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| 1 | A Robust CRISPR/Cas9 System for Convenient, High-Efficiency Multiplex Genome Editing in Monocot and Dicot Plants显示文摘CRISPR/Cas9 染色体指向系统被用于许多种类。然而,为植物报导的 mostCRISPR/Cas9 系统能仅仅修改一个或一些指向地点。这里,我们报导一个柔韧的 CRISPR/Cas9 向量系统,利用植物 codon 优化了 Cas9 基因,为方便、高效率的复合染色体在 monocot 和 dicot 植物编辑。我们设计了基于 PCR 的过程很快产生多重 sgRNA 表达式盒子,它能在一个轮由金门结扎或吉布森汇编克隆被装配进二进制 CRISPR/Cas9 向量。与这个系统,我们与 85.4% 变化评估的一般水准在米饭编辑了 46 个目标地点,主要在 biallelic 和同型结合的地位。我们推想在米饭的大约 16% 同型结合的变化通过相应基于再结合的修理跟随的非相应的加入结束的机制被产生。我们也获得了一致 biallelic,在 Arabidopsis T 1 植物的异质接合、同型结合、妄想的变化。在米饭和 Arabidopsis 的指向的变化是可继承的。我们在 T 0 米饭和 T 1 由同时的指向的 Arabidopsis 植物多重(多达八) 一个基因家庭,在一条 biosynthetic 小径的多重基因,或在单个基因的多重地点的成员。这个系统为为基本研究和基因改进在植物学习多重基因和基因家庭的功能提供了一个万用的工具箱。 | Xingliang Ma Qunyu Zhang Qinlong Zhu Wei Liu Yan Chen Rong Qiu Bin Wang Zhongfang Yang Heying Li Yuru Lin Yongyao Xie Rongxin Shen Shuifu Chen Zhi Wang Yuanling Chen Jingxin Guo Letian Chen Xiucai Zhao Zhicheng Dong Yao-Guang Liu | 2015 | Molecular Plant2015，8，8： | 272 |
| 2 | Massive individual orbital angular momentum channels for multiplexing enabled by Dammann gratings显示文摘Data transmission rates in optical communication systems are approaching the limits of conventional multiplexing methods.Orbital angular momentum(OAM)in optical vortex beams offers a new degree of freedom and the potential to increase the capacity of free-space optical communication systems,with OAM beams acting as information carriers for OAM division multiplexing(OAM-DM).We demonstrate independent collinear OAM channel generation,transmission and simultaneous detection using Dammann optical vortex gratings(DOVGs).We achieve 80/160 Tbit s^(-1) capacity with uniform power distributions along all channels,with 1600 individually modulated quadrature phase-shift keying(QPSK)/16-QAM data channels multiplexed by 10 OAM states,80 wavelengths and two polarizations.DOVG-enabled OAM multiplexing technology removes the bottleneck of massive OAM state parallel detection and offers an opportunity to raise optical communication systems capacity to Pbit s^(-1) level. | Ting Lei Meng Zhang Yuru Li Ping Jia Gordon Ning Liu Xiaogeng Xu Zhaohui Li Changjun Min Jiao Lin Changyuan Yu Hanben Niu Xiaocong Yuan | 2015 | Light(Science & Applications)2015，4，1： | 47 |
| 3 | The chromosome-level reference genome assembly for Panax notoginseng and insights into ginsenoside biosynthesis显示文摘Panax notoginseng,a perennial herb of the genus Panax in the family Araliaceae,has played an important role in clinical treatment in China for thousands of years because of its extensive pharmacological effects.Here,we report a high-quality reference genome of P.notoginseng,with a genome size up to 2.66 Gb and a contig N50 of 1.12 Mb,produced with third-generation PacBio sequencing technology.This is the first chromosome-level genome assembly for the genus Panax.Through genome evolution analysis,we explored phylogenetic and whole-genome duplication events and examined their impact on saponin biosynthesis.We performed a detailed transcriptional analysis of P.notoginseng and explored genelevel mechanisms that regulate the formation of characteristic tubercles.Next,we studied the biosynthesis and regulation of saponins at temporal and spatial levels.We combined multi-omics data to identify genes that encode key enzymes in the P.notoginseng terpenoid biosynthetic pathway.Finally,we identified five glycosyltransferase genes whose products catalyzed the formation of different ginsenosides in P.notoginseng.The genetic information obtained in this study provides a resource for further exploration of the growth characteristics,cultivation,breeding,and saponin biosynthesis of P.notoginseng. | Zhouqian Jiang Lichan Tu Weifei Yang Yifeng Zhang Tianyuan Hu Baowei Ma Yun Lu Xiuming Cui Jie Gao Xiaoyi Wu Yuru Tong Jiawei Zhou Yadi Song Yuan Liu Nan Liu Luqi Huang Wei Gao | 2021 | Plant Communications2021，2，1： | 11 |
