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| 1 | Evolution of Sedimentation and Tectonics of the Youjiang Composite Basin, South China显示文摘Located at the southern margin of the South China plate, the Youjiang basin is a closely related to the NW- and NE-trending syndepositional faults in respect to the configuration and structure of the basin. The evolution of the Youjiang basin progressed through two stages. In the Hercynian period, the opening of the Ailaoshan-Honghe ocean basin gave rise to a number of NW-trending rift belts in the Youjiang area. During this period, deep-water sediments were dominant and the basin was possesed of the characteristics of the rift system of passive continental margins. In the early Indosinian after the Dongwu movement, the circum - Pacific tectonism led to a major change in the configuration and structure of the basin. In the meantime, the Ailaoshan ocean basin began to be subducted towards the northeast, thus causing the basin to be split and expand again, and then the basin developed into the stage of the back -arc basin. At the end of the Indosinian period, the basin gradually closed from east to west, | Zeng Yunfu, Liu Wenjun, Cheng Hongde, Zheng Rongcai, Zhang Jinquan Chengdu Institute of Technology, Chengdu, SichuanLi Xiaoquan and Jiang Tingcao Regional Geological Survey Party of Guangxi,Guilin,Guangxi Jiang M inxi | 1995 | Acta Geologica Sinica(English Edition)1995，69，4： | 18 |
| 2 | Neuroprotective effect of ischemic preconditioning in focal cerebral infarction: relationship with upregulation of vascular endothelial growth factor显示文摘Neuroprotection by ischemic preconditioning has been confirmed by many studies, but the precise mechanism remains unclear. In the present study, we performed cerebral ischemic preconditioning in rats by simulating a transient ischemic attack twice(each a 20-minute occlusion of the middle cerebral artery) before inducing focal cerebral infarction(2 hour occlusion-reperfusion in the same artery). We also explored the mechanism underlying the neuroprotective effect of ischemic preconditioning. Seven days after occlusion-reperfusion, tetrazolium chloride staining and immunohistochemistry revealed that the infarct volume was significantly smaller in the group that underwent preconditioning than in the model group. Furthermore, vascular endothelial growth factor immunoreactivity was considerably greater in the hippocampal CA3 region of preconditioned rats than model rats. Our results suggest that the protective effects of ischemic preconditioning on focal cerebral infarction are associated with upregulation of vascular endothelial growth factor. | Yong Liu Suiqiang Zhu Yunfu Wang Jingquan Hu Lili Xu Li Ding Guangjian Liu | 2014 | Neural Regeneration Research2014，9，11： | 15 |
| 3 | Architecture design for reliable and reconfigurable FPGA-based GNC computer for deep space exploration显示文摘SRAM(static random access memory)-based FPGA(field programmable gate array), owing to its large capacity, high performance, and dynamical reconfiguration, has become an attractive platform for So PC(system on programmable chip) development. However, as the configuration memory and logic memory of the SRAM-based FPGA are highly susceptible to SEUs(single-event upsets) in deep space, it is a challenge to design and implement a highly reliable FPGA-based system for spacecraft, and no practical architecture has been proposed. In this paper, a new architecture for a reliable and reconfigurable FPGAbased computer in a highly critical GNC(guidance navigation and control) system is proposed. To mitigate the effect of an SEU on the system, multi-layer reconfiguration and multi-layer TMR(triple module redundancy) techniques are proposed, with a reliable reconfigurable real-time operating system(Space OS) managing the system level fault tolerance of the computer in the architecture. The proposed architecture for the reconfigurable FPGA-based computer has been implemented with COTS(commercial off the shelf) FPGA and has firstly been applied to the GNC system of a circumlunar return and reentry flight vehicle. The in-orbit results show that the proposed architecture is capable of meeting the requirements of high reliability and high availability, and can provide the expressive varying functionality and runtime flexibility for an FPGA-based GNC computer in deep space. | YANG MengFei LIU Bo GONG Jian LIU HongJin HU HongKai DONG YangYang SHI Lei ZHAO YunFu MIAO ZhiFu | 2016 | Science China(Technological Sciences)2016，59，2： | 10 |
