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| 1 | Incidence and mortality of stomach cancer in China,2014显示文摘Objective: In this study,we aimed to estimate the updated incidence and mortality rate of stomach cancer based on the cancer registration data in 2014,collected by the National Central Cancer Registry of China(NCCRC).Methods: In 2017,339 registries' data were qualified based on the criteria of data quality control of the NCCRC.Cases of stomach cancer were retrieved from the national database.We estimated numbers of stomach cancer cases and deaths in China using age-specific rates and corresponding national population stratified by area,sex,agegroup(0,1–4,5–9,10–14,…,85+).Chinese standard population in 2000 and Segi's world population were applied for age-standardized incidence and mortality rates.Results: In 2014,410,400 new stomach cancer cases and 293,800 cancer-associated deaths were estimated to have occurred in China.The crude incidence rate of stomach cancer was 30.00/100,000,age-standardized incidence rates by Chinese standard population(ASIRC) and by world standard population(ASIRW) were 19.62/100,000 and19.51/100,000,respectively.The crude mortality rate of stomach cancer was 21.48/100,000,age-standardized mortality rates by Chinese(ASMRC) and by world standard population(ASMRW) were 13.44/100,000 and13.30/100,000,respectively.Incidence and mortality rates in rural areas were both higher than that in urban areas.Stomach cancer has a strong relationship with gender and age.The disease has occurred more frequently among men than women with a male to female ratio of 2.4 for ASIRC.After age group of 40-44 years,incidence rates are substantially higher in men than in women,same pattern was seen for age-specific mortality rates.Conclusions: There is still a heavy burden of stomach cancer in China.The incidence and mortality patterns of stomach cancer show substantial gender and regional disparities.Great effort is needed to provide more accessible health services,sufficient financial resources,and adequate cancer-care infrastructure for the Chinese population,especially for people living in rural areas. | Lei Yang Rongshou Zheng Ning Wang Yannan Yuan Shuo Liu Huichao Li Siwei Zhang Hongmei Zeng Wanqing Chen | 2018 | Chinese Journal of Cancer Research2018，30，3： | 114 |
| 2 | Transplantation of UC-MSCs on collagen scaffold activates follicles in dormant ovaries of POF patients with long history of infertility显示文摘Premature ovarian failure(POF) is a refractory disease for clinical treatment with the goal of restoring fertility. In this study,umbilical cord mesenchymal stem cells on a collagen scaffold(collagen/UC-MSCs) can activate primordial follicles in vitro via phosphorylation of FOXO3 a and FOXO1. Transplantation of collagen/UC-MSCs to the ovaries of POF patients rescued overall ovarian function, evidenced by elevated estradiol concentrations, improved follicular development, and increased number of antral follicles. Successful clinical pregnancy was achieved in women with POF after transplantation of collagen/UC-MSCs or UC-MSCs. In summary, collagen/UC-MSC transplantation may provide an effective treatment for POF. | Lijun Ding Guijun Yan Bin Wang Lu Xu Yan Gu Tong Ru Xiaoying Cui Lei Lei Jingyu Liu Xiaoqiang Sheng Bin Wang Chunxue Zhang Yanjun Yang Ruiwei Jiang Jianjun Zhou Na Kong Feifei Lu Huaijun Zhou Yannan Zhao Bing Chen Yali Hu Jianwu Dai Haixiang Sun | 2018 | Science China(Life Sciences)2018，61，12： | 43 |
| 3 | Deficient plastidic fatty acid synthesis triggers cell death by modulating mitochondrial reactive oxygen species显示文摘 | Jian Wu Yuefeng Sun Yannan Zhao Jian Zhang Lilan Luo Meng Li Jinlong Wang Hong Yu Guifu Liu Liusha Yang Guosheng Xiong Jian-Min Zhou Jianru Zuo Yonghong Wang Jiayang Li | 2015 | Cell Research2015，25，5： | 13 |
