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| 1 | Association of KIR Genotypes and Haplotypes with Susceptibility to Chronic Hepatitis B Virus Infection in Chinese Han Population显示文摘Killer immunoglobulin-like receptor (KIR) genes can regulate the activation of NK and T cells upon interaction with HLA class I molecules. Hepatitis B virus (HBV) infection has been regarded as a multi-factorial disorder disease. Previous studies revealed that KIRs were involved in HCV and HIV infection or clearance. The aim of this study was to explore the possibility of the inheritance of KIR genotypes and haplotypes as a candidate for susceptibility to persistent HBV infection or HBV clearance. The sequence specific primer polymerase chain reaction (SSP-PCR) was employed to identify the KIR genes and pseudogenes in 150 chronic hepatitis B (CHB) patients, 251 spontaneously recovered (SR) controls, and 412 healthy controls. The frequencies of genotype G, M, FZ1 increased in CHB patients compared with healthy control subjects. The frequency of genotype AH was higher in SR controls than that in both CHB patients and healthy controls. The carriage frequencies of genotype G and AH were higher; while, the frequencies of AF and AJ were lower in SR controls than those in healthy control subjects. The frequency of A haplotype was lower, whereas, the frequency of B haplotype was higher in CHB patients and SR controls than those in healthy controls. In healthy controls, haplotype 4 was found lower compared with that in CHB patients and SR controls and the frequency of haplotype 5 was higher in SR controls than that in other two groups. Based on these findings, it seems that the genotypes M and FZ1 are HBV susceptive genotypes; AH, on the other hand, may be protective genotypes that facilitate the clearance of HBV. It appears that the haplotype 4 is HBV susceptive haplotype, whereas, haplotype 5 may be the protective haplotype that facilitates the clearance of HBV. | Zhiming Lu Bingchang Zhang Shijun Chen Zhongtao Gai Zhaolei Feng Xiangdong Liu Yiqing Liu Xin Wen Li Li Yulian Jiao Chunyan Ma Song Shao Xiangfa Cui Guojian Chen Jianfeng Li Yneran Zhao | 2008 | Cellular & Molecular Immunology2008，5，6： | 13 |
| 2 | Anti-scourability of purple soil on hillslopes with different land uses显示文摘A large-scale flume (40 cm×10 cm×10 cm) was used to determine soil anti-scourability of 4 different land uses of purple soil in hilly areas of Sichuan, China under artificial removal of vegetation to examine the effects of land uses on sediment production by runoff. The results showed that soil anti-scourability declined with the increase of slope gradients in the form of power function, but there was a significant difference in the effects of slope gradients on anti-scourability between different land uses. The ratio of the mean values of soil anti-scourability was 1︰2.2︰2.5︰3.6 for forest land, new waste pasture, old waste pasture, crop land respectively, indicating that forest and grass use can significantly improve soil anti-scourability. Compared with the observations from the runoff plots located at the same sites in this region, an inconsistent result was found between anti-scourability and anti-erodibility in hilly areas of Sichuan. Essential causes of the differences in soil anti-scourability were further discussed based on analyzing the influence of inherent soil characteristics induced by different land uses on soil anti-scourability. | ZHANG Jianhui, LIU Gangcai, NI Shijun, ZHU Bo & GE Fanglong Institute of Mountain Hazards and Environment, Chinese Academy of Sciences and Ministry of Water Resources, Chengdu 610041, China Chengdu University of Technology, Chengdu 610059, China | 2003 | Science China(Technological Sciences)2003，46，z1： | 8 |
