstrates low cytotoxicity of PGA-g-PEA.Therefore,hydrophobic PEA-modified PGA with enhanced intracellular trehalose-loading ability can be potentially applied in glycerol-free RBC cryopreservation or other related biomacromolecule delivery systems. | ZHANG QiFa LIU Bo CHONG JingHui REN LiXia ZHAO YunHui YUAN XiaoYan | 2021 | Science China(Technological Sciences)2021，64，4： | 4 |
| 19 | Impact of Meteorological Drought on Streamflow Drought in Jinghe River Basin of China显示文摘Under global climate change, drought has become one of the most serious natural hazards, affecting the ecological environment and human life. Drought can be categorized as meteorological, agricultural, hydrological or socio-economic drought. Among the different categories of drought, hydrological drought, especially streamflow drought, has been given more attention by local governments, researchers and the public in recent years. Identifying the occurrence of streamflow drought and issuing early warning can provide timely information for effective water resources management. In this study, streamflow drought is detected by using the Standardized Runoff Index, whereas meteorological drought is detected by the Standardized Precipitation Index. Comparative analyses of frequency, magnitude, onset and duration are conducted to identify the impact of meteorological drought on streamflow drought. This study focuses on the Jinghe River Basin in Northwest China, mainly providing the following findings. 1) Eleven meteorological droughts and six streamflow droughts were indicated during 1970 and 1990 after pooling using Inter-event time and volume Criterion method. 2) Streamflow drought in the Jinghe River Basin lagged meteorological drought for about 127 days. 3) The frequency of streamflow drought in Jinghe River Basin was less than meteorological drought. However, the average duration of streamflow drought is longer. 4) The magnitude of streamflow drought is greater than meteorological drought. These results not only play an important theoretical role in understanding relationships between different drought categories, but also have practical implications for streamflow drought mitigation and regional water resources management. | ZHAO Lin LYU Aifeng WU Jianjun Michael HAYES TANG Zhenghong HE Bin LIU Jinghui LIU Ming | 2014 | Chinese Geographical Science2014，24，6： | 4 |
| 20 | The Sm-Nd Geochronology of the High Pressure Basic Granulite in Laixi, Eastern Shandong显示文摘A high pressure basic granulite ultramafic rock belt, which is about 200km long and trends toward NE, occurs in the late Archaean orthogneiss in Laixi Laiyang Qixia area, eastern Shangdong. This belt is located east to the Su Lu UHPM terrane and west to the Archaean rocks of the North China craton, therefore, its geological situation and implication for collision between the North China plate and the Yangtze plate is very important. The analyzed sample of high pressure basic granulite has decreasing pressure metamorphic texture. The mineral assemblage of retrograde metamorphism is of granulite facies. The sample yields an internal mineral whole rock Sm Nd isochron age of 1725Ma. The T(DM) age of whole rock is 2788Ma. These data are very similar to those of high pressure basic granulites in Northern China craton. Considering the petrological and geochemical characteristics and isotopic ages, the high pressure granulite ultramafic rock belt in eastern Shandong is suggested to belong to the North China craton and to be of the early Precambrian lower crust. Their lifting from the lower crustal level is related to collision between the North China plate and the Yangtze plate. | Li Yonggang,Zhai Mingguo,Liu Wenjun,Guo Jinghui and Li Tiesheng (Institute of Geology, Chinese Academy of Sciences, Beijing 100029 China) | 1999 | Global Geology1999，4，1： | 4 |
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