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| 1 | Heavy Metal Transfer from Soil to Vegetable in Southern Jiangsu Province, China显示文摘Vegetable fields in peri-urban areas receive large amounts of extraneous heavy metals because of rapid urbanization and industrialization in China. The concentrations of Cu, Zn, and Pb in 30 soil samples and 32 vegetable samples, collected from 30 different sites in southern Jiangsu Province of China, were measured and their transfer from soil to vegetable was determined. The results showed that the soil samples had wide ranges of pH (4.25–7.85) and electrical conductivity (EC) (0.24–3.42 dS m-1). Among the soil samples, there were four soil samples containing higher Cu and two soil samples containing higher Zn concentrations than those specified in the Chinese Soil Environmental Quality Standard II. However, no vegetable sample was found to contain a high level of Cu or Zn. In contrast, one vegetable sample contained 0.243 mg Pb kg-1 FW, which was above the Chinese Food Hygiene Standard, whereas the corresponding soil Pb concentration was lower than the Chinese Soil Environmental Quality Standard II. The transfer coefficients of Cu of all vegetable samples exceeded the suggested coefficient range, implying that extraneous Cu had high mobility and bioavailability to vegetables. There was no significant correlation between extractable soil heavy metal concentrations with four kinds of extractants and soil pH, EC, heavy metal concentrations in vegetables and soils, except that soil pH correlated well with the extractable soil Cu, Zn, and Pb concentrations with 1.0 mol L-1 NH4NO3. Moreover, diethylenetriamine pentaacetic acid (DTPA) extraction method was a more effcient method of extracting heavy metals from the soils independent of soil pH and EC than other three methods used. | HAO Xiu-Zhen ZHOU Dong-Mei HUANG De-Qian CANG Long ZHANG Hai-Lin WANG Hui | 2009 | Pedosphere2009，19，3： | 46 |
| 2 | Three-field vs two-field lymph node dissection for esophageal cancer:A meta-analysis显示文摘AIM:To assess the effects of 3-field lymphadenectomy for esophageal carcinoma.METHODS:We conducted a computerized literature search of the Pub Med,Cochrane Controlled Trials Register,and EMBASE databases from their inception to present.Randomized controlled trials(RCTs)or observational epidemiological studies(cohort studies)that compared the survival rates and/or postoperative complications between 2-field lymphadenectomy(2FL)and3-field lymphadenectomy(3FL)for esophageal carcinoma with R0 resection were included.Meta-analysis was conducted using published data on 3FL vs 2FL in esophageal carcinoma patients.End points were 1-,3-,and 5-year overall survival rates and postoperativecomplications,including recurrent nerve palsy,anastomosis leak,pulmonary complications,and chylothorax.Subgroup analysis was performed on the involvement of recurrent laryngeal lymph nodes.RESULTS:Two RCTs and 18 observational studies with over 7000 patients were included.There was a clear benefit for 3FL in the 1-(RR=1.16;95%CI:1.09-1.24;P<0.01),3-(RR=1.44;95%CI:1.19-1.75;P<0.01),and 5-year overall survival rates(RR=1.37;95%CI:1.18-1.59;P<0.01).For postoperative complications,3FL was associated with significantly more recurrent nerve palsy(RR=1.43;95%CI:1.28-1.60;P=0.02)and anastomosis leak(RR=1.26;95%CI:1.05-1.52;P=0.09).In contrast,there was no significant difference for pulmonary complications(RR=0.93;95%CI:0.75-1.16,random-effects model;P=0.27)or chylothorax(RR=0.77;95%CI:0.32-1.85;P=0.69).CONCLUSION:This meta-analysis shows that 3FL improves overall survival rate but has more complications.Because of the high heterogeneity among outcomes,definite conclusions are difficult to draw. | Guo-Wei Ma Dong-Rong Situ Qi-Long Ma Hao Long Lan-Jun Zhang Peng Lin Tie-Hua Rong | 2014 | World Journal of Gastroenterology2014，20，47： | 25 |