| 4 | ECONOMIC GROWTH AND CYCLES IN MODERN CHINA显示文摘If the theory of cyclical fluctuation can be applied to modern China, the economic development ofChina in this period can be seen as consisting of several stages. At each stage as well as in the wholeperiod, chosen index system is likely to help measure the growth rate. By vertical and horizontal com-parison, this paper will try to settle the disputes on China’s modern economic development. | Liu Foding Wang Yuru Yu Jianwei 1937- Professor of Institute of Economics of NANKAI UNIVERSITY. Supervisor to Ph. D. candidates Ph. D. of Economics. Associate Professor of Institute of Economics of NANKAI UNIVERSITY Master of economics. Lecturer of Department of Economics atSICHUAN UNIVERSITY | 1994 | 南开经济研究1994，，S3： | 6 |
| 5 | Change of Soil Organic Carbon after Cropland Afforestation in ′Beijing-Tianjin Sandstorm Source Control′ Program Area in China显示文摘Land use change is one of the major factors that affect soil organic carbon(SOC) variation and global carbon balance. However, the effects of land use change on SOC are always variable. In this study, using a series of paired-field experiments, we estimated the effects of revegetation types and environmental conditions on SOC stock and vertical distribution after replacement of cropland with poplar(Populus tomentosa) and korshinsk peashrub(Caragana korshinskii) in three climate regions(Chifeng City, Fengning City and Datong City of the ′Beijing-Tianjin Sandstorm Source Control′(BTSSC) program area. The results show that SOC sequestration rate ranges from 0.15 Mg/(ha·yr) to 3.76 Mg/(ha·yr) in the soil layer of 0–100 cm in early stage after cropland afforestation in the BTSSC program area. The SOC accumulation rates are the highest in Fengning for both the two vegetation types. Compared to C. korshinskii, P. tomentosa has greater effects on SOC accumulation in the three climate regions, but significantly greater effect only appears in Datong. The SOC density increases by 20%–111% and 15%–59% for P. tomentosa and 9%–63% and 0–73% for C. korshinskii in the 0–20 cm and 20–100 cm soil layers, respectively. Our results indicate that cropland afforestation not only affects SOC stock in the topsoil, but also has some effects on subsoil carbon. However, the effect of cropland afforestation on SOC accumulation varied with climate regions and revegetation types. Considering the large area of revegetation and relatively high SOC accumulation rate, SOC sequestration in the BTSSC program should contribute significantly to decrease the CO2 concentration in the atmosphere. | ZENG Xinhua ZHANG Wanjun LIU Xiuping CAO Jiansheng SHEN Huitao ZHAO Xin ZHANG Nan-nan BAI Yuru Yi Mei | 2014 | Chinese Geographical Science2014，24，4： | 6 |
| 6 | Molecular cloning and functional identification of sterol C24-methyltransferase gene from Tripterygium wilfordii显示文摘Sterol C24-methyltransferase(SMT) plays multiple important roles in plant growth and development. SMT1, which belongs to the family of transferases and transforms cycloartenol into 24-methylene cycloartenol, is involved in the biosynthesis of 24-methyl sterols. Here, we report the cloning and characterization of a cDNA encoding a sterol C24-methyltransferase from Tripterygium wilfordii(Tw SMT1). Tw SMT1(Gen Bank access number KU885950) is a 1530 bp cDNA with a 1041 bp open reading frame predicted to encode a 346-amino acid, 38.62 k Da protein. The polypeptide encoded by the SMT1 cDNA was expressed and purified as a recombinant protein from Escherichia coli(E. coli) and showed SMT activity. The expression of Tw SMT1 was highly up-regulated in T. wilfordii cell suspension cultures treated with methyl jasmonate(Me JA). Tissue expression pattern analysis showed higher expression in the phellem layer compared to the other four organs(leaf, stem, xylem and phloem), which is about ten times that of the lowest expression in leaf. The results are meaningful for the study of sterolbiosynthesis of T. wilfordii and will further lay the foundations for the research in regulating both the content of other main compounds and growth and development of T. wilfordii. | Hongyu Guan Yujun Zhao Ping Su Yuru Tong Yujia Liu Tianyuan Hu Yifeng Zhang Xianan Zhang Jia Li Xiaoyi Wu Luqi Huang Wei Gao | 2017 | Acta Pharmaceutica Sinica B2017，7，5： | 4 |