| 4 | Cancer incidence in Beijing, 2014显示文摘Objective: To analyze cancer incidence data in Beijing in 2014 and temporal trends for selected common cancers during 2005 and 2014.Methods: A total of 144 secondary and tertiary hospitals reported newly diagnosed cancer cases to Beijing Cancer Registry, which covers 13 million residents in Beijing. The cancer incidence rate was calculated in strata by cancer type, sex, age group and area. The population composition of China in 1982 and Segi's population structure were used to calculate age-standardized rates. Extensive procedures were used to assure the quality of the data.Results: The overall data quality indicators of the percentage of morphology verification(MV)(%), the percentage of death certificate-only(DCO)(%) and the mortality to incidence ratio(M/I) were 72.15%, 0.94% and0.54 respectively. A total of 45,300 new cancer cases were diagnosed in Beijing in 2014. The incidence rate was341.92/100,000(343.50/100,000 in males, 340.33/100,000 in females), and the age-standardized incidence rates by Chinese standard population(ASIRC) and by world standard population(ASIRW) were 143.48/100,000 and182.99/100,000, respectively. The cumulative incidence rate for cancer before 75 years was 20.61%. Cancers of lung, colorectum, liver, stomach and prostate were the top five common cancer types for males, while cancers of breast, lung, thyroid, colorectum and uterus were the top five common cancer types for females. The different patterns were also observed between rural and urban areas. Regarding temporal trends, the incidence of thyroid cancer has the fastest growth between 2005 and 2014. The incidence of liver cancer decreased, and stomach and esophageal cancer also decreased significantly for males in the last decade. Incidence rate for lung cancer was relatively stable during that period of time.Conclusions: With more than 45,000 new cases in Beijing in 2014, cancer remains an important public health problem. Actions should be taken to diminish total cancer incidence in Beijing. | Shuo Liu Lei Yang Yannan Yuan Huichao Li Jing Tian Sijia Lu Ning Wang Jiafu Ji | 2018 | Chinese Journal of Cancer Research2018，30，1： | 11 |
| 5 | Inhibition of miR-144-3p exacerbates non-small cell lung cancer progression by targeting CEP55显示文摘Increasing evidence has indicated that microRNA dysregulation is closely related to the occurrence and development of cancers.Herein,we investigated the relationship between miR-144-3p&CEP55 expression.We then evaluated the association between miR-144-3p&CEP55 expression,&proliferation,invasion&apoptosis of non-small cell lung cancer[NSCLC]cells.Real-time quantitative PCR results revealed that CEP55 was over-expressed whereas miR-144-3p was underexpressed in NSCLC tissues.CCK-8 assay,wound healing assay,&flow cytometry further revealed that overexpression of miR-144-3p significantly inhibited proliferation&migration,but promoted apoptosis of A549 cells.Conversely,inhibition of miR-144-3p promoted proliferation. | Ming Li Yannan Liu Xinglin Jiang Yuanxin Hang Haiying Wang Hang Liu Zhuo Chen Yubo Xiao | 2021 | Acta Biochimica et Biophysica Sinica2021，53，10： | 7 |
| 6 | A curve flow evolved by a fourth order parabolic equation显示文摘We study a fourth order curve flow, which is the gradient flow of a functional describing the shapes of human red blood cells. We prove that for any smooth closed initial curve in R2, the flow has a smooth solution for all time and the solution subconverges to a critical point of the functional. | LIU YanNan JIAN HuaiYu | 2009 | Science China Mathematics2009，52，10： | 6 |