| 3 | miR-126 enhances the sensitivity of non-small cell lung cancer cells to anticancer agents by targeting vascular endothelial growth factor A显示文摘增加的证据建议 hsa-miR-126 (miR-126 ) 在房间衬里的非小的房间肺癌症(NSCLC ) 是下面调整的, miR-126 的恢复由指向特定的分子损害肿瘤房间增长,移植,侵略,和幸存。这里,我们第一次报导 miR-126 涉及调整 NSCLC 房间的反应到癌症化疗。在有 miR-126 的房间模仿的 transfected A549 或禁止者以后,我们发现 miR-126 的提高的水平显著地与减少的一半被联系 adriamycin ( ADM )和长春新碱的最大的禁止的集中, ADM 的增加的累积,脉管的 endothelial 生长因素 A ( VEGFA )和 multidrug 的下面规定联系抵抗的蛋白质 1 ( MRP1 ),并且 Akt 的 inactivation 发信号的小径。而且,提高了 miR-126 的表示压制了 A549 异种皮移植的生长并且禁止了 VEGFA 和 MRP1 的表示。miR-126 能高效地通过和 VEGFA 3-untranslated 区域的相互作用的下面调整 VEGFA 表示,而 VEGFA 的恢复能部分由 miR-126 稀释 MRP1 的抑制。然而, LY294002,表明小径的 PI3K/Akt 的一个禁止者,减少这效果,建议 miR-126 的那提高的表情通过发信号的 VEGF/PI3K/Akt/MRP1 的否定规定增加了 NSCLC 房间的敏感到 anticancer 代理人小径。 | Xiaolan Zhu Hao Li Lulu Long Lulu Hui Haining Chen Xuefeng Wang Huiling Shen Wenlin Xu | 2012 | Acta Biochimica et Biophysica Sinica2012，44，6： | 23 |
| 4 | A review of atmospheric mercury emissions, pollution and control in China显示文摘作为一种全球污染物质,水银在环境和人的健康上有重要影响。在中国的大气的水银排出物,污染和控制的当前的国家包括地在这份报纸被考察。与人为的水银排出物的大约 500800 t,中国贡献 25%40% 到全球水银排出物。在中国的主导的水银排放来源是煤燃烧,熔炼的非铁的金属,水泥生产和钢生产。从在中国的生来的来源的水银排出物等价于人为的水银排出物。在中国的大气的水银集中是乘诺思半球的背景水平的大约 210。在在中国的遥远的区域的水银免职流动通常在 1050 g 的范围吗? | Shuxiao WANG Lei ZHANG Long WANG Qingru WU FengyangWANG Jiming HAO | 2014 | Frontiers of Environmental Science & Engineering2014，8，5： | 20 |
| 5 | Eavesdropping in a quantum secret sharing protocol based on Grover algorithm and its solution显示文摘A detailed analysis has showed that the quantum secret sharing protocol based on the Grover algorithm (Phys Rev A, 2003, 68: 022306) is insecure. A dishonest receiver may obtain the full information without being detected. A quantum secret-sharing protocol is presents here, which mends the security loophole of the original secret-sharing protocol, and doubles the information capacity. | HAO Liang1, LI JunLin1 & LONG GuiLu1,2 1Key Laboratory for Atomic and Molecular NanoSciences and Department of Physics, Tsinghua University, Beijing 100084, China 2Tsinghua National Laboratory for Information Science and Technology, Beijing 100084, China | 2010 | Science China(Physics,Mechanics & Astronomy)2010，53，3： | 20 |
| 6 | Knockdown of survivin expression by siRNAs enhances chemosensitivity of prostate cancer cells and attenuates its tumorigenicity显示文摘Survivin, apoptosis 家庭蛋白质的禁止者的一个成员,为肿瘤房间生存能力在肿瘤房间和它的重要角色由于它的选择表示在癌症成为了一个吸引人的治疗学的目标。这里,我们在前列腺癌症房间显示出那基于向量的小介入 RNA (siRNAs ) silenced survivin 表情,导致显著地减少了房间增长并且提高了 apoptosis,并且增加了前列腺癌症房间(PC-3 ) 的敏感到导致 apoptosis 代理人, platinol。而且,有表示 siRNA 向量的 PC-3 房间 transfected 在 vivo 在裸体老鼠异种皮移植显示出更低的肿瘤形成。这些结果证明由 siRNA 的 survivin 表示的抑制稀释了前列腺癌症房间的恶意的显型,并且可以为雄激素无关的前列腺癌症的基因治疗提供一条新奇途径。 | Jianjun Shen Jiayun Liu Yin Long Yinye Miao Mingquan Su Qing Zhang Hua Han Xiaoke Hao | 2009 | Acta Biochimica et Biophysica Sinica2009，41，3： | 19 |
| 7 | Effectiveness of Different Waist Circumference Cut-off Values in Predicting Metabolic Syndrome Prevalence and Risk Factors in Adults in China显示文摘Objective To study the effectiveness of waist circumference cut-off values in predicting the prevalence of metabolic syndrome(MetS) and risk factors in adults in China. Methods A cross-sectional survey was condcuted in 14 provinces(autonomous region, municipality) in China. A total of 47 325 adults aged ≥20 years were selected by multistage stratified sampling, and questionnaire survey and physical and clinical examination were conducted among them. MetS was defined according to the International Diabetes Federation(IDF) criteria and modified IDF criteria.Results The age-standardized prevalence of MetS was 24.2%(22.1% in men and 25.8% in women) and 19.5%(22.1% in men and 18.0% in women) according to the IDF criteria and modified IDF criteria respectively. The age-standardized prevalence of pre-MetS was 8.1%(8.6% in men and 7.8% in women) according to the modified IDF criteria. The prevalence of MetS was higher in urban residents than rural residents and in northern China residents than in southern China residents. The prevalence of central obesity was about 30% in both