| 3 | Evaluation of drinking water treatment combined filter backwash water recycling technology based on comet and micronucleus assay显示文摘Based on the fact that recycling of combined filter backwash water(CFBW)directly to drinking water treatment plants(WTP)is considered to be a feasible method to enhance pollutant removal efficiency,we were motivated to evaluate the genotoxicity of water samples from two pilot-scale drinking water treatment systems,one with recycling of combined backwash water,the other one with a conventional process.An integrated approach of the comet and micronucleus(MN)assays was used with zebrafish(Danio rerio)to investigate the water genotoxicity in this study.The total organic carbon(TOC),dissolved organic carbon(DOC),and trihalomethane formation potential(THMFP),of the recycling process were lower than that of the conventional process.All the results showed that there was no statistically significant difference(P>0.05)between the conventional and recycling processes,and indicated that the genotoxicity of water samples from the recycling process did not accumulate in 15 day continuous recycling trial.It was worth noting that there was correlation between the concentrations of TOC,DOC,UV_(254),and THMFPs in water and the DNA damage score,with corresponding R^2 values of 0.68,0.63,0.28,and 0.64.Nevertheless,both DNA strand breaks and MN frequency of all water samples after disinfection were higher than that of water samples from the two treatment units,which meant that the disinfection by-products(DBPs)formed by disinfection could increase the DNA damage.Both the comet and MN tests suggest that the recycling process did not increase the genotoxicity risk,compared to the traditional process. | Ting Chen Yongpeng Xu Zhiquan Liu Shijun Zhu Wenxin Shi Fuyi Cui | 2016 | Journal of Environmental Sciences2016，28，4： | 8 |
| 4 | Seasonal variation of snow microbial community structure in the East Rongbuk glacier, Mt. Everest显示文摘The bacterial diversity and abundance in the snow of East Rongbuk glacier, Mt. Everest were examined through 16S rRNA gene clone library and flow cytometry approaches. In total, 35 16S rRNA gene sequences were obtained, which belong to α, β, γ-Proteobacteria, Actinobacteria, Firmicutes, CFB, Cyanobacteria, Eukaryotic chloroplast, and TM7 candidate phylum respectively. γ-Proteobacteria was the dominant bacterial group in this region, while the genera Acinetobacter and Leclercia were domi- nant on the genus level. The community structure varied seasonally. The bacterial abundance in sum- mer snow was higher than that in winter. Moreover, the snow bacterial community structures in both seasons were diverse, with not only common species but season-specific species. The common species most likely originated from the Tibet Plateau. Bacteria in summer snow are affiliated with marine environ- ment, whereas bacteria in winter snow are closely related to more diverse environments and show the feature of resistance to cold. Seasonal variations of abundance and bacterial diversity were most proba- bly due to the seasonal characteristics of climate and atmospheric circulation in Mt. Everest. | LIU Yongqin YAO Tandong KANG Shichang JIAO Nianzhi ZENG Yonghui SHI Yang LUO Tingwei JING Zhefang HUANG Shijun | 2006 | Chinese Science Bulletin2006，51，12： | 7 |
| 5 | Rational cutting height for large cutting height fully mechanized top-coal caving显示文摘Large cutting height fully mechanized top-coal caving is a new mining method that improves recovery ratio and single-pass production. It also allows safe and efficient mining. A rational cutting height is one key parameter of this technique. Numerical simulation and a granular-media model experiment were used to analyze the effect of cutting height on the rock pressure of a fully mechanized top-coal caving work face. The recovery ratio was also studied. As the cutting height increases the top-coal thickness is reduced. Changing the ratio of cutting to drawing height intensifies the face pressure and