| 7 | Secular trends in incidence of lung cancer by histological type in Beijing, China, 2000-2016显示文摘Objective: The objective of this study was to characterize secular trends in the sex-specific, age-standardized incidence of lung cancer by histological type in Beijing, China, from 2000 to 2016 based on data from a populationbased cancer registry.Methods: Data on the incidence of cancer from 2000 to 2016 were obtained from the Beijing Cancer Registry.We examined trends in the sex-specific, age-standardized incidence of lung cancer by histological type using a Joinpoint regression model.Results: A total of 117,409 cases of lung cancer were diagnosed from 2000 to 2016. Overall, 73,062(62.23%)patients were males. The most common histological type among both sexes was adenocarcinoma; however, the proportion of adenocarcinoma differed significantly between males and females(45.36% vs. 77.14%, respectively,P<0.0001). The age-standardized incidence of total lung cancer increased from 2000 to 2010 with an annual percent change(APC) of 2.2% [95% confidence interval(95% CI), 1.5% to 2.9%] and stabilized thereafter. Among males, the incidence of total lung cancer peaked in 2008 and then decreased slightly, with an APC of-1.1%(95%CI,-2.1% to-0.1%). Among females, the incidence increased continuously during the study period, with an APC of 1.4%(95% CI, 0.9% to 1.9%). The incidence of squamous cell carcinoma decreased significantly in recent years among both sexes, with APCs of-2.6%(95% CI,-4.5% to-0.6%) from 2007 to 2016 for males and-5.4%(95%CI,-7.2% to-3.6%) from 2004 to 2016 for females. In contrast, the incidence of adenocarcinoma increased continuously throughout the study period, by APCs of 4.0%(95% CI, 2.6% to 5.4%) for males and 6.2%(95% CI,4.8% to 7.6%) for females. The incidence of small cell carcinoma peaked in 2007 and stabilized thereafter among males, whereas it peaked in 2012 and then decreased with an APC of-14.7%(95% CI,-25.3% to-2.6%) among females. The incidence of large cell carcinoma and other specified malignant neoplasm did not change much,whereas the incidence of unspecified type decreased among both sexes during the study period.Conclusions: Although the incidence of squamous cell carcinoma decreased significantly among both sexes in recent years in Beijing, China, adenocarcinoma increased continuously throughout the study period among both sexes. Knowledge of differences in trends is useful for surveillance and control of lung cancer. However, the reason for the increase in adenocarcinoma remains unclear and warrants investigation. | Lei Yang Ning Wang Yannan Yuan Shuo Liu Huichao Li Jing Tian Jiafu Ji Aiguo Ren | 2019 | Chinese Journal of Cancer Research2019，31，2： | 6 |
| 8 | Systematics,Behavior and Living Environment of Shantungosaurus Giganteus(Dinosauria:Hadrosauridae)显示文摘根据 taphonomy,骨学的解剖和个体发生的变化, Zhuchengosaurus 敲奏编钟的一种技巧赵等, 2007 被认为是与 Shantungosaurus giganteus 胡,一起的 synonymic 1973 此处。这份报纸也处理 S 的生活行为。giganteus 和环境在哪个 S。giganteus 生活了。S。giganteus 被认为是一条陆上、群居的食草的恐龙并且与丰富的雨和繁荣的植被在温暖的天气在山和丘陵间的低地住在一起。 | JI Yannan WANG Xuri LIU Yongqing JI Qiang | 2011 | Acta Geologica Sinica(English Edition)2011，85，1： | 5 |
| 9 | Total ionizing dose effects and annealing behaviors of HfO2-based MOS capacitor显示文摘With the continuously scaling down of semiconductor technology,the traditional SiO_2as gate dielectric is approaching the physical and electrical limits.Some problems,such as the increasing leakage current and reliability issues,seriously affect the transistor performance[1].HfO_2 has been considered to be one of the reasonable alternative solutions due to a suitable dielectric constant(about 25),the relatively large band gap(5.68 e V) | Yannan XU Jinshun BI Gaobo XU Kai XI Bo LI Ming LIU | 2017 | Science China(Information Sciences)2017，60，12： | 4 |