men and women according to the ethnicity-specific cut-off values of waist circumference for central obesity(90 cm for men and 85 cm for women). Multivariate regression analysis revealed no significant difference in risk factors between the two MetS definitions. Conclusion Using both the modified IDF criteria and ethnicity-specific cut-off values of waist circumference can provide more useful information about the prevalence of MetS in China. | ZHOU Hai Cheng LAI Ya Xin SHAN Zhong Yan JIA Wei Ping YANG Wen Ying LU Ju Ming WENG Jian Ping JI Li Nong LIU Jie TIAN Hao Ming JI Qiu He ZHU Da Long CHEN Li GUO Xiao Hui ZHAO Zhi Gang Li Qiang ZHOU Zhi Guang GE Jia Pu SHAN Guang Liang | 2014 | Biomedical and Environmental Sciences2014，27，5： | 17 |
| 8 | High Serum Resistin Level may be an Indicator of the Severity of Coronary Disease in Acute Coronary Syndrome显示文摘Objective To investigate the correlation between serum resistin level, cardiovascular risk factors and severity of coronary disease in acute coronary syndrome (ACS). Methods After evaluated by clinical history, electrocardiography, exercise tolerance tests, laboratory tests, and coronary angiography, 220 consecutive patients with suspected chest pain were divided into normal control group, stable angina pectoris (SAP) group, and ACS group, respectively. Baseline clinical characteristics, including height, weight, waist circumference, hip circumference, white blood cell count, high-sensitive C-reactive protein (hsCRP), total cholesterol, triglyceride, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol, were compared among three groups. ELISA was used to detect serum resistin levels. Pearson's correlation coefficient analysis was used to assess association between resistin and other traditional cardiovascular risk factors. Multinomial logistic regression analyses were used to define the relationship between serum resistin level and SAP or ACS. Results Serum resistin level in ACS group (1.18±0.48 μg/L) was significantly higher than that in normal control and SAP groups (0.49±0.40 and 0.66±0.40 μg/L; P<0.01). Only in ACS group, increased serum resistin level was significantly correlated with hsCRP (r=0.262, P=0.004) and white blood cell count (r=0.347, P=0.001). Furthermore, serum resistin levels showed a stepwise increase with the number increase of > 50% stenosed coronary vessels. Multinomial logistic regression test demonstrated that serum resistin was a strong risk factor for ACS (OR=29.132, 95%CI: 10.939-77.581, P<0.001). Conclusion These findings suggested the potential role of resistin in atherosclerosis and especially its involvement in ACS. | Hao Wang De-you Chen Jian Cao Zuo-yun He Bing-po Zhu Min Long | 2009 | Chinese Medical Sciences Journal2009，24，3： | 16 |
| 9 | Novel Cold-adaptive Penicillium Strain FS010 Secreting Thermo-labile Xylanase Isolated from Yellow Sea显示文摘新奇寒冷适应的 xylanolytic 毛丛紧张 FS010 从黄海沉积被孤立。海洋的真菌从 4 ~ 20 度成长了很好;一更低(0 度) 或(37 度) 更高,温度限制它的生长。紧张作为毛丛 chrysogenum 被识别。与 mesophilic P 相比。chrysogenum,寒冷适应的真菌分泌了显示出高水疗院的寒冷活跃的 xylanase (XYL ) 在低温度(2-15 度) 的 lysin 的活动和到高温度(>50 度) 的高敏感。XYL 基因从寒冷适应的 P 被孤立。chrysogenum FS010 并且指定了为 xyl。xyl 编码的蛋白质的推出的氨基酸顺序与 glycoside 水疗院的顺序显示出高相同放射激光家庭 10。基因是克隆进表示向量 pGEX-4T-1 的潜水艇,编码蛋白质完了在 Escherichia 关口 i BL21 与 glutathione-S-transferase 表示了为熔化蛋白质。表示产品被净化并且使遭到了到酶的描述。为 recombinant XYL 的最佳的温度和 pH 是 25 度并且 5.5 分别地。Recombinant XYL 在 4 度显示出将近 80% 它的最大的活动并且在 pH 范围 3.0-9.5 是活跃的。 | Yun-Hua HOU Tian-Hong WANG Hao LONG Hui-Yuan ZHU | 2006 | Acta Biochimica et Biophysica Sinica2006，38，2： | 15 |