the top-coal shattering. A maximum cutting height exists under a given set of conditions due to issues with surrounding rock-mass control. An increase in cutting height makes the top-coal cave better and the recovery ratio when drawing top-coal is then improved. A method of adjusting the face rock pressure is presented. Changing the cutting to drawing height ratio is the technique used to control face rock pressure. The recovery ratio when cutting coal exceeds that when caving top-coal so the face recovery ratio may be improved by over sizing the cutting height and increasing the top-coal drawing ratio. An optimum ratio of cutting to drawing height exists that maximizes the face recovery ratio. A rational cutting height is determined by comprehensively considering the surrounding rock-mass control and the recovery ratio. At the same time increasing the cutting height can improve single pass mining during fully mechanized top-coal caving. | Huang Bingxiang Li Hongtao Liu Changyou Xing Shijun Xue Weichao | 2011 | Mining Science and Technology2011，21，3： | 7 |
| 6 | Contribution of Baroreflex Afferent Pathway to NPY-Mediated Regulation of Blood Pressure in Rats显示文摘Neuropeptide Y (NPY), a metabolism-related cardiovascular factor, plays a crucial role in blood pressure(BP) regulation via peripheral and central pathways. The expression of NPY receptors (Y1R/Y2R) specific to baroreflex afferents impacts on the sexually dimorphic neural control of circulation. This study was designed to investigate the expression profiles of NPY receptors in the nodose ganglion (NG) and nucleus tractus solitary (NTS) under hypertensive conditions. To this end, rats with hypertension induced by NG-nitro-L-arginine methylester (L-NAME) or high fructose drinking (HFD), and spontaneously hypertensive rats (SHRs) were used to explore the effects/mechanisms of NPY on BP using functional, molecular, and electrophysiological approaches. The data showed that BP was elevated along with baroreceptor sensitivity dysfunction in model rats;Y1R was up-or down-regulated in the NG or NTS of male and female HFD/L-NAME groups,while Y2R was only down-regulated in the HFD groups as well as in the NG of the male L-NAME group. In SHRs,Y1R and Y2R were both down-regulated in the NTS, and not in the NG. In addition to NPY-mediated energy homeostasis, leptin-melanocortin activation may be essential for metabolic disturbance-related hypertension. We found that leptin and a-melanocyte stimulating hormone (aMSH) receptors were aberrantly down-regulated in HFD rats. In addition, a-MSH concentrations were reduced and NPY concentrations were elevated in the serum and NTS at 60 and 90 min after acute leptin infusion. Electrophysiological recordings showed that the decay time-constant and area under the curve of excitatory post-synaptic currents were decreased by Y1R activation in A-types, whereas, both were increased by Y2R activation in Ah-or C-types. These results demonstrate that sex-and afferent-specific NPY receptor expression in the baroreflex afferent pathway is likely to be a novel target for the clinical management of metabolism-related and essential hypertension. | Yang Liu Shu-Yang Zhao Yan Feng Jie Sun Xiao-Long Lu Qiu-Xin Yan Ying Li Zhuo Liu Lu-Qi Wang Xun Sun Shijun Li Guo-Fen Qiao Bai-Yan Li | 2020 | Neuroscience Bulletin2020，36，4： | 5 |