| 7 | Haptic display for virtual reality: progress and challenges显示文摘Immersion, interaction, and imagination are three features of virtual reality (VR). Existing VR systems possess fairly realistic visual and auditory feedbacks, and however, are poor with haptic feedback, by means of which human can perceive the physical world via abundant haptic properties. Haptic display is an interface aiming to enable bilateral signal communications between human and computer, and thus to greatly enhance the immersion and interaction of VR systems. This paper surveys the paradigm shift of haptic display occurred in the past 30 years, which is classified into three stages, including desktop haptics, surface haptics, and wearable haptics. The driving forces, key technologies and typical applications in each stage are critically reviewed. Toward the future high-fidelity VR interaction, research challenges are highlighted concerning handheld haptic device, multimodal haptic device, and high fidelity haptic rendering. In the end, the importance of understanding human haptic perception for designing effective haptic devices is addressed. | Dangxiao WANG Yuan GUO Shiyi LIU Yuru ZHANG Weiliang XU Jing XIAO | 2019 | Virtual Reality & Intelligent Hardware2019，1，2： | 2 |
| 8 | Histamine level and histamine-forming bacteria in dried fish products sold in Penghu island of Taiwan显示文摘 | HUANG Yuru LIU Kuanju HSIEH Htmgsheng | 2010 | Food Control2010，21，9： | 1 |
| 9 | Surface properties, aggregation behavior and micellization thermodynamics of a class of gemini surfactants with ethyl ammonium headgroups显示文摘 | Ting Lu Yuru Lan Chenjiang Liu Jianbin Huang Yilin Wang | 2012 | Journal of Colloid And Interface Science2012，，1： | 1 |
| 10 | Improving the positioning accuracy of a neurosurgical robot system显示文摘 | LIU Junchuan ZHANG Yuru | 2007 | IEEE/ASME Transactions on Mechtronics2007，12，5： | 1 |
| 11 | Lipase - catalyzed production of a bioactive terpene ester in supercritical carbon dioxide 显示文摘 | Liu Kuanju Huang Yuru | 2010 | Journal of Biotechnology2010，146，4： | 1 |
| 12 | Force modeling for tooth preparation in a dental training system显示文摘 | LIU Guanyang ZHANG Yuru TOWNSEND W T | 2008 | VirtualReality2008，12，3： | 1 |
| 13 | Emergence of a novel reassortant avian influenza virus(H10N3) in Eastern China with high pathogenicity and respiratory droplet transmissibility to mammals显示文摘Decades have passed since the first discovery of H10-subtype avian influenza virus(AIV) in chickens in 1949,and it has been detected in many species including mammals such as minks,pigs,seals and humans.Cases of human infections with H10N8viruses identified in China in 2013 have raised widespread attention.Two novel reassortant H10N3 viruses were isolated from chickens in December 2019 in eastern China during routine surveillance for AIVs.The internal genes of these viruses were derived from genotype S(G57) H9N2 and were consistent with H5N6,H7N9 and H10N8,which cause fatal infections in humans.Their viral pathogenicity and transmissibility were further studied in different animal models.The two H10N3 isolates had low pathogenicity in chickens and were transmitted between chickens via direct contact.These viruses were highly pathogenic in mice and could be transmitted between