| 10 | Implementation and security analysis of practical quantum secure direct communication显示文摘Rapid development of supercomputers and the prospect of quantum computers are posing increasingly serious threats to the security of communication.Using the principles of quantum mechanics,quantum communication offers provable security of communication and is a promising solution to counter such threats.Quantum secure direct communication(QSDC)is one important branch of quantum communication.In contrast to other branches of quantum communication,it transmits secret information directly.Recently,remarkable progress has been made in proof-of-principle experimental demonstrations of QSDC.However,it remains a technical feat to bring QSDC into a practical application.Here,we report the implementation of a practical quantum secure communication system.The security is analyzed in the Wyner wiretap channel theory.The system uses a coding scheme of concatenation of lowdensity parity-check(LDPC)codes and works in a regime with a realistic environment of high noise and high loss.The present system operates with a repetition rate of 1 MHz at a distance of 1.5 kilometers.The secure communication rate is 50 bps,sufficient to effectively send text messages and reasonably sized files of images and sounds. | Ruoyang Qi Zhen Sun Zaisheng Lin Penghao Niu Wentao Hao Liyuan Song Qin Huang Jiancun Gao Liuguo Yin Gui-Lu Long | 2019 | Light(Science & Applications)2019，8，1： | 15 |
| 11 | Underestimated ^(14)C-based chronology of late Pleistocene high lake-level events over the Tibetan Plateau and adjacent areas: Evidence from the Qaidam Basin and Tengger Desert显示文摘The palaeolake evolution across the Tibetan Plateau and adjacent areas has been extensively studied, but the timing of late Pleistocene lake highstands remains controversial. Robust dating of lacustrine deposits is of importance in resolving this issue. This paper presents 14 C or optically stimulated luminescence(OSL) age estimates from two sets of late Quaternary lacustrine sequences in the Qaidam Basin and Tengger Desert(northeastern Tibetan Plateau). The updated dating results show:(1) the radiocarbon dating technique apparently underestimated the age of the strata of >30 ka BP in Qaidam Basin;(2) although OSL and 14 C dating agreed with each other for Holocene age samples in the Tengger Desert area, there was a significant offset in dating results of sediments older than ~30 ka BP, largely resulting from radiocarbon dating underestimation;(3) both cases imply that most of the published radiocarbon ages(e.g., older than ~30 ka BP) should be treated with caution and perhaps its geological implication should be revaluated; and(4) the high lake events on the Tibetan Plateau and adjacent areas, traditionally assigned to MIS 3a based on 14 C dating, are likely older than ~80 ka based on OSL chronology. | LONG Hao SHEN Ji | 2015 | Science China Earth Sciences2015，58，2： | 13 |
| 12 | Recurrent atrial tachycardia and atrial fribrillation after circumferential pulmonary vein ablation:What’s the difference?显示文摘Background Recurrent atrial tachyarrhythmia (ATa) after circumferential pulmonary vein ablation (CPVA) includes atrial tachycardia (AT) and atrial fribrillation (AF). However, whether there are some differences in clinical course and mechanisms between the recurrent AT and the recurrent AF remained unclear. This study was conducted to investigate the incidence, mechanism, clinical course of the recurrent AT and AF in patients under CPVA.Methods One hundred and thirty consecutive patients (M/F=95/35) with highly symptomatic and multiple antiarrhythmic drugs (AADs) refractory paroxysmal (n=91) or persistent (n=39) AF were included. The ablation protocol consisted solely of two continuous circular lesions around the ipsilateral pulmonary veins (PV) guided by CARTO system. The endpoint of CPVA is PV isolation. For patients with recurrent ATa within 2 months after the initial procedure, cardioversion with direct current was attempted if the ATa lasted for more than 24 hours. A repeat ablation procedure was performed only for patients with AADs refractory recurrent ATa and at least followed up for 2 months after the initial procedure.Results Within 2 months after the initial procedure, 52 patients (40.0%) had experienced episodes of symptomatic recurrent ATa. Among them, 23 patients (44.2%) with recurred AT alone (AT group), 14 patients (26.9%) with