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| 1 | Copper ions influence the toxicity of β-amyloid(1-42) in a concen-tration-dependent manner in a Caenorhabditis elegans model of Alzheimer’s disease显示文摘β-amyloid (Aβ) and copper play important roles in the pathogenesis of Alzheimer’s disease (AD).However,the behavioral correlativity and molecular mechanisms of Aβ and copper toxicity have been investigated less often.In the present study,we investigated the interaction and toxicity of Aβ1-42 and copper in the Aβ1-42 transgenic Caenorhabditis elegans worm model CL2006.Our data show that the paralysis behavior of CL2006 worms significantly deteriorated after exposure to 10-3 mol L-1 copper ions.However,the paralysis behavior was dramatically attenuated with exposure to 10-4 mol L-1 copper ions.The exogenous copper treatment also partially changed the homeostatic balance of zinc,manganese,and iron.Our data suggest that the accumulation of reactive oxygen species (ROS) was responsible for the paralysis induced by Aβ and copper in CL2006.The ROS generation induced by Aβ and copper appear to be through sod-1,prdx-2,skn-1,hsp-60 and hsp-16.2 genes. | LUO YunFeng ZHANG Jie LIU NianQing LUO Yuan ZHAO BaoLu | 2011 | Science China(Life Sciences)2011，54，6： | 26 |
| 2 | Vertical ozone profiles deduced from measurements of SBUS on FY-3 satellite显示文摘The FY-3 satellite is a second-generation Chinese polar-orbit meteorological satellite.The Solar Backscatter Ultraviolet Sounder (SBUS),one of the main payloads on the FY-3 satellite,is the first Chinese ozone-monitoring instrument on a meteorological satellite.As part of the in-orbit validation of FY-3,we carried out a retrieval trial using measurements from SBUS during the period of 17-30 July,2008,and compared those data with measurements and retrieved profiles from the National Oceanic and Atmospheric Administration (NOAA) satellite SBUV/2.The results show that the precision of the measurements and retrieved profiles are quite good.The averaged relative difference percentages of the ozone profiles retrieved from SBUS and those from SBUV/2 are within ±7%. | HUANG FuXiang LIU NianQing ZHAO MingXian WANG ShuRong HUANG Yu | 2010 | Chinese Science Bulletin2010，55，10： | 9 |
| 3 | Monitoring of the 2011 spring low ozone events in the Arctic region显示文摘Data from FY-3B SBUS and NOAA SBUV/2 were used to monitor ozone levels in the Arctic region from March 1 to April 5, 2011. Results revealed a significant ozone depletion in the area, with total ozone levels between 200-250 DU. The ozone levels recorded were 100-200 DU below normal, and in some parts the levels were as low as 200 DU, indicating a mini ozone-hole. During the sampling period, the ozone depletion area underwent identifiable expansion and detraction, a rotation around the North Pole from the west to the east, and a longitudinal movement from the Pole, spreading to the mid latitudes. The effects of these rare low ozone events were not only felt in the Arctic, but also extended to densely populated areas between Europe and the middle of Russia. In this region, rapidly increasing levels of ultraviolet radiation were detected at the Earth's surface. Given the significant risk that this poses to both the environment and people's health, this occurrence has significant global implications. | LIU NianQing 1,2 , HUANG FuXiang 1,2 WANG WeiHe 1,2 1 National Satellite Meteorological Center, Beijing 100081, China 2 Key Laboratory of Radiometric Calibration and Validation for Environmental Satellites, China Meteorological Administration, Beijing 100081, China | 2011 | Chinese Science Bulletin2011，56，27： | 8 |
| 4 | Effect of iodine supplement on iodine status and 5′-deiodinase activity in the brain of neonatal rats with iodine deficiency显示文摘 | Nianqing Liu Aijun Zuo Dongchun Liang Zhiyong Zhang Gang Guo Zhifang Chai | 2006 | Biological Trace Element Research (-)2006，，1： | 1 |
| 5 | Compositional change in human enamel irradiated with MIR free electron laser显示文摘The purpose of this study was to investigate compositional changes in human enamel irradiated with the free electron laser (FEL). The exposure on dental enamel at the wavelength of 9.64 μm was observed with the Beijing free electron laser. The distribution of elements in the irradiated or non-irradiated enamel was measured by scanning electron microscope (SEM) with energy-dispersive spectroscopy and synchrotron radiation X-ray fluorescence (SRXRF) in Beijing Synchrotron Radiation Facility (BSRF). The results showed that the P/Ca ratio in the ablation region of enamel at the maximum wavelength of infrared absorption was obviously smaller than that at the non-maximum wavelength. In the ablation region the ratios of P/Ca and Ca/Sr were smaller than those in the non-ablation region. The distributions of P, Ca and Sr in the ablation region were heterogeneous due to the element change caused by FEL irradiation. | LIU Nianqing LI Yonggui ZHU Junbiao ZHANG Liwen WANG Mingkai WU Gang YANG Xueping Li Guangcheng Huang Yuying DONG Yanmei GAO Xuejun | 2001 | Chinese Science Bulletin2001，46，23： | 0 |
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