| 4 | On the Carboniferous Sequence Stratigraphy in the Tazhong Area, Xinjiang——A Model of the Sequence Stratigraphy Framework of Intracratonic Depressional Basins显示文摘The Carboniferous prototype sedimentary basin in the Tazhong (Central Tarimbasin) area is recognized as a compressive intracratonic depressional one. Three type Ⅰ sequenceboundaries and three type Ⅱ sequence boundaries can be identified in the CarboniferousSystem, which can accordingly be divided into five sedimentary sequences. These sequencespossess stratigraphic characters of the standard sequence and correspond to the depositionalstratigraphic unit of a third-order eustatic cycle. They can be regionally or globally correlatedwith each other. The framework of sequence stratigraphy of the intracratonict basin in thestudy area distinctly differs from that of the passive continental-margin basin in the lack ofdepositional systems of early-middle lowstand, poor development of the deeply incised valleyand condensed section of the maximum sea-flood, good development of type Ⅱ sequenceboundaries and coastal plain depositional systems coexisting with shelf-type fan deltas underwet climatic conditions, Which consequently led to the formation of a paralic lithofacies frame-work. | Guo Jianhua Zeng Yunfu Zhai Yonghong and Gao Zhenzhong Jianghan Petroleum Institute, Jingsha, Hubei Chengdu Institute of Technology, Chengdu, Sichuan Jianghan Petroleum Institute, Jingsha, Hubei Liu Xinzhu | 1997 | Acta Geologica Sinica(English Edition)1997，71，3： | 4 |
| 5 | Subepicardial endothelial cells invade the embryonic ventricle wall to form coronary arteries显示文摘冠的动脉把血流动带到心肌肉。理解冠的动脉的发展程序提供卓见进冠的动脉疾病的治疗。多重来源被描述了为包括 proepicardium,湾穴 venosus (SV ) ,和心内膜贡献冠的动脉。然而,冠的容器的发展起源仍然在强烈学习下面。我们为学习冠的开发生产了一个新基因工具,一只 AplnCreER 老鼠在开发冠的容器明确地衬里 recombinase,它表示可诱导的 Cre。冠的开发和 AplnCreER 命运跟踪的预定正式就职的定量分析证明 subepicardial endothelial 房间(EC ) 的子孙两个都入侵紧缩的心肌层形成冠的动脉并且在表面上留下生产静脉。我们发现这些 subepicardial EC 是 intramyocardial 的主要来源在发展中的心的冠的容器。在 vitro 将生物的活组织移植于培养基中培养,试金显示这些 subepicardial EC 的多数从 SV 和中庭的心内膜,然而并非从室的心内膜产生。Apln 积极的房间的同种细胞的分析显示单个 subepicardial EC 同等地作出贡献到冠的动脉和静脉。一起,这些数据建议 subepicardial EC 是 intramyocardial 的主要来源在室的冠的动脉墙,和那冠的动脉和静脉在发展中的心有普通起源。 | Xueying Tian Tianyuan Hu Hui Zhang Lingjuan He Xiuzhen Huang Qiaozhen Liu Wei Yu Liang He Zhongzhou Yang Zhen Zhang Tao P Zhong Xiao Yang Zhen Yang Yan Yan Antonio Baldini Yunfu Sun Jie Lu Robert J Schwartz Sylvia M Evans Adriana C Gittenberger-de Groot Kristy Red-Horse Bin Zhou | 2013 | Cell Research2013，23，9： | 3 |
| 6 | Cyclin-dependent kinase 4 is a novel target in micoRNA-195-mediated cell cycle arrest in bladder cancer cells显示文摘 | Yiwei Lin Jian Wu Hong Chen Yeqing Mao Yunfu Liu Qiqi Mao Kai Yang Xiangyi Zheng Liping Xie | 2012 | FEBS Letters2012，，4： | 2 |
| 7 | Global antimicrobial resistance:a system-wide comprehensive investigation using the Global One Health Index显示文摘Background:Antimicrobial resistance(AMR)is one of the top ten global public health challenges.However,given the lack of a comprehensive assessment of worldwide AMR status,our objective is to develop a One Health-based system-wide evaluation tool on global AMR.Methods:We have further developed the three-hierarchical Global One Health Index(GOHI)-AMR indicator scheme,which consists of five key indicators,17 indicators,and 49 sub-indicators,by incorporating 146 countries'data from diverse authoritative databases,including WHO's Global Antimicrobial Resistance and Use Surveillance System(GLASS)and the European CDC.We investigated the overall-or sub-rankings of GOHI-AMR at the international/regional/national levels for data preprocessing and score calculation utilizing the existing GOHI methodology.Additionally,a correlation analysis was conducted between the GOHI-AMR and other socioeconomic factors.Results:The average GOHI-AMR score for 146 countries is 38.45.As expected,high-income countries(HICs)outperform the other three income groups on overall rankings and all five key indicators of GOHI-AMR,whereas lowincome countries unexpectedly outperform upper-middle-income countries and lower-middle-income countries on the antibiotics-resistant key indicator(ARR)and ARR-subordinate indicators,including carbapenem-,β-lactam-,and quinolone resistance,and even HICs on aminoglycoside