| 7 | Distinct immune signatures discriminate between asymptomatic and presymptomatic SARS-CoV-2^(pos)subjects显示文摘Increasing numbers of SARS-CoV-2-positive(SARS-CoV-2^(pos))subjects are detected at silent SARS-CoV-2 infection stage(SSIS).Yet,SSIS represents a poorly examined time-window wherein unknown immunity patterns may contribute to the fate determination towards persistently asymptomatic or overt disease.Here,we retrieved blood samples from 19 asymptomatic and 12 presymptomatic SARS-COV-2^(pos)subjects,47 age/gender-matched patients with mild or moderate COVID-19 and 27 normal subjects,and interrogated them with combined assays of 44-plex CyTOF,RNA-seq and Olink.Notably,both asymptomatic and presymptomatic subjects exhibited numerous readily detectable immunological alterations,while certain parameters including more severely decreased frequencies of CD107a^(low)classical monocytes,intermediate monocytes,non-classical monocytes and CD62L^(hi)CD8^(+)Tnaive cells,reduced plasma STC1 level but an increased frequency of CD4^(+)NKT cells combined to distinguish the latter.Intercorrelation analyses revealed a particular presymptomatic immunotype mainly manifesting as monocytic overactivation and differentiation blockage,a likely lymphocyte exhaustion and immunosuppression,yielding mechanistic insights into SSIS fate determination,which could potentially improve 5ARS-CoV-2 management. | Shanhe Yu Caixia Di Shijun Chen Mingquan Guo Jiayang Yan Zhaoqin Zhu Li Liu Ruixue Feng Yinyin Xie Ruihong Zhang Juan Chen Mengxi Wang Dong Wei Hai Fang Tong Yin Jinyan Huang Saijuan Chen Hongzhou Lu Jiang Zhu Jieming Qu | 2021 | Cell Research2021，31，11： | 4 |
| 8 | Chromosome-scale genome assembly of sweet cherry(Prunus avium L.)cv.Tieton obtained using long-read and Hi-C sequencing显示文摘Sweet cherry(Prunus avium)is an economically significant fruit species in the genus Prunus.However,in contrast to other important fruit trees in this genus,only one draft genome assembly is available for sweet cherry,which was assembled using only Illumina short-read sequences.The incompleteness and low quality of the current sweet cherry draft genome limit its use in genetic and genomic studies.A high-quality chromosome-scale sweet cherry reference genome assembly is therefore needed.A total of 65.05 Gb of Oxford Nanopore long reads and 46.24 Gb of Illumina short reads were generated,representing~190x and 136x coverage,respectively,of the sweet cherry genome.The final de novo assembly resulted in a phased haplotype assembly of 344.29 Mb with a contig N50 of 3.25 Mb.Hi-C scaffolding of the genome resulted in eight pseudochromosomes containing 99.59%of the bases in the assembled genome.Genome annotation revealed that more than half of the genome(59.40%)was composed of repetitive sequences,and 40,338 protein-coding genes were predicted,75.40%of which were functionally annotated.With the chromosomescale assembly,we revealed that gene duplication events contributed to the expansion of gene families for salicylic acid/jasmonic acid carboxyl methyltransferase and ankyrin repeat-containing proteins in the genome of sweet cherry.Four auxin-responsive genes(two GH3s and two SAURs)were induced in the late stage of fruit development,indicating that auxin is crucial for the sweet cherry ripening process.In addition,772 resistance genes were identified and functionally predicted in the sweet cherry genome.The high-quality genome assembly of sweet cherry obtained in this study will provide valuable genomic resources for sweet cherry improvement and molecular breeding. | Jiawei Wang Weizhen Liu Dongzi Zhu Po Hong Shizhong Zhang Shijun Xiao Yue Tan Xin Chen Li Xu Xiaojuan Zong Lisi Zhang Hairong Wei Xiaohui Yuan Qingzhong Liu | 2020 | Horticulture Research2020，7，1： | 4 |
| 9 | Evolvement behavior of microstructure and H_2O adsorption of lignite pyrolysis显示文摘The effect of pyrolysis on the microstructure and moisture adsorption of lignite was investigated with low field nuclear magnetic resonance spectroscopy. Changes in oxygen-containing groups were analyzed by Fourier transform infrared spectroscopy(FTIR), and H2 O adsorption mechanism on the surface of lignite pyrolysis was inferred. Two major changes in the pore structure of lignite char were observed as temperature increased in 105–200 °C and500–700 °C. Pyrolysis temperature is a significant factor in removing carboxyl and phenolic hydroxyl from lignite.Variation of ether bond content can be divided into three stages; the content initially increased, then decreased,and finally increased. The equilibrium adsorption ratio, content of oxygen-containing groups, and variation of pore volume below 700° were closely correlated with each other. The amount of adsorbed water on char pyrolyzed at700 °C increased. Moreover, the adsorption capacity of the lignite decreased, and the adsorption state changed. | Yingyue Teng Shijun Lian Quansheng Liu Yuzhe Liu Yinmin Song Runxia He Keduan Zhi | 2016 | Chinese Journal of Chemical Engineering2016，24，6： | 3 |