recurred AF alone (AF group), and 15 patients (28.8%) with recurred AT and AF (AT plus AF group). The delayed cure rate (65.2%) in AT group was significant higher than that in AF group (21.4%, P<0.05) and AF plus AT group (26.7%, P<0.05). A repeat ablation was performed in 21 patients, including 6 patients with recurrent AT alone, 8 patients with recurrent AF alone, and 7 patients with recurrent AF plus AT. The mean number of PV gaps was 1.2±0.4 in AT group, which was significantly lower than that in AF group (2.6±0.7, P<0.05) and AF plus AT group (2.0±0.6, P<0.05). Delayed cure rate and number of PV gaps between AF group and AF plus AT group were comparable (P>0.05).Conclusions Present study indicates that recurrent AT and AF after CPVA have the different clinical course and different electrophysiological findings during repeat procedure as follows: ⑴After CPVA, spontaneous resolution of recurrent ATa was mainly found in patients with recurrent AT alone (about two thirds patients). ⑵The type of recurrent ATa after CPVA is associated with the number of PV gaps. | LIU Xing-peng LONG De-yong DONG Jian-zeng LIU Xiao-qing FANG Dong-ping HAO Peng MA Chang-sheng | 2005 | Chinese Medical Journal2005，，21： | 13 |
| 13 | A study on arsenic trioxide inducing in vitro apoptosis of gastric cancer cell lines显示文摘INTRODUCTION Cell apoptosis,which involves the biologic regulation of the numbers and vital activity of cells,is an important metaboloc process in both normal cells and tumor cells. | Qin Long Gu Ning Li Li Zheng Gang Zhu Hao Ran Yin Yan Zhen Lin | 2000 | World Journal of Gastroenterology2000，6，3： | 12 |
| 14 | Seasonal and inter-annual variations in carbon fluxes and evapotranspiration over cotton field under drip irrigation with plastic mulch in an arid region of Northwest China显示文摘Xinjiang is the largest semi-arid and arid region in China, and drip irrigation under plastic mulch is widely used in this water-limited area. Quantifying carbon and water fluxes as well as investigating their environmental drivers over cotton fields is critical for understanding regional carbon and water budgets in Xinjiang, the largest cotton production basin of China. In this study, an eddy covariance(EC) technique was used to measure the carbon and water fluxes of cotton field under drip irrigation with plastic mulch in the growing seasons of 2009, 2010, 2012 and 2013 at Wulanwusu Agrometeorological Experiment Station, a representative oasis cropland in northern Xinjiang. The diurnal patterns of gross primary production(GPP), net ecosystem exchange(NEE) and evapotranspiration(ET) showed obviously sinusoidal variations from June to September, while the diurnal ecosystem respiration(Res) was stable between daytime and nighttime. The daytime hourly GPP and ET displayed asymptotic relationships with net solar radiation(Rnet), while showed concave patterns with raising vapor pressure deficit(VPD) and air temperature(Ta). The increases in hourly GPP and ET towards the maximum occurred over half ranges of VPD and Ta. The seasonal variations of GPP, NEE and ET were close to the cotton phenology, which almost reached the peak value in July. The cumulative GPP averaged 816.2±55.0 g C/m2 in the growing season(from April to October), and more than half of GPP was partitioned into NEE(mean value of –478.6±41.4 g C/m2). The mean seasonal ET was 501.3±13.9 mm, and the mean water use efficiency(WUE) was 1.0±0.1(mg C/g H2O)/d. The agro-ecosystem behaved as a carbon sink from squaring to harvest period, while it acted as a carbon source before the squaring time as well as after the harvest time. | Jie BAI Jin WANG Xi CHEN Ge Ping LUO Hao SHI Long Hui LI Jun Li LI | 2015 | Journal of Arid Land2015，7，2： | 12 |
| 15 | A Systemic Review of Autologous Fat Grafting Survival Rate and Related Severe Complications显示文摘 | Nan-Ze Yu Jiu-Zuo Huang Hao Zhang Yang Wang Xiao-Jun Wang Ru Zhao Ming Bai Xiao Long | 2015 | Chinese Medical Journal2015，，9： | 12 |