resistance.There were no significant differences among the four groups on the environmental-monitoring indicator(P>0.05).GOHI-AMR was positively correlated with gross domestic product,life expectancy,and AMR-related publications,but negatively with natural growth rate and chronic respiratory disease.In contrast to Cyprus,the remarkably lower prevalence of'ESKAPE pathogens'in high-scoring Sweden and Denmark highlights Europe's huge gaps.China and Russia outperformed the other three BRICS countries on all key indicators,particularly India's ARR and Brazil's AMR laboratory network and coordination capacity.Furthermore,significant internal disparities in carbapenem-resistant Klebsiella pneumoniae(CRKP)and methicillin-resistant Staphylococcus aureus(MRSA)prevalence were observed between China and the USA,with MRSA prevalence both gradually declining,whereas CRKP prevalence has been declining in the USA but increasing in China,consistent with higher carbapenems-related indicator'performance in USA.Conclusions:GOHI-AMR is the most comprehensive tool currently available for the assessment of AMR status worldwide.We discovered unique features impacting AMR in each country and offered precise recommendations to improve the capacity to tackle AMR in low-ranking countries. | Nan Zhou Zile Cheng Xiaoxi Zhang Chao Lv Chaoyi Guo Haodong Liu Ke Dong Yan Zhang Chang Liu Yunfu Chang Sheng Chen Xiaokui Guo Xiao-Nong Zhou Min Li Yongzhang Zhu | 2022 | Infectious Diseases of Poverty2022，11，4： | 2 |
| 8 | Rapamycin reverses ferroptosis by increasing autophagy in MPTP/MPP+-induced models of Parkinson's disease显示文摘Parkinson’s disease is a neurodegenerative disorder,and fe rroptosis plays a significant role in the pathological mechanism underlying Parkinson’s disease.Rapamycin,an autophagy inducer,has been shown to have neuroprotective effects in Parkinson’s disease.However,the link between rapamycin and ferroptosis in Parkinson’s disease is not entirely clear.In this study,rapamycin was administe red to a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson’s disease mouse model and a 1-methyl-4-phenylpyridinium-induced Parkinson’s disease PC12 cell model.The results showed that rapamycin improved the behavioral symptoms of Parkinson’s disease model mice,reduced the loss of dopamine neurons in the substantia nigra pars compacta,and reduced the expression of ferroptosis-related indicators(glutathione peroxidase 4,recombinant solute carrier family 7,member 11,glutathione,malondialdehyde,and reactive oxygen species).In the Parkinson’s disease cell model,rapamycin improved cell viability and reduced ferro ptosis.The neuroprotective effect of rapamycin was attenuated by a ferroptosis inducer(methyl(1S,3R)-2-(2-chloroacetyl)-1-(4-methoxycarbonylphenyl)-1,3,4,9-tetrahyyridoindole-3-carboxylate)and an autophagy inhibitor(3-methyladenine).Inhibiting ferro ptosis by activating autophagy may be an important mechanism by which rapamycin exerts its neuroprotective effects.Therefo re,the regulation of ferroptosis and autophagy may provide a therapeutic target for drug treatments in Parkinson’s disease. | Tongyu Liu Peihan Wang Huan Yin Xiangfei Wang Jing Lv Jiang Yuan Jing Zhu Yunfu Wang | 2023 | Neural Regeneration Research2023，18，11： | 1 |
| 9 | Ionothermal synthesis and characterization of Li 2 MnSiO 4 /C composites as cathode materials for lithium-ion batteries显示文摘 | Xueliang Li Yunfu Liu Zhenghui Xiao Wei Guo Rui Zhang | 2014 | Ceramics International2014，，1： | 1 |
| 10 | License plate localiza- tion and character segmentation with feedback self- learning and hybrid binarization techniques 显示文摘 | Guo Jingming LIU Yunfu | 2008 | IEEE Transaction on Vehicular Technology2008，57，3： | 1 |
| 11 | MicroRNA-204 is required for differentiation of human-derived cardiomyocyte progenitor cells显示文摘 | Junjie Xiao Dandan Liang Hong Zhang Ying Liu Dasheng Zhang Yi Liu Lei Pan Xiaoli Chen Pieter A. Doevendans Yunfu Sun Xingqun Liang Joost P.G. Sluijter Yi-Han Chen | 2012 | Journal of Molecular and Cellular Cardiology2012，，6： | 1 |
| 12 | Hiding multitone watemarks in halftone images显示文摘 | Jingming Guo Yunfu Liu | | 0，，01： | 1 |
| 13 | Joint compression watermarking scheme using majority-parity guidance and halftoning-based block trun- cation coding显示文摘 | Guo Jingming Liu Yunfu | 2010 | IEEE Transactions on Image Processing2010，19，7： | 1 |