| 10 | Arbuscular mycorrhizal fungi differ in affecting the flowering of a host plant under two soil phosphorus conditions显示文摘Aims Studies have showed that arbuscular mycorrhizal fungi(AMF)can greatly promote the growth of host plants,but how AMF affect flow-ering phenology of host plants is not well known.Here,we con-ducted a pot experiment to test whether life cycle and flowering phenology traits of host plant Medicago truncatula Gaertn can be altered by AMF under low and high soil phosphorus(P)levels.Methods the experiment was conducted in a greenhouse at Zhejiang University in China(120°19′E,30°26′N)and had a completely ran-domized design with two factors:AMF treatments and soil P levels.Six AMF species(Acaulospora scrobiculata,As;Gigaspora marga-rita,Gma;Funneliformis geosporum,Fg;Rhizophagus intraradices,Ri;Funneliformis mosseae,Fmo and Glomus tortuosum,Gt.)were used,and two soil P levels(24.0 and 5.7 mg kg−1 Olsen-soluble P)were designed.the six AMF species were separately inoculated or in a mixture(Mix),and a non-AMF control(NAMF)was included.When plants began to flower,the number of flowers in each pot was recorded daily.During fruit ripening,the number of mature fruits was also recorded daily.After~4 months,the biomass,bio-mass P content and AMF colonization of host plant were measured.Correlation between root colonization and first flowering time,or P content and first flowering time was analyzed.Important Findings Under the low P level,first flowering time negatively correlated with root colonization and biomass P.Only host plants with AMF spe-cies As,Fg,Ri,or Mix were able to complete their life cycle within 112 days after sowing.And treatment with AMF species Fg,Gt,or As resulted in two periods of rapid flower production while other fungi treatments resulted in only one within 112 days after sowing.the cumulative number of flowers produced and biomass P content were highest with species Fg.Host biomass allocation significantly differed depending on the species of AMF.Under both soil P levels,the host plant tended to allocate more biomass to fruits in the Mix treatment than in the other treatments.these results indicated that the effects of AMF on host flowering phenology and biomass allocation differed depending on AMF species and soil P levels. | Shijun Liu Hanling Guo Jing Xu Zeyuan Song Shurui Song Jianjun Tang Xin Chen | 2018 | Journal of Plant Ecology2018，11，4： | 3 |
| 11 | A review of Behcet's disease from the perspectives of both Western and Chinese Medicine显示文摘Behcet's disease is a condition with a complicated and unclear etiology that comprises multi-systemic, chronic, inflammatory vasculitis. Behcet's disease can affect every tissue and organ in the body,and is characterized by recurrent oral and genital ulcers, ocular inflammation, skin lesions, and other manifestations. The incidence of Behcet's disease has a distinct regional specificity, and is most prevalent along the Silk Road, a route that stretched between the Mediterranean, Middle East and Far East.This article reviews the recent literature to evaluate the prevalence, clinical manifestations, pathogenesis and mechanism, and current treatments of Behcet's disease. Furthermore, the etiology of Behcet's disease will be evaluated from the aspect of Traditional Chinese Medicine(TCM) syndrome