guinea pigs via direct contact and respiratory droplets.More importantly,these viruses can bind to both human-type SAα-2,6-Gal receptors and avian-type SAα-2,3-Gal receptors.Asymptomatic shedding in chickens and good adaptability to mammals of these H10N3 isolates would make it easier to transmit to humans and pose a threat to public health. | Kaituo Liu Pingyun Ding Yuru Pei Ruyi Gao Wenwen Han Huafen Zheng Zhuxing Ji Miao Cai Jinyuan Gu Xiuli Li Min Gu Jiao Hu Xiaowen Liu Shunlin Hu Pinghu Zhang Xiaobo Wang Xiaoquan Wang Xiufan Liu | 2022 | Science China(Life Sciences)2022，65，5： | 1 |
| 14 | MIDRIB AND LEDGE OF BAINITE IN A Cu-Zn-Al-Mn ALLOY显示文摘The bainitic transformation in a Cu-Zn-Al-Mn alloy has been examined with TEM.The re-sults show that the stacking faults and also the bainitic midrib are found at the beginning ofbainite formation in the alloy.The stacking fault planes can pass continuously through themidrib in bainite.The growth ledges occur at the broad faces and rims of bainite.The broadand narrow faces of th ledges are parallel to the fault plane and habit plane respectively.Boththeir Miller indices are {110}B2.The moving direction of ledges is parallel to the fault plane.It may be deduced that the bainite in alloy are initially formed by shear and the process ofgrowth are go verned by propagation o f fault planes. | HAN Ming CHEN Fumin CHEN Jinming CHEN Yuru LIU Wenxi Tianjin University,Tianjin,China CHEN Fumin Professor,Dept.of Material Science and Engineering,Tianjin University Tianjin 300072,China | 1990 | Acta Metallurgica Sinica(English Letters)1990，3，5： | 1 |
| 15 | Force modeling for tooth preparation in a dental training system显示文摘 | Guanyang Liu Yuru Zhang William T. Townsend | 2008 | Virtual Reality2008，，3： | 1 |
| 16 | Reduced cardiac output is associated with decreased mitochondrial efficiency in the non-ischemic ventricular wall of the acute myocardial-infarcted dog显示文摘心脏性的吃惊是在与尖锐心肌的梗塞(MI ) 就医的病人之中的死亡的领先的原因。为尖锐的泵失败理解机制因此是重要的。这研究的目的是在一个尖锐 MI 狗模型检验是否 mitochondrial 在 non-ischemic 墙区域以内的简历精力充沛的功能与泵失败被联系。前面的 MI 经由左前面的下降的结扎(男孩) 在狗被生产冠的动脉,那导致了大约 30% 左室的墙的一种犯尺寸。解开的血液动力学的地位, mitochondrial 功能,免费激进的生产和 mitochondrial 的大小蛋白质 3 (UCP3 ) 表示在 24 h 时期上被决定。血液动力学的大小揭示了 >
在在 24 h 帖子梗塞的心脏的输出的 50% 减小什么时候与基线相比。活体检视样品在尖锐梗塞期间从以后的 non-ischemic 墙被获得。当与在内的 ADP/O 比率相比一样有或没有十六酸酸(PA ) 取样时,为从在 6 h 和 24 h 的 non-ischemic 心肌层的孤立的线粒体的 ADP/O 比率被减少。GTP 抑制(PA ) 刺激了在从 non-ischemic 墙的孤立的线粒体的 4 呼吸在 6 h 和 24 h 增加了 7% 和 33% 的状态梗塞以后分别地什么时候与相比假冒并且梗塞前样品。这将建议线粒体被解开,这被从这些一样的活体检视样品在西方的污点上观察的 UCP3 表示的联系增加支持。从电子测量的冠的湾穴的血样品顺磁的回声(EPR ) 方法在 6 h 和 24 h 在基线上在反应的氧种类(ROS ) 显示出增加梗塞以后。在结论, mitochondrial 由于尖锐梗塞的简历精力充沛的 ADP/O 比率在 non-ischemic 墙以内是反常的。线粒体看起来精力充沛地被解开,这与衰退被联系泵功能。免费激进的生产可以与解开的正式就职被联系在线粒体的蛋白质。 | Zakaria A Almsherqi Craig S McLachlan Malgorzata B Slocinska Francis E Sluse Rachel Navet Nikolai Kocherginsky Iouri Kostetski Dong-Yun Shi Shan-Lin Liu Peter Mossop Yuru Deng | 2006 | Cell Research2006，16，3： | 1 |
| 17 | Force modeling for tooth preparation in a dental training system显示文摘 | Guanyang Liu Yuru Zhang William T. Townsend | 2008 | Virtual Reality2008，，3： | 1 |
| 18 | Adding power of artificial intelligence to situational awareness of large interconnections dominated by inverter‐based resources显示文摘Large‐scale power systems exhibit more complex dynamics due to the increasing inte-gration of inverter‐based resources(IBRs).Therefore,there is an urgent need to enhance the situational awareness capability for better monitoring and control of power grids dominated by IBRs.As a pioneering Wide‐Area Measurement System,FNET/GridEye has developed and implemented various advanced applications based on the collected synchrophasor measurements to enhance the situational awareness capability of large‐scale power grids.This study provides an overview of the latest progress of FNET/GridEye.The sensors,communication,and