| 14 | Analysis of gas-particle flow characteristics in impinging streams显示文摘 | Liu Xiangdong Chen Yongping Chen Yunfu | 2014 | Chem Eng Process2014，79，： | 1 |
| 15 | License plate localization and character segmentation with feedback self-learning and hybrid binarization techniques显示文摘 | Guo Jingming Liu Yunfu | 2008 | IEEE Transactions on Vehicular Technology2008，57，3： | 1 |
| 16 | Inverse Halftoning Based on the Bayesian Theorem显示文摘 | Liu Yunfu Guo Jingming Lee Jiann Der | 2011 | IEEE Transactions on lmageProcessing2011，20，4： | 1 |
| 17 | Berberine targets the electron transport chain complex I and reveals the landscape of OXPHOS dependency in acute myeloid leukemia with IDH1 mutation显示文摘Metabolic reprogramming,a newly recognized trait of tumor biology,is an intensively studied prospect for oncology medicines.For numerous tumors and cancer cell subpopulations,oxidative phosphorylation(OXPHOS)is essential for their biosynthetic and bioenergetic functions.Cancer cells with mutations in isocitrate dehydrogenase 1(IDH1)exhibit differentiation arrest,epigenetic and transcriptional reprogramming,and sensitivity to mitochondrial OXPHOS inhibitors.In this study,we report that berberine,which is widely used in China to treat intestinal infections,acted solely at the mitochondrial electron transport chain(ETC)complex I,and that its association with IDH1 mutant inhibitor(IDH1^(m)i)AG-120 decreased mitochondrial activity and enhanced antileukemic effect in vitro and in vivo.Our study gives a scientific rationale for the therapy of IDH1 mutant acute myeloid leukemia(AML)patients using combinatory mitochondrial targeted medicines,particularly those who are resistant to or relapsing from IDH1m i. | HUANG Zhe SHEN Yunfu LIU Wenjun YANG Yan GUO Ling YAN Qin WEI Chengming GUO Qulian FAN Xianming MA Wenzhe | 2023 | Chinese Journal of Natural Medicines2023，21，2： | 0 |
| 18 | A Lower Ordovician Carbonate Contourite Drift on the Margin of the South China Paleocontinent at Jiuxi,Northern Hunan显示文摘Carbonate contourite drift at Jiuxi. Taoyuan, northern Hunan, was developed in a deepwater area ofnorthern Hunan on the margin of the Early Ordovician South China palcocontinent. The Lower Ordoviciansequence in the area is more than 350 m thick and contains well-developed contourites that can be groupedinto the following five types: the calcilutitic, the arenitic, the siltitic. the fine ruditic and the bioclastic. Thefirst three often constitute a complete or incomplete contourite succession. The arenitic contourite is nearlyuniformly distributed as interlayers throughout the succession, creating a monotonously rhythmic texture inthe contourite drift. The pattern of spatial distribution of the succession shows that the contourite drift is ahuge ridge-like sedimentary body extending along the trend of paleoslope. Numerous marks of flow direc-tion have pointed to an eastward paleoflow direction along the slope. | Duan Taizhong Guo Jianhua Gao Zhenzhong Li Zenghua Zeng Yunfu Jianghan Petroleum Institute, Shashi, Hubei Chengdu College of Geology, Sichuan Liu Linqun | 1990 | Acta Geologica Sinica(English Edition)1990，64，4： | 0 |
| 19 | Roles and Molecular Mechanisms of Biomarkers in Hepatocellular Carcinoma with Microvascular Invasion: A Review显示文摘Hepatocellular carcinoma(HCC)being a leading cause of cancer-related death,has high associated mortality and recurrence rates.It has been of great necessity and urgency to find effective HCC diagnosis and treatment measures.Studies have shown that microvascular invasion(MVI)is an independent risk factor for poor prognosis after hepatectomy.The abnormal expression of biomacromolecules such as circ-RNAs,lncRNAs,STIP1,and PD-L1 in HCC patients is strongly correlated with MVI.Deregulation of several markers mentioned in this review affects the proliferation,invasion,metastasis,EMT,and anti-apoptotic processes of HCC cells through multiple complex mechanisms.Therefore,these biomarkers may have an important clinical role and serve as promising interventional targets for HCC.In this review,we provide a comprehensive overview on the functions and regulatory mechanisms of MVI-related biomarkers in HCC. | Xudong Zhao Yudan Wang Haoming Xia Shuqiang Liu Ziyue Huang Risheng He Liang Yu Nanfeng Meng Hang Wang Junqi You Jinglin Li Judy Wai Ping Yam Yi Xu Yunfu Cui | 2023 | Journal of Clinical and Translational Hepatology2023，11，5： | 0 |
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