differentiation. As Behcet's disease is complex and intractable, its treatment warrants further research.Traditionally, Behcet's disease is treated with Western Medicine(WM) via medications that act locally and systemically; this WM treatment protocol usually has a good effect, but relapse can occur after reducing the dosage. Thus, it may be ideal to treat Behcet's disease via a combination of WM and TCM.Recent studies have indicated that such a combination of Chinese and Western treatments has a better effect than either treatment alone. The aim of the present review is to describe the clinical features of Behcet's disease, and to outline its possible pathogenesis in terms of both TCM and WM. Based on these findings, the present review proposes a Behcet's disease treatment protocol composed of a combination of Chinese and WM that can effectively improve the occurrence of relapse caused by the reduction of the dosage of Western medication. | Zhang Jing Tang Yuping Liu Pei Zhou Guisheng Kang An Yue Shijun Chen Yanyan Duan Jinao | 2019 | Journal of Traditional Chinese Medicine2019，39，1： | 3 |
| 12 | On the Mechanism of Transformation fromPrimary Ores into Oxidized Ores in FinelyDisseminated Gold Deposits显示文摘This paper, taking the finely disseminated gold deposits in southwestern Guizhou and northwestern Guangxi as examples, discusses the difference between the occurrence of primary ores and that of oxidized ores, analyzes the occurrence mechanism in terms of crystallochemistry and geochemistry, and especially studies the chemical model for supergene leaching transformation of clay minerals in the two types of ores. This study proposes a new idea for dressing and smelting technology for primary gold ores. | LIU Xianfan NI Shijun JIN Jingfu LU Qiuxia ZHANG Xingchun | 1998 | Acta Geologica Sinica(English Edition)1998，72，3： | 2 |
| 13 | Hydrogen storage of multiwalled carbon nanotubes coated with Pd-Ni nanoparticles under moderate conditions显示文摘A type of novel material with a high hy-drogen storage capacity was prepared by supporting PdNi18 alloy nanoparticles,which were synthesized by using a new colloid method,on the surface of pretreated multiwalled carbon nanotubes (MWCNTs). The average PdNi18 alloy particle sizes calculated from XRD patterns were ca. 3 nm,and the high dis-persion of these particles on MWCNTs was con-firmed by TEM image. Hydrogen storage perform-ance of the composite was investigated under mod-erate pressure (0.1―1.5 MPa) at room temperature,and a maximum storage capacity of ca. 2.3 wt% was achieved under 1.5 MPa at room temperature,which was much higher than that reported previously under the same conditions. | REN Jianwei LIAO Shijun LIU Junmin | 2006 | Chinese Science Bulletin2006，51，24： | 2 |
| 14 | Label propagation dictionary learning based process monitoring method for industrial process with between-mode similarity显示文摘With the development of the industrial cyber-physical systems,a small amount of labeled data and a large amount of unlabeled data are collected from the industrial process.Due to the variation of internal operation conditions and external environment,there is a between-mode similarity between data samples.The scarcity of labeled data and the existence of similarity make it challenging to extract data characteristics.In addition,it creates new challenges to process monitoring.To solve these problems,this study proposes a label propagation dictionary learning method.We first establish the connection between atoms and corresponding profiles and realize the propagation of their labels through graph Laplacian regularization.Then,considering the similarity of samples in the same class,the low-rank constraint is added to sparse coding to strengthen the mutual propagation of labels.Finally,an optimization method is designed to obtain the dictionary and classifier simultaneously.When new data samples arrive,we conduct process monitoring and condition prediction based on the learned dictionary and classifier.Experiments show that the proposed method can achieve satisfactory monitoring performance when compared to several state-of-the-art methods,indicating the superiority of the proposed method. | Keke HUANG Shijun TAO Yishun LIU Chunhua YANG Weihua GUI | 2022 | Science China(Information Sciences)2022，65，1： | 2 |