| 16 | Recent Progress in Dual-Polarization Radar Research and Applications in China显示文摘Dual-polarization(dual-pol)radar can measure additional parameters that provide more microphysical information of precipitation systems than those provided by conventional Doppler radar.The dual-pol parameters have been successfully utilized to investigate precipitation microphysics and improve radar quantitative precipitation estimation(QPE).The recent progress in dual-pol radar research and applications in China is summarized in four aspects.Firstly,the characteristics of several representative dual-pol radars are reviewed.Various approaches have been developed for radar data quality control,including calibration,attenuation correction,calculation of specific differential phase shift,and identification and removal of non-meteorological echoes.Using dual-pol radar measurements,the microphysical characteristics derived from raindrop size distribution retrieval,hydrometeor classification,and QPE is better understood in China.The limited number of studies in China that have sought to use dual-pol radar data to validate the microphysical parameterization and initialization of numerical models and assimilate dual-pol data into numerical models are summarized.The challenges of applying dual-pol data in numerical models and emerging technologies that may make significant impacts on the field of radar meteorology are discussed. | Kun ZHAO Hao HUANG Mingjun WANG Wen-Chau LEE Gang CHEN Long WEN Jing WEN Guifu ZHANG Ming XUE Zhengwei YANG Liping LIU Chong WU Zhiqun HU Sheng CHEN | 2019 | Advances in Atmospheric Sciences2019，36，9： | 12 |
| 17 | Effect of Different Amendments on Ryegrass Growth in Copper Mine Tailings显示文摘Montmorillonite, rice straw, organic manure and chemical fertilizer were used as amendment materials for copper mine tailings, and their effects on mine tailing pH, nutrients and metal availability to ryegrass were investigated. Chemical fertilization was the most effective one in improving ryegrass growth in mine tailings among the amendment materials examined. It was found that montmorillonite raised biomass of ryegrass at the 1st and 2nd cuts, but it did not give further positive effects at the 3rd and 4th cuts. The effect of organic materials on ryegrass growth was not so good as expected, mainly due to their slow decomposition in mine tailings with less soil microorganisms. Available Cu and Zn contents in mine tailings decreased in the presence of montmorillonite but increased when rice straw and organic manure were used as amendments. Cu and Zn contents in ryegrass decreased with increasing the rate of montmorillonite application but increased with the rate of rice straw. Zn showed much stronger mobility from soil to ryegrass than Cu, and almost all the available N and P in mine tailings, except for the treatments with organic manure, were completely consumed after ryegrass had grown in mine tailings for more than four months and been harvested for four times. Owing to its large biomass and high metal uptake, ryegrass is a potential plant for remediation of metal contaminated soils in practice. | HAO Xiu-Zhen, ZHOU Dong-Mei, WANG Yu-Jun, CANG Long and CHEN Huai-ManInstitute of Soil Science, the Chinese Academy of Sciences, Nanjing 210008 (China). E-mail: xzhao@issas. ac.cn | 2003 | Pedosphere2003，13，4： | 11 |
| 18 | Pd-Ag alloy hollow nanostructures with interatomic charge polarization for enhanced electrocatalytic formic acid oxidation显示文摘蚁的酸氧化是在膜(PEM ) 燃料细胞,活跃地点和种吸附 / 激活在玩调音的 protonexchange 的重要 electrocatalytic 反应角色。在这研究,我们为申请与高活跃的表面区域开发了空 Pd-Ag 合金 nanostructures 到 electrocatalytic 蚁的酸氧化。当 Ag 的某个数量被合并到 Pd 时格子,已经是为蚁的酸氧化的高度活跃的材料, electrocatalytic 活动能显著地被增加。是由理论模拟显示了,在 Pd 和 Ag 之间联合在 Pd 催化地点上导致极化费用,它能提高 HCOO 的吸附 * 种类。作为结果,设计 electrocatalysts 能完成减少的 Pd 用法并且同时提高催化性质。这研究代表同时制作空结构增加活跃地点的数字并且利用 interatomic 相互作用向改进 electrocatalytic 性能调节种类吸附 / 激活的一条途径。 | Dong Liu Maolin Xie Chengming wang Lingwen Liao Lu Qiu Jun Ma Hao Huang Ran Long Jun Jiang Yujie Xiong | 2016 | Nano Research2016，9，6： | 11 |