| 10 | A biomimetic bi-layered tissue engineering scaffolds for osteochondral defects repair显示文摘Osteochondral defects are most commonly characterized by damages to both cartilage and underlying subchondral bone tissues,thus developing bi-layered scaffold that can concurrently regenerate these two specific lineages becomes challenge.In this study,the highly biomimetic bi-layered scaffolds were successfully prepared using human-like-collagen(HLC),hyaluronan(HA)and nano hydroxyapatite(HAP)particles,combined with'liquid phase synthesis'technology,freeze-drying and chemical crosslinking techniques,which was simulated the composition of natural extracellular matrix to repair osteochondral defects.This novel bilayer osteochondral graft had a seamlessly integrated layer structure,suitable pore size,high levels of porosity,and excellent mechanical properties.In vitro cell experiments of the bilayer scaffold indicated that the scaffold could promote the proliferation and adhesion of human bone marrow mesenchymal stem cells.In vivo osteochondral defects and micro-CT experiment revealed that bilayer scaffolds showed complete closure of the defect.Histology confirmed collagen and glycosaminoglycans were deposited in the new matrix of hyaline cartilage and bone in the bilayer scaffold group.Therefore,the developed bionic bilayer scaffold enhanced the regeneration of hyaline cartilage through subchondral bone formation and lateral host-tissue integration.In conclusion,this bilayer scaffold based on HLC could be used as the desired strategy for osteochondral defects regeneration. | LIU KaiQiang LIU YanNan DUAN ZhiGuang MA XiaoXuan FAN DaiDi | 2021 | Science China(Technological Sciences)2021，64，4： | 4 |
| 11 | In vivo oxidative stress alters thiol redox status of peroxiredoxin 1 and 6 and impairs rat sperm quality显示文摘氧化应力,在反应的氧种类(ROS ) 和抗氧化剂活动的生产之间的不平衡是男不孕的一个主要犯人。Peroxiredoxins (PRDX ) 由以一种剂量依赖者方式的 ROS 是哺乳动物的精子的主要抗氧化剂酶, thiol 被氧化并且使失去活性。他们的缺乏或 inactivation 与人不孕被联系了。这研究的目的是阐明氧化应力的影响,产生了由在里面老鼠 epididymal 精子上的 vivo tert 丁基 hydroperoxide (tert-BHP ) 处理在他们的成熟过程期间。成年 Sprague-Dawley 男性与 μ 被对待;鼹鼠 tert-BHP/kg 或盐(控制) 每为 15 天的天 intraperitoneal。类脂化合物 peroxidation (2-thibarbituric 酸反应物质试金) ,与 superoxide dismutase (草皮) 的全部的数量一起的 PRDX 的全部的数量和 thiol 氧化,活动性和 DNA 氧化(8-hydroxy-deoxyguanosine ) 在 epididymal 精子被决定。PRDX 和过氧化氢酶和 PRDX 的 thiol 氧化的全部的数量在头和尾 epididymis 被决定。当动物没被处理影响时,他们的 epididymal 精子减少了活动性, DNA 氧化的增加的层次和与增加的 PRDX 一起的类脂化合物 peroxidation (并且不草皮) 数量。而且,精子 PRDX 是高度, thiol 氧化了。在为 PRDX 建议一个片断特定的角色的 epididymis 在 PRDX1 和 PRDX6 的表示有一条微分规定。在结论, PRDX 在一次尝试在 epididymal 精子被增加与 tert-BHP 在 epididymis 产生的氧化压力斗争。这些调查结果在 epididymal 成熟期间在精子功能和 DNA 完整的保护加亮 PRDX 的角色。 | Yannan Liu Cristian O'Flaherty | 2017 | Asian Journal of Andrology2017，19，1： | 3 |
| 12 | 控制气管插管套囊压力与术后并发症关系的多中心研究显示文摘背景与气管插管相关的术后呼吸系统并发症通常表现为咳嗽、咽喉痛、声嘶、痰中带血。该研究中,我们研究了短时间(数小时)测量和控制气管插管套囊(endotracheal tube cuff,ETrc)压力对术后并发症的影响。方法选择中国上海4所大学附属三级医院拟在全身麻醉下行择期手术的患者509例,分为不测量ETTc压力的对照组和测量并调整ETTc压力的研究组,记录手术时间和插管时间。每组选择插管时间在120—180分钟的20例患者,拔管后即刻行纤维支气管镜检查。拔管后24小时记录咳嗽、咽喉痛、声嘶、痰中带血等气管插管相关并发症。结果两组间性别、年龄、身高、体重、手术时间和插管时问均无显著性差异。研究组调整前通过触摸指示气囊估计的平均ETTc压力为43±23.3mmHg(最高210mmHg),调整后为20±3.1mmHg(P〈0.001)。对照组术后咽喉痛、声嘶、痰中带血的发生率明显高于研究组。随着插管时间的增加,对照组中咽喉痛和痰中带血的发生率增加。研究组中咽喉痛的发生率也随插管时间增加而增加。对40例患者的纤维支气管镜检查结果显示支气管黏膜均有不同程度的损伤,对照组的损伤比研究组更严重。结论依据个人经验通过触捏估计ETTc压力明显高于测量结果或最适压力。即使在短时间(1—3小时)手术中,通过压力计合理控制ETTc压也有助于减少E]丌相关的咳嗽、咽喉痛、声嘶、痰中带血等术后呼吸系统并发症。 | Jianhui Liu Xiaoqing Zhang Wei Gong Shitong Li Fen Wang Shukun Fu Mazhong Zhang Yannan Hang 安博(译) 杜金(校) | 2013 | 麻醉与镇痛2013，，1： | 3 |