| 15 | RAMAN SPECTRAL STUDY ON ISOPOLYTUNGSTATES IN AQUEOUS SOLUTION显示文摘INTRODUCTIONAlargenumberofstudieshavebendoneinthefieldoftheaqueouschemistryofisopolytungstateusingnumerousexperimentalmetho... | Liu, Shijun Chen, Qiyuan Zhang, Pingmin Li, Songqin | 1998 | 中国有色金属学会会刊:英文版1998，8，4： | 2 |
| 16 | Accurate annotation of accessible chromatin in mouse and human primordial germ cells显示文摘广泛、精确的染色质改变在初发的细菌房间(PGC ) 期间是必要的为越过代的基因信息的永存的开发。这里,我们报导 DNase 我过分敏感的地点(DHS ) 标记的远侧的 cis 规章的元素(CRE ) 在鼠标和人的 PGC 开发期间显示出时间地限制的活动。把 DHS 地图用作代理,我们精确地在老鼠 PGC 定位 pluripotency 抄写因素的染色体宽的有约束力的地点。出人意料地,我们发现老鼠女性 meiotic 再结合热点能被 DHS 捕获,并且第一次,我们在老鼠女性 PGC 识别了 12,211 个再结合热点。与 meiotic 女性 PGC 的相对照,有丝分裂拘捕的男 PGC 的染色质 ? 通过在远侧的规章的区域的原子抄写因素 Y (NFY ) 绑定是容许的。而且,我们在 PGC CRE 上检验了进化压力,并且比较 genomic 分析表明那只老鼠和人的 PGC CRE evolutionarily 在哺乳动物外面越过脊椎动物树被保存并且出现强壮的保存。因此,我们的结果在鼠标和人的 PGC 开发期间揭示唯一的、时间地可存取的染色质配置。 | Jingyi Li Shijun Shen Jiayu Chen Wenqiang Liu Xiaocui Li Qianshu Zhu Beiying Wang Xiaolong Chen Li Wu Mingzhu Wang Liang Gu Hong Wang Jiqing Yin Cizhong Jiang Shaorong Gao | 2018 | Cell Research2018，28，11： | 2 |
| 17 | Artemisinin analogue SM934 protects against lupus-associated antiphospholipid syndrome via activation of Nrf2 and its targets显示文摘Kidney is a major target organ in both antiphospholipid syndrome(APS)and systemic lupus erythematosus(SLE).The etiology of antiphospholipid syndrome nephropathy associated lupus nephritis(APSN-LN)is intricate and remains largely unrevealed.We proposed in present work,that generation of antiphospholipid antibodies(aPLs),especially those directed towards the oxidized neoepitopes,are largely linked with the redox status along with disease progression.Moreover,we observed that compromised antioxidative capacity coincided with turbulence of inflammatory cytokine profile in the kidney of male NZW×BXSB F1 mice suffered from APSN-LN.SM934 is an artemisinin derivative that has been proved to have potent immunosuppressive properties.In current study,we elaborated the therapeutic benefits of SM934 in male NZW×BXSB F1 mice,a murine model develops syndrome resembled human APS associated with SLE,for the first time.SM934 treatment comprehensively impeded autoantibodies production,inflammatory cytokine accumulation and excessive oxidative stress in kidney.Among others,we interpreted in present work that both anti-inflammatory and antioxidative effects of SM934 is closely correlated with the enhancement of Nrf2 signaling and expression of its targets.Collectively,our finding confirmed that therapeutic strategy simultaneously exerting antioxidant and anti-inflammatory efficacy provide a novel feasible remedy for treating APSN-LN. | Zemin Lin Yuting Liu Li Chen Shiqi Cao Yueteng Huang Xiaoqian Yang Fenghua Zhu Wei Tang Shijun He Jianping Zuo | 2021 | Science China(Life Sciences)2021，64，10： | 2 |
| 18 | Mycobacterium tuberculosis latency-associated antigen Rv1733c SLP improves the accuracy of differential diagnosis of active tuberculosis and latent tuberculosis infection显示文摘Background: Differential diagnosis of active tuberculosis (ATB) and latent tuberculosis infection (LTBI) has been a challenge for clinicians in high TB burden countries. The purpose of this study was to improve the accuracy of differential diagnosis of ATB and LTBI by using fluorescent immunospot (FluoroSpot) assay to detect specific Th1 cell immune responses. The novelmycobacterium tuberculosis (MTB) latency-associated antigens Rv1733c and synthetic long peptides derived from Rv1733c (Rv1733c