| 19 | Generation of a Hutchinson-Gilford progeria syndrome monkey model by base editing显示文摘Many human genetic diseases,including Hutchinson-Gilford progeria syndrome(HGPS),are caused by single point mutations.HGPS is a rare disorder that causes premature aging and is usually caused by a de novo point mutation in the LMNA gene.Base editors(BEs)composed of a cytidine deaminase fused to CRISPR/Cas9 nickase are highly efficient at inducing C to T base conversions in a programmable manner and can be used to generate animal disease models with single amino-acid substitutions.Here,we generated the first HGPS monkey model by delivering a BE mRNA and guide RNA(gRNA)targeting the LMNA gene via microinjection into monkey zygotes.Five out of six newborn monkeys carried the mutation specifically at the target site.HGPS monkeys expressed the toxic form of lamin A,progerin,and recapitulated the typical HGPS phenotypes including growth retardation,bone alterations,and vascular abnormalities.Thus,this monkey model genetically and clinically mimics HGPS in humans,demonstrating that the BE system can efficiently and accurately generate patient-specific disease models in non-human primates. | Fang Wang Weiqi Zhang Qiaoyan Yang Yu Kang Yanling Fan Jingkuan Wei Zunpeng Liu Shaoxing Dai Hao Li Zifan Li Lizhu Xu Chu Chu Jing Qu Chenyang Si Weizhi Ji Guang-Hui Liu Chengzu Long Yuyu Niu | 2020 | Protein & Cell2020，11，11： | 11 |
| 20 | Major advances in studies of the physical geography and living environment of China during the past 70 years and future prospects显示文摘The natural environment provides material essentials for human survival and development. The characteristics,processes, regional differentiation and forcing mechanisms of the elements of the natural environment(e.g. geomorphology,climate, hydrology, soil, etc.) are the main objects of research in physical geography. China has a complex natural environment and huge regional differentiation and therefore it provides outstanding reserach opportunities in physical geography. This review summarizes the most important developments and the main contributions of research in the physical geography and human living environment in China during the past 70 years. The major topics addressed are the uplift of the Tibetan Plateau and the evolution of its cryosphere, the development of fluvial systems, the acidification of the vast arid region of the Asian interior, variations in the monsoon and westerly climate systems on multiple timescales, the development of lakes and wetlands, the watershed system model, soil erosion, past human-environment interactions, biogeography, and physical geographic zonality. After briefly introducing international research developments, we review the history of research in physical geography in China, focusing on the major achievements and major academic debates, and finally we summarize the status of current research and the future prospects. We propose that in the context of the national demand for the construction of an ecological civilization, we should make full use of the research findings of physical geography, and determine the patterns and mechanisms of natural environmental processes in order to continue to promote the continued contribution of physical geography to national development strategies, and to further contribute to the theory of physical geography from a global perspective. | Fahu CHEN Bojie FU Jun XIA Duo WU Shaohong WU Yili ZHANG Hang SUN Yu LIU Xiaomin FANG Boqiang QIN Xin LI Tingjun ZHANG Baoyuan LIU Zhibao DONG Shugui HOU Lide TIAN Baiqing XU Guanghui DONG Jingyun ZHENG Wei YANG Xin WANG Zaijun LI Fei Wang Zhenbo HU Jie WANG Jianbao LIU Jianhui CHEN Wei HUANG Juzhi HOU Qiufang CAI Hao LONG Ming JIANG Yaxian HU Xiaoming FENG Xingguo MO Xiaoyan YANG Dongju ZHANG Xiuhong WANG Yunhe YIN Xiaochen LIU | 2019 | Science China Earth Sciences2019，62，11： | 11 |
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