| 13 | Recent advances in systemic and local delivery of ginsenosides using nanoparticles and nanofibers显示文摘Ginsenosides are the main pharmacologically active constituents of ginseng which have been used in East Asian countries for centuries to modulate blood pressure,metabolism and immune function.Following the technological advances in isolation,purification and mass production,their mechanisms of action are gradually elucidated,providing solid basis for clinical applications.Ginseng extracts(total ginsenosides)and ginsenoside Rg3,CK,Rd have been marketed or entered clinical trials as drugs or dietary supplements.Despite the proven safety and efficacy of some ginsenosides,their applications are hindered by inferior pharmacokinetics such as low solubility,poor membrane permeability and metabolic instability.Nanoparticle formulation of drugs and implantable drug depots are effective strategies to improve the pharmacokinetics of therapeutic agents by enhancing solubility,providing protection,facilitating intracellular transport,and enabling sustained and controlled release.This mini-review summarizes the recent advances in systemic delivery of ginsenosides using liposomes,micelles,albumin-based nanoparticles,and inorganic nanoparticles,as well as local delivery of ginsenosides by electronspun fibrous membranes and hydrogels. | Jing Zhao Zhiguang Duan Xiaoxuan Ma Yannan Liu Daidi Fan | 2021 | Chinese Journal of Chemical Engineering2021，34，2： | 3 |
| 14 | Total ionizing dose effects on graphene-based charge-trapping memory显示文摘This study investigates the total ionizing dose effects in graphene-based charge-trapping memory(GCTM) capacitors by using60 Co γ-irradiation. Electrical properties including C-V hysteresis window,gate leakage current, and flat band voltage shifts are evaluated with ionizing dose levels up to 1 Mrad(Si).The C-V hysteresis memory window is hardly affected by the irradiation. The gate leakage current increases with the increase of ionizing dose due to the multiple-trap assisted tunneling mechanism. Significant electrical degrade of the devices in programmed and erased states has been observed with the increase of the dose levels. Mechanisms behind the degradation are attributed to the photo-emission in the graphene nanodisc charge-trapping sets, radiation-induced holes trapping in the peripheral oxides, and the recombination of the stored electrons with the radiation-induced holes. | Kai XI Jinshun BI Sandip MAJUMDAR Bo LI Jing LIU Yannan XU Ming LIU | 2019 | Science China(Information Sciences)2019，62，12： | 2 |
| 15 | Dissecting the genome of star fruit(Averrhoa carambola L.)显示文摘Averrhoa carambola is commonly known as star fruit because of its peculiar shape,and its fruit is a rich source of minerals and vitamins.It is also used in traditional medicines in countries such as India,China,the Philippines,and Brazil for treating various ailments,including fever,diarrhea,vomiting,and skin disease.Here,we present the first draft genome of the Oxalidaceae family,with an assembled genome size of 470.51 Mb.In total,24,726 protein-coding genes were identified,and 16,490 genes were annotated using various well-known databases.The phylogenomic analysis confirmed the evolutionary position of the Oxalidaceae family.Based on the gene functional annotations,we also identified enzymes that may be involved in important nutritional pathways in the star fruit genome.Overall,the data from this first sequenced genome in the Oxalidaceae family provide an essential resource for nutritional,medicinal,and cultivational studies of the economically important star-fruit plant. | Yannan Fan Sunil Kumar Sahu Ting Yang Weixue Mu Jinpu Wei Le Cheng Jinlong Yang Ranchang Mu Jie Liu Jianming Zhao Yuxian Zhao Xun Xu Xin Liu Huan Liu | 2020 | Horticulture Research2020，7，1： | 2 |