SLP) were used based on virulence factors early secreting antigen target-6 (ESAT-6) and culture filtrate protein-10 (CFP-10).Methods: Fifty-seven ATB cases, including 20 pathogen-confirmed ATB and 37 clinically diagnosed ATB, and 36 LTBI cases, were enrolled between January and December 2017. FluoroSpot assay was used to detect the interferon γ (IFN-γ) and interleukin 2 (IL-2) secreted by the specific T cells after being stimulated with MTB virulence factors ESAT-6 and CFP-10, MTB latency-associated antigens Rv1733c and Rv1733c SLP. The receiver operating characteristic (ROC) curve was used to define the best cutoff value of latency-associated antigens in the use of differentiating ATB and LTBI. The sensitivity, specificity, predictive value, and likelihood ratio of ESAT-6 and CFP-10-FluoroSpot combined with latency-associated antigen in the differential diagnosis of ATB and LTBI were also calculated.Results: Following the stimulation with Rv1733c and Rv1733c SLP, the frequency of single IL-2-secreting T cells stimulated by Rv1733c SLP had the largest area under the ROC curve, which was 0.766. With a cutoff value of 1 (spot-forming cells [SFCs]/2.5 × 105 peripheral blood mononuclear cells) for frequency, the sensitivity and specificity of distinguishing ATB from LTBI were 72.2% and 73.7%, respectively. ESAT-6 and CFP-10-FluoroSpot detected the frequency and proportion of single IFN-γ-secreting T cells;the sensitivity and specificity of distinguishing ATB from LTBI were 82.5% and 66.7%, respectively. Combined with the frequency of single IL-2-secreting T cells stimulated by Rv1733c SLP on the basis of ESAT-6 and CFP-10-FluoroSpot, the sensitivity and specificity increased to 84.2% and 83.3%, respectively.Conclusion: Rv1733c SLP, combined with ESAT-6 and CFP-10, might be used as a candidate antigen for T cell-based tuberculosis diagnostic tests to differentiate ATB from LTBI. | Lifan Zhang Huimin Ma Shijun Wan Yueqiu Zhang Mengqiu Gao Xiaoqing Liu | 2022 | Chinese Medical Journal2022，，1： | 2 |
| 19 | An imputed whole-genome sequence-based GWAS approach pinpoints causal mutations for complex traits in a specific swine population显示文摘Sequencing-based genome-wide association studies(GWAS) have facilitated the identification of causal associations between genetic variants and traits in diverse species. However, it is cost-prohibitive for the majority of research groups to sequence a large number of samples. Here, we carried out genotype imputation to increase the density of single nucleotide polymorphisms in a large-scale Swine F;population using a reference panel including 117 individuals, followed by a series of GWAS analyses. The imputation accuracies reached 0.89 and 0.86 for allelic concordance and correlation, respectively. A quantitative trait nucleotide(QTN) affecting the chest vertebrate was detected directly, while the investigation of another QTN affecting the residual glucose failed due to the presence of similar haplotypes carrying wild-type and mutant allelesin the reference panel used in this study. A high imputation accuracy was confirmed by Sanger sequencing technology for the most significant loci. Two candidate genes,CPNE5 and MYH3, affecting meat-related traits were proposed. Collectively, we illustrated four scenarios in imputation-based GWAS that may be encountered by researchers, and our results will provide an extensive reference for future genotype imputation-based GWAS analyses in the future. | Guorong Yan Xianxian Liu Shijun Xiao Wenshui Xin Wenwu Xu Yiping Li Tao Huang Jiangtao Qin Lei Xie Junwu Ma Zhiyan Zhang Lusheng Huang | 2022 | Science China(Life Sciences)2022，65，4： | 2 |
| 20 | Heat capacity of potassium tungstates K2WnO3n+1(n=2,3,4) at temperature from 273 K to 979 K显示文摘 | Chen Qiyuan Liu Shijun Zang Pingmin | 1999 | J Chem Thermodynamics1999，31，4： | 1 |
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