data servers are upgraded to handle ultra‐high density synchrophasor and point‐on‐wave data to monitor system dynamics with more details.More importantly,several artificial intelligence(AI)‐based advanced appli-cations are introduced,including AI‐based inertia estimation,AI‐based disturbance size and location estimation,AI‐based system stability assessment,and AI‐based data authentication. | Lin Zhu Yinfeng Zhao Yi Cui Shutang You Wenpeng Yu Shengyuan Liu He Yin Chang Chen Yuru Wu Wei Qiu Mirka Mandich Hongyu Li Adedasola Ademola Chengwen Zhang Chujie Zeng Xinlan Jia Weikang Wang Haoyu Yuan Huaiguang Jiang Jin Tan Yilu Liu | 2021 | High Voltage2021，6，6： | 0 |
| 19 | Glass-compatible and self-powered temperature alarm system by temperature-responsive organic manganese halides via backward energy transfer process显示文摘A pioneering glass-compatible transparent temperature alarm system self-powered by luminescent solar concentrators(LSCs) is reported.Single green-emitted organic manganese halides(OMHs) of PEA_(2)MnBr_(2)I_(2),which has a unique temperature-dependent backward energy transfer process from selftrapped state to^(4)T_(1)energy level of Mn,is used for triggering the temperature alarm.The LSC with redemitted CsPbI_(3)perovskite-polymer composite films on the glass substrate is used for power supply.The spectrally separated nature between the green-emitted OMHs for temperature alarm and red-emitted CsPbI3in LSC for power supply allows for probing the signal light of temperature-responsive OMHs without the interference of LSCs,making it possible to calibrate the temperature visually just by a self-powered brightness detection circuit with LED indicators.Taking advantage of LSC without hot spot effects plaguing the solar cells,as-prepared temperature alarm system can operate well on both sunny and cloudy day. | Pengfei Xia Fan Liu Yuru Duan Xuefang Hu Changgui Lu Shuhong Xu Chunlei Wang | 2023 | Journal of Energy Chemistry2023，，3： | 0 |
| 20 | Epithelial stem cells and niches in lung alveolar regeneration and diseases显示文摘Alveoli serve as the functional units of the lungs,responsible for the critical task of blood-gas exchange.Com-prising type I(AT1)and type II(AT2)cells,the alveolar epithelium is continuously subject to external aggressors like pathogens and airborne particles.As such,preserving lung function requires both the homeostatic renewal and reparative regeneration of this epithelial layer.Dysfunctions in these processes contribute to various lung diseases.Recent research has pinpointed specific cell subgroups that act as potential stem or progenitor cells for the alveolar epithelium during both homeostasis and regeneration.Additionally,endothelial cells,fibroblasts,and immune cells synergistically establish a nurturing microenvironment-or“niche”-that modulates these ep-ithelial stem cells.This review aims to consolidate the latest findings on the identities of these stem cells and the components of their niche,as well as the molecular mechanisms that govern them.Additionally,this article highlights diseases that arise due to perturbations in stem cell-niche interactions.We also discuss recent technical innovations that have catalyzed these discoveries.Specifically,this review underscores the heterogeneity,plastic-ity,and dynamic regulation of these stem cell-niche systems.It is our aspiration that a deeper understanding of the fundamental cellular and molecular mechanisms underlying alveolar homeostasis and regeneration will open avenues for identifying novel therapeutic targets for conditions such as chronic obstructive pulmonary disease(COPD),fibrosis,coronavirus disease 2019(COVID-19),and lung cancer. | Jilei Zhang Yuru Liu | 2024 | Chinese Medical Journal Pulmonary and Critical Care Medicine2024，2，1： | 0 |
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