| 16 | 3UVH2 and SUVH9 Couple Two Essential Steps For Transcriptional Gene Silencing in Arabidopsis显示文摘在 Arabidopsis,一条指导 RNA 的 DNA methylation 小径(RdDM ) 为 DNA methylation 的 de novo 建立负责并且贡献 transcriptional 基因 silencing。最近, microrchidia (MORC ) 类型 ATPases 被显示在由调整高顺序的染色质建筑学的形成强制基因和 transposons 的一个子集的 transcriptional 基因 silencing 起必要作用。然而, MORC 蛋白质怎么与 RdDM 小径部件合作调整基因表示,仍然保持大部分不清楚。在这研究, SUVH9 和 MORC6 从一屏蔽 idm1 的 suppressors 被识别,它是在活跃 DNA demethylation 的一个变异的有缺陷者。没有提高 DNA methylation 层次, SUVH9 和 MORC6 为二记者基因和一些内长的基因的 silencing 被要求。SUVH9,苏(增值商) 3-9 相当或相同的事物之一在 RdDM 包含了,直接与 MORC6 和它的二个靠近的相当或相同的事物交往, MORC1 和 MORC2。类似于 MORC6, SUVH9 和它的相当或相同的事物 SUVH2 在 SDC 和 Solo-LTR loci 为 heterochromatin 冷凝作用和 3D 染色质建筑学的形成被要求。我们建议 SUVH2 和 SUVH9 绑在 methylated DNA 并且与 MORC 蛋白质联合便于改变染色质的建筑群的招募到目标 loci。 | Yuqing Jing Han Sun Wei Yuan Yue Wang Qi Li Yannan Liu Yan Li Weiqiang Qian | 2016 | Molecular Plant2016，9，8： | 2 |
| 17 | A chromosome-level genome assembly of rugged rose (Rosa rugosa) provides insights into its evolution, ecology, and floral characteristics显示文摘Rosa rugosa,commonly known as rugged rose,is a perennial ornamental shrub.It produces beautiful flowers with a mild fragrance and colorful seed pods.Unlike many other cultivated roses,R.rugosa adapts to a wide range of habitat types and harsh environmental conditions such as salinity,alkaline,shade,drought,high humidity,and frigid temperatures.Here,we produced and analyzed a high-quality genome sequence for R.rugosa to understand its ecology,floral characteristics and evolution.PacBio HiFi reads were initially used to construct the draft genome of R.rugosa,and then Hi-C sequencing was applied to assemble the contigs into 7 chromosomes.We obtained a 382.6Mb genome encoding 39,704 protein-coding genes.The genome of R.rugosa appears to be conserved with no additional whole-genome duplication after the gamma whole-genome triplication(WGT),which occurred~100 million years ago in the ancestor of core eudicots.Based on a comparative analysis of the high-quality genome assembly of R.rugosa and other high-quality Rosaceae genomes,we found a unique large inverted segment in the Chinese rose R.chinensis and a retroposition in strawberry caused by post-WGT events.We also found that floral development-and stress response signaling-related gene modules were retained after the WGT.Two MADS-box genes involved in floral development and the stress-related transcription factors DREB2A-INTERACTING PROTEIN 2(DRIP2)and PEPTIDE TRANSPORTER 3(PTR3)were found to be positively selected in evolution,which may have contributed to the unique ability of this plant to adapt to harsh environments.In summary,the high-quality genome sequence of R.rugosa provides a map for genetic studies and molecular breeding of this plant and enables comparative genomic studies of Rosa in the near future. | Fei Chen Liyao Su Shuaiya Hu Jia-Yu Xue Hui Liu Guanhua Liu Yifan Jiang Jianke Du Yushan Qiao Yannan Fan Huan Liu Qi Yang Wenjie Lu Zhu-Qing Shao Jian Zhang Liangsheng Zhang Feng Chen Zong-Ming(Max)Cheng | 2021 | Horticulture Research2021，8，1： | 2 |
| 18 | Quenching rate constants for metastable molecule PC1(b^1∑^+,v' = 0)显示文摘IN this decade, great attention has been paid to PCl(b1∑+) because of its potential importance in chemical laser. Coxon et al. studied the reaction of Ar(3Po,2) with PCl3 and observed two band systems of PCl(A3Ⅱ→X3∑-) and (b1∑+→X3∑-). Beielefeld et al. and Setser et al. measured the radiative lifetime of PCl(b1∑+) and its quenching rate constants for some small molecule quenchers. Recently, we have prepared a clean source of PCl(b,υ′= O) in | LIU Chuanpu, ZOU Shengli, GUO Jingzhong, GU Yueshu, CAO Dezhao and CHU Yannan Department of Chemistry, Shandong University, Jinan 250100, China Anhui Institute of Optics and Fine Mechanics, Chinese Academy of Sciences, Hefei 230031, China | 1997 | Chinese Science Bulletin1997，42，17： | 2 |
| 19 | Lineage tracing reveals the origin of Nestin-positive cells are heterogeneous and rarely from ependymal cells after spinal cord injury显示文摘Nestin is expressed extensively in neural stem/progenitor cells during neural development, but its expression is mainly restricted to the ependymal cells in the adult spinal cord. After spinal cord injury(SCI), Nestin expression is reactivated and Nestinpositive(Nestin;) cells aggregate at the injury site. However, the derivation of Nestin;cells is not clearly defined. Here, we found that Nestin expression was substantially increased in the lesion edge and lesion core after SCI. Using a tamoxifen inducible CreER(T2)-loxP system, we verified that ependymal cells contribute few Nestin;cells either to the lesion core or the lesion edge after SCI. In the lesion edge, GFAP+astrocytes were the main cell type that expressed Nestin;they then formed an astrocyte scar.In the lesion core, Nestin;cells expressed αSMA or Desmin, indicating that they might be derived from pericytes. Our results reveal that Nestin;cells in the lesion core and edge came from various cell types and rarely from ependymal cells after complete transected SCI, which may provide new insights into SCI repair. | Xiaoyu Xue Muya Shu Zhifeng Xiao Yannan Zhao Xing Li Haipeng Zhang Yongheng Fan Xianming Wu Bing Chen Bai Xu Yaming Yang Weiyuan Liu Sumei Liu Jianwu Dai | 2022 | Science China(Life Sciences)2022，65，4： | 2 |
| 20 | GPP(composition of Ganoderma lucidum polysaccharides and Polyporus umbellatus polysaccharides) protects against DSS-induced murine colitis by enhancing immune function and regulating intestinal flora显示文摘Previous study have demonstrated that a compound composed of water-soluable Ganoderma lucidum polysaccharides(GLP)and Polyporus umbellatus polysaccharides(PUP)in a ratio of 3:1 named GPP enhances innate immune function in mice through enhancing the function of macrophage cells and activity of natural killer(NK)cells.Here in our research,we further investigated the effect of GPP on the diversity and composition of intestinal flora,and explored its effect on colitis model mice.The immunoregulatory verification experiments of GPP were conducted in both normal and DSS-induced mice model.Our research showed that GPP increased the diversity of intestinal microorganisms in mice with the extension of administration time.Daily GPP intake attenuated DSS-induced colon injury,protected the splenic lymphocyte proliferation ability,enhanced the serum hemolysin synthesis,and increased peripheral phagocytes and NK cell activity in model mice.Comparisons of the predominant gene pathways of the bacterial microbiota showed that DNA repair and recombination,base mismatch repair pathways was stronger in GPP-treatment group than in control group,indicating the possible molecular mechanisms of immune function regulation.Our study showed that GPP regulated immune function in both health and colitis model,and had a positive effect on maintaining intestinal flora homeostasis. | Liyuan Li Yannan Guo Qing Huang Xiaojin Shi Qingqing Liu Fang Wang Qingfei Liu Kang Yu Zhao Wang | 2022 | Food Science and Human Wellness2022